检索结果-南通市图书馆

前列腺癌和癌前病灶中p53和bcl-2蛋白表达在移行区和非移行区的差异

在线全文

学校读者我要写书评

暂无评论

中华外科杂志 2001年第7期39卷 535-537页

作者：叶定伟李慧 land richard Jane Tseng 孙颖浩钱松溪郑家富马永江第二军医大学长海医院泌尿外科上海200433 第二军医大学长海医院内分泌科上海200433 美国UTMD Anderson癌症中心

目的　比较研究p5 3和bcl 2蛋白在前列腺移行区和非移行区 (即中央区和外周区 )内前列腺癌 (PCa)和高分级前列腺上皮内瘤 (PIN)细胞中的表达 ,探讨移行区和非移行区内PCa发病率和生物学行为差别的分子机制。　方法　采用免疫组织化学分... 详细信息

目的　比较研究p5 3和bcl 2蛋白在前列腺移行区和非移行区 (即中央区和外周区 )内前列腺癌 (PCa)和高分级前列腺上皮内瘤 (PIN)细胞中的表达 ,探讨移行区和非移行区内PCa发病率和生物学行为差别的分子机制。　方法　采用免疫组织化学分析 ,以 30例前列腺癌患者根治术切除标本作为检测对象 ,检测前列腺癌和高分级PIN细胞中p5 3和bcl 2蛋白的表达。　结果　共发现高分级PIN灶 97处和PCa灶 5 8处。在癌灶中p5 3蛋白表达非移行区内 (35 3% )明显高于移行区内(8 3% ,χ2 =4.2 0 9,P 0 .0 5 ) ;bcl 2蛋白表达在癌灶的非移行区内(2 3 5 % )也高于移行区内 (16 7% ) ,但差异无显著意义 (χ2 =0 .0 16 ,P >0 .0 5 ) ;高分级PIN灶中bcl 2蛋白表达在非移行区内 (85 5 % )高于移行区内 (75 % ,χ2 =0 .44 0 ,P >0 0 5 ) ,差异亦无显著意义。　结论　癌灶和高分级PIN灶在移行区和非移行区内p5 3和bcl

关键词：前列腺肿瘤前列腺上皮内瘤病癌基因癌前病灶 p53 bcl-2 基因表达

Bound and Resonating Multiquark Configurations

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2024年第8期41卷 8-12页

作者： Jean-Marc richard Institut de Physique des 2 Infinis de Lyon Université Claude Bernard(Lyon 1) CNRS-IN2P34 rue Enrico Fermi69622 VilleurbanneFrance

We review the predictions of quark models for multiquark configurations that are bound or resonant states,and compare different methods for estimating the properties of resonances.

关键词： quark Configuration resonant

RecBERT:Semantic recommendation engine with large language model enhanced query segmentation for k-nearest neighbors ranking retrieval

在线全文

学校读者我要写书评

暂无评论

Intelligent and Converged Networks 2024年第1期5卷 42-52页

作者： richard Wu the Dublin Unified School District and the SF Artificial Intelligence Club DublinCA 94568USA

The increasing amount of user traffic on Internet discussion forums has led to a huge amount of unstructured natural language data in the form of user *** modern recommendation systems rely on manual tagging,relying on administrators to label the features of a class,or story,which a user comment corresponds *** common approach is to use pre-trained word embeddings to compare class descriptions for textual similarity,then use a distance metric such as cosine similarity or Euclidean distance to find top k ***,neither approach is able to fully utilize this user-generated unstructured natural language data,reducing the scope of these recommendation *** paper studies the application of domain adaptation on a transformer for the set of user comments to be indexed,and the use of simple contrastive learning for the sentence transformer fine-tuning process to generate meaningful semantic embeddings for the various user comments that apply to each *** order to match a query containing content from multiple user comments belonging to the same class,the construction of a subquery channel for computing class-level similarity is *** channel uses query segmentation of the aggregate query into subqueries,performing k-nearest neighbors(KNN)search on each individual *** achieves state-of-the-art performance,outperforming other state-of-the-art models in accuracy,precision,recall,and F1 score for classifying comments between four and eight classes,*** outperforms the most precise state-of-the-art model(distilRoBERTa)in precision by 6.97%for matching comments between eight classes.

关键词： sentence transformer simple contrastive learning large language models query segmentation k-nearest neighbors

Near-infrared Emissive 1,2-Dioxetane-based Chemiluminescent Probes

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 2024年第5期40卷 806-823页

作者： Chen, Yingqi Budianta, richard Ning, Yingying South China Univ Technol Spin X Inst Sch Chem & Chem Engn Sch Biomed Sci & EngnState Key Lab Luminescent Ma Hong Kong 510641 Guangdong Peoples R China

Chemiluminescence, a phenomenon emitting light from chemical reactions rather than photon absorption, has gained significant interest for applications in bioimaging and biosensing due to its high sensitivity and low background interference. Now there is a growing interest in near-infrared (NIR) chemiluminescent probes for improved tissue penetration and reduced autofluorescence. This review summarizes NIR emissive chemiluminescent probes based on 1,2-dioxetane and discusses their chemical structures and applications. Structure modification strategies for red-shifting wavelength and enhancing brightness include incorporating electron-withdrawing groups, designing chemiluminophore-fluorophore cassettes, and exploring alternative chemiluminescent scaffolds. This review aims to inspire the exploration of NIR chemiluminescent probes in disease detection and treatment.

关键词： Chemiluminescence Near-infrared Dioxetane Bioimaging Biosensing RESONANCE ENERGY-TRANSFER ELECTRON-EXCHANGE LUMINESCENCE AGGREGATION-INDUCED EMISSION BICYCLIC DIOXETANES BEARING IN-VIVO PHOTODYNAMIC THERAPY SINGLET-OXYGEN TRANSFER CASSETTES BIOLUMINESCENCE GENERATION

Parameter-Free Shifted Laplacian Reconstruction for Multiple Kernel Clustering

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1072-1074页

作者： Xi Wu Zhenwen Ren F.richard Yu the School of National Defence Science and Technology Southwest University of Science and TechnologyMianyang 621010China the School of National Defence Science and Technology Southwest University of Science and TechnologyMianyang 621010 the Guangxi Key Laboratory of Machine Vision and Intelligent Control Wuzhou UniversityWuzhou 543002 the Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ) Shenzhen 518060China

Dear Editor,This letter proposes a parameter-free multiple kernel clustering(MKC)method by using shifted Laplacian *** MKC can effectively cluster nonlinear data,but it faces two main challenges:1)As an unsupervised method,it is up against parameter problems which makes the parameters intractable to tune and is unfeasible in real-life applications;2)Only considers the clustering information,but ignores the interference of noise within Laplacian.

关键词： parameter letter Parameter

Liver transplantation as an alternative for the treatment of non-resectable liver colorectal cancer: Advancing the therapeutic algorithm

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 154-159页

作者： Badi Rawashdeh richard Bell Abdul Hakeem Raj Prasad Division of Transplant Surgery Department of General SurgeryMedical College of WisconsinMilwaukeeWI53226USA Leeds Teaching Hospital LeedsUK

Colorectal cancer is a leading cause of cancerrelated mortality,with nearly half of the affected patients developing liver *** three decades,liver resection(LR)has been the primary curative strategy,yet its applicability is limited to about 20%of *** transplantation(LT)for unresectable metastases was attempted unsuccessfully in the 1990s,with high rates of perioperative death and *** is now more interest in this strategy due to improvements in systemic therapies and surgical techniques.A significant study conducted by the Oslo group showed that patients receiving liver transplants had a 60%chance of survival after five *** better results have been achieved by using advanced imaging for risk stratification and further refining selection criteria,especially in the Norvegian SECA *** review carefully charts the development and history of LT as a treatment option for colorectal cancer liver *** revolutionary path from the early days of exploratory surgery to the current situation of cautious optimism is traced,highlighting the critical clinical developments and improved patient selection standards that have made LT a potentially curative treatment for such challenging very well selected cases.

关键词： Liver transplantation Colorectal cancer liver metastases Non-resectable liver metastases

New analytical modelling of fractional generalized Kuramoto-Sivashinky equation via Atangana-Baleanu operator and J-transform method

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean Engineering and Science 2024年第1期9卷 66-88页

作者： Metonou richard Weidong Zhao Shehu Maitama School of Mathematics Shandong UniversityJinanShandongChina

In this paper,we propose a new analytical modelling of the well-known fractional generalized Kuramoto-Sivashinky equation(FGKSE)using fractional operator with non-singular kernel and the homotopy anal-ysis transform method via J-transform ***,using fixed-point theorem,we prove the existence and uniqueness of our proposed solution to the fractional Kuramoto-Sivashinky *** further val-idate the efficiency of the suggested technique,we proved the convergence analysis of the method and provide the error *** obtained solutions of the FGKSE,describing turbulence processes in the field of ocean engineering are analytically and numerically compared to show the behaviors of many parameters of the present model.

关键词： Homotopy analysis J-transform method J-transform method Fractional generalized Kuramoto-Sivashinky equation Fixed-point theorem Numeric-symbolic computation

Amino acid and mineral digestibility,bone ash,and plasma inositol is increased by including microbial phytase in diets for growing pigs

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第2期15卷 699-712页

作者： Liz Vanessa Lagos Mike richard Bedford Hans Henrik Stein Division of Nutritional Sciences University of IllinoisUrbanaIL 61801USA AB Vista Marlborough SN84ANUK

Background The effect of microbial phytase on amino acid and energy digestibility is not consistent in pigs,which may be related to the phytase dosage or the adaptation length to the ***,an experiment was conducted to test the hypotheses that increasing dietary phytase after an 18-day adaptation period:1)increases nutrient and energy digestibility;2)increases plasma P,plasma inositol,and bone ash of young pigs;and 3)demonstrates that maximum phytate degradation requires more phytase than maximum P *** Data indicated that increasing inclusion of phytase[0,250,500,1,000,2,000,and 4,000 phytase units(FTU)/kg feed]in corn-soybean meal-based diets increased apparent ileal digestibility(AID)of Trp(quadratic;P<0.05),and of Lys and Thr(linear;P<0.05),and tended to increase AID of Met(linear;P<0.10).Increasing dietary phytase also increased AID and apparent total tract digestibility(ATTD)of Ca and P(quadratic;P<0.05)and increased ATTD of K and Na(linear;P<0.05),but phytase did not influence the ATTD of Mg or gross *** of plasma P and bone ash increased(quadratic;P<0.05),and plasma inositol also increased(linear;P<0.05)with increasing inclusion of *** concentrations of inositol phosphate(IP)6 and IP5(quadratic;P<0.05),reduced IP4 and IP3(linear;P<0.05),but increased inositol concentrations(linear;P<0.05)were observed in ileal digesta as dietary phytase *** ATTD of P was maximized if at least 1,200 FTU/kg were used,whereas more than 4,000 FTU/kg were needed to maximize inositol *** Increasing dietary levels of phytase after an 18-day adaptation period increased phytate and IP ester degradation and inositol release in the small ***,increasing dietary phytase resulted in improved digestibility of Ca,P,K,Na,and the first 4 limiting amino acids,and in increased concentrations of bone ash and plasma P and *** a corn-soybean meal diet,maximum inositol release requires appr

关键词： Bone ash Inositol Nutrient digestibility Phytase Phytate degradation Pigs

p53和bcl-2在人前列腺癌和高分级前列腺上皮内瘤细胞中的表达及意义

在线全文

学校读者我要写书评

暂无评论

中华泌尿外科杂志 2002年第3期23卷 183-183页

作者：叶定伟李慧 richard land 钱松溪孙颖浩郑家富马永江第二军医大学长海医院泌尿外科上海200433 第二军医大学长海医院内分泌科上海200433 美国UTMD安德逊癌症中心

研究发现前列腺上皮内瘤（PIN）可能为人前列腺癌（PCa）的前趋病变。我们采用免疫组织化学方法检测并比较PCa和高分级PIN细胞中p53和bcl-2蛋白的表达，探讨人PCa的发生机制。

关键词：前列腺癌前列腺上皮瘤 p53 bcl-2 基因表达临床意义