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What did we learn from preparing for cross-border transmission of Ebola virus disease into a complex humanitarian setting-The Republic of South Sudan?

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Infectious Diseases of Poverty 2020年第2期9卷 106-107页

作者： Olushayo Oluseun Olu richard lako Joseph Francis Wamala Patrick Otim Ramadan Caroline Ryan Ifeanyi Udenweze Kibebu Berta Argata Guracha Guyo Alex Sokemawu Michael Tukuru Henry John Gray Alex Chimbaru World Health Organization Ebola Virus Disease preparedness team JubaRepublic of South Sudan 不详

Background:Following the West Africa Ebola virus disease(EVD)outbreak(2013-2016),WHO developed a preparedness checklist for its member *** checklist is currently being applied for the first time on a large and systematic scale to prepare for the cross border importation of the ongoing EVD outbreak in the Democratic Republic of Congo hence the need to document the lessons learnt from this *** is more pertinent considering the complex humanitarian context and weak health system under which some of the countries such as the Republic of South Sudan are implementing their EVD preparedness *** text:We identified four main lessons from the ongoing EVD preparedness efforts in the Republic South ***,EVD preparedness is possible in complex humanitarian settings such as the Republic of South Sudan by using a longer-term health system strengthening ***,the Republic of South Sudan is at risk of both domestic and cross border transmission of EVD and several other infectious disease outbreaks hence the need for an integrated and sustainable approach to outbreak preparedness in the ***,a phased and well-prioritized approach is required for EVD preparedness in complex humanitarian settings given the costs associated with preparedness and the difficulties in the accurate prediction of outbreaks in such ***,EVD preparedness in complex humanitarian settings is a massive undertaking that requires effective and decentralized ***:Despite a very challenging context,the Republic of South Sudan made significant progress in its EVD preparedness drive demonstrating that it is possible to rapidly scale up preparedness efforts in complex humanitarian contexts if appropriate and context-specific approaches are *** research,systematic reviews and evaluation of the ongoing preparedness efforts are required to ensure comprehensive documentation and application of the lessons learnt for future EV

关键词： Lessons learnt Ebola virus disease Preparedness Complex humanitarian settings The Republic of South Sudan

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The effect of bi-annual community-directed treatment with ivermectin on the incidence of epilepsy in onchocerciasis endemic villages in South Sudan:a study protocol

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Infectious Diseases of Poverty 2018年第1期7卷 1177-1184页

作者： Gasim Abd-Elfarag Makoy Yibi Logora Jane YCarter Morrish Ojok Jackson Songok Sonia Menon Ferdinand Wit richard lako Robert Colebunders Department of Global Health Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands Amsterdam Institute for Global Health and Development AmsterdamThe Netherlands Neglected Tropical Diseases Unit Ministry of HealthJubaRepublic of South Sudan Amref International University NairobiKenya Amref Health Africa JubaSouth Sudan Global Health Institute University of AntwerpAntwerpBelgium Policy PlanningBudgeting and ResearchMinistry of HealthJubaRepublic of South Sudan Global Health Institute University of AntwerpKinsbergen CentrumDoornstraat 3312610 AntwerpBelgium

Background:Nodding syndrome(NS)is a devastating epileptic illness of unknown aetiology mainly affecting children 5-15 years of *** nodding distinguishes NS from other forms of *** manifestations of the illness include mental and physical growth *** children die as a result of falling in fires or ***,it was shown that NS is only one of the phenotypic presentations of onchocerciasis associated epilepsy(OAE).Despite the strong epidemiological association between epilepsy and onchocerciasis,the causal mechanism is *** implementation of bi-annual community directed treatment with ivermectin(CDTi)and larviciding of rivers in northern Uganda,new cases of NS have ceased,while new cases continue to emerge in South Sudanese onchocerciasis-endemic areas with an interrupted CDTi *** study is designed to evaluate the potential effects of bi-annual CDTi on reducing the incidence of NS/OAE in onchocerciasisendemic areas in South ***:A pre-intervention door-to-door population-based household survey will be conducted in selected onchocerciasis-endemic villages in Mundri and Maridi Counties,which have a high prevalence of *** a validated questionnaire,the entire village will be screened by community research assistants for suspected epilepsy *** cases will be interviewed and examined by a trained clinical officer or medical doctor who will confirm or reject the diagnosis of ***-annual CDTi will be implemented in the villages and a surveillance system for epilepsy set *** implementing an epilepsy onchocerciasis awareness campaign we expect to obtain>90%CDTi coverage of eligible *** door-to-door survey will be repeated two years after the baseline *** incidence of NS/OAE will be compared before and after bi-annual ***:Our study is the first population-based study to evaluate the effect of bi-annual CDTi to reduce the incidence of NS/*** the study

关键词： Onchocerciasis Epilepsy Nodding syndrome South Sudan Ivermectin Community directed treatment Mundri Maridi

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