检索结果-南通市图书馆

Neural Regeneration Research 2022年第10期17卷 2197-2199页

作者： Jason HY Yeung Henry J Waldvogel richard lm faull Andrea Kwakowsky Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand

Alzheimer’s disease(AD)constitutes the largest proportion of dementia worldwide,with a significant associated medical *** major pathological hallmarks of AD include the gradual accumulation and deposition of amyloid-beta(Aβ)plaques and hyperphosphorylated tau protein(Revett et al.,2013).Whilst investigations centered around the tau and Aβhypothesis have been the main focus for the previous decades,the lack of therapeutic solutions has pushed for research into other potential therapeutic targets.

关键词： Alzheimer Aβ tau

The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第7期16卷 1399-1401页

作者： Andrea Kwakowsky Henry J.Waldvogel richard lm faull Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand

The leading form of dementia worldwide,Alzheimer's disease(AD)is a common neurodegenerative *** underlying causes of AD are not well understood,and no current treatments are preventing the onset or delay progression of the ***,most investigation is directed towards the amyloid-beta(Aβ)and tau pathologies,中文标题:The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression中文关词:Glu;AMPAR;APP;The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression;中文摘要:The leading form of dementia worldwide,Alzheimer's disease(AD)is a common neurodegenerative *** underlying causes of AD are not well understood,and no current treatments are preventing the onset or delay progression of the disease.

关键词： Alzheimer tau Aβ treatment

Therapeutic potential of alpha 5 subunit containing GABA_(A) receptors in Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第8期16卷 1550-1551页

作者： Andrea Kwakowsky Henry J.Waldvogel richard L.M.faull Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand

Alheimer's disease(AD) is a common neurodegenerative disorder and the leading cause of dementia. It has been estimated that over 50 million people worldwide were affected by dementia in 2019, and the prevalence of dementia is expected to double approximately once every 20 years(Govindpani et al., 2017). Most people who die with AD require high levels of care for long periods of time.

关键词： al. Alzheimer Therapeutic

Vascular dysfunction in Alzheimer’s disease: a biomarker of disease progression and a potential therapeutic target

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第6期15卷 1030-1032页

作者： Karan Govindpani Chitra Vinnakota Henry J.waldvogel richard L.faull Andrea Kwakowsky Centre for Brain Research Department of Anatomy and Medical Imaging Faculty of Medical and Health Sciences University of Auckland

Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the predominant form of *** its initial description by Alois Alzheimer in 1906,several advances have been made in our understanding of the progression of the disease and its clinical consequences,yet the underlying etiology remains *** the stereotyped patterns of cortical and hippocampal neuronal loss and the progressive degeneration of key neurotransmitter pathways,research has traditionally been focused on factors affecting neuronal viability,including the contribution of glial dysfunction to neuronal *** a clinical perspective,the fruits of this work have been *** pathological markers of the disease,includingβ-amyloid(Aβ)plaque formation and tau hyperphosphorylation,have yielded no effective therapies,highlighted by the recent discontinuations of several high profile Aβimmunotherapy *** few current symptomatic therapies for AD are predicated on the amelioration of cholinergic or glutamatergic *** from underscoring the inadequacy of current therapeutic approaches,this also points to the importance of alternative contributors to AD *** recent years,there has been a growing appreciation for the multimodal and multifactorial nature of the condition;the case for combinatorial therapies is thus strong.

关键词： Alzheimer degeneration dysfunction

Gamma-aminobutyric acid A receptors in Alzheimer＇s disease： highly localized remodeling of a complex and diverse signaling pathway

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第8期13卷 1362-1363页

作者： Andrea Kwakowsky Beatriz Calvo-Flores Guzman Karan Govindpani Henry J. Waldvogel richard L. faull Centre for Brain Research Department of Anatomy and Medical ImagingFaculty of Medical and Health Sciences University of Auckland AucklandNew Zealand

Alzheimer＇s disease （AD）, the predominant form of dementia, is a chronic, incurable neurodegenerative disorder presenting with symptoms includ- ing progressive memory loss and disturbed emotional state. It has been estimated that dementia affects over 47 million people worldwide （Prince et al., 2015）, and with 60-80% of cases attributable to AD.

关键词： AD highly localized remodeling of a complex and diverse signaling pathway Gamma-aminobutyric acid A receptors in Alzheimer’s disease

Applications of cutting-edge artificial intelligence technologies in biomedical literature and document mining

在线全文

学校读者我要写书评

暂无评论

Medical Review 2023年第3期3卷 200-204页

作者： Fei He Kai Liu Zhiyuan Yang Mark Hannink richard D.Hammer Mihail Popescu Dong Xu School of Information Science and Technology Northeast Normal UniversityChangchunJilin ProvinceChina Department of Electrical Engineer and Computer Science Christopher S.Bond Life Sciences CenterUniversity of MissouriColumbiaUSA Department of Biochemistry Christopher S.Bond Life Sciences CenterUniversity of MissouriColumbiaUSA Department of Pathology and Anatomical Sciences University of MissouriColumbiaUSA Department of Health Management and Informatics University of MissouriColumbiaUSA Department of Electrical Engineer and Computer Science Christopher S.Bond Life Sciences CenterUniversity of MissouriColumbia65211MOUSA

The biomedical literature is a vast and invaluable resource for biomedical *** knowledge from the literature with biomedical data can help biological studies and the clinical decision-making *** have been made to gather information from the biomedical literature and create biomedical knowledge bases,such as KEGG and ***,manual curation remains the primary method to retrieve accurate biomedical entities and *** curation becomes increasingly challenging and costly as the volume of biomedical publications quickly ***,recent advancements in Artificial Intelligence(AI)technologies offer the potential to automate the process of curating,updating,and integrating knowledge from the ***,we highlight the AI capabilities to aid in mining knowledge and building the knowledge base from the biomedical literature.

关键词： artificial intelligence technologies biomedical literature mining pathway figure mining text mining

FAST IMPLEMENTATION OF TIME-FREQUENCY REPRESENTATIONS MODIFIED BY THE REASSIGNMENT METHOD

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

FAST IMPLEMENTATION OF TIME-FREQUENCY REPRESENTATIONS MODIFI...

马来西亚部分豆科植物的花粉形态及其研究意义

1996 3rd International Conference on Signal Processing(ICSP’96)

作者： Cedric richard Regis LENGELLE Laboratoire lm2S Université de Technologie de Troyes10000 Troyes（France）

＜正＞Cohen’s class Time-Frequency Distributions （CTFDs） have significant potential for the analysis of non-stationary signals,even if the poor readability of their representations makes visual interpretations *** concentrate signal components,Auger and Flandrin generalized the reassignment method（first applied to the spectrogram） to any bilinear ***,this process is computationally *** order to quicken computation time and to improve representations readability,we first introduce a new fast algorithm which allows the recursive evaluation of classical spectrograms and spectrograms modified by the reassignment *** show that rectangular,half-sine, Hamming,Hanning and Blackmail functions can be used as running *** the previous algorithm is extended to *** show that the windows mentioned above can also be used to compute recursively reassigned smoothed pseudo Wigner-Ville ***,we show that the constraints on candidate windows are not very restrictive:any function（assumed periodic） can be used in practice as long as it admits a "short enough" Fourier series decomposition.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

生态学杂志 2022年第4期41卷 693-702页

作者：张庆云戴璐 Foong Swee Yeok richard Chung Cheng Kong 宁波大学地理科学与旅游文化学院浙江宁波315211 School of Biological Sciences University Sains MalaysiaPenang 11800Malaysia Forest Research Institute Malaysia Kepong 52109Malaysia

豆科(Leguminosae)植物是东南亚热带雨林中重要的乔木成分之一,其花粉形态分类对于精确重建植物群落具有重要的古生态学意义。本研究使用光学显微镜和扫描电子显微镜(SEM)对广布于马来西亚26种豆科植物花粉(隶属21属)进行了形态观察与... 详细信息

豆科(Leguminosae)植物是东南亚热带雨林中重要的乔木成分之一,其花粉形态分类对于精确重建植物群落具有重要的古生态学意义。本研究使用光学显微镜和扫描电子显微镜(SEM)对广布于马来西亚26种豆科植物花粉(隶属21属)进行了形态观察与描述。结果表明:花粉形态包括三孔、三孔合沟、三孔沟、九孔沟和多合体(16合)花粉等类型,其中,三孔沟型最为常见,占比65%;花粉形状以近球形居多,还有长球形和扁球形;花粉最大的为Albizzia(89.8μm×98.7μm),最小的为Ormosia bancana(18.1μm×19.2μm),花粉极轴长度在25~50μm占比77%;外壁纹饰以网状为主(53.8%),另外也有瘤状和光滑类型;根据SEM观察结果和已发表的豆科花粉形态资料,通过三孔沟型花粉不同体积、纹饰、孔的形状等特征可以比较好地将豆科花粉鉴定到属一级水平;各亚科[云实亚科(Caesalpinioideae)、含羞草亚科(Mimosoideae)、蝶形花亚科(Papilionoideae)]花粉有明显的形态差异。通过对花粉类型的母体植物生长环境的归纳,讨论了其对于不同植被群落的指示意义,为利用花粉化石记录重建古植被、古环境及气候演化提供依据。

关键词：马来西亚豆科花粉形态外壁纹饰光学显微镜扫描电子显微镜

在线全文

学校读者我要写书评

暂无评论

能显示驻波比的LED驱动电路

电子设计技术 1999年第10期 56-56页

作者： richard Panosh Vista Bolingbrook IL

图1所示电路采用lm3914发光二极管（LED）驱动电路,在低廉而耐用的射频仪器中。直接显示驻波比（SWR）。感测SWR的探头的制作资料来自ARRL Atenna Handbook（美国航空无线电与雷达实验室出版的天线手册）中的一篇讲述级联匹配的文章。... 详细信息

图1所示电路采用lm3914发光二极管（LED）驱动电路,在低廉而耐用的射频仪器中。直接显示驻波比（SWR）。感测SWR的探头的制作资料来自ARRL Atenna Handbook（美国航空无线电与雷达实验室出版的天线手册）中的一篇讲述级联匹配的文章。前向电压和反射电压（V;+V;）信号驱动引脚6(R;),而（V;-V;）信号则驱动正常的信号输入端,即引脚

关键词：驱动电路脉冲电路驻波比 LED

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

构成低频循环器的电路

电子设计技术 2002年第4期 72-72页

作者： richard Kurzrok Queens Village NY

电子循环器在10年前已投放市场(参考文献1)。它工作在甚高频段(VHF),是一种三端口循环器,采用Comlinear公司(现为National Semiconductor公司的一部分,***)的CLC406型运算放大器。图1所示电路采用现有的941(等效于现在广泛使用的741)和L... 详细信息

电子循环器在10年前已投放市场(参考文献1)。它工作在甚高频段(VHF),是一种三端口循环器,采用Comlinear公司(现为National Semiconductor公司的一部分,***)的CLC406型运算放大器。图1所示电路采用现有的941(等效于现在广泛使用的741)和lm318运算放大器,使这种三端口循环器扩展成为能在低频工作的四端口循环器。表1给出了与741等效的运放的已

关键词：循环器端口电子轻子运算放大器