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世界核心医学期刊文摘（儿科学分册） 2006年第6期2卷 39-40页

作者： Hsiao A.l. moore C.l. 王经纬 Department of Pediatric Emergency Medicine Yale University School of Medicine WP143 20 York St New Haven CT 06511 United States

Background. Urethral catheterization is the method of choice for obtaining samples for urine culture and urine analysis in infants. Before the procedure, there is little certainty of the presence or amount of urine in the bladder. Consequently, this relatively invasive and uncomfortable procedure often needs to be repeated. The newly available technology of portable ultrasound may be useful in reducing the number of unsuccessful procedures. Objective. To investigate the utility of bedside ultrasound of the bladder performed by pediatric emergency medicine physicians before catheterization in reducing the number of unsuccessful attempts. Methods. A prospective, 2-phase study was performed in the setting of an urban pediatric emergency department from August 2003 to February 2004. Children who were between the ages of 0 and 24 months were enrolled. During the observation phase, the amount of urine obtained during the first catheterization was recorded for each patient. During the intervention period, a rapid bedside ultrasound of the bladder was performed by a pediatric emergency medicine physician immediately before urethral catheterization. When a sufficient amount of urine was seen, catheterization was conducted as usual. Otherwise, catheterization was deferred and repeated ultrasound was performed at 30-minute intervals until sufficient urine was identified. The amount of urine obtained was recorded. Results. During the observation phase, 136 infants underwent urethral catheterization. Overall, the rate of success during the first attempt,defined as obtaining > 2 ml of urine, sufficient for culture and other routine studies, was 72%(95%confidence interval: 66%-78%). A total of 112 subjects were enrolled during the intervention phase. Sufficient urine was identified on the first ultrasound in 76%(n = 85) of the patients. Among these, 98%(n = 83)-underwent successful urethral catheterization during the first attempt. Among those in whom insufficient urine was identi

关键词：超声检查导尿术低龄儿童膀胱内术前床边尿液量检查技术插管失败急诊医生

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在线过程控制中的专家系统

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计算机仿真 1993年第2期10卷 49-55页

作者： R.l.moore M A Kramer 候贵海

推理机的计时虽然我们将推理机描述为程序上松散,但并不意味着在程序上当调用子程序时就放松控制,直到被调用子程序完成功能。当一个启发框架必须评价其状态时,则需要其它变量的状态,这些变量在当前状态下不能被获得,它便激活这些变量... 详细信息

推理机的计时虽然我们将推理机描述为程序上松散,但并不意味着在程序上当调用子程序时就放松控制,直到被调用子程序完成功能。当一个启发框架必须评价其状态时,则需要其它变量的状态,这些变量在当前状态下不能被获得,它便激活这些变量并且立即终止。仅在终止前。

关键词：在线控制专家系统过程控制

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在线过程控制中的专家系统

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计算机仿真 1993年第1期10卷 49-54页

作者： R.l.moore M A Kramer 候贵海

专家系统已成为化工过程监控的一种富有吸引力的工具,其应用包括:报警处理,故障检测与诊断,以及优化控制与过程管理。PICON软件提出了专家系统用于动态环境的问题。本文所要讨论的第一个要点是在动态数据快速变化的推理过程中的硬件和... 详细信息

专家系统已成为化工过程监控的一种富有吸引力的工具,其应用包括:报警处理,故障检测与诊断,以及优化控制与过程管理。PICON软件提出了专家系统用于动态环境的问题。本文所要讨论的第一个要点是在动态数据快速变化的推理过程中的硬件和软件问题。所要讨论的第二个要点是执行故障检测和诊断任务的知识库构成。在此应用中,基于模型的推理机制要比基于启发的推理机制更有效。为在此领域的进一步研究提出了建议。

关键词：在线控制专家系统过程控制

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Rad7 E3 Ubiquitin ligase Attenuates Polyubiquitylation of Rpn10 and Dsk2 Following DNA Damage in <i>Saccharomyces cerevisiae</i>

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Advances in Biological Chemistry 2015年第7期5卷 239-254页

作者： Joseph M. Benoun Danielle lalimar-Cortez Analila Valencia Adriana Granda Destaye M. moore Eric P. Kelson Paula l. Fischhaber Department of Chemistry and Biochemistry California State University Northridge Northridge CA USA

During Nucleotide Excision Repair (NER) in the yeast S. cerevisiae, ubiquitylation of Rad4 is carried out by the E3 ubiquitin ligase that includes Rad7-Elc1-Cul3 and is critical to optimal NER. Rad7 E3 activity targets Rad4 for degradation by the proteaseome but, in principle, could also trigger other DNA damage responses. We observed increased nuclear ubiquitin foci (Ub-RFP) formation in S. cerevisiae containing a Rad7 E3 ligase mutant (rad7SOCS) in response to DNA damage by benzo[a]pyrenediolepoxide (BPDE) in dividing cells. Immunoblots reveal that ubiquitin conjugates of Rpn10 and Dsk2 accumulate in greater abundance in rad7SOCS compared to RAD7 in dividing cells in response to BPDE which makes Rpn10 and Dsk2 candidates for being the ubiquitylated species observed in our microscopy experiments. Microscopy analysis with strains containing Dsk2-GFP shows that Dsk2-GFP and Dsk2-GFP/Ub-RFP colocalized in nuclear foci form to an increased extent in a rad7SOCS mutant background in dividing cells than in a RAD7 wild-type strain. Further, Dsk2-GFP in the rad7SOCS strain formed more foci at the plasma membrane following BPDE treatment in dividing cells relative to strains containing RAD7 or a rad7△?deletion mutant. In response to a different agent, UV irradiation, levels of ubiquitylated proteins were increased in rad7SOCS relative to RAD7, and the proteasomal deubiquitylase subunit, Rpn11 was even monoubiquitylated in the absence of damaging agents. Together these data show that Rad7 E3 activity attenuates ubiq-uitylation of proteins regulating the shuttling of polyubiquitylated proteins to the proteasome (Dsk2 and Rpn10) and removal of ubiquitin chains just prior to degradation (Rpn11). Since Rad7 E3 ligase activity has been shown to increase ubiquitylation of its target proteins, yet our results show increased ubiquitylation in the absence of Rad7 E3, we suggest that Rad7 E3 action regulates ubiquitin ligase and deubiquitylase (DUB) activities that act on Rpn10, Dsk2 a

关键词： Ubiquitin Rad7 Rpn10 Rpn11 Dsk2 DNA Damage Response

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A clinically relevant combination treatment with doxorubicin and cyclophosphamide does not induce hepatotoxicity in C57Bl/6J mice

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liver Research 2021年第4期5卷 239-242页

作者： Satyanarayana R Pondugula Julia M Salamat Kodye l Abbott Patrick C Flannery Mohammed Majrashi Mohammed Almaghrabi Manoj Govindarajulu Sindhu Ramesh Maninder Sandey Suneel K Onterue Chen-Che J Huang Yoshimi Iwaki Kristina Gill Natasha Narayanan Edwin McElroy Darshini Desai Rishi Nadar Timothy moore Muralikrishnan Dhanasekaran Department of Anatomy Physiology and PharmacologyCollege of Veterinary MedicineAuburn UniversityAuburnALUSA Department of Pharmacology Faculty of MedicineUniversity of JeddahJeddahSaudi Arabia Department of Drug Discovery and Development Harrison School of PharmacyAuburn UniversityAuburnALUSA Department of Pathobiology College of Veterinary MedicineAuburn UniversityAuburnALUSA Animal Biochemistry Division National Dairy Research InstituteICAR-National Dairy Research InstituteKarnalHaryanaIndia Department of Clinical Science College of Veterinary MedicineAuburn UniversityAuburnALUSA

Background and aims:Chronic exposure to chemotherapeutics can lead to severe adverse events including hepatotoxicity.A combination chemotherapy regimen of doxorubicin(DOX)and cyclophos-phamide(CPS)is employed in treatment of several cancers such as leukemia,lymphoma,and breast *** is not well understood whether a combination therapy with DOX and CPS can induce *** therefore sought to determine whether co-administration of DOX and CPS at their clini-cally relevant doses and frequency results in ***:Male C57Bl/6J mice received one intraperitoneal injection of saline or DOX-2 mg/kg and CPS-50 mg/kg once a week for 4 *** the treatment period,liver histology and various serum bio-markers of hepatotoxicity were ***:Co-treatment with DOX and CPS did not alter the serum levels of alanine aminotransferase(AlT),alkaline phosphatase(AlP),bilirubin,albumin,globulin,or total ***,co-administration of DOX and CPS did not result in a noticeable change in liver ***,it was notable that the concomitant treatment with DOX and CPS resulted in a significant increase in serum levels of aspartate aminotransferase(AST).Elevated serum AST levels were also associated with increased serum creatinine kinase(CK)levels,suggesting that the elevated serum AST levels are likely due to muscle injury following the co-administration of DOX and ***:Taken together,our results,for the first time,suggest that co-administration of DOX and CPS,at their clinically relevant doses and frequency does not induce a significant hepatotoxicity in the mice.

关键词： Cyclophosphamide(CPS) Doxorubicin(DOX) Hepatotoxicity liver injury Muscle injury

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优步和lyft司机的不满让网约车新公司看到机会

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商业周刊（中文版） 2022年第15期 20-21页

作者： Elizabeth l.T.moore Prarthana Prakash 王忠(译) 不详

几家新兴的网约车平台承诺善待司机,由此与优步和lyft展开了较量。总部位于达拉斯的Alto就是其中之一,这家公司将司机视为正式员工,并采取年薪制。总部设在弗吉尼亚州麦克莱恩市的Empower,以及得克萨斯州奥斯汀市的Wridz,将把全部出车... 详细信息

几家新兴的网约车平台承诺善待司机,由此与优步和lyft展开了较量。总部位于达拉斯的Alto就是其中之一,这家公司将司机视为正式员工,并采取年薪制。总部设在弗吉尼亚州麦克莱恩市的Empower,以及得克萨斯州奥斯汀市的Wridz,将把全部出车费用提供给司机。纽约的The Drivers Cooperative承诺司机可以在公司利润中获得分成。

关键词：年薪制优步弗吉尼亚州达拉斯网约车正式员工得克萨斯州司机

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Phylogenetic patterns suggest frequent multiple origins of secondary metabolites across the seed-plant ‘tree of life’

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National Science Review 2021年第4期8卷 66-77页

作者： Yongzeng Zhang Tao Deng lu Sun Jacob B.landis Michael J.moore Hengchang Wang Yuehua Wang Xiaojiang Hao Jijun Chen Shenghong li Maonian Xu Pema-Tenzin Puno Peter H.Raven Hang Sun CAS Key laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences University of the Chinese Academy of Sciences Department of Botany and Plant Sciences University of California Riverside School of Integrative Plant Science Section of Plant Biology and the L.H.Bailey HortoriumCornell University Department of Biology Oberlin College CAS Key laboratory of Plant Germplasm Enhancement and Specialty Agriculture Chinese Academy of Sciences School of life Science Yunnan University State Key laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences Pharmaceutical Sciences University of Iceland Missouri Botanical Garden

To evaluate the phylogenetic patterns of the distribution and evolution of plant secondary metabolites(PSMs), we selected 8 classes of PSMs and mapped them onto an updated phylogenetic tree including 437 families of seed plants. A significant phylogenetic signal was detected in 17 of the 18 tested seed-plant clades for at least 1 of the 8 PSM classes using the D statistic. The phylogenetic signal, nevertheless, indicated weak clustering of PSMs compared to a random distribution across all seed plants. The observed signal suggests strong diversifying selection during seed-plant evolution and/or relatively weak evolutionary constraints on the evolution of PSMs. In the survey of the current phylogenetic distributions of PSMs, we found that multiple origins of PSM biosynthesis due to external selective forces for diverse genetic pathways may have played important roles. In contrast, a single origin of PSMs seems rather uncommon. The distribution patterns for PSMs observed in this study may also be useful in the search for natural compounds for medicinal purposes.

关键词： secondary metabolites phylogenetic tree phylogenetic signal co-diversification evolution bioprospecting seed plants

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Hydrogen sutfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocvanate induced apoptosis

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World Journal of Gastroenterology 2005年第26期11卷 3990-3997页

作者： Peter Rose Philip K moore Shen Han Ming Ong Choon Nam Jeffrey S Armstrong Matt Whiteman Department of Biochemistry National University of Singapore 8 Medical Drive117597Singapore Department of Pharmacology National University of Singapore 18 Medical Drive117597 Singapore Department of Community Occupational and Family Medicine National University of Singapore 16 Medical Drive 117597 Singapore

AIM:Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/l in the GI tract of mice and humans. Considering such high levels we speculate that, at non-toxic concentrations, H2S may interact with chemical agents and alter the response of colonic epithelium cells to such compounds. The GI tract is a major site for the absorption of phytochemical constituents such as isothiocyanates, flavonoids, and carotenoids, with each group having a role in the prevention of human diseases such as colon cancer. The chemopreventative properties of the phytochemical agent p-phenyethyl isothiocyanate (PEITC) are well recognized. However, little is currently known about the physiological or biochemical factors present in the GI tract that may influence the biological properties of ITCs. The current study was undertaken to determine the effects of H2S on PEITC mediated apoptosis in colon cancer cells. METHODS: Induction of apoptosis by PEITC in human colon cancer HCT116 cells was assessed using classic apoptotic markers namely SubGl population analysis, caspase-3 like activity and nuclear fragmentation and condensation coupled with the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrasodium bromide) viability assay and lDH leakage. RESUlTS: PEITC significantly induced apoptosis in HCT116 cells as assessed by SubGl population formation, nuclear condensation, lDH leakage and caspase-3 activity after 24 h, these data being significant from control groups (Plls with physiological concentrations of H2S (0.1-1 mmol/l) prevented PEITC mediated apoptosis as assessed using the parameters described. CONClUSION: PEITC effectively induced cell death in the human adenocarcinoma cell line HCT116 in vitro through classic apoptotic mechanisms. However, in the presence of H2S, apoptosis was abolished. These data sugg

关键词： Apoptosis Colon cancer Hydrogen sulfide β-phenylethyl isothiocyanate

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燃烧室隔热对CUMMINS公司 V-903发动机低散热量性能的影响

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车用发动机 1986年第4期 47-58页

作者： Christine H.moore,John l.Hoehne,尼鲜利 Cummins发动机公司 Cummins发动机公司

根据美国陆军坦克与机动车指挥部的合同,Cummins公司已在研制一台低散热量的450kw发动机。本文论述了为达到6.6kcal/kw·min单位制动散热量及200g/kw·h制动燃油消耗率方案目标而进行的工作情况,介绍了在低散热量发动机上测量散热量的方... 详细信息

根据美国陆军坦克与机动车指挥部的合同,Cummins公司已在研制一台低散热量的450kw发动机。本文论述了为达到6.6kcal/kw·min单位制动散热量及200g/kw·h制动燃油消耗率方案目标而进行的工作情况,介绍了在低散热量发动机上测量散热量的方法,讨论了原准机的改进设计及其对改善油耗的影响。同时根据第一定律能量平衡和冷却负荷分布,评定了性能试验数据。通过散热量数据更深入地了解了隔热部件和两种冷却系统设计的性能。用柴油机循环模拟计算结果与试验数据进行比较,并用来预测陶瓷隔热对发动机散热量的影响。

关键词：散热量排气管燃油耗 CUMMINS V-903 发动机结构涡轮增压器燃油消耗率缸盖中冷器活塞顶氧化锆涂层机油冷却器冷却液蓄冷材料火焰面燃烧室热风炉

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测试基础

测试基础

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丛书名：书名原文: Measurement fundamentals

1985年

作者：（美）摩尔（moore R.l.）胡鼎昌夏仲平译

书名原文: Measunement fundamentuls.

ISBN: (纸本)15033·6282H

书名原文: Measunement fundamentuls.

关键词：测量仪器工程测量

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