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Weight regain after intragastric balloon for pre-surgical weight loss

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World journal of Gastrointestinal Surgery 2024年第7期16卷 2040-2046页

作者： Danielle Abbitt Kevin Choy Alexandra Kovar Teresa S jones Krzysztof j Wikiel Edward L jones Department of Surgery University of ColoradoAuroraCO 80045United States Department of Surgery Rocky Mountain Regional Veteran Affairs Medical CenterAuroraCO 80045United States

BACKGROUND Over one-third of Americans carry the diagnosis of obesity,many also with obesity-related *** can place patients at increased risk of operative and postoperative *** intragastric balloon has been shown to aid in minor weight loss,however its weight recidivism in patients requiring short interval weight loss has not been well *** To evaluate weight loss,ability to undergo successful elective surgery after intragastric balloon placement,and weight management after balloon *** This study is a retrospective review of patients in a single academic institution undergoing intragastric balloon placement from 2019-2023 to aid in weight loss prior to undergoing elective *** outcomes including weight loss,duration of balloon placement,successful elective surgery,weight regain postballoon and post-procedure complications were *** criteria included those with balloon in place at time of *** Thirty-three patients completed intragastric balloon therapy from 2019-2023 as a bridge to elective *** patients were required to participate in a 12-month weight management program to be eligible for balloon *** surgeries included incisional hernia repair,umbilical hernia repair,inguinal hernia repair,and knee and hip *** average age at placement was 53 years±11 years,majority(91%)were *** average duration of intragastric balloon therapy was 186 days±41 *** average weight loss was 14.0 kg±7.4 kg and with an average percent excess body weight loss of 30.0%(7.9%-73.6%).Over half of the patients(52.0%)achieved the goal of 30-50 lbs(14-22 kg)weight ***-one patients(64%)underwent their intended elective surgery,2 patients(6%)deferred surgery due to symptom relief with weight loss ***-one of the patients(64%)have documented weights in 3 months after balloon removal,in these patients the majority(76%)gained weight after balloon *** pat

关键词： Intragastric balloon Weight loss Obesity Bariatric Body mass index

Innovative hydrogel-based delivery systems for immunotherapy:A review of pre-clinical progress

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Nano Research 2024年第10期17卷 9031-9043页

作者： Narsimha Mamidi Michael Poellmann Kaila javius-jones KiChang Nam Seungpyo Hong Wisconsin Center for NanoBioSystems University of Wisconsin-MadisonMadisonWI 53705USA Pharmaceutical Sciences Division School of PharmacyUniversity of Wisconsin-MadisonMadisonWI 53705USA Department of Medical Engineering College of MedicineDongguk UniversityGoyang 10326Republic of Korea Department of Pharmacy Yonsei UniversityIncheon 21983Republic of Korea Lachman Institute for Pharmaceutical Development University of Wisconsin-MadisonMadisonWI 53705USA

Immunotherapy has markedly reinvented how we treat cancer,as shown by numerous Food and Drug Administration(FDA)drug approvals that have made significant clinical impact and ongoing clinical ***,undesirable side effects,such as autoimmunity and inflammation,and inconsistent clinical outcomes remain a major *** response rates across various immunotherapeutic reagents is imperative to enhance overall effectiveness and reduce adverse side *** address this challenge,interdisciplinary approaches have been explored by incorporating immunotherapies into hydrogels,enabling finecontrolled delivery to target *** review focuses on recent progress in the utilization of hydrogel-based delivery systems for cancer immunotherapy and their potential to further enhance treatment response ***,recent preclinical advances in hydrogels implemented with immune checkpoint inhibitors,combination therapies,and vaccines,along with selfassembled peptide hydrogels,are *** also discuss technological advances and drawbacks in this area and provide insights to ultimately realize the clinical application of hydrogels in cancer immunotherapy.

关键词： cancer immunotherapy drug delivery hydrogels immunotherapeutic agents immune modulation clinical outcomes

Using Twitter Bios to Measure Changes in Self-Identity:Are Americans Defining Themselves More Politically Over Time?

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journal of Social Computing 2021年第1期2卷 1-13页

作者： Nick Rogers jason j.jones Department of Sociology Stony Brook UniversityStony BrookNY 11794USA

Are Americans weaving their political views more tightly into the fabric of their self-identity over time?If so,then we might expect partisan disagreements to continue becoming more emotional,tribal,and *** recent scholarship has speculated that this politicization of Americans’identity is occurring,but there has been little compelling attempt to quantify the phenomenon,largely because the concept of identity is notoriously difficult to *** introduce here a methodology,Longitudinal Online Profile Sampling(LOPS),which affords quantifiable insights into the way individuals amend their identity over *** this method,we analyze millions of“bios”on the microblogging site Twitter over a 4-year span,and conclude that the average American user is increasingly integrating politics into their social *** on the site are adding political words to their bios at a higher rate than any other category of words we measured,and are now more likely to describe themselves by their political affiliation than their religious *** data suggest that this is due to both cohort and individual-level effects.

关键词： identity social identity theory social media ideology political polarization Twitter

A tale of motor neurons and CD4＋ T cells： moving forward by looking back

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Neural Regeneration Research 2017年第4期12卷 562-565页

作者： Abhirami Kannan Iyer Kathryn j.jones Department of Anatomy and Cell Biology Indiana University School of Medicine

Amyotrophic lateral sclerosis （ALS） is a fatal progressive disorder characterized by the selective degeneration of motor neurons （MN）. The impact of peripheral immune status on disease progression and MN survival is becoming increasingly recognized in the ALS research field. In this review, we briefly discuss findings from mouse models of peripheral nerve injury and immunodeficiency to understand how the immune system regulates MN survival. We extend these observations to similar studies in the widely used superoxide dismutase 1 （SOD1） mouse model of ALS. Last, we present future hypotheses to identify potential causative factors that lead to immune dysregulation in ALS. The lessons from preceding work in this area offer new exciting directions to bridge the gap in our current understanding of immune mediated neuroprotection in ALS.

关键词： amyotrophic lateral sclerosis (ALS) superoxide dismutase 1 (SOD1) immune system SOD1 mice motor neuron CD4+ T cells neuroprotection

Reservoir quality of fluvial sandstone reservoirs in salt-walled mini- basins： an example from the Seagull field, Central Graben, North Sea, UK

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Petroleum Science 2018年第1期15卷 1-27页

作者： Stephan Stricker Stuart j.jones Neil Meadows Leon Bowen Department of Earth Sciences Durham University South Road Durham DH1 3LE UK RedRock Associates International Limited 38 Queens DrivePrenton Wirral CH43 0RP UK Department of Physics Durham University South RoadDurham DH1 3LE UK

The Triassic fluvial sandstones of the Skagerrak Formation were deposited in a series of salt-walled mini-basins and act as important hydrocarbon reservoirs for several high-pressure, high-temperature（HPHT） fields in the Central Graben, North Sea. The HPHT reservoirs exhibit excellent reservoir quality considering their depth of burial and hence have been of high interest for hydrocarbon exploration. This research uses a multidisciplinary approach to assess the Skagerrak Formation fluvial reservoir quality from the Seagull field incorporating core analysis, petrography, electron microscopy, XRD analysis, fluid inclusion appraisal and burial history modelling. Halokinesis and salt withdrawal at the margin of the saltwalled mini-basin induced early disaggregation bands and fractures at shallow burial and led to increased influx of meteoric water and clay mineral infiltration from overlying sedimentation. The density of disaggregation bands correlates with the occurrence and magnitude of pore-filling authigenic clay minerals, concentrated along the margin of the saltwalled mini-basin. The fluvial channel sandstones of the Skagerrak Formation are subject to strong intra-basinal spatial reservoir quality variations despite diagenesis and low vertical effective stress having played a favourable role in arresting porosity loss.

关键词： Reservoir quality Halokinesis - Diagenesis Clay minerals Porosity Disaggregation bands Salt-walled mini-basin

Lipid nanoparticles deliver mRNA to the blood-brain barrier

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Nano Research 2024年第10期17卷 9126-9134页

作者： Yanina Kuzminich Avraham Shakked Randi Calkins Sebastian Rudden Camille jones jessie Doan Bora jang Elisa Schrader Echeverri Ryan Zenhausern Liming Lian David Loughrey Hannah E.Peck Rachelle Wiese Dorothy Koveal Philip j.Santangelo james E.Dahlman George C.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Emory University School of Medicine and Georgia Institute of TechnologyAtlantaGA 30332USA

Lipid nanoparticles(LNPs)have delivered RNA to hepatocytes in patients after intravenous *** clinical data support efforts to design LNPs that transfect cells in the central nervous system(CNS).However,delivery to the CNS has been difficult,in large part because quantifying on-target delivery alongside common off-target cell types in adult mice remains *** we report methods to isolate different cell types from the CNS,and subsequently present mRNA delivery readouts using a liver-detargeted *** data suggest that LNPs without targeting ligands can transfect cerebral endothelial cells in mice after intravenous *** the difficulty of crossing the blood-brain barrier,they also underscore the value of quantifying delivery in the CNS with cell-type resolution instead of whole-tissue resolution.

关键词： lipid nanoparticle mRNA nanomedicine central nervous system blood-brain barrier

Surgical or medical treatment of obesity-associated type 2 diabetesan increasing clinical conundrum

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World journal of Diabetes 2024年第10期15卷 2036-2040页

作者： Ryan j jalleh Karen L jones Md Shahidul Islam Lu Cai Michael Horowitz Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Endocrine and Metabolic Unit Royal Adelaide HospitalAdelaide 5000South AustraliaAustralia Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa Pediatric Research Institute Departments of PediatricsRadiation OncologyPharmacology and ToxicologyUniversity of LouisvilleWendy Novak Diabetes InstituteNorton Children’s HospitalLouisvilleKY 40202United States

In this editorial,we comment on the article by He et al,specifically in relation to the efficacy of bariatric surgery vs glucagon-like peptide-1 receptor agonist(GLP-1RA)therapy in the management of type 2 diabetes(T2D)associated with *** surgery has now also been shown to be safe and effective in pre-teens and teenagers with obesity and T2D,but information on newer GLP-1RAs in these groups is predictably *** older individuals(age>65 years),both bariatric surgery and GLP-1RA therapy improve cardiovascular ***-tric surgery is not infrequently associated with post-operative postprandial hypoglycemia,which is not the case with GLP-1RAs and,paradoxically,there is evidence that GLP-1RAs may reduce both the frequency and severity of postprandial *** trials of the long-term efficacy of bariatric surgery and GLP-1RAs are indicated.

关键词： Glucagon-like peptide-1 Glucagon-like peptide-1 receptor agonist Obesity Diabetes Weight loss Bariatric surgery Metabolic surgery Hypoglycemia

Dual ecological and socio-cultural fragmentation induced by hydropower dams: Case studies from the Greater Himalayan region of India

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 117-120页

作者： Garima Gupta Rahul Kotiyal Isabel L.jones Biological and Environmental Sciences University of StirlingScotland FK94LAUK Baramasa.in Narrating Himalaya 248001India

Climate change and biodiversity loss are pressing global challenges(Pörtner et al.,2021).However,as global energy demand continues to increase(IEA,2021),nations face significant challenges to decarbonization and reaching“net zero”due to trade-offs between the often-competing needs of renewable energy generation and biodiversity *** example,hydropower generates renewable energy(Gibson et al.,2017),yet there are well-documented and severe consequences of dam development for biodiversity(e.g.,Zarfl et al.,2019)and people(e.g.,Bisht,2009)due to reservoir creation and disruption of river *** such potentially damaging ecological and social trade-offs,hydropower currently contributes 70%of global renewable energy and there are at least 3700 large dams planned or under construction globally(Zhang&Gu,2023).

关键词： reservoir consequences globally

Manipulating active layer morphology of molecular donor/polymer acceptor based organic solar cells through ternary blends

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Science China Chemistry 2018年第8期61卷 1025-1033页

作者： Zijian Zhang Zicheng Ding David j.jones Wallace W.H.Wong Bin Kan Zhaozhao Bi Xiangjian Wan Wei Ma Yongsheng Chen Xiaojing Long ChuANDong Dou jun Liu Lixiang Wang State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China School of Chemistry Bio21 Institute the University of Melbourne Parkville Victoria 3010 Australia Key Laboratory for Functional Polymer Materials and Centre for Nanoscale Science and Technology Institute of Polymer Chemistry College of Chemistry Nankai University Tianjin 300071 China Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Xi'an 710049 China University of the Chinese Academy of Sciences Beijing 100049 China

The development of molecular donor/polymer acceptor blend(MD/PA)-type organic solar cells(OSCs) lags far behind other type OSCs. It is due to the large-size phase separation morphology of MD/PAblend, which results from the high crystallinity of molecular donors. In this article, to suppress the crystallinity of molecular donors, we use ternary blends to develop OSCs based on one polymer acceptor(P-BNBP-f BT) and two molecular donors(DR3 TBDTT and BTR) with similar chemical *** ternary OSC exhibits a power conversion efficiency(PCE) of 4.85%, which is higher than those of the binary OSCs(PCE=3.60% or 3.86%). To our best knowledge, it is the first report of ternary MD/PA-type OSCs and this PCE is among the highest for MD/PA-type OSCs reported so far. Compared with the binary blends, the ternary blend exhibits decreased crystalline size and improved face-on orientation of the donors. As a result, the ternary blend exhibits improved and balanced charge mobilities, suppressed charge recombination and increased donor/acceptor interfacial areas, which leads to the higher shortcircuit current density. These results suggest that using ternary blend is an effective strategy to manipulate active layer morphology and enhance photovoltaic performance of MD/PA-type OSCs.

关键词： organic solar cells molecular donor polymer acceptor blend morphology ternary blend