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npj Computational Materials 2022年第1期8卷 548-573页

作者： Kamal Choudhary Brian DeCost Chi Chen Anubhav jain Francesca Tavazza Ryan cohn Cheol Woo Park Alok Choudhary Ankit Agrawal Simon j.L.Billinge Elizabeth Holm Shyue Ping Ong Chris Wolverton Materials Science and Engineering Division National Institute of Standards and TechnologyGaithersburgMD20899USA Theiss Research La JollaCA92037USA DeepMaterials LLC Silver SpringMD20906USA Material Measurement Science Division National Institute of Standards and TechnologyGaithersburgMD20899USA Department of NanoEngineering University of California San DiegoSan DiegoCA92093USA Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCAUSA Department of Materials Science and Engineering Carnegie Mellon UniversityPittsburghPA15213USA Department of Materials Science and Engineering Northwestern UniversityEvanstonIL60208USA Department of Electrical and Computer Engineering Northwestern UniversityEvanstonIL60208USA Department of Applied Physics and Applied Mathematics and the Data Science Institute Fu Foundation School of Engineering and Applied SciencesColumbia UniversityNew YorkNY10027USA

Deep learning(DL)is one of the fastest-growing topics in materials data science,with rapidly emerging applications spanning atomistic,image-based,spectral,and textual data *** allows analysis of unstructured data and automated identification of *** recent development of large materials databases has fueled the application of DL methods in atomistic prediction in *** contrast,advances in image and spectral data have largely leveraged synthetic data enabled by high-quality forward models as well as by generative unsupervised DL *** this article,we present a high-level overview of deep learning methods followed by a detailed discussion of recent developments of deep learning in atomistic simulation,materials imaging,spectral analysis,and natural language *** each modality we discuss applications involving both theoretical and experimental data,typical modeling approaches with their strengths and limitations,and relevant publicly available software and *** conclude the review with a discussion of recent cross-cutting work related to uncertainty quantification in this field and a brief perspective on limitations,challenges,and potential growth areas for DL methods in materials science.

关键词： learning limitations textual

硝酸酯治疗慢性充血性心力衰竭的疗效:支持者的观点

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国外医学（心血管疾病分册） 1991年第2期18卷 79-80页

作者： cohn j N 盛净节

作者认为硝酸酯治疗充血性心衰安全有效而且价格低廉,并讨论了硝酸酯的耐受性、最佳剂量,联合用药及其前景。

关键词：心力衰竭充血性慢性硝酸酯

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血管扩张剂治疗心衰的生理基础

心血管病学进展 1982年第2期 53-54页

作者： cohn j N 卢介夫

了解血管扩张剂在心衰时改善心脏功能的机制,有赖于对外周循环和左室泵出功能关系的认识。许多术语曾用以描绘抵抗左室射血的总力,这个力包括血管阻力、顺应性、血液粘性和惯性等因素,并且这个力量在收缩期射血中是不断变化的。后负荷... 详细信息

了解血管扩张剂在心衰时改善心脏功能的机制,有赖于对外周循环和左室泵出功能关系的认识。许多术语曾用以描绘抵抗左室射血的总力,这个力包括血管阻力、顺应性、血液粘性和惯性等因素,并且这个力量在收缩期射血中是不断变化的。后负荷作为一个心肌的力学术语,其定义是当心肌缩短时室

关键词：心衰心脏功能左室外周循环血管扩张室壁应力

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预应力优化及其在设计中的意义

世界桥梁 1988年第4期 68-77+82页

作者： M.Z.cohn A.j.Macrae 刘钊铁四局科研所

本文运用非线性规划技术对240片RC(钢筋混凝土)、PC(预应力混凝土)和PPC(部分预应力混凝土)梁进行了优化,并给出了综合研究结果。在一定程度上说明了部分预应力的可行性、适用性和经济利用范围,并与普通钢筋混凝土和预应力混凝土进行了... 详细信息

本文运用非线性规划技术对240片RC(钢筋混凝土)、PC(预应力混凝土)和PPC(部分预应力混凝土)梁进行了优化,并给出了综合研究结果。在一定程度上说明了部分预应力的可行性、适用性和经济利用范围,并与普通钢筋混凝土和预应力混凝土进行了比较,同时对RC、PC和PPC构件采用统一设计方法的好处作了说明。

关键词：截面类型经济最优解 PPC 基本变量设计变量部分预应力比混凝土无机非金属材料预应力筋

IMMUNOCYTOCHEMICAL LOCALIZATION OF cDNA ENCODING GLUCOSE TRANSPORTER PROTEIN FROM THE SCHISTOSOMA MANSONI

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IMMUNOCYTOCHEMICAL LOCALIZATION OF cDNA ENCODING GLUCOSE TRA...

限定性片段长度多态性分析用于发展中国家结核病流行病学研究

The Eighth Chinese-japanese Electron Microscopy Seminar

作者： P.j.Skelly D.Leaffer R.L.cohn j.P.Caulfield C.B.Shoemaker Department of Tropical Public Health Harvard School of Public HealthMA/USA Institute of Immunology and Biological Sciences Syntex Discovery Research Palo AltoCA/USA

The blood-dwelling schistosomes consume prodigious quantities of host glucose for their *** the adult worm possesses a mouth and a functional gut,internalization of glucose transporting through their surface or tegument was reported by facilitated diffusion(Cornford et al.,1988)). Skelly et aI.(1994))obtained cDNA clones encoding three functional facilitated diffusion glucose transporter proteins, designated schistosome glucose transpoter protein 1(SGTP 1), SGTP 2 and SGTP 4,which has been expressed in Xenopus *** on mRNA analysis,one of the functional S. mansoni glucose transpoters,SGTP 1,is more abundant than the other in adult *** work presents the immunochemical localization of SGTP 1 to elucidate morphologically the correlation between its distribution and function.

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国际结核病与肺部疾病杂志 1998年第2期 63-73页

作者： D.L.cohn R.j.O’Brien 丁北川 Research and Surveillance Unit Global Tuberculosis ProgrammeWorld Health Organzation.GenevaSwitzerlandDenver Disease Control ServiceDenver Public Health and Department of MedicineDivision of Infectious DiseasesUniversity Colorado Health Sciences CenterDenverCO Research and Surveillance Unit Global Tuberculosis Programme.World Health Organization.GenevaSwitzerlandDivision of Tuberculosis Elimination.National Center for HIVSTDand TB PreventionCenters for Dontrol and PreventionAtlantaGAUSA

限定性片段长度多态性(RFLP)分型的DNA指纹是最常使用的方法,该方法使结核病流行病学和病因学调查得以进行革新的研究。在结核分支杆菌中存在的插入序列IS6110的使用,通常被考虑为标准的RFLP方法,但另一些辅助方法的分子分型技术可以在... 详细信息

限定性片段长度多态性(RFLP)分型的DNA指纹是最常使用的方法,该方法使结核病流行病学和病因学调查得以进行革新的研究。在结核分支杆菌中存在的插入序列IS6110的使用,通常被考虑为标准的RFLP方法,但另一些辅助方法的分子分型技术可以在选择的环境中使用。在发达国家和发展中国家中,都有一些流行病学研究使用RFLP分型。其主要发现包括传播链的证实和鉴定(敏感和耐药的结核菌菌种都有)、人群中菌种簇的分布、外源性再感染与复发的区分、更好的理解结核病病因学、实验室交叉污染的鉴定和洞察菌种的分子学进化。对于那些结核病负担极重的发展中国家来说,已明确在结核病流行病学研究中,使用RFLP分析主要为下列三方面:1)人群传播,2)医院内传播,和3)人类免疫缺陷病毒相关的结核病。作为规程的要点,建议研究者在经过完好设计的、涉及发展中国家控制措施有影响的流行病学研究中可被采用。

关键词： RFLP DNA指纹结核病分子流行病学传播

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在内皮素A受体拮抗剂的心衰试验(EARTH)中达芦生坦对左室重塑和临床预后的长期疗效观察:随机、双盲、安慰剂对照试验

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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 10-11页

作者： Anand P.I. McMurray P.j. cohn P.j.N. P.T.F. Lüscher 高峰 Cardiovascul ar Centre Cardiology University Hospital Zürich SwitzerlandDr.

Background Endothelin-receptor blockade provides haemodynamic benefit in expe rimental and clinical heart failure. We aimed to measure the effects of long-te rm endothelin-blockade on left-ventricular (LV) remodelling and clinical outco mes in patients with chronic heart failure. Methods 642 patients with chronic he art failure were assigned the oral endothelinA-antagonist darusentan at 10, 25, 50, 100, or 300 mg daily or placebo for 24 weeks in addition to standard therap y in a randomised, doubleblind, placebo-controlled trial. In the 50-300 mg gro ups, darusentan was uptitrated over 6 weeks. Primary endpoint was change in LV e nd-systolic volume (LVESV) at 24 weeks from baseline, measured by MRI. All pati ents for whom assessable MRI scans were available at baseline and follow-up wer e included in the analysis. Findings Darusentan was well tolerated. LVESV could be assessed in 485 (76%) patients with paired MRI data at baseline and 6 months . The change in LVESV was not significantly different from that with placebo at any dose (mean difference from placebo 1.27 mL > with 10 m g dose, -1.84 mL > with 25 mg, -5.68 mL > with 50 mg, -4.05 mL > with 100 mg, and -4.34 mL > with 300 mg). Heart failure worsened in 71 (11.1%) patients, and 30 (4.7%) died dur ing the study with no difference between groups. Interpretation EndothelinA bloc kade with darusentan did not improve cardiac remodelling or clinical symptoms or outcomes in patients with chronic heart failure receiving an angiotensin-conve rting-enzyme inhibitor, βblocker, or aldosterone antagonist. Thus, endothelinA blockade is unlikely to be useful as an add-on treatment in such patients.

关键词：左室重塑长期疗效观察 EARTH 受体拮抗剂内皮素安慰剂对照目标剂量阻滞剂慢性心力衰竭 LVESV

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Study of the products of C3N4H4 treated by high pressure-high temperature

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Study of the products of C3N4H4 treated by high pressure-hig...