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Practical Art of Motion Picture Sound

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The Roles of Different CLE Domains in Arabidopsis CLE Polypeptide Activity and Functional Specificity

2012年

作者： David lewis Yewdall

ISBN: (纸本)9780240812403

Practical Art of Motion Picture Sound, 4th edition relies on the professional experience of the author and other top sound craftspeople to provide a comprehensive explanation of film sound, including mixing, dubbing, workflow, budgeting, and digital audio techniques. Practically grounded with real-world stories from the trenches throughout, the book also provides relevant technical data, as well as an appreciation of all the processes involved in creating optimal motion picture sound. New to this edition are exclusive sound artist lessons from the field (including 2 new production cases studies), including insight from craftspeople who have worked on the latest Harry Potter and Batman films. All technological changes have been updated to reflect the most current systems. **Due to a manufacturing error, the Yewdall Sound FX Library is not available on the DVD included with the book. Please visit the book’s website, to download the full library.**

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Molecular Plant 2010年第4期3卷 760-772页

作者： Ling Meng Kenneth C. Ruth j.nnifer C. Fletcher lewis Feldman Department of Plant and Microbial Biology 111 Koshland Hall University of California Berkeley CA 94720-3102 USA Plant Gene Expression Center USDA-UC Berkeley 800 Buchanan Street Albany CA 94710 USA

The CLE （CLVATA3/ESR-related） family of plant polypeptide signaling molecules shares a conserved 14-aminoacid （aa） motif, designated the CLE motif, which recent studies suggest is sufficient for CLE function in vitro. In this study, we report that Arabidopsis CLE proteins can function in a tissue-specific manner and confirm some CLE factors can act through different receptors. Using domain swapping, we show for the first time that the CLE motif likely determines much of the functional tissue-specificity of the proteins in planta. However, we also provide evidence in support of the new view that sequences outside the CLE motif （14 aa） contribute to CLE function and functional specificity in vivo. Additionally, we report that deletion of the putative signal peptide from different CLE proteins completely inactivates CLE function in vivo, whereas exchanging the CLE signal peptides with a conventional signal peptide from a rice glycine-rich cell wall protein also influences CLE function. We thus propose that the CLE motif itself determines its functional tissue-specificity by dic- tating the direct recognition and interaction of each CLE peptide with its optimal receptor（s）, whereas the receptor（s） may be available in a tissue-specific manner. On the other hand, the sequences outside the CLE motif may influence CLE function by affecting the processing of CLE peptides, resulting in a change in the availability and/or abundance of CLE peptides in specific tissues and/or cells.

关键词： Arabidopsis cell signaling CLE meristem polypeptide protein domain.

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用硫酸氯奎宁治疗慢性盘状红斑狼疮

中华皮肤科杂志 1956年第3期4卷 249-250页

作者：夏廉博上海第二医学院附属广慈医院皮肤科

我们于1955年曾应用发得烈阿祥氏溶甲疗法(以下简称安氏法)在门诊治疗了甲癣病人60例,灰甲181只。现将操作过程中观察所见及详细步骤作一介绍,以便在使用安氏法治疗时不致发生不良情况,而能更好学习苏联先进经验。操作中发生的问题及讨论

关键词：红斑红斑狼疮治疗

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Alice in Wonderland

Alice in Wonderland

Bone Morphogenetic Protein (BMP) signaling in development and human diseases

作者： lewis Carroll authoritative texts of Alice's Adventures in Wonderland Through the Looking-Glass the Hunting of the Snark backgrounds criticism edited by Donald j. Gray Indiana University.

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Genes & Diseases 2014年第1期1卷 87-105页

作者： richard N.Wang j.rdan Green Zhongliang Wang Youlin Deng Min Qiao Michael Peabody Qian Zhang j.xing Ye Zhengj.an Yan Sahitya Denduluri Olumuyiwa Idowu Melissa Li Christine Shen Alan Hu Rex C.Haydon richard Kang j.mes Mok Michael j.Lee Hue L.Luu lewis L.Shi The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Departments of Orthopaedic Surgery Medicineand Gynecologythe Affiliated Hospitals of Chongqing Medical UniversityChongqing 400016China School of Bioengineering Chongqing UniversityChongqingChina

Bone Morphogenetic Proteins(BMPs)are a group of signaling molecules that belongs to the Transforming Growth Factor-b(TGF-b)superfamily of *** discovered for their ability to induce bone formation,BMPs are now known to play crucial roles in all organ *** are important in embryogenesis and development,and also in maintenance of adult tissue *** knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects,highlighting the essential functions of *** this review,we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in development.A significant portion of this review is devoted to the prominent human pathologies associated with dysregulated BMP signaling.

关键词： BMP signaling Development Genetics Mouse knockout Pathogenesis Signal transduction

Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations

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Translational Neurodegeneration 2022年第1期11卷 514-531页

作者： Federico Rodriguez-Porcel Kathryn A.Wyman-Chick Carla Abdelnour Ruiz j.n B.Toledo Daniel Ferreira Prabitha Urwyler Rimona S.Weil j.seph Kane Andrea Pilotto Arvid Rongve Bradley Boeve j.hn-Paul Taylor Ian McKeith Dag Aarsland Simon j.G.lewis the Lewy Body Dementias Clinical Trials Workgroup from the Lewy Body Dementias Professional Interest Area-Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment(ISTAART) Department of Neurology Medical University of South Carolina208b Rutledge Av.CharlestonSC 29403USA Department of Neurology Center for Memory and AgingHealthPartnersSaint PaulMNUSA Autonomous University of Barcelona BarcelonaSpain Fixel Institute for Neurological Diseases University of FloridaGainesvilleFLUSA Division of Clinical Geriatrics Department of NeurobiologyCare Sciencesand SocietyCenter for Alzheimer’s ResearchKarolinska InstitutetStockholmSweden Department of Radiology Mayo ClinicRochesterMNUSA ARTORG Center for Biomedical Engineering Research University of BernBernSwitzerland Dementia Research Centre University College LondonLondonUK Centre for Public Health Queen’s UniversityBelfastUK Neurology Unit Department of Clinical and Experimental SciencesUniversity of BresciaBresciaItaly Department of Research and Innovation Helse FonnaHaugesund HospitalHaugesundNorway Institute of Clinical Medicine(K1) The University of Ber-genBergenNorway Department of Neurology Center for Sleep MedicineMayo ClinicRochesterMNUSA Translational and Clinical Research Institute Newcastle UniversityNewcastle upon TyneUK Department of Old Age Psychiatry Institute of Psychiatry Psychology and Neuroscience King’s College LondonLondonUK ForeFront Parkinson’s Disease Research Clinic Brain and Mind CentreSchool of Medical SciencesUniversity of Sydney100 Mallett StreetCamperdownNSW 2050Australia. 不详

The selection of appropriate outcome measures is fundamental to the design of any successful clinical trial. Although dementia with Lewy bodies (DLB) is one of the most common neurodegenerative conditions, assessment of therapeutic benefit in clinical trials often relies on tools developed for other conditions, such as Alzheimer’s or Parkinson’s disease. These may not be sufficiently valid or sensitive to treatment changes in DLB, decreasing their utility. In this review, we discuss the limitations and strengths of selected available tools used to measure DLB-associated outcomes in clinical trials and highlight the potential roles for more specific obj.ctive measures. We emphasize that the existing outcome measures require validation in the DLB population and that DLB-specific outcomes need to be developed. Finally, we highlight how the selection of outcome measures may vary between symptomatic and disease-modifying therapy trials.

关键词： Dementia with Lewy bodies Clinical trials Outcomes Measurement properties

Mapping an on-chip terahertz antenna by a scanning near-field probe and a fixed field-effect transistor

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Chinese Physics B 2015年第2期24卷 485-489页

作者：吕利孙建东 Roger A.lewis 孙云飞吴东岷蔡勇秦华 Key Laboratory of Nanodevices and Applications Suzhou Institute of Nano-tech and Nano-bionicsChinese Academy of Sciences Graduate University of Chinese Academy of Sciences Institute for Superconducting and Electronic Materials and School of Physics University of WollongongWollongong i-Lab Suzhou Institute of Nano-tech and Nano-bionicsChinese Academy of Sciences

In the terahertz（THz） regime,the active region for a solid-state detector usually needs to be implemented accurately in the near-field region of an on-chip *** of the near-field strength could allow for rapid verification and optimization of new antenna/detector ***,we report a proof-of-concept experiment in which the field mapping is realized by a scanning metallic probe and a fixed AlGaN/GaN field-effect *** results agree well with the electromagnetic-wave *** results also suggest a field-effect THz detector combined with a probe tip could serve as a high sensitivity THz near-field sensor.

关键词： terahertz detector terahertz antenna near-field probe high electron mobility transistor

Low-dose morphine elicits ventilatory excitant and depressant responses in conscious rats: Role of peripheral <i>µ</i>-opioid receptors

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Open j.urnal of Molecular and Integrative Physiology 2013年第3期3卷 111-124页

作者： Fraser Henderson j.. Walter j. May Ryan B. Gruber Alex P. Young Lisa A. Palmer Benj.min Gaston Stephen j. lewis Pediatric Respiratory Medicine University of Virginia School of Medicine Charlottesville USA Division of Biology Galleon Pharmaceuticals Horsham USA Department of Pediatrics Case Western Reserve University Cleveland USA

The systemic administration of morphine affects ventilation via a mixture of central and peripheral actions. The aims of this study were to characterize the ventilatory responses elicited by a low dose of morphine in conscious rats;to determine whether tolerance develops to these responses;and to determine the potential roles of peripheral μ-opioid receptors (μ-ORs) in these responses. Ventilatory parameters were monitored via unrestrained whole-body plethysmography. Conscious male Sprague-Dawley rats received an intravenous inj.ction of vehicle or the peripherally-restricted μ-OR antagonist, naloxone methiodide (NLXmi), and then three successive inj.ctions of morphine (1 mg/kg) given 30 min apart. The first inj.ction of morphine in vehicle-treated rats elicited an array of ventilatory excitant (i.e., increases in frequency of breathing, minute volume, respiratory drive, peak inspiratory and expiratory flows, accompanied by decreases in inspiratory time and end inspiratory pause) and inhibitory (i.e., a decrease in tidal volume and an increase in expiratory time) responses. Subsequent inj.ctions of morphine elicited progressively and substantially smaller responses. The pattern of ventilatory responses elicited by the first inj.ction of morphine was substantially affected by pretreatment with NLXmi whereas NLXmi minimally affected the development of tolerance to these responses. Low-dose morphine elicits an array of ventilatory excitant and depressant effects in conscious rats that are subj.ct to the development of tolerance. Many of these initial actions of morphine appear to involve activation of peripheral μ-ORs whereas the development of tolerance to these responses does not.

关键词： Morphine Minute Ventilation Tolerance Peripheral and Central Opioid Receptors Conscious Rats

Morphine has latent deleterious effects on the ventilatory responses to a hypoxic challenge

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Open j.urnal of Molecular and Integrative Physiology 2013年第3期3卷 166-180页

作者： Walter j. May Ryan B. Gruber j.seph F. Discala Velj.o Puskovic Fraser Henderson j.. Lisa A. Palmer Stephen j. lewis Pediatric Respiratory Medicine University of Virginia School of Medicine Charlottesville USA Division of Biology Galleon Pharmaceuticals Horsham USA

The aim of this study was to determine whether morphine depresses the ventilatory responses elicited by a hypoxic challenge (10% O2, 90% N2) in conscious rats at a time when the effects of morphine on arterial blood gas (ABG) chemistry, Alveolar-arterial (A-a) gradient and minute ventilation (Vm) had completely subsided. In vehicle-treated rats, each episode of hypoxia stimulated ventilatory function and the responses generally subsided during each normoxic period. Morphine (5 mg/kg, i.v.) induced an array of depressant effects on ABG chemistry, A-a gradient and Vm (via decreases in tidal volume). Despite resolution of these morphine-induced effects, the first episode of hypoxia elicited substantially smaller increases in Vm than in vehicle-treated rats, due mainly to smaller increases in frequency of breathing. The pattern of ventilatory responses during subsequent episodes of hypoxia and normoxia changed substantially in morphine-treated rats. It is evident that morphine haslatent deleterious effects on ventilatory responses elicited by hypoxic challenge.

关键词： Morphine Hypoxia Minute Ventilation Arterial Blood Gas Chemistry Conscious Rats