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Molecular rotor based on an oxidized resorcinarene

Organic Chemistry Frontiers 2022年第1期9卷 39-50页

作者： Daniel T.payne jan Labuta Zdeněk Futera Václav Březina Lenka Hanyková Mandeep K.Chahal jonathan P.Hill International Center for Materials Nanoarchitectonics National Institute for Materials ScienceNamiki 1-1TsukubaIbaraki 305-0044Japan bInternational Center for Young Scientists National Institute for Materials ScienceNamiki 1-1TsukubaIbaraki 305-0044Japan Institute of Physics Faculty of ScienceUniversity of South BohemiaBranišovská1760ČeskéBudějovice 37005Czech Republic Faculty of Mathematics and Physics Charles UniversityV Holešovičkách 218000 Prague 8Czech Republic

Molecular rotors are an important class of dynamic molecules which have been studied not only for their possible uses as components of molecular machines but also because of potential applications as probes of local viscosity in biological media,especially self-assembled *** the former,factors affecting rotational motility are critical while for the latter the rotor activity must be complexed with an output signal(often fluorescence)for reporting of local *** single stator-double rotor activity of an oxidized resorcinarene(fuchsonarene)macrocycle containing unsaturated hemiquinonoid groups at its meso positions was *** contain two hemiquinonoid substituents at diagonally-opposed meso-positions with two electron rich phenol groups at the remaining meso-positions between the hemiquinonoid *** meso-substituents are in proximity at one side of the resorcinarene macrocycle(so-called rccc-type isomer)with rotational activity of the phenol *** rates of the phenol moieties can be controlled by varying temperature,solvent polarity and acidity of the medium of study with rotation being thermally activated in neutral and acidic media and tunable in the range from 2 s^(−1) to 20000 s^(−1).Experimental and computational data indicate that rotation of the mobile phenol meso-substituents is remotely affected by interactions with acidic solvents at the carbonyl CvO groups of macrocyclic acetyloxy groups,which occurs with the emergence of a lower energy electronic absorption band whose intensity is correlated with both the acidity of the medium and the rotation rate of the phenol ***-dependent DFT calculations suggest that the low energy band is due to a molecular conformational adjustment affecting electronic conjugation caused by strong interaction of macrocyclic acetyloxy carbonyl groups with the acid *** work presents a molecular mechanical model for estimating solution acidity a

关键词： substituent rotation oxidized

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Simple diagnostic algorithm identifying at-risk nonalcoholic fatty liver disease patients needing specialty referral within the United States

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World journal of Hepatology 2022年第8期14卷 1598-1607页

作者： Naim Alkhouri Pankaj Aggarwal Phuc Le julia payne Celine Sakkal Prido Polanco Stephen Harrison Mazen Noureddin Department of Hepatology Arizona Liver HealthChandlerAZ 85712United States Center for Value-Based Care Research Cleveland ClinicClevelandOH 44195United States Department of Research Pinnacle ResearchSan AntonioTX 78229United States Department of Hepatology Cedars Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND There is an urgent need to risk stratify patients with suspected nonalcoholic fatty liver disease(NAFLD)and identify those with fibrotic nonalcoholic *** study aims to apply a simple diagnostic algorithm to identify subjects with at-risk NAFLD in the general *** To apply a simple diagnostic algorithm to identify subjects with at-risk NAFLD in the general *** Adult subjects were included from the National Health and Nutrition Examination Survey database(2017-2018)if they had elevated alanine aminotransferase(ALT)and excluded if they had evidence of viral hepatitis or significant alcohol consumption.A fibrosis-4(FIB4)cutoff of 1.3 differentiated patients with low risk vs high risk *** patients had FIB4>1.3,a FAST score0.35 were referred to a *** same algorithm was applied to subjects with type 2 diabetes mellitus(T2DM).RESULTS Three thousand six hundred and sixty-nine patients were identified who met all inclusion and exclusion *** this cohort,911(28.6%)patients had elevated ALT of which 236(22.9%)patients had elevated FIB4 scores≥*** patients with elevated FIB4 score,75(24.4%)had elevated FAST scores,ruling in advanced *** accounts for 2.0%of the overall study *** this algorithm to 737 patients with T2DM,213(35.4%)patients had elevated ALT,85(37.9%)had elevated FIB4,and 42(46.1%)had elevated FAST *** accounts for 5.7%of the population with *** The application of this algorithm to identify at-risk NAFLD patients in need for specialty care is feasible and demonstrates that the vast majority of patients do not need subspecialty referral for NAFLD.

关键词： Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Hepatology Diabetes Endocrinology Primary care

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Bacterial cellulose cookbook: A systematic review on sustainable and cost-effective substrates

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journal of Bioresources and Bioproducts 2024年第4期9卷 379-409页

作者： Luis Quijano Raquel Rodrigues Dagmar Fischer jorge David Tovar-Castro Alice payne Laura Navone Yating Hu Hao Yan Phitsanu Pinmanee Edgar Poon jinghe Yang Eve Barro Faculty of Science Queensland University of TechnologyQueensland 4000Australia ARC Centre of Excellence in Synthetic Biology Queensland 4000Australia Faculty of Creative Industries Education and Social JusticeQueensland University of TechnologyQueensland 4059Australia Independent Researcher Portugal Division of Pharmaceutical Technology and Biopharmacy Friedrich-Alexander-Universität Erlangen-NürnbergCauerstraße 491058 ErlangenGermany FAU NeW-Research Center for New Bioactive Compounds Nikolaus-Fiebiger-Straße 1091058 ErlangenGermany Miller School of Medicine University of MiamiFlorida 33136USA School of Fashion and Textiles RMITVictoria 3056Australia School of Education University of QueenslandQueensland 4102Australia Enzyme Technology Research Team National Center for Genetic Engineering and Biotechnology(BIOTEC)National Science and Technology Development Agency(NSTDA)Khlong NuengKhlong LuangPathum Thani 12120Thailand School of Pharmacy University of QueenslandQueensland 4102Australia School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001PR China Department of Life Sciences Imperial College LondonLondon SW72AZUK

Bacterial cellulose is a versatile material with applications in many industries. However, the widespread uptake of bacterial cellulose faces challenges including high production costs and lack of scalability. One approach to address these obstacles is the use of alternative substrates and media, compared to the Hestrin-Schramm (HS) media. By evaluating and selecting appro- priate media and substrates, the production of bacterial cellulose can be more efficient: enabling sustainable systems and supply chains where less energy and materials are lost, and the output production is increased. The purpose of this paper is to analyze the current landscape of bac- terial cellulose alternative media and substrates (ingredients). Through a systematic review of 198 papers, this review identifies 299 alternative substrates from 12 industries and 101 bacte- rial cellulose-producing strains, which were systematically compared. This review also finds that there are methodological gaps in this field such as data variability, papers mislabelling the HS media or not using a comparison media, and a lack of strain names. This alternative substrate analysis for bacterial cellulose production demonstrates that overall, for some applications al- ternative substrates can be taken into consideration that are not only cheaper, but also produce higher yields than HS media.

关键词： Bacterial cellulose Cost-effective Fermentation Hestrin-Schramm Substrates Systematic review Sustainability

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Validation of Automated Dilution and Transfer Methods for Rapid Assessment of Functional Immune Responses to Meningococcal Vaccines

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World journal of Vaccines 2013年第3期3卷 98-101页

作者： Angela M. payne Xu Liu Michael j. Caulfield jon H. Heinrichs Vaccines Basic Research Merck Sharp and Dohme Corp. West Point USA Vaccines Basic Research Merck Sharp and Dohme Corp. West Point USA.

A high-throughput Serum Bactericidal Assay (SBA) was developed to monitor the functional antibody responses to capsular polysaccharide antigens from multiple serotypes of Neisseria meningitidis. This assay measures the ability of an antibody, aided by complement, to mediate killing of bacteria. Functional assays of this type are increasingly used in the quality control arena as potency release tests. Consequently, there has been an enhanced requirement for reproducibility in the performance of this type of assay. Assay validation is, therefore, important to facilitate understanding of the significance of values obtained, and to enable appropriate and informed use of the assay. This study involved the evaluation of the high-throughput serum bactericidal assay including the effects of different dilution and transfer techniques on assay performance. The results presented here demonstrate the repeatability, and the precision and ruggedness of the assay.

关键词： Serum Bactericidal Assay SBA Neisseria meningitides Automation Repeatability

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制粒工艺疑难解答

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饲料研究 2010年第5期33卷 73-76页

作者： john D payne 程宗佳(摘译) 美国大豆协会国际项目北京办事处 100004 不详

1颗粒质量与生产率问题颗粒质量问题是指颗粒耐久性低于可接受水平,生产效率问题是指低于可接受的颗粒质量和设计能力。国家和地区间的可接受水平各不相同,这取决于很多因素,如：技术、生产能力、饲料原料和市场方面的压力。从实践上,... 详细信息

1颗粒质量与生产率问题颗粒质量问题是指颗粒耐久性低于可接受水平,生产效率问题是指低于可接受的颗粒质量和设计能力。国家和地区间的可接受水平各不相同,这取决于很多因素,如：技术、生产能力、饲料原料和市场方面的压力。从实践上,很可能是市场情况决定了非综合性生产企业的颗粒质量。因此,生产企业必须首先建立颗粒质量可接受性和保持接近耐久性的目的。

关键词：制粒工艺颗粒质量解答生产企业市场情况质量问题设计能力效率问题

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Understanding the agronomic impacts of defoliation strategies in“Bulldog 805”Alfalfa+“Tifton 85”bermudagrass mixed stands

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Grassland Research 2023年第4期2卷 251-259页

作者： Lisa L.Baxter justin C.Burt Mary Kimberly Mullenix Sydney L.payne Kaylyn R.Reagin Katie M.Mason Chris G.Prevatt jennifer j.Tucker Department of Crop and Soil Science University of GeorgiaTiftonGeorgiaUSA Department of Animal Science Auburn UniversityAuburnAlabamaUSA Department of Animal Science University of TennesseeKnoxvilleTennesseeUSA Beef Cattle and Forage Commodity Director Alabama Farmers Federation MontgomeryMontgomeryAlabamaUSA Department of Animal and Dairy Science University of GeorgiaTiftonGeorgiaUSA

Background:The incorporation of legumes,specifically alfalfa(Medicago sativa L.),into bermudagrass(Cynodon spp.)-based pasture systems in the southeastern United States has increased in recent years as an alternative to synthetic nitrogen(N)***:A small plot evaluation was conducted in Shorter,Alabama,and Tifton,Georgia,USA,to evaluate the impact of harvest height(HH)and harvest frequency(HF)on agronomic characteristics of alfalfa+bermudagrass mixtures in southeastern United ***:Results from both locations revealed that the longer the HF and the shorter the HH,the greater the alfalfa retention was in the stand(p<0.01).HH did not impact any of the reported nutritive value parameters,while longer HF resulted in lower total digestible nutrients,lower crude protein,higher acid detergent fiber,and lower 48 h in vitro dry matter digestibility(p<0.01).Both HH and HF impacted forage accumulation at both locations(p<0.01).HH resulted in different trends at each location,while longer frequencies generally increased forage ***:This research confirmed recent findings from comparable evaluations in the southeastern United States,in that increasing HH and decreasing HF improved alfalfa retention while having a negligible effect on nutritive value or forage accumulation.

关键词： alfalfa+bermudagrass mixtures defoliation management forage management

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在制粒机压模处喷涂油脂

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粮食与饲料工业 1988年第1期 40-43页

作者： j payne 陈汉东

压模处喷脂工艺是对颗粒冷却后喷脂的一个自然且合乎逻辑的发展。这一新发展的最引人注目之处在于它的产生和15～20年前推广的颗粒喷脂法之间的时间跨度。压模处喷脂法是二年前由丹麦的诺维丹首创的,1984年由霍尔曼介绍到英国。这么说,... 详细信息

压模处喷脂工艺是对颗粒冷却后喷脂的一个自然且合乎逻辑的发展。这一新发展的最引人注目之处在于它的产生和15～20年前推广的颗粒喷脂法之间的时间跨度。压模处喷脂法是二年前由丹麦的诺维丹首创的,1984年由霍尔曼介绍到英国。这么说,是因为笔者可以肯定有一、二个饲料公司会声称他们也做

关键词：制粒机控制器计算机流量计成型机调节器流量仪表海洋仪器油脂加工调制饲料颗粒饲料压模

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TONAL HARMONY, WITH AN INTRODUCTION TO TWENTIETH-CENTURY MUSIC / 4th ed.

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2000年

作者： STEFAN KOSTKA DOROTHY payne.

来源：畅想之星图书光盘版（南... 评论

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Comparason of Peri-Articular Multimodal Drug Injection with Femoral and Sciatic Nerve Block after Total Knee Arthroplasty

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Open journal of Orthopedics 2012年第4期2卷 155-158页

作者： Calum H. C. Arthur Alexander M. Wood Charles Leeson-payne Steffen j. Breusch Orthopaedic Department Royal Infirmary of Edinburgh Edinburgh UK

Good perioperative analgesia following total knee arthroplasty facilitates rehabilitation and may reduce hospital stay. We present the patient analgesic requirements and rehabilitation of a prospective single surgeon series after the introduction of a multimodal drug injection during his total knee arthroplasty. Basic epidemiological data as well as analgesic, antiemetic requirements and time to straight leg raised was collected on 27 consecutive patients (group 1) whom received the multimodal drug injection, consisting of levobupivacaine, ketorolac and adrenaline at the time of their total knee arthroplasty under spinal anaesthesia. Their rehabilitation was compared to a retrospective review of patients who were case matched by age and sex (group 2n = 26), whom had received the unit standard of spinal anaesthetic and a femoral and sciatic block at the time of their operation. Patients in group 1 had significantly lower analgesic and antiemetic requirements than group 2. Group 1 also had a significantly shorter hospital stay. We have demonstrated that periarticular multimodal drug injection can improve perioperative analgesia and mobilisation following total knee arthroplasty as well as reducing opioid requirements and side effects.

关键词： Analgesia Total Knee Replacement Multimodal Drug Injection Peripheral Nerve Blocks Rehabilitation

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垫片试验进展——里程碑试验结果

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化工设备设计 1985年第5期 51-64页

作者： A.Bazergui j.R.payne 陈树宁北京化工学院

由美国压力容器研究委员会主办,六个国家的三十多个发起者赞助的一个广泛的垫片试验计划正接近完成。该计划是在美国机械工程师协会(ASME)要求和为了解决复杂的垫片性能的需要,作为压力容器研究委员会长期法兰连接改善计划的一部分而制... 详细信息

由美国压力容器研究委员会主办,六个国家的三十多个发起者赞助的一个广泛的垫片试验计划正接近完成。该计划是在美国机械工程师协会(ASME)要求和为了解决复杂的垫片性能的需要,作为压力容器研究委员会长期法兰连接改善计划的一部分而制定的。该试验计划是在美国机械工程师协会、美国石油学会和美国材料与试验学会标准委员会的协作下正式提出的。在这些试验中,用复杂的载荷/压力加载程序来确定常用的四种类型垫片在室温下的泄漏性能和变形响应。本文综述该试验的情况——该试验研究了流体压力、流体种类、法兰表面加工光洁度、最大垫片应力、垫片变形和应力循环等因素的影响;还介绍了石棉缠绕垫的首批两组试验结果,以便强调观察到的一些趋向。为了导出类似于ASME压力容器规范m和y系数的有意义的设计参数,对试验结果做了分析。可是分析结果表明,就已知的垫片类型来说,这样的系数并不具有一个唯一的值,m与y之间是相互关联的,并且它们的数值决定于所确定的紧密性水平,它们还受上述的各种参数的影响。

关键词：垫片紧密性泄漏率试验结果

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