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A Many Worlds Interpretation of the Dark Universe

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第2期10卷 828-835页

作者： richard Douglas Bateson Cavendish Laboratory Cambridge UK

In this paper, we discuss a Many Worlds Interpretation (MWI) of Dark Energy and Dark Matter. The universe is viewed cosmologically as a fermionic fluid with a hydrostatic pressure from “Zitterbewegung”, the quantum “zig-zagging” of Dirac particles. At each point in space-time, the pressure from all possible velocity states existing in the Many Worlds sums to provide a dark energy. This provides a ratio of matter energy to pressure energy close to that observed experimentally. Visible matter is the matter observed or measured in a particular velocity state and dark matter is then considered as the unobserved fermion contributions from different orthogonal spatial directions.

关键词： Dark Energy Dark Matter Many Worlds

Survival outcomes in early-onset oesophageal adenocarcinoma patients:A systematic review and meta-analyses

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World Journal of Gastroenterology 2024年第38期30卷 4221-4231页

作者： Ashleigh Russell Shauna Mitchell richard C Turkington Helen G Coleman Centre for Public Health Queen's University BelfastBelfast BT126BAUnited Kingdom Patrick G Johnston Centre for Cancer Research Queen's University BelfastBelfast BT71NNUnited Kingdom

BACKGROUND The incidence of oesophageal adenocarcinoma(OAC)has been reported to be increasing in many *** this trend,an increase in incidence of early-onset OAC,defined as OAC in adults aged under 50 years,has been *** is unclear whether survival outcomes for early-onset OAC patients differ from older age *** To investigate survival outcomes in early-onset OAC *** Ovid Medline and Embase were searched from inception to January 2022 for relevant studies relating to early-onset OAC and survival *** regarding the overall five-year survival and risk of death of younger and older patients with OAC were extracted and pooled using meta-analyses to produce pooled estimates and 95%CIs where *** Eleven studies which compared survival of early-onset OAC,defined as age at diagnosis off median and mean survival demonstrated conflicting results,with studies showing early-onset OAC patients having both better and worse outcomes compared to older age groups.A meta-analysis of five-year survival demonstrated similar outcomes across age groups,with 22%-25%of patients in the young,middle and older age groups alive after five years.A meta-analysis of four studies demon-strated that early-onset OAC patients did not have a significantly increased risk of death compared to middle-aged patients(hazard ratio 1.12,95%CI:0.85-1.47).INTRODUCTION There is concern that the incidence of oesophageal adenocarcinoma(OAC)in patients under 50,described as early-onset OAC,is ***,data regarding survival of younger patients with OAC is ***,while increasing age remains a major non-modifiable risk factor for cancer,the incidence of early-onset cancers,largely accepted to be in adults aged under 50 years,is increasing[1].This includes an observed increase in the incidence of gastrointestinal malignancies such as colorectal,oesophageal,gastric and he

关键词： Early-onset cancer Early-onset oesophageal adenocarcinoma Survival Cancer epidemiology Systematic review Meta-analysis

Improved Units of Measure in Rotational Mechanics

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World Journal of Mechanics 2024年第1期14卷 1-7页

作者： richard James Petti Independent Researcher Arlington USA

The SI system of units in rotational mechanics yields correct numerical results, but it produces physically incorrect units of measure in many cases. SI units also violate the principle of general covariance—the general rule for defining continuous coordinates and units in mathematics and mathematical physics. After 30+ years of wrestling with these problems, the ultimate authority on units of measure has declared that Newton–meter and Joule are not equivalent in rotational mechanics, as they are in the rest of physics. This article proposes a simple modification to SI units called “Nonstandard International units” (“NI units”) until a better name is agreed upon. NI units yield correct numerical results and physically correct units of measure, and they satisfy the principle of general covariance. The main obstacle to the adoption of NI units is the consensus among users that the radius of rotation should have the unit meter because the radius can be measured with a ruler. NI units assigned to radius should have units meter/radian because the radius is a conversion factor between angular size and circumferential length, as in arclength = rθ. To manage the social consensus behind SI units, the author recommends retaining SI units as they are, and informing users who want correct units that NI units solve the technical problems of SI units.

关键词： Rotational Mechanics Angular Unit Torque Moment of Inertia Angular Momentum General Covariance

Endoplasmic reticulum stress,autophagy,neuroinflammation,and sigma 1 receptors as contributors to depression and its treatment

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Neural Regeneration Research 2024年第10期19卷 2202-2211页

作者： Chika fujii Charles f.Zorumski Yukitoshi Izumi Department of Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor family Institute for Innovative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA

The etiological factors contributing to depression and other neuropsychiatric disorders are largely undefined. Endoplasmic reticulum stress pathways and autophagy are well-defined mechanisms that play critical functions in recognizing and resolving cellular stress and are possible targets for the pathophysiology and treatment of psychiatric and neurologic illnesses. An increasing number of studies indicate the involvement of endoplasmic reticulum stress and autophagy in the control of neuroinflammation, a contributing factor to multiple neuropsychiatric illnesses. Initial inflammatory triggers induce endoplasmic reticulum stress, leading to neuroinflammatory responses. Subsequently, induction of autophagy by neurosteroids and other signaling pathways that converge on autophagy induction are thought to participate in resolving neuroinflammation. The aim of this review is to summarize our current understanding of the molecular mechanisms governing the induction of endoplasmic reticulum stress, autophagy, and neuroinflammation in the central nervous system. Studies focused on innate immune factors, including neurosteroids with anti-inflammatory roles will be reviewed. In the context of depression, animal models that led to our current understanding of molecular mechanisms underlying depression will be highlighted, including the roles of sigma 1 receptors and pharmacological agents that dampen endoplasmic reticulum stress and associated neuroinflammation.

关键词： allopregnanolone fluvoxamine ketamine neurosteroids postpartum depression quercetin

fire and retention island remnants have similar deadwood carbon stock a decade after disturbances in boreal forests of Alberta

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forest Ecosystems 2024年第5期11卷 677-684页

作者： richard Osei Lance P.Moore Rosanise A.Odell Marcel Schneider Tanvir Ahmed Shovon Charles A.Nock Department of Renewable Resources University of AlbertaEdmontonCanada Institut des Sciences de La for^et Temperee Universite Du Quebec en Outaouais58 Rue PrincipaleRiponJ0V 1V0QCCanada

In an attempt to reconcile wood extraction and forest biodiversity in managed boreal forests,ecosystem-based forest management(EBM)has become the de facto management *** forestry represents one prominent way that EBM is implemented in many parts of the *** patches commonly left after harvesting serve as analogues of fire island remnants,which are patches of unburned forests in the burned forest *** the persistence of retention patches has been questioned,few studies have attempted to quantitatively compare forest attributes in both burned and harvested *** part of a larger program examining multiple aspects of ecosystem function in fire and harvest island remnants,we investigated the impact of disturbance type(fire/harvest)and forest edges on C stock in snags and coarse woody debris(CWD)found in island remnants in mixedwood boreal forests of Alberta,*** C stock(in snags and CWD)was similar between the two disturbance types and edge plots had similar total deadwood C stocks to *** edges of island remnants had about two-fold more snag C stock than their interiors in both disturbance types,but C stock in CWD was unaffected by edge effects and disturbance *** results suggest that deadwood C dynamics in island remnants in fire and harvest disturbed boreal forests were similar,thus lending support for the continued implementation of retention forestry in Alberta.

关键词： Retention forestry Deadwood Ecosystem-based management Wildfires Boreal forest

How Prime Numbers Are Interconnected and Built with Two Equations: Addition and Subtraction Rules the function (6µ)

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Advances in Pure Mathematics 2024年第4期14卷 228-241页

作者： John richard Wisdom Centre of Pedagogical Innovation (Capsule) Sorbonne University Paris France

Are all prime numbers linked by four simple functions? Can we predict when a prime will appear in a sequence of primes? If we classify primes into two groups, Group 1 for all primes that appear before ζ (such that , for instance 5, ), an even number divisible by 3 and 2, and Group 2 for all primes that are after ζ (such that , for instance 7), then we find a simple function: for each prime in each group, , where n is any natural number. If we start a sequence of primes with 5 for Group 1 and 7 for Group 2, we can attribute a μ value for each prime. The μ value can be attributed to every prime greater than 7. Thus for Group 1, and . Using this formula, all the primes appear for , where μ is any natural number.

关键词： Number Theory Prime Number Groups Twin Primes Prime Structure and Sequence Prime Subtraction and Addition

The effects of local variations in conditions on carbon storage and release in the continental mantle

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National Science Review 2024年第6期11卷 22-36页

作者： Stephen f.foley Chunfei Chen Dorrit E.Jacob School of Natural Sciences Macquarie University Research School of Earth Sciences Australian National University State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences China University of Geosciences

Recent advances indicate that the amount of carbon released by gradual degassing from the mantle needs to be revised upwards, whereas the carbon supplied by plumes may have been overestimated in the *** in rock types and oxidation state may be very local and exert strong influences on carbon storage and release mechanisms. Deep subduction may be prevented by diapirism in thick sedimentary packages,whereas carbonates in thinner sequences may be subducted. Carbonates stored in the mantle transition zone will melt when they heat up, recognized by coupled stable isotope systems(e.g. Mg, Zn, Ca). There is no single ‘mantle oxygen fugacity’, particularly in the thermal boundary layer(TBL) and lowermost lithosphere, where very local mixtures of rock types coexist. Carbonate-rich melts from either subduction or melting of the uppermost asthenosphere trap carbon by redox freezing or as carbonate-rich dykes in this zone. Deeply derived, reduced melts may form further diamond reservoirs, recognized as polycrystalline diamonds associated with websteritic silicate minerals. Carbon is released by either edge-driven convection,which tears sections of the TBL and lower lithosphere down so that they melt by a mixture of heating and oxidation, or by lateral advection of solids beneath rifts. Both mechanisms operate at steps in lithosphere thickness and result in carbonate-rich melts, explaining the spatial association of craton edges and carbonate-rich magmatism. High-pressure experiments on individual rock types, and increasingly on reactions between rocks and melts, are fine-tuning our understanding of processes and turning up unexpected results that are not seen in studies of single rocks. future research should concentrate on elucidating local variations and integrating these with the interpretation of geophysical signals. Global concepts such as average sediment compositions and a uniform mantle oxidation state are not appropriate for small-scale processes; an increa

关键词： lithospheric mantle carbonate melts deep carbon cycle craton destruction continental rifts

Understanding the neighborhoods’in-between spaces on spatial perception,social interaction,and security

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frontiers of Architectural Research 2024年第1期13卷 21-36页

作者： Lizeth félix Mariel Organista Autonomous University of Baja California Ensenada 22860Mexico

This study reflects on the impact that the neighborhoods’in-between spaces have on:spatial perception,social interaction,and *** sites,characterized by their abandonment and deterioration,can also be seen as crucial spaces of opportunity for cities,in the architectural,urban and landscape *** paper aims to analyze the sociospatial relationships in the neighborhoods’in-between spaces and examine the impact of inbetween space configuration on urban *** investigation draws on a survey of perception to residents about the requirements for a suitable social interaction in these *** study was developed in a neighborhood in the city periphery,characterized by their social dynamics and location in a nature conservation *** findings indicate that the appropriation process,activities,and collective practices are dependent on the spatial legibility,in this case when this increases,gives rise to improve the habitability and the rehabilitation of the in-between ***,the lack of design on in-between spaces substantially affects the use of these spaces and the social interaction among residents.

关键词： In-between spaces Socio-spatial relationships Habitability Neighborhoods Security

Preparation of Regenerated Silk fibroin Hybrid fibers with Hydrogen Peroxide Sensing Properties by Wet Spinning

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Journal of Renewable Materials 2024年第6期12卷 1043-1055页

作者： Song Lu Jianjun Guo richard Ansah Herman Xinyi Wu Lin Ma Guohua Wu College of Biotechnology Jiangsu University of Science and TechnologyZhenjiang212100China College of Agriculture Anshun UniversityAnshun561000China

Silk is widely used in the production of high-quality *** the same time,the amount of silk textiles no longer in use and discarded is increasing,resulting in significant waste and *** issue is of great concern in many countries where silk is *** peroxide as a naturally occurring compound is an important indicator of detection in both biology and the *** study aims to develop a composite fiber with hydrogen peroxide-sensing properties using discarded silk *** achieve this goal,firstly,polydopamine(PDA)was used to encapsulate the Znfe_(2)O_(4) NPs to achieve the improvement of dispersion,and then regenerated silk fibroin(RSf)and PDA@Znfe_(2)O_(4)/RSf hybrid fibers are prepared by wet *** has shown that PDA@Znfe_(2)O_(4)/RSf demonstrates exceptional sensitivity,selectivity,and stability in detecting hydrogen peroxide,while maintaining high mechanical ***,the complete hybridization of PDA@Znfe_(2)O_(4) with silk fibroin not only results in the combination of the durability of silk fibroin and PDA@Znfe_(2)O_(4)’s rigidity,ensuring a reliable service life,but also makes PDA@Znfe_(2)O_(4)/RSf exhibit excellent catalytic activity and ***,the composite fiber exhibits exceptional mechanical properties and reliable hydrogen peroxide sensing capabilities,making it a promising material for biological and medical applications.

关键词： Regenerated silk fibroin modified zinc ferrite nanoparticles composite fiber hydrogen peroxide sensor wet spinning