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Evaluation of Serum Anti-Müllerian Hormone (AMH) Values for 28,016 Bulgarian Women: Prognostic Statistical Model of Age Specific AMH Declining

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 651-673页

作者： Martin Vladimirov evan Gatev Desislava Tacheva Aleksandra Kalacheva Milena Bojilova Serpil Izet Alexander Angelov Nedyalko Kalatchev Iavor K. Vladimirov Sbalagrm-Sofia Sofia Bulgaria Bulgarian Academy of Science Institute of Molecular Biology Sofia Bulgaria Department of Cytology-Histology and Embryology Sofia University &#8220St. Kliment Ohridski&#8221 Sofia Bulgaria Cibalab Boulevard &#8220Akademik Ivan Evstratiev Geshov&#8221 Sofia Bulgaria Synevo Bulgaria Sofia Bulgaria

The present study aims to establish a relationship between serum AMH levels and age in a large group of women living in Bulgaria, as well as to establish reference age-specific AMH levels in women that would serve as an initial estimate of ovarian age. A total of 28,016 women on the territory of the Republic of Bulgaria were tested for serum AMH levels with a median age of 37.0 years (interquartile range 32.0 to 41.0). For women aged 20 - 29 years, the Bulgarian population has relatively high median levels of AMH, similar to women of Asian origin. For women aged 30 - 34 years, our results are comparable to those of women living in Western Europe. For women aged 35 - 39 years, our results are comparable to those of women living in the territory of India and Kenya. For women aged 40 - 44 years, our results were lower than those for women from the Western European and Chinese populations, close to the Indian and higher than Korean and Kenya populations, respectively. Our results for women of Bulgarian origin are also comparable to US Latina women at age 30, 35 and 40 ages. On the base on constructed a statistical model to predicting the decline in AMH levels at different ages, we found non-linear structure of AMH decline for the low AMH 3.5) the dependence of the decline of AMH on age was confirmed as linear. In conclusion, we evaluated the serum level of AMH in Bulgarian women and established age-specific AMH percentile reference values based on a large representative sample. We have developed a prognostic statistical model that can facilitate the application of AMH in clinical practice and the prediction of reproductive capacity and population health.

关键词： Anti-Müllerian Hormone Women Age Ovarian Response Ethnicity Prognostic Statistical Model

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就地养老:蒙蒂菲奥里的M养老住宅

当代建筑 2024年第7期 110-117页

作者：无 Brett Boardman(摄影) Justin Alexander(摄影) evan Zell(摄影) 杰克逊蒂斯建筑设计事务所不详

蒙蒂菲奥里的M养老住宅是悉尼市中心一个高品质养老社区中的独立住宅部分,是对原有养老社区的扩建和更新。这两栋新独立住宅楼位于兰德威克国王街,这里曾经是悉尼电车中心的所在地。

关键词：就地养老适应性社会责任

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摩天大楼的公共性——范德比尔特一号大楼

当代建筑 2024年第4期 96-105页

作者：无 Raimund Koch(摄影) Michael Moran/OTTO(摄影) evan Joseph Studios(摄影) KPF建筑设计事务所

范德比尔特一号大楼改变了大中央区的公众体验,成为纽约市的门户,每天迎接成千上万的通勤者。该项目为城市最大的交通枢纽之一——纽约中央车站(以下简称“大中央车站”)引入了新的可通行路径,比任何其他建筑能更好地融入城市的公共交... 详细信息

范德比尔特一号大楼改变了大中央区的公众体验,成为纽约市的门户,每天迎接成千上万的通勤者。该项目为城市最大的交通枢纽之一——纽约中央车站(以下简称“大中央车站”)引入了新的可通行路径,比任何其他建筑能更好地融入城市的公共交通网络,实现了私人企业和公共领域的结合。一个复杂的地下结构连接了大中央车站、东侧通道项目和纽约地铁。一个优雅的城市基座,包括一个活跃的行人广场和综合交通大厅,使这个项目成为21世纪洛克菲勒中心的继承者。

关键词：办公楼以公共交通为导向开发低碳足迹超高层公私合作开发

大国数字货币对小国宏观金融形势溢出效应研究

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新金融 2024年第7期 53-58页

作者： Anh H.Le Alexander Copestake Brandon Tan evan Papageorgiou SJay Peiris Umang Rawat 唐成千(译) 周正铭(译) 国际货币基金组织不详

央行数字货币(CBDC)快速发展,与传统法定货币不同,CBDC对宏观经济,尤其是对邻国的宏观经济有哪些影响值得关注。本文建立了一个考虑内生货币替代和金融摩擦的两国新凯恩斯模型,以考察大型外国经济体发行的稳定币对小型发展中经济体的影... 详细信息

央行数字货币(CBDC)快速发展,与传统法定货币不同,CBDC对宏观经济,尤其是对邻国的宏观经济有哪些影响值得关注。本文建立了一个考虑内生货币替代和金融摩擦的两国新凯恩斯模型,以考察大型外国经济体发行的稳定币对小型发展中经济体的影响。研究发现,外国稳定币为国内经济中的家庭提供流动性服务,并为国内通胀提供额外的对冲;同时,它的引入放大了货币替代效应,减少了银行中介作用,削弱了货币政策传导作用,加剧了衰退冲击的影响,增加了银行业经营压力;而资本管制提高了稳定币作为规避手段的使用率,增加了对外国冲击溢出效应的敞口。与国内中央银行数字货币不同,禁止外国稳定币支付可以缓解这些影响。本刊编译此篇国际货币基金组织(IMF)的工作论文,以期为读者带来启示。

关键词：央行数字货币(CBDC) 宏观金融形势溢出效应开放经济体金融摩擦

Prostate cancer cells metastasize to the hematopoietic stem cell niche in bone

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Asian Journal of Andrology 2011年第4期13卷 622-623页

作者： evan T Keller Departments of UroJogy and Pathology University of Michigan Ann Arbor MI 48109 USA

The majority of men with advanced prostate cancer develop bone metastases as opposed to metastases at other sites. It has been unclear why prostate cancer selectively metastasizes to and proliferates in bone. Recently, Shiozawa et al. delineated a mechanism that may account for the establishment of prostate cancer in bone. Specifically, they identified that prostate cancer cells compete with hematopoietic stem cells （HSC） for the osteoblast in the HSC niche of the bone. Defining the mechanisms through which prostate cancer cells establish themselves in bone is critical towards developing effective therapeutic strategies to prevent or target bone metastases.

关键词： Biological sciences Cell biology Microbiology

Predicting the synthesizability of crystalline inorganic materials from the data of known material compositions

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npj Computational Materials 2023年第1期9卷 733-743页

作者： evan R.Antoniuk Gowoon Cheon George Wang Daniel Bernstein William Cai evan J.Reed Materials Science Division Physical and Life Sciences DirectorateLawrence Livermore National LaboratoryLivermoreCAUSA Department of Chemistry Stanford UniversityStanfordCAUSA Department of Applied Physics Stanford UniversityStanfordCAUSA Google Research Mountain ViewCAUSA Department of Physics Stanford UniversityStanfordCAUSA Department of Mathematics Stanford UniversityStanfordCAUSA Department of Computer Science Stanford UniversityStanfordCAUSA Department of Materials Science and Engineering Stanford UniversityStanfordCAUSA

Reliably identifying synthesizable inorganic crystalline materials is an unsolved challenge required for realizing autonomous materials *** this work,we develop a deep learning synthesizability model(SynthNN)that leverages the entire space of synthesized inorganic chemical *** reformulating material discovery as a synthesizability classification task,SynthNN identifies synthesizable materials with 7×higher precision than with DFT-calculated formation *** a head-to-head material discovery comparison against 20 expert material scientists,SynthNN outperforms all experts,achieves 1.5×higher precision and completes the task five orders of magnitude faster than the best human ***,without any prior chemical knowledge,our experiments indicate that SynthNN learns the chemical principles of charge-balancing,chemical family relationships and ionicity,and utilizes these principles to generate synthesizability *** development of SynthNN will allow for synthesizability constraints to be seamlessly integrated into computational material screening workflows to increase their reliability for identifying synthetically accessible materials.

关键词： inorganic crystalline utilize

A Group of Cu(Zr)-based BMGs with Critical Diameter in the Range of 12 to 18 mm

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Journal of Materials Science & Technology 2008年第2期24卷 149-152页

作者： Yong SHEN evan MA Jian XU Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Department of Materials Science and Engineering The Johns Hopkins University Baltimore Maryland 21218 USA

A group of Cu（Zr）-based bulk metallic glasses （BMGs） with critical diameter （De） in the 12 to 18 mm range have been obtained using copper mould casting. In the Cu-Zr-Y-Al quaternary system, a new record of Dc=14 mm was established for Cu-based compositions, and 16 mm for compositions based on equi-atomic CuZr. Additional partial substitution of Hf for Zr further elevated the Dc to 18 mm at Cu42Zr43Hf1.5Y3.5Al10.

关键词： Bulk metallic glasses Glass-forming ability Copper Zirconium

SPDEF： a molecular switch for E-cadherin expression that promotes prostate cancer metastasis

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Asian Journal of Andrology 2013年第5期15卷 584-585页

作者： Mary Osisami evan T Keller Department of Urology University of Michigan AnnArbor M148105 USA

In order to design effective therapies for prostate cancer, a clear understanding of mechanisms that contribute to various components of prostate cancer progression is necessary. Study of metastasis suppressor genes, i.e., genes that can inhibit metastasis, is an important field of study that can lead to identification of therapeutic targets to diminish metastasis.

关键词： SPDEF a molecular switch metastasis

China’s transitioning class identity

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China Finance and Economic Review 2016年第1期5卷 71-87页

作者： evan Osborne Department of Economics Wright State University

China’s rapid economic transformation is similar in some ways to those that have occurred in other East Asian *** the changing structure of perceived class identity that occurs in many rapidly growing economies is found to be absent in China,and in fact as China has continued to grow such change as has occurred is found to be downward,despite the immense material improvement *** data on income distribution in China do not explain this phenomenon,but anomalies in China’s urban real-estate market might.

关键词： Housing market class identity middle class social effects of economic growth