检索结果-南通市图书馆

Hepatitis C virus infection and apoptosis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第36期13卷 4865-4872页

作者： richard Fischer Thomas Baumert Hubert e Blum Department of InternalMedicine II University of Freiburg Germany Inserm U748 Service d’Hépatogastro-entérologie Hpitaux Universitaires de Strasbourg Strasbourg France

Apoptosis is central for the control and elimination of viral infections. In chronic hepatitis C virus (HCV) infection, enhanced hepatocyte apoptosis and upregulation of the death inducing ligands CD95/Fas, TRAIL and TNFα occur. Nevertheless, HCV infection persists in the majority of patients. The impact of apoptosis in chronic HCV infection is not well understood. It may be harmful by triggering liver fibrosis, or essential in interferon (IFN) induced HCV elimination. For virtually all HCV proteins, pro- and anti-apoptotic effects have been described, especially for the core and NS5A protein. To date, it is not known which HCV protein affects apoptosis in vivo and whether the infectious virions act pro- or anti- apoptotic. With the availability of an infectious tissue culture system, we now can address pathophysiologically relevant issues. This review focuses on the effect of HCV infection and different HCV proteins on apoptosis and of the corresponding signaling cascades.

关键词： Hepatitis C Spoptosis TRAIL CD95/Fas TNFα Perforin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

易拉罐美容记

小哥白尼（趣味科学） 2009年第8期 24-25页

作者： Jan McHarry e.davis P.Sanford

一.惊魂记：首先它和其他易拉罐兄弟们一起，被像压面包一样地压成一个个大大的金属面包!二.粉身记：金属面包被喂进切割机切成零零碎碎的小铁片。看着支离破碎的身躯，那个惨啊!据操作师说“这样是为了对每个铁片的每个部位都进行充分... 详细信息

一.惊魂记：首先它和其他易拉罐兄弟们一起，被像压面包一样地压成一个个大大的金属面包!二.粉身记：金属面包被喂进切割机切成零零碎碎的小铁片。看着支离破碎的身躯，那个惨啊!据操作师说“这样是为了对每个铁片的每个部位都进行充分挺作……”

关键词：易拉罐美容面包切割机金属铁片

Study of the Characteristics of Large-Diameter Iron Bars Obtained by Rolling at the ODHAV Foundry in the Republic of Guinea

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science and Chemical engineering 2024年第6期12卷 43-54页

作者： Alpha Issa Diallo Jean Ahmadou Kourouma Adama Moussa Sakho Younoussa Moussa Baldé Mamadou Madaniou Sow Alexandre Lucien richard Mechanical Laboratory Higher Institut of Technology of Mamou Mamou Republic of Guinea Materials Laboratory of the Gamal Abdel Nasser University of Conakry Conakry Republic of Guinea Dpartment of Laboratory Technology Higher Institut of Technology of Mamou Mamou Republic of Guinea Department of energy Science Higher Institut of Technology of Mamoun Mamou Republic of Guinea

This work consists of evaluating the quality of the mechanical parameters of large-diameter steels, i.e. 20, 25, 28 and 32, through a process of recycling scrap metal that fills garages, rubbish dumps, gutters and other abandoned sites, as well as imported concrete reinforcing steel sold in the Republic of Guinea. To carry out this important work, a number of mechanical tensile and bending tests and a microscopic analysis combining two devices, an electron microscope and a photographic camera, were carried out. The samples were taken from sampling areas in the major communes of Conakry, namely: Casse Sonfonia, Matoto and Kagbélen. The tensile strength values of the large dimensions 20, 25, 28 and 32 are given in the tables.

关键词： Recycled Scrap Large Diameter Rolling Tensile Testing Bending

Numerical Simulation of Single Microparticle Trajectory in an electrodynamic Balance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemical engineering 2004年第3期12卷 444-447页

作者：冯昭华朱家骅杨雪峰夏素兰关国强 davis e.J. School of Chemical engineering Sichuan University Chengdu 610065 China Department of Chemical engineering University of Washington Seattle Washington 98195-1750 USAy introducing Oseen's formula to describe the viscous drag force a more complete motion equation for a charged microparticle levitated in an electrodynamic balance (EDB) has been put forward and solved numerically by the classic Runge-Kutta method in this paper. The theoretical results have firstly demonstrated the existence of the particle oscillations and their characteristics especially of the springpoint oscillation at large amplitude. And through the comparisons of theoretical and experimental trajectories the adopted motion equation has proved to be able to rigorously describe the particle motion in non-Stokes region-the shape of trajectory and frequency characteristics are fairly consistent and the deviations of amplitude can usually be less than 10%.

By introducing Oseen's formula to describe the viscous drag force, a more complete motion equation for a charged microparticle levitated in an electrodynamic balance (eDB) has been put forward and solved numerically by the classic Runge-Kutta method in this paper. The theoretical results have firstly demonstrated the existence of the particle oscillations and their characteristics, especially of the springpoint oscillation at large amplitude. And through the comparisons of theoretical and experimental trajectories, the adopted motion equation has proved to be able to rigorously describe the particle motion in non-Stokes region-the shape of trajectory and frequency characteristics are fairly consistent and the deviations of amplitude can usually be less than 10%.

关键词： electrodynamic balance microparticle oscillation trajectory numerical simulation

effect of drug therapies on self-reported chemosensory outcomes after COVID-19

在线全文

学校读者我要写书评

暂无评论

World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： Marco A.Fornazieri Bruno M.Cunha Samuel P.Nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides Fernandes Neto Deusdedit Brandão Neto richard L.Voegels Fábio D.R.Pinna Department of Surgery Londrina State UniversityLondrinaBrazil Department of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Department of Otorhinolaryngology University of São PauloSao PauloBrazil Department of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or smell ***:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personally interviewed regarding specific medications they were administered following the acute phase of the *** dependent measure—self-reported total recovery of chemosensory symptoms—was subjected to stepwise logistic *** predictors included demographic and clinical variables,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated groups did not differ ***,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or smell *** who took oral zinc were less likely to ***:No medication employed during the first months after SARS-CoV-2 infection had a clear positive effect on returning self-reported smell or taste function to normal,although nitrazoxide trended in a positive *** zinc had a negative effect on the reported recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 smell loss taste loss

Graphene-based electrodes and catalysts for electroreduction of CO_(2)to low-carbon alcohols

在线全文

学校读者我要写书评

暂无评论

Materials Reports(energy) 2023年第2期3卷 142-153,I0004页

作者： Lei Wang Patrick Lira Guangzhi Hu Jianmin Luo Zhao Sun richard davis Yudai Huang Sam Toan Department of Chemical engineering University of Minnesota-DuluthDuluthMN55812USA Institute for ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan UniversityKunming650504China School of Chemistry and Civil engineering Shaoguan UniversityShaoguan512005China School of energy Science and engineering Central South UniversityChangsha410083China State Key Laboratory of Chemistry and Utilization of Carbon Based energy Resources College of ChemistryXinjiang UniversityUrumqi830017China

The electrochemical reduction of CO_(2)(CO_(2)eR)into the renewable and sustainable green fuels,such as low-carbon alcohols,is one of several workable ***_(2)eR can be combined with renewable electricity to transform intermittent energy sources(such as wind,hydro,and solar)into a fuel that can be stored until it is ready to be *** intrinsic characteristics of the employed catalyst have a significant and substantial effect on the efficiency of CO_(2)eR and the ensuing economic *** paradigmatic multicarbon alcohol catalysts should increase the concentration of*CO in the reaction environment,stabilize the key intermediate products during the reaction,and facilitate the C-C coupling *** graphene has a large surface area and exceptional conductivity,it has been used as a support for active phases(nanoparticles or nanosheets).It is possible for graphene to enhance charge transport and accelerate CO_(2)conversion through its electronic and structural coupling *** the interface,a synergy can be produced that improves CO_(2)eR by increasing*CO adsorption,intermediate binding,and *** article focuses on recent advancements in graphene-based catalysts that promote CO_(2)eR to ***,this paper also describes and discusses the key role graphene plays in catalyzing CO_(2)eR into ***,we hope to provide future ideas for the design of graphene-based electrocatalysts.

关键词： Graphene electrocatalysts CO_(2)reduction Alcohol electrode

Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structures of coxsackievirus, rhinovirus, and poliovirus pol...

第四届中国结构生物学学术讨论会

作者： Peng Gong Matthew G.Kortus Jay C.Nix Ralph e.davis Olve B.Peersen Department of Biochemistry & Molecular Biology Colorado State UniversityFort Collins CO 80523 USA State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Molecular Biology Consortium Advanced Light SourceLawrence Berkeley National Laboratory Berkeley CA 94720 USA

RNA-dependent RNA polymerases play a vital role in the growth of RNA viruses where they are responsible for genome replication, but do so with rather low fidelity that allows for the rapid adaptation to different host cell environments. These polymerases are also a target for antiviral drug development. However, both drug discovery efforts and our understanding of fidelity determinants have been hampered by a lack of detailed structural information about functional polymerase-RNA complexes and the structural changes that take place during the elongation cycle. Many of the molecular details associated with nucleotide selection and catalysis were revealed in our recent structure of the poliovirus polymerase-RNA complex solved by first purifying and then crystallizing stalled elongation complexes. In the work presented here we extend that basic methodology to determine nine new structures of poliovirus, coxsackievirus, and rhinovirus elongation complexes at 2.2-2.9 A resolution. The structures highlight conserved features of picornaviral polymerases and the interactions they make with the template and product RNA strands, including a tight grip on eight base pairs of the nascent duplex, a fully pre-positioned templating nucleotide, and a conserved binding pocket for the +2 position template strand base. At the active site we see a pre-bound magnesium ion and there is conservation of a non-standard backbone conformation of the template strand in an interaction that may aid in triggering RNA translocation via contact with the conserved polymerase motif B. Moreover, by engineering plasticity into RNA-RNA contacts, we obtain crystal forms that are capable of multiple rounds of in-crystal catalysis and RNA translocation. Together, the data demonstrate that engineering flexible RNA contacts to promote crystal lattice formation is a versatile platform that can be used to solve the structures of viral RdRP elongation complexes and their catalytic cycle intermediates.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

露天矿规划的最佳方法

中国矿山工程 1981年第1期 50-56页

作者： Ronald e.davis Carl e.Williams 黄燮中

在露天矿的整个服务年限内,为了最大程度地减少流动资金,在每个连续的回采周期中,都需要用最优化的生产过程来选择所开采的原料。当满足仔细选择的一套生产约束条件时(例如:电铲总班数,选厂能力,精矿产量,工作邦边坡角,矿石堆场及开拓矿量

关键词：约束条件程序所有规划长远计划露天矿矿山

Quantitative evaluation of the results of digital forensic investigations:a review of progress

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Forensic Sciences Research 2021年第1期6卷 13-18页

作者： richard e.Overill Jan Collie Department of Informatics King’s College LondonLondonUK Department of Computing&Communication The Open UniversityMilton KeynesUK

Unlike conventional forensics,digital forensics does not at present generally quantify the results of its *** is suggested that digital forensics should aim to catch up with other forensic disciplines by using Bayesian and other numerical methodologies to quantify its investigations’*** the plausibility of alternative hypotheses(or propositions,or claims)which explain how recovered digital evidence came to exist on a device could assist both the prosecution and the defence sides in criminal proceedings:helping the prosecution to decide whether to proceed to trial and helping defence lawyers to advise a defendant how to *** paper reviews some numerical approaches to the goal of quantifying the relative weights of individual items of digital evidence and the plausibility of hypotheses based on that *** potential advantages enabling the construction of cost-effective digital forensic triage schemas are also outlined.

关键词： Forensic sciences digital forensic metrics measures of plausibility Bayesian networks probability theory statistical theory complexity theory information theory