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矿山机械 1991年第8期19卷 40-42页

作者： richard e.Gady 刘玉红高静波

介绍背景高弹体悬挂支撑{ 汽—液式悬挂支撑流体弹簧{ 流体式悬挂支撑悬挂系统的目的和任务悬挂系统的应用(以上系原文标题,内容略——编者注)

关键词：矿用自卸车悬挂系统

Ventricular repolarization markers for predicting malignant arrhythmias in clinical practice

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World Journal of Clinical Cases 2015年第8期3卷 705-720页

作者： Yaniel Castro-Torres Raimundo Carmona-Puerta richard e Katholi Facultad de Medicina Universidad de Ciencias Médicas Dr.Serafín Ruiz de Zárate Ruiz Cardiocentro ernesto Che Guevara Southern Illinois University School of Medicine and Prairie Cardiovascular Consultants

Malignant cardiac arrhythmias which result in sudden cardiac death may be present in individuals apparently healthy or be associated with other medical conditions. The way to predict their appearance represents a challenge for the medical community due to the tragic outcomes in most cases. In the last two decades some ventricular repolarization(VR) markers have been found to be useful to predict malignant cardiac arrhythmias in several clinical conditions. The corrected QT, QT dispersion, Tpeak-Tend, Tpeak-Tend dispersion and Tp-e/QT have been studied and implemented in clinical practice for this purpose. These markers are obtained from 12 lead surface electrocardiogram. In this review we discuss how these markers have demonstrated to be effective to predict malignant arrhythmias in medical conditions such as long and short QT syndromes, Brugada syndrome, early repolarization syndrome, acute myocardial ischemia, heart failure, hypertension, diabetes mellitus, obesity and highly trained athletes. Also the main pathophysiological mechanisms that explain the arrhythmogenic predisposition in these diseases and the basis for the VR markers are discussed. However, the same results have not been found in all conditions. Further studies are needed to reach a global consensus in order to incorporate these VR parameters in risk stratification of these patients.

关键词： electrocardiographic predictor Ventricular repolarization markers Ventricular fibrillation Sudden cardiac death QT interval Corrected QT interval QT dispersion Tpeak-Tend interval Tpeak-Tend QT ratio

Ribosomal proteins and human diseases:molecular mechanisms and targeted therapy

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2748-2769页

作者： Jian Kang Natalie Brajanovski Keefe T.Chan Jiachen Xuan richard B.Pearson elaine Sanij Division of Cancer Research Peter MacCallum Cancer CentreMelbourneVICAustralia Sir Peter MacCallum Department of Oncology University of MelbourneMelbourneVICAustralia Department of Biochemistry and Molecular Biology Monash UniversityClaytonVICAustralia Department of Biochemistry and Molecular Biology University of MelbourneMelbourneVICAustralia Department of Clinical Pathology University of MelbourneMelbourneVICAustralia St.Vincent's Institute of Medical Research FitzroyVICAustralia

Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and *** ribosomal proteins(RPs),comprising the structural parts of the ribosome,are essential for ribosome assembly and *** addition to their canonical ribosomal functions,multiple RPs have extra-ribosomal functions including activation of p53-dependent or p53-independent pathways in response to stress,resulting in cell cycle arrest and *** in ribosome biogenesis,translation,and the functions of individual RPs,including mutations in RPs have been linked to a diverse range of human congenital disorders termed *** are characterized by tissue-specific phenotypic abnormalities and higher cancer risk later in *** discoveries of somatic mutations in RPs in multiple tumor types reinforce the connections between ribosomal defects and *** this article,we review the most recent advances in understanding the molecular consequences of RP mutations and ribosomal defects in ribosomopathies and *** particularly discuss the molecular basis of the transition from hypo-to hyper-proliferation in ribosomopathies with elevated cancer risk,a paradox termed"Dameshek's riddle."Furthermore,we review the current treatments for ribosomopathies and prospective therapies targeting ribosomal *** also highlight recent advances in ribosome stress-based cancer ***,insights into the mechanisms of resistance to therapies targeting ribosome biogenesis bring new perspectives into the molecular basis of cancer susceptibility in ribosomopathies and new clinical implications for cancer therapy.

关键词： elevated mechanisms consequences

Fuel-ion diffusion in shock-driven inertial confinement fusion implosions

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Matter and Radiation at extremes 2019年第5期4卷 50-54页

作者： Hong Sio Chikang Li Cody e.Parker Brandon Lahmann Ari Le Stefano Atzeni richard D.Petrasso Plasma Science and Fusion Center Massachusetts Institute of TechnologyCambridgeMassachusetts 02139USA Los Alamos National Laboratory Los AlamosNew Mexico 87545USA Dipartimento SBAI Universita degli Studi di Roma“La Sapienza”Via Antonio Scarpa 1400161RomaItaly

The impact of fuel-ion diffusion in inertial confinement fusion implosions is assessed using nuclear reaction yield ratios and reaction *** T3He-gas-filled(with trace D)shock-driven implosions,the observed TT/T3He yield ratio is∼23lower than expected from temperature ***3He-gas-filled(with trace T)shock-driven implosions,the timing of theD3He reaction history is∼50 ps earlier than those of the DT reaction histories,and average-ion hydrodynamic simulations cannot reconcile this timing *** experimental observations are consistent with reduced T ions in the burn region as predicted by multi-ion diffusion theory and particle-in-cell simulations.

关键词： diffusion shock filled

Molecular mechanisms involved in high glucose-induced heme oxygenase-1 expression in bovine aortic endothelial cells

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Molecular mechanisms involved in high glucose-induced heme o...

An Analog Method for Seasonal Forecasting in Northern High Latitudes

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： richard C.M.Siow Giovanni e.Mann Cardiovascular Division School of Medicine

Hyperglycaemia and diabetes are associated with cell dysfunction arising from enhanced oxidative injury, leading to the progression of diabetic vascular *** transcription factor Nrf2 mediates the induction of cytoprotective genes such as heme oxygenase-1(HO-1) via activation of antioxidant response elements(ARe). HO-1 catabolises the degradation of pro-oxidant heme to generate the vasodilator carbon monoxide and antioxidants biliverdin and *** present study has investigated whether high glucose enhances superoxide generation, Nrf2 activation and HO-1 induction,as well as related molecular mechanisms in bovine aortic endothelial cells (BAeC).Confluent monolayers were treated in medium containing 1%FCS with 25 mmol/L D-glucose in the presence or absence of superoxide scavengers SOD(200 U/ mL) and Tiron(10μmol/L),NADPH oxidase inhibitors apocynin(100μmol/L) and DPI(10μmol/L),eNOS inhibitor L-NAMe(50μmol/L),or MAPK inhibitors SB203580(10μmol/L),SP600125(20μmol/L),and U0126(10μmol/L) for 0-24 h.D-mannintol(20 mmol/L) was used as osmotic *** expression of HO-1,nuclear Nrf2,and phosphorylated MAPKinases were determined by western blot analyses and Nrf2 translocation by *** of superoxide was assessed in live cells using the L-012 chemiluminescence *** of BAeC with 25 mmol/L D-glucose(0-24 h),but not D-mannitol,elicited a significantly enhanced generation of superoxide,nuclear translocation of Nrf2 and induction of HO-1 expression in a dose and time dependent *** HO-1 expression induced by high glucose was attenuated by intracellular superoxide scavenger Tiron and eNOS inhibitor L-NAMe,but not by extracellular superoxide scavenger SOD or NADPH inhibitors apocynin and *** glucose could also induce the phosphorylation of p38 and JNK,but only JNK inhibitor could block high glucose-induced HO-1 expression,suggesting that JNK signaling pathway is possibly involved in high glucose-induced HO-1 ex

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Atmospheric and Climate Sciences 2021年第3期11卷 469-485页

作者： John e. Walsh Brian Brettschneider Nathan P. Kettle richard L. Thoman International Arctic Research Center University of Alaska Fairbanks Fairbanks Alaska USA National Weather Service Alaska Region NOAA Anchorage Alaska USA

An analog forecast method designed for monthly and seasonal outlooks is applied to the Arctic. The analog selection process uses pattern matches based on agreement with historical data to identify past years with similar distributions of sea level pressure, upper-air geopotential height, surface and upper-air temperatures, precipitation, and sea surface temperatures. The evolution of the atmosphere in the analog years is then the basis of a prediction for the target year. Users can choose the predictor domain, the predictand domain, the variable to be predicted, and the number of antecedent months on which the analog selection is based. We provide an example of a monthly forecast generated by the analog forecast tool. In comparisons with operational dynamical model forecasts over the period 2012-2019, the analog system underperforms the dynamical models in middle latitudes but generally outperforms the dynamical models in monthly forecasts of surface air temperatures in the Arctic. The improvement over the dynamical models is especially apparent in the late summer and early autumn (August-October).

关键词： Arctic Climate Analog Forecasting

LIFe： Costing the Digital Preservation Lifecycle

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现代图书情报技术 2008年第1期 69-74页

作者： PAUL WHeATLeY PAUL AYRIS richard DAVIeS RORY MCLeOD HeLeN SHeNTON The British Library Boston Spa Wetherby UK UCL Gower Street London UK The British Library St Pancras London UK

The LIFe project creates a digital lifecycle model based on previous work undertaken on the lifecycle of paper-based *** Archiving, Voluntarity Deposited electronic Publications (VDeP), and e-Journal are chosen as case study for application and evaluation of the LIFe *** studies show its potential for further use in a numble of roles,such as improving assessment of the financial commitment,more effective planning for preservation activities *** LIFe Mode will be revised and refined in LIFe2 Project.

关键词：数字资源长期保存生命周期成本 LIFe模型方案

Investigating the impact of preoperative corneal astigmatism orientation on the postoperative spherical equivalent refraction following intraocular lens implantation

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eye and Vision 2018年第1期5卷 70-77页

作者： richard N.McNeely Salissou Moutari eric Pazo Jonathan e.Moore Cathedral eye Clinic 89-91 Academy StreetBelfastCounty Antrim BT12 LSNorthern IrelandUK Biomedical Sciences Research Institute University of UlsterColeraineNorthern IrelandUK School of Mathematics and Physics Queens University BelfastBelfastNorthern IrelandUK

Background:To investigate the impact of the orientation of preoperative corneal astigmatism on achieving the postoperative target refraction following monofocal intraocular lens(IOL)***:This study enrolled 339 eyes who had uneventful cataract surgery or refractive lens exchange(RLe)with subsequent monofocal IOL *** were initially categorized dependent upon axial length and then on the orientation of preoperative anterior corneal *** 1 had against-the-rule(ATR)anterior corneal astigmatism,group 2 had with-the-rule(WTR)anterior corneal astigmatism,and group 3 had oblique(OB)anterior corneal *** preoperative corneal astigmatism was determined by the IOLMaster(Carl Zeiss Meditec AG).Postoperative refraction was completed for all eyes,and the results were calculated and compared for the separate ***:In eyes with axial lengths greater than 22.0 mm and less than 25.0 mm there was a significant difference between the magnitude of preoperative corneal astigmatism between groups 2 and 3 with 0.827±0.376 D in group 2,and 0.677±0.387 D in group *** mean postoperative spherical equivalent(Se)prediction error was−0.132±0.475 D in group 1,0.026±0.497 D in group 2,and−0.130±0.477 D in group *** was a significant difference between groups 1 and *** was no significant difference in the magnitude of preoperative corneal astigmatism and postoperative Se prediction error between the anterior corneal astigmatism orientation groups in eyes with axial lengths of less than or equal to 22.0 mm and greater than or equal to 25.0 ***:The orientation of preoperative anterior corneal astigmatism significantly affected the postoperative biometry prediction error in eyes with astigmatism of 1.75 D or less in eyes with the axial length between 22.0 mm and 25.0 ***,the results were not clinically significant.

关键词： Biometry accuracy Prediction error Corneal astigmatism With-the-rule astigmatism Against-the-rule astigmatism Oblique astigmatism

Relativistic domain-wall dynamics in van der Waals antiferromagnet MnPS_(3)

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npj Computational Materials 2022年第1期8卷 27-35页

作者： Ignacio M.Alliati richard F.L.evans Kostya S.Novoselov elton J.G.Santos School of Mathematics and Physics Queen’s University BelfastBelfastBT71NNUK Department of Physics The University of YorkYorkYO105DDUK Institute for Functional Intelligent Materials National University of SingaporeSingapore117544Singapore Institute for Condensed Matter Physics and Complex Systems School of Physics and AstronomyThe University of EdinburghEdinburghEH93FDUK Higgs Centre for Theoretical Physics The University of EdinburghEdinburghEH93FDUK

The discovery of two-dimensional(2D)magnetic van der Waals(vdW)materials has flourished an endeavor for fundamental problems as well as potential applications in computing,sensing and storage *** particular interest are antiferromagnets,which due to their intrinsic exchange coupling show several advantages in relation to ferromagnets such as robustness against external magnetic *** we show that,despite of this cornerstone,the magnetic domains of recently discovered 2D vdW MnPS_(3)antiferromagnet can be controlled via magnetic fields and electric *** achieve ultrafast domain-wall dynamics with velocities up to~3000 m s^(−1)within a relativistic *** contraction and emission of spin-waves in the terahertz gap are observed with dependence on the edge termination of the *** results indicate that the implementation of 2D antiferromagnets in real applications can be further controlled through edge engineering which sets functional characteristics for ultrathin device platforms with relativistic features.

关键词： relativistic dynamics antiferromagnet