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Frey procedure for the treatment of chronic pancreatitis associated with common bile duct stricture

Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 637-644页

作者： Lionel Rebibo Thierry Yzet Cyril Cosse richard delcenserie Eric Bartoli Jean-Marc Regimbeau Department of Digestive Surgery Amiens University Medical Center the Jules Verne University of Picardie Department of Radiology Amiens University Medical Center and the Jules Verne University of Picardie Department of Digestive SurgeryAmiens University Medical Center and the Jules Verne University of Picardie Department of Gastroenterology Amiens University Medical Center and the Jules Verne University of Picardie

BACKGROUND:The Frey procedure(FP)is the treatment of choice for symptomatic chronic pancreatitis(CP).In cases of biliary stricture,biliary derivation can be performed by choledochoduodenostomy,Roux-en-Y choledochojejunostomy or,more recently,reinsertion of the common bile duct(CBD)into the resection *** objective of the present study was to evaluate the outcomes associated with each of these three types of biliary ***:We retrospectively analyzed demographic,CPrelated,surgical and follow-up data for patients having undergone FP for CP with biliary derivation between 2004and 2012 in our university medical *** primary efficacy endpoint was the rate of CBD stricture *** secondary endpoints were surgical parameters,postoperative complications,postoperative follow-up and the presence of risk factors for secondary CBD ***:Eighty patients underwent surgery for CP during the study *** these,15 patients received biliary derivation with the *** of the FPs(53.3%)were combined with choledochoduodenostomy,4(26.7%)with choledochojejunostomy and 3(20.0%)with reinsertion of the CBD into the resection *** mean operating time was *** complications(73.3%)were recorded,including one major complication(6.7%)that necessitated radiologicallyguided drainage of an abdominal *** mean(range)length of stay was 17 days(8-28)and the median(range)follow-up time was 35.2 months(7.2-95.4).Two patients presented stricture after CBD reinsertion into the resection cavity;one was treated with radiologically-guided dilatation and the other underwent revisional Roux-en-Y *** patients presented alkaline reflux gastritis(37.5%),one(12.5%)cholangitis and one CBD stricture after FP with *** risk factors for secondary CBD stricture were ***:As part of a biliary derivation,the FP gave good *** did not observe any complications specifically relat

关键词： common bile duct stricture chronic pancreatitis Frey procedure pancreatectomy

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Combined radiologic and endoscopic treatment(using the “rendezvous technique”) of a biliary fistula following left hepatectomy

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World Journal of Gastroenterology 2016年第30期22卷 6955-6959页

作者： Aurélien Gracient Lionel Rebibo richard delcenserie Thierry Yzet Jean-Marc Regimbeau Service de Chirurgie Digestive H?pital Sud CHU d'Amiens Avenue René LaennecF-80054 Amiens cedex 01 France Department of Gastroenterology Amiens University Hospital Avenue René Laennec F-80054 Amiens cedex 01 France Department of Radiology Amiens University Hospital Avenue René Laennec F-80054 Amiens cedex 01 France EA4294 Jules Verne University of Picardie F-80054 Amiens cedex 01 France Clinical Research Center Amiens University Hospital Avenue René Laennec F-80054 Amiens cedex 01 France

Despite the ongoing decrease in the frequency of complications after hepatectomy, biliary fistulas still occur and are associated with high morbidity and mortality rates. Here, we report on an unusual technique for managing biliary fistula following left hepatectomy in a patient in whom the right posterior segmental duct joined the left hepatic duct. The biliary fistula was treated with a combined radiologic and endoscopic procedure based on the "rendezvous technique". The clinical outcome was good, and reoperation was not required.

关键词： Left hepatectomy Rendezvous technique biliary stent biliary fistula Anatomic variation

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Growth and Freeze-Drying Optimization of Bifidobacterium crudilactis

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Food and Nutrition Sciences 2016年第7期7卷 616-626页

作者： Jean Tanimomo Véronique delcenserie Bernard Taminiau Georges Daube Catherine Saint-Hubert Alain Durieux Meurice R & D Brussels Belgium Food Sciences Department Faculty of Veterinary Medicine Fundamental and Applied Research for Animal & Health (FARAH) University of Liège Liège Belgium Institut de Recherches Microbiologiques Jean-Marie Wiame Campus CERIA Brussels Belgium

Bifidobacterium crudilactis FR62/b/3 belongs to a new population of bifidobacteria isolated from raw milk and raw milk cheese. The objective of this work was to study the large scale culture of the strain and its stability in a dry formulation. Growth rate of Bifidobacterium crudilactis FR62/b/3 was optimal at a pH of 5.0 and a temperature of 37°C. At a temperature growth of 33°C and a pH of 5.0, the stationary phase was reached after 22 h, the viable cell number and the mean dry biomass concentration were respectively of 8.3 × 109 CFU/mL and of 2.1 g/L. Resistance of Bifidobacterium crudilactis FR62/b/3 to freeze-drying and effect of a variety of cryoprotectants to maintain the viability were also evaluated. Sorbitol was the most suitable cryoprotectant for freeze-drying as well as storage whereas sucrose and monosodium glutamate were only efficient during storage.

关键词： Probiotic Bifidobacteria Crudilactis Cryoprotectant Freeze-Drying

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慢性胰腺炎的内镜治疗

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世界核心医学期刊文摘（胃肠病学分册） 2005年第10期1卷 22-23页

作者： Bartoli E. delcenserie R. Yzet T. 徐瑞 Service d'Hépato-Gastroentérologie Centre Hospitalier Universitaire d'Amiens 80054 Amiens Cedex France

Objectives -Endoscopy offers an alternative to surgery for the treatment of ductal complications in patients with chronic pancreatitis. The aim of this study was to evaluate the efficacy of endoscopic treatment on pain, cholestasis and pseudocysts in these patients. Patients and methods -Thirty-nine patients (37 M, 2 F, mean age 44), were included in the study. All patients had at least one of the following criteria demonstrated by imaging tests: dilatation of the main pancreatic duct (MPD)-with or without stricture (N = 13), bile duct stricture (N = 12), or pa-ncreatic pseudocyst (N = 14) with pancreatic duct stricture (N = 11) or biliary stricture (N = 3). Pancreatic or biliary sphincterotomy, insertion of pancreatic or biliary stent, pseudocyst drainage with stent placement were performed according to ductal abnormalities. Patients were evaluated early and followed up during the stenting period, and after stent removal. Results -Patients underwent a median of 3.5 endoscopic procedures with an interval of 2.2 months between 2 stenting sessions. A pancreatic or biliary stent was inserted in 25 patients with ductal abnormalities and in 11 patients with pseudocysts. Endoscopic pseudocyst drainage was performed in 6 cases. The mean stenting time was 6 months (range: 3-21). Mean followup after stent removal was 9.7(2-48) months. Complications of endoscopic treatment were encountered in 7%of patients with no deaths. Pain relief was achieved after the first endoscopic procedure and during the overall stenting period in all patients. Recurrence of pain was observed after stent removal in 5/11 patients, requiring surgery in 4. Cholestasis decreased and biochemical values normalized within one month after biliary stenting. Recurrence of cholestasis was observed early after stent removal in 4/9 patients who required complementary surgical treatment. No recurrence of pancreatic pseudocyst was observed after endoscopic drainage and stent removal during the follow-up period. Co

关键词：慢性胰腺炎胰腺假性囊肿假性囊肿引流胆管狭窄胰管狭窄导管并发症胆汁淤积主胰管影像学间隔期

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