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Statin, testosterone and phosphodiesterase 5-inhibitor treatments and age related mortality in diabetes

World Journal of Diabetes 2017年第3期8卷 104-111页

作者： Geoffrey Hackett Peter W Jones richard c Strange Sudarshan Ramachandran Department of Urology University of Bed-fordshire Department of Urology Heart of England NHS Foundation Trust Metabolic Research Group Institute of Science and Technology in Medicine Keele University Department of clinical Biochemistry Heart of England NHS Foundation Trust Department of clinical Biochemistry University Hospitals of North Midlands/Faculty of Health Sciences Staffordshire University

AIMTo determine how statins, testosterone (T) replacement therapy (TRT) and phosphodiesterase 5-inhibitors (PDE5I) influence age related mortality in diabetic *** studied 857 diabetic men screened for the BLAST study, stratifying them (mean follow-up = 3.8 years) into: (1) Normal T levels/untreated (total T > 12 nmol/L and free T > 0.25 nmol/L), Low T/untreated and Low T/treated; (2) PDE5I/untreated and PDE5I/treated; and (3) statin/untreated and statin/treated groups. The relationship between age and mortality, alone and with T/TRT, statin and PDE5I treatment was studied using logistic regression. Mortality probability and 95%cI were calculated from the above models for each *** was associated with mortality (logistic regression, OR = 1.10, 95%cI: 1.08-1.13, P ctors included, age (OR = 1.08, 95%cI: 1.06-1.11, P cI: 0.15-0.92, P = 0.033), PDE5I/treated (OR = 0.17, 95%cI: 0.053-0.56, P = 0.004) and statin/treated (OR = 0.59, 95%cI: 0.36-0.97, P = 0.038) were associated with lower mortality. Age related mortality was as described by Gompertz, r2 = 0.881 when Ln (mortality) was plotted against age. The probability of mortality and 95%cI (from logistic regression) of individuals, treated/untreated with the drugs, alone and in combination was plotted against age. Overlap of 95%cI lines was evident with statins and TRT. No overlap was evident with PDE5I alone and with statins and TRT, this suggesting a change in the relationship between age and *** show that statins, PDE5I and TRT reduce mortality in diabetes. PDE5I, alone and with the other treatments significantly alter age related mortality in diabetic men.

关键词： Type 2 diabetes Mortality Gompertz-Makeham equation Phosphodiesterase 5 inhibitors Male hypogonadism Statins Testosterone replacement therapy

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In Memoriam:*** ***

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International Soil and Water conservation Research 2021年第4期9卷 485-489页

作者： Dennis c.Flanagan richard M.cruse James L.Baker Paige chyu USDA-Agricultural Research Service National Soil Erosion Research LaboratoryWest LafayetteINUSA Department of Agronomy Iowa State UniversityAmesIAUSA Department of Agricultural&Biosystems Engineering Iowa State UniversityAmesIAUSA International Research and Training center on Erosion and Sedimentation BeijingChina

The soil erosion research and soil and water conservation global community lost a treasured member on November 20,2020,when *** Matthew Laflen(Fig.1)*** one with a friendly welcoming smile,John had hundreds of friends,both personally and professionally throughout the *** article includes many of his professional and scientific contributions,and impacts from his research and outreach activities.

关键词： soil hundreds professional

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Microbial starch-binding domains are superior to granule-bound starch synthase I for anchoring luciferase to potato starch granules

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Progress in Natural Science:Materials International 2006年第12期16卷 1295-1299页

作者： Jean-Paul VINcKEN Luc c.J.M. SUURS richard G.F. VISSER Laboratory of Plant Breeding Department of Plant Sciences Wageningen University Wageningen The Netherlands

Microbial starch-binding domains (SBD) and granule-bound starch synthase I (GBSSI) are proteins which are accumulated in potato starch granules. The efficiency of SBD and GBSSI for targeting active luciferase reporter proteins to granules during starch biosynthesis was compared. GBSSI or SBD sequences were fused to the N- or c-terminus of the luciferase (LUc) gene, via an artificial Pro-Thr encoding linker sequence. The genes were introduced into an amylose-free (amf) potato mutant. It appeared that SBD was superior to GBSSI as a targeting sequence, mainly because the luciferase retained higher activity in the SBD-containing fusion proteins than in the GBSSI-containing ones.

关键词： luciferase GBSS I SBD amf potato.

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Radiocarbon calibration:The next generation

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Science china Earth Sciences 2021年第3期64卷 507-510页

作者： richard A STAFF Ruiliang LIU Scottish Universities Environmental Research centre(SUERc) University of GlasgowEast KilbrideG750QFUK School of Archaeology University of OxfordOxfordOX13TGUK

The discovery of the radiocarbon(14c)dating technique in the mid-twentieth century by Willard Libby and colleagues(Libby et al.,1949)revolutionised such fields as archaeology and palaeoclimatology that require robust chronological information to inform their *** sample yielding sufficient quantities of carbon could be dated in this manner,with the older age limit of the method(currently circa 50 to 60 thousand years ago)having been pushed back significantly since its inception.

关键词： dating dated carbon

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commentary on “Prevalence and evolution of drug resistance HIV-1 vari-ants in Henan, china”

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cell Research 2005年第Z1期15卷 850-851页

作者： Bruce L GILLIAM Robert R REDFIELD richard Y ZHAO Robert c GALLO Institute of Human Virology University of Maryland Baltimore MD 21201 USA Institute of Human Virology University of Maryland Baltimore MD 21201 USA Department of Microbiology-Immunology University of Maryland School of Medicine Baltimore MD 21201 USA Institute of Human Virology University of Maryland Baltimore MD 21201 USA .Department of Pathology University of Maryland School of Medicine Baltimore MD 21201 USA

critical to the implementation and scale-up of successful antiretroviral therapy worldwide is an understanding of the effcacy, toxicitie and durability of antiretroviral regimens in the specific populations, which the... 详细信息

关键词： HIV commentary on Prevalence and evolution of drug resistance HIV-1 vari-ants in Henan

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Direct molecular-level near-field plasmon and temperature assessment in a single plasmonic hotspot

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Light(Science & Applications) 2020年第1期9卷 1673-1685页

作者： Marie richard-Lacroix Volker Deckert Leibniz Institute of Photonic Technology(IPHT) Albert-Einstein-Strasse 9D-07745 JenaGermany Institute of Physical chemistry and Abbe center of Photonics University of JenaHelmholtzweg 4D-07743 JenaGermany

Tip-enhanced Raman spectroscopy(TERS)is currently widely recognized as an essential but still emergent technique for exploring the ***,our lack of comprehension of crucial parameters still limits its potential as a user-friendly analytical *** tip’s surface plasmon resonance,heating due to near-field temperature rise,and spatial resolution are undoubtedly three challenging experimental parameters to ***,they are also the most fundamentally relevant parameters to explore,because they ultimately influence the state of the investigated molecule and consequently the probed *** we propose a straightforward and purely experimental method to access quantitative information of the plasmon resonance and near-field temperature experienced exclusively by the molecules directly contributing to the TERS *** detailed near-field optical response,both at the molecular level and as a function of time,is evaluated using standard TERS experimental equipment by simultaneously probing the Stokes and anti-Stokes spectral ***-assembled 16-mercaptohexadodecanoic acid monolayers covalently bond to an ultra-flat gold surface were used as a *** of blinking lines in the spectra also provides crucial information on the lateral resolution and indication of atomic-scale thermally induced morphological changes of the tip during the *** study provides access to unprecedented molecular-level information on physical parameters that crucially affect experiments under TERS *** study thereby improves the usability of TERS in day-to-day *** obtained information is of central importance for any experimental plasmonic investigation and for the application of TERS in the field of nanoscale thermometry.

关键词： straight purely thereby

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Virtual reality based apps are the future of patient:counseling

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World Journal of clinical cases 2025年第6期13卷 58-60页

作者： Ranjan K Behera Arvind K Morya Parul c Gupta Arshi Singh Department of Ophthalmology MMIMSR Mullana AmbalaAmbala 133207HaryānaIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology Post Graduate Institute of Medical Education and ResearchChandigarh 160012PunjabIndia Department of Ophthalmology Guru Nanak Eye CentreNew Delhi 110001New DelhiIndia

The use of virtual reality to educate preoperative patients has a positive impact on nurses as well as patients undergoing *** can help improve patient satisfaction and improve favorable outcomes by reducing patient anxiety and proving adequate knowledge about the procedure and possible outcomes to the *** also reduces burden on nursing staff and *** and more diverse cohort studies will help us understand the wider application of this tool on the patient *** may be difficult to apply this tool on elderly patients with failing eyesight,multiple physical ***,there may be reduced acceptance of this modality by older nursing staff and practitioners who may prefer the traditional verbal version for *** will benefit from a combined approach of using virtual reality apps with tradition one-on-one counselling to help alleviate patient concerns and improve patient and healthcare professional satisfaction.

关键词： Nurse Patient Virtual reality counselling Healthcare

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Biomarker and animal models for assessment of retinoid efficacy in cancer chemoprevention

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Acta Pharmacologica Sinica 2007年第9期28卷 1383-1391页

作者： richard M NILES Department of Biochemistry and Microbiology Joan C Edwards School of MedicineMarshall UniversityHuntingtonWV 25701USA

Vitamin A is essential for normal growth and *** andlaboratory studies suggest that decreased vitamin A levels and defective metabo-lism/action may contribute to the genesis of certain *** on thisinformation,natural and synthetic derivatives of vitamin A (retinoids) have beenused for chemoprevention of *** have had some success in thechemoprevention of leukoplakia and in the decreased incidence of second prima-ries in head and neck *** is little information on biomarkers that can beused to assess the efficacy of the chemopreventive activity of *** of retinoids to induce RARb has been consistently shown to correlate withthe response of cells and tissues to retinoic acid,but few other biomarkers havebeen certified as indicators of retinoid *** light of the failure of the ATBcand cARET clinical intervention trials for chemoprevention of lung cancer,greateruse of animal models for chemoprevention studies is *** potentialcombination of phytochemicals that inhibit DNA methyltransferase activity withretinoids holds promise for more effective chemoprevention of retinoid-unrespon-sive premalignant lesions.

关键词： vitamin A retinoic acid chemoprevention biomarkers animal models transgenic animals

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Innovative approaches towards an economic fusion reactor

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National Science Review 2020年第2期7卷 245-247页

作者： Houyang Guo Francis Y c Thio Michl W Binderbauer richard J Buttery Thomas R Jarboe Rajesh Maingi John S Sarff Peter c Stangeby Derek A SutherlAND Mickey R Wade Michael c Zarnstorff General Atomics Breakthrough Fusion International corporation

Nuclear fusion potentially offers a clean,environmentally friendly and intrinsically safe energy source with an abundant fuel supply. Magnetic fusion energy research is approaching a new era of fusion power reactor design and construction planning. New physics understanding and powerful predictive tools have become available for improving fusion performance, developing and optimizing various magnetic confinement concepts. Emerging transformative

关键词： Innovative approaches towards an economic fusion reactor

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Ascovirus and its Evolution

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中国病毒学 2007年第2期22卷 137-147页

作者： Xiao-Wen cheng Xiu-Feng Wan Jianli Xue richard c. Moore Department of Microbiology Department of Botany Miami University Oxford Ohio 45056 USA

Ascoviruses, iridoviruses, asfarviruses and poxviruses are all cytoplasmic DNA viruses. The evolutionary origins of cytoplasmic DNA viruses have never been fully addressed. Morphological, genetic and molecular data were used to test if all four cytoplasmic virus families (Ascoviridae, Iridoviridae, Asfarviridae, and Poxvirirdae) evolved from nuclear replicating baculoviruses and how the four virus groups are related. Molecular phylogenetic analyses using DNA polymerase predicted that cytoplasmic DNA viruses might have evolved from nuclear replicating baculoviruses, and that poxviruses and asfarviruses share a common ancestor with iridoviruses. These three cytoplasmic viruses again shared a common ancestor with ascoviruses. Morphological and genetic data predicted the same evolutionary trend as molecular data predicted. A genome sequence comparison showed that ascoviruses have more baculovirus protein homologues than do iridoviruses, which suggested that ascoviruses have evolved from baculoviruses and iridoviruses evolved from ascoviruses. Poxviruses showed genetic and morphological similarity to other cytoplamic viruses, such as ascoviruses, suggesting it has undergone reticulate evolution via hybridization, recombination and lateral gene transfer with other viruses. Within the ascovirus family, we tested if molecular phylogenetic analyses agree with biological inference; that is, ascovirus had an evolutionary trend of increasing genome size, expanding host range and widening tissue tropism for these viruses. Both molecular and biological data predicted this evolutionary trend. The phylogenetic relationship among the four species of ascovirus was predicted to be that TnAV-2 and HvAV-3 shared a common ancestor with SfAV-1 and the three virus species again shared a common ancestor with DpAV-4.

关键词：细胞病毒分子种系系统识别技术

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