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CFTR is a negative regulator ofγδT cell IFN-γproduction and antitumor immunity

Cellular & Molecular Immunology 2021年第8期18卷 1934-1944页

作者： Yuanyuan Duan Guangqiang Li Miaomiao Xu Xiaofei Qi Mingxia Deng Xuejia Lin Zhiwei Lei Yi Hu Zhenghu Jia Quanli Yang Guangchao Cao Zonghua Liu Qiong Wen Zhenhua Li Jie Tang Wei Kevin Zhang Pingbo Huang Limin Zheng richard a.flavell Jianlei Hao Zhinan Yin Zhuhai Precision Medical Center Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Jinan UniversityZhuhai519000GuangdongChina The Biomedical Translational Research Institute Faculty of Medical ScienceJinan UniversityGuangzhou510632GuangdongChina Department of Physiology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515GuangdongChina The First Affiliated Hospital Jinan UniversityGuangzhou510632China School of Pharmaceutical Sciences South-Central University for NationalitiesWuhan430074HubeiChina Division of Life Science Hong Kong University of Science and Technology(HKUST)Hong KongChina State Key Laboratory of Oncology in Southern China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou510060China Department of Immunobiology School of MedicineYale UniversityNew HavenCT06520USA

CFTR,a chloride channel and ion channel regulator studied mostly in epithelial cells,has been reported to participate in immune regulation and likely affect the risk of cancer ***,little is known about the effects of CFTR on the differentiation and function ofγδT *** this study,we observed that CFTR was functionally expressed on the cell surface ofγδT *** deletion and pharmacological inhibition of CFTR both increased IFN-γrelease by peripheralγδT cells and potentiated the cytolytic activity of these cells against tumor cells both in vitro and in ***,the molecular mechanisms underlying the regulation ofγδT cell IFN-γproduction by CFTR were either TCR dependent or related to Ca^(2+)*** was recruited to TCR immunological synapses and attenuated Lck-P38 MAPK-c-Jun *** addition,CFTR was found to modulate TCR-induced Ca^(2+)influx and membrane potential(Vm)-induced Ca^(2+)influx and subsequently regulate the calcineurin-NFATc1 signaling pathway inγδT ***,CFTR serves as a negative regulator of IFN-γproduction inγδT cells and the function of these cells in antitumor *** investigation suggests that modification of the CFTR activity ofγδT cells may be a potential immunotherapeutic strategy for cancer.

关键词： CFTR γδT cells TCR Membrane potential Antitumor immunity

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m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway

m6A mRNA methylation controls T cell homeostasis by targetin...

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第十二届全国免疫学学术大会

作者： Li Huabing Tong Jiyu Shu Zhu Yuval Kluger Matthew D.Simon Howard Y.Chang Zhinan Yin richard a.flavell Department of Immunobiology Yale University School of Medicine Shanghai Institute of Immunology Department of Microbiology and Immunology The First Affiliated Hospital Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering Department of Pathology Yale University School of Medicine Department of Molecular Biophysics & Biochemistry Yale University Dynamic Regulomes Stanford University Howard Hughes Medical Institute

N6-methyladenosine(m6A)is the most common and abundant messenger RNA modification,modulated by‘writers’‘erasers’and‘readers’of this *** vitro data have shown that m6A influences all fundamental aspects of mRNA m... 详细信息

关键词： m6A methylation T cells STAT signaling Inflammation

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Long time Cola beverages consumption aggravates the pathogenesis of EAE through modulating intestinal microbiota.

Long time Cola beverages consumption aggravates the pathogen...

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第十届全国免疫学学术大会

作者： Guangchao Cao Wanjun Huang Zonghua Liu Jiyu Tong Hao Cheng Yiming Wen Hengwen Yang Zhenzhou Wu Liqing Zhao richard a.flavell Zhinan Yin State Key Laboratory of Medicinal Chemical Biology College of Life Sicences Nankai University Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering Biomedical Translational Innovative Entrepreneurial Team of Pearl River Talent ProgramBiomedical Translational Research Institute Jinan University Department of Immunology Yale School of Medicine

Epidemiological evidence has linked dietary changes,which may greatly disturb the homeostasis between immune system and microbiota,to the increasing incidence of autoimmune diseases in developed countries over recent *** Cola beverages had dramatically changed the dietary component all over the world in the past *** hypothesized that these commercial drinks may affect the pathogenesis of autoimmune diseases via modulating the composition of microbiota.

关键词： Cola beverages Microbiota EAE ATP

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RNA m^6A modification and its function in diseases

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Frontiers of Medicine 2018年第4期12卷 481-489页

作者： Jiyu Tong richard A. flavell Hua-Bing Li Shanghai Institute of Immunology Department of Microbiology and Immunology Shanghai Jiao Tong University School of Medicine (SJTU- SM) Shanghai 200025 China Department of Immunobiology Yale University School of Medicine New Haven CT 06520 USA Howard Hughes Medical Institute Chevy Chase MD 20815-6789 USA

N^6-methyladenosine （m^6A） is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism, m^6A modification could be installed by m^6A ＂writers＂ composed of core catalytic components （METTL3/METTL14/WTAP） and newly defined regulators and removed by m^6A ＂erasers＂（FTO and ALKBH5）. The function of m^6A is executed by m^6A ＂readers＂ that bind to m^6A directly （YTH domain-containing proteins, eIF3 and IGF2BPs） or indirectly （HNRNPA2B1）. In the past few years, advances in m^6A modulators （＂writers,＂＂erasers,＂ and ＂readers＂） have remarkably renewed our understanding of the function and regulation of m^6A in different cells under normal or disease conditions. However, the mechanism and the regulatory network of m^6A are still largely unknown. Moreover, investigations of the m^6A physiological roles in human diseases are limited. In this review, we summarize the recent advances in m^6A research and highlight the functional relevance and importance of m^6A modification in in vitro cell lines, in physiological contexts, and in cancers.

关键词： RNA modification m^6A immunity cancer epigenetics

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The innate immune sensing of genomic integrity

The innate immune sensing of genomic integrity

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第十一届全国免疫学学术大会

作者： richard a.flavell Yale University School of Medicine Department of Immunobiology

Genomic instability is a hallmark of cancer,and policing this is therefore essential to *** this and many other reasons,extensive DNA repair mechanisms are encoded in our *** of these require sensing of DNA damage as a prerequisite for *** exposure to ionizing radiation induces massive cell death and severe damage to tissues containing actively

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reatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs

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Cellular & Molecular Immunology 2013年第6期10卷 497-505页

作者： Xi Chen Ti Wen Jun Wei Zhenzhou Wu Puyue Wang Zhangyong Hong Liqing Zhao Bin Wang richard flavell Shumei Gao Min Wang Zhinan Yin Key Laboratory of Industrial Fermentation Microbiology (Tianjin University of Science and Technology) Ministry of Education College of Biotechnology Tianjin University of Science and Technology Tianjin China State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University Tianjin China Department of Medical Oncology The First Hospital of China Medical University Shenyang China Key Laboratory of Medical Molecular Virology of MOE and MOH Fudan University Shanghai Medical College Shanghai China Department of Immunobiology Yale School of Medicine New Haven CT USA Tianjin University of Traditional Chinese Medicine Tianjin China

Asthmatic inflammation is mediated by a type 2 helper T cell （Th2） cytokine response, and blocking Th2 cytokine production is proven to have a potent therapeutic effect against asthmatic inflammation. Using IL-4-green fluorescent protein （GFP） reporter mice, we demonstrated that Bavachinin, a single compound isolated from a Chinese herb, significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin （OVA）-sensitized animal asthma model. Furthermore, we demonstrated that this chemical selectively affects the level of GATA-3, most likely by affecting the stability of GATA-3 mRNA. Our results demonstrate, for the first time, the potential therapeutic value of this single compound derived from Chinese herbs.

关键词： asthma bavachinin IL-4

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Toll-like receptors (TLRs) signaling suppresses the apoptosis of virus-infected cells

Toll-like receptors (TLRs) signaling suppresses the apoptosi...

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中国畜牧兽医学会畜牧兽医生物技术学分会暨中国免疫学会兽医免疫分会第八次学术研讨会

作者： Vincent Deubel Mustapha Si-Tahar Lena Alexopoulou richard flavell Institut Pasteur Shanghai Chinese Academy of Sciences

Toll-like receptors(TLRs) are a family of immune receptors that recognize molecular patterns associated with microbial pathogens,and induce antimicrobial immune *** of viruses produce double-stranded RNA(dsRNA) during their *** of dsRNA by TLR3 as well as a growing list of cytosolic sensors,such as dsRNA-activated protein kinase

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植物生物技术研究和发展——今后的十年

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生物技术通报 1996年第4期12卷 1-4页

作者： richard B.flavell 朱遐

作为农业、园艺、食品、化学和制药工业更新基础的植物生物技术,日益受到重视。它为深化了解并改变植物生长和再产生新产物的基本过程和提高产力提供了方法。在今后的十年内,很可能将对植物基因组进行完全测序并对调控植物发育过程的大... 详细信息

作为农业、园艺、食品、化学和制药工业更新基础的植物生物技术,日益受到重视。它为深化了解并改变植物生长和再产生新产物的基本过程和提高产力提供了方法。在今后的十年内,很可能将对植物基因组进行完全测序并对调控植物发育过程的大量基因的功能进行分析。将分离农业上主要害虫、真菌、细菌和病毒的抗性基因并应用于农业。将开发含商业价值油类、蛋白和淀粉的种子,并将这种转基因作物应用于农业。由此将产生为消费者和工业提供新的选择形式的许多种植物;这将有利于与环境相适应的农业的发展。

关键词：植物生物技术研究和发展分子标记转基因作物马铃薯卷叶病毒抗性基因等位基因经济价值基因型与环境互作植物基因组

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细菌感染的核素显像:研究现状与发展方向

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中华核医学与分子影像杂志 2022年第7期42卷 436-444页

作者：翁诗佳(译) 王茜(审校) 北京大学人民医院核医学科北京100044

感染性疾病所致死亡率上升是越来越令人关注的公共卫生问题。早期诊断和治疗是成功治愈急性细菌感染的关键,但这并非易事。CT和MRI等结构影像技术常被引入这一诊疗过程,然而这些技术通常依赖于继发性炎性反应改变,对诊断感染并没有特异... 详细信息

感染性疾病所致死亡率上升是越来越令人关注的公共卫生问题。早期诊断和治疗是成功治愈急性细菌感染的关键,但这并非易事。CT和MRI等结构影像技术常被引入这一诊疗过程,然而这些技术通常依赖于继发性炎性反应改变,对诊断感染并没有特异性。核医学技术可提供关键的补充信息,并能可视化结构影像无法观察的感染病理生理改变。该篇综述将讨论目前用于诊断细菌感染的结构影像和功能影像技术及其在不同临床情况下的作用。文中还将介绍几种正在开发的新型显像剂,重点关注于靶向细菌特异性代谢的探针。病毒病原体的显像也可遵循类似思路。

关键词：感染显像核医学 PET SPECT

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当代英语写作手册

当代英语写作手册

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作者： R.H.flavellandL.M.flavell

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