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Classification of yearly extreme precipitation events and associated flood risk in the yangtze-Huaihe River Valley

Science China Earth Sciences 2018年第9期61卷 1341-1356页

作者： Zhiqing XIE Yin DU yan ZENG Qian MIAO Jiangsu Climate Center Nanfing 210009 China Key Laboratory of Meteorological Disaster Ministry of Education International Joint Laboratory on Climate and Environment Change Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Climate Dynamics Research Center Nanjing University of Information Science and Technology Nanjing 210044 China Huaihe Basin Meteorological Center Hefei 230031 China

Fifty cases of regional yearly extreme precipitation events （RYEPEs） were identified over the yangtze-Huaihe River Valley （YHRV） during 1979-2016 applying the statistical percentile method. There were five types of RYEPEs, namely yangtze Meiyu （YM-RYEPE）, Huaihe Meiyu （HM-RYEPE）, southwest-northeast-oriented Meiyu （SWNE-RYEPE） and typhoon I and II （TC-RYEPE） types of RYEPEs. Potential vorticity diagnosis showed that propagation trajectories of the RYEPEs along the Western Pacific Subtropical High and its steering flow were concentrated over the southern YHRV. As a result, the strongest and most frequently RYEPEs events, about 16-21 cases with average rainfall above 100 mm, occurred in the southern YHRV, particularly in the Nanjing metropolitan area. There have been 14 cases of flood-inducing RYEPEs since 1979, with the submerged area exceeding 120 km2 as simulated by the FloodArea hydraulic model, comprising six HM-RYEPEs, five YM- RYEPEs, two TC-RYEPEs, and one SWNE-RYEPE. The combination of evolving RYEPEs and rapid expansion of urban agglomeration is most likely to change the flood risk distribution over the Nanjing metropolitan area in the future. In the RCP6.0 （RCPS.5） scenario, the built-up area increases at a rate of about 10.41 km2 （10 yr）-t（24.67 km2 （10 yr）-1） from 2010 to 2100, and the area of high flood risk correspondingly increases from 3.86 km2（3.86 km2） to 9.00 kin2（13.51 km2）. Areas of high flood risk are mainly located at Chishan Lake in Jurong, Lukou International Airport in Nanjing, Dongshan in Jiangning District, Lishui District and other low-lying areas. The accurate simulation of flood scenarios can help reduce losses due to torrential flooding and improve early warnings, evacuation planning and risk analysis. More attention should be paid to the projected high flood risk because of the concentrated population, industrial zones and social wealth throughout the Nanjing metropolitan area.

关键词： yangtze-Huaihe River Valley Extreme precipitation events FloodArea model Flood risk

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Molecular basis of von Hippel-Lindau syndrome in Chinese patients

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Chinese Medical Journal 2011年第2期124卷 237-241页

作者： SIU Wai-kwan MA Ronald Ching-wan LAM Ching-wan MAK Chloe Miu YUEN Yuet-ping LO Fai-man Ivan CHAN kin-wan LAM Siu-fung LING Siu-cheung TONG Sui-fan SO Wing-yee CHOW Chun-chung TANG Mary Hoi-yin TAM wing-hung CHAN Albert yan-wo Department of Pathology Princess Margaret Hospital Hong Kong China Department of Medicine & Therapeutics The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China Department of Pathology Li Ka Shing Faculty of Medicine The University of Hong Kong Queen Mary Hospital Hong Kong China Clinical Genetic Service Department of Health Hong Kong China Department of Medicine and Geriatrics Princess Margaret Hospital Hong Kong China Department of Paediatrics and Adolescent Medicine Princess Margaret Hospital Hong Kong China Department of Obstetrics & Gynaecology Tsan Yuk Hospital Hong Kong China Department of Obstetrics & Gynaecology The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China

Background Von Hippel-Lindau （VHL） syndrome is an autosomal dominant familial cancer syndrome predisposing the affected individuals to multiple tumours in various *** genetic basis of VHL in Southern Chinese is largely *** this study,we characterized the mutation spectrum of VHL in nine unrelated Southern Chinese *** Nine probands with clinical features of VHL,two symptomatic and eight asymptomatic family members were included in this *** diagnosis was performed twice for one *** probands had only isolated bilateral *** VHL gene was screened for mutations by polymerase chain reaction,direct sequencing and multiplex ligation-dependent probe amplification （MLPA）.Results The nine probands and the two symptomatic family members carried heterozygous germline *** different VHL mutations were identified in the nine *** splicing mutation,NM_000551.2：c.463＋1G〉T,was *** other seven VHL mutations,c.233A〉G [***78Ser],c.239G〉T [***80lle],c.319C〉G [***107Gly],c.481C〉T [***161X],c.482G〉A [***161GIn],c.499C〉T [***167Trp] and an exon 2 deletion,had been previously *** asymptomatic family members were positive for the mutation and the other five tested *** prenatal diagnosis,the fetuses were positive for the *** Genetic analysis could accurately confirm VHL syndrome in patients with isolated tumours such as sporadic phaeochromocytoma or epididymal papillary *** detection in asymptomatic family members allows regular tumour surveillance and early intervention to improve their ***-based diagnosis can have an important impact on clinical management for VHL families.

关键词： von Hippel-Lindau syndrome VHL gene Chinese VHL mutations

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Inhibition of angiogenesis and HCT-116 xenograft tumor growth in mice by kallistatin

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World Journal of Gastroenterology 2007年第34期13卷 4615-4619页

作者： Yong Diao Jian Ma Wei-Dong Xiao Jia Luo Xin-yan Li kin-Wah Chu Peter WC Fung Nagy Habib Farzin Farzaneh Rui-An Xu Molecular Medicine Engineering Research Center of the Ministry of Education Institute of Molecular Medicine Huaqiao University Quanzhou362021 Fujian Province China Department of Medicine Hong Kong University Hong Kong China Department of Pharmacy Chicago UniversityUnited States Department of Transplantation Imperial College London United Kingdom Department of Haematological & Molecular Medicine King's College London London SE5 9NUUnited Kingdom

AIM： TO investigate the inhibitory effect of kallistatin （KAL） on angiogenesis and HCT-116 xenograft tumor growth.METHODS： Heterotopic subcutaneous injection of 2 Seven days later, 2 x 1011 injected intratumorally （n tumors were induced by x 106 HCT-11 cells in mice. rAAV-GFP or rAAV-KAL was = 5 for each group）. The mice were sacrificed at d 28, by which time the tumors in the rAAV-GFP group had grown to beyond 5% of the total body weight. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density （MVD） by immunohistology. Tumor cell proliferation was assessed by Ki-67 staining.RESULTS： Intratumor injection of rAAV-KAL inhibited tumor growth in the treatment group by 78% （171 ＋ 52 mm^3） at d 21 after virus infection compared to the control group （776 ＋ 241 mm^3）. Microvessel density was significantly inhibited in tumor tissues treated with rAAV-KAL, rAAV-KAL also decreased the proportion of proliferating cells （Ki-67 positive cells） in tumors compared with the control group.CONCLUSION： rAAV-mediated expression of KAL inhibits the growth of colon cancer by reducing angiogenesis and proliferation of tumor cells, and may provide a promising anti-angiogenesis-based approach to the treatment of metastatic colorectal cancer.

关键词： Kallistatin Adeno-associated virus Angiogenesis inhibitors Colon Neoplasm

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Areas of the global major river plumes

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Acta Oceanologica Sinica 2013年第1期32卷 79-88页

作者： KANG yan PAN Delu BAI yan HE Xianqiang CHEN Xiaoyan CHEN Chen-Tung Arthur WANG Difeng Department of Earth Sciences Zhejiang University State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyState Oceanic Administration Institute of Marine Geology and Chemistry National Sun Yat-sen University Kaohsiung

River plumes are the regions where the most intense river-sea-land interaction occurs, and they are char- acterized by complex material transport and biogeochemical processes. However, due to their highly dy- namic nature, global river plume areas have not yet been determined for use in synthetic studies of global oceanography. Based on global climatological monthly averaged salinity data from the NOAA World Ocean Atlas 2009 （WOA09）, and monthly averaged salinity contour maps of the East and South China Seas from the Chinese Marine Atlas, we extract the monthly plume areas of major global rivers using a geographic information system （GIS） technique. Only areas with salinities that are three salinity units lower than the average salinity in each ocean are counted. This conservative estimate shows that the minimum and max- imum monthly values of the total plume area of the world＇s 19 largest rivers are 1.72× 106 kin2 in May and 5.38× 106 klTl2 inAugust. The annual mean area of these river plumes （3.72× 106 knl2） takes up approximately 14.2% of the total continental shelves area worldwide （26.15 × 106 km2）. This paper also presents river plume areas for different oceans and latitude zones, and analyzes seasonal variations of the plume areas and their relationships with river discharge. These statistics describing the major global river plume areas can now provide the basic data for the various flux calculations in the marginal seas, and therefore will be of useful for many oceanographic studies.

关键词： river plume World Ocean Atlas geography information system Changjiang River marginal sea

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银杏叶提取物联合胞磷胆碱钠胶囊治疗脑梗死的临床疗效

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当代医学 2024年第4期30卷 82-86页

作者：彭孑婧鄢雨晴宜春市人民医院药学部江西宜春336000

目的探究银杏叶提取物联合胞磷胆碱钠胶囊治疗脑梗死的临床疗效。方法选取2019年7月至2021年7月宜春市人民医院接诊的92例脑梗死患者作为研究对象,按照随机抽签法分为对照组与观察组,每组46例。对照组给予胞磷胆碱钠胶囊口服治疗,观察... 详细信息

目的探究银杏叶提取物联合胞磷胆碱钠胶囊治疗脑梗死的临床疗效。方法选取2019年7月至2021年7月宜春市人民医院接诊的92例脑梗死患者作为研究对象,按照随机抽签法分为对照组与观察组,每组46例。对照组给予胞磷胆碱钠胶囊口服治疗,观察组给予银杏叶提取物联合胞磷胆碱钠胶囊口服治疗。比较两组临床疗效、炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、实验室指标[神经元特异性烯醇化酶(NSE)、S-100B蛋白、血清基质金属蛋白酶-9(MMP-9)]及神经功能缺损程度[美国国立卫生研究院卒中量表(NIHSS)评分]。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。用药14d后,两组CRP、IL-6、TNF-α水平均低于用药前,且观察组低于对照组,差异有统计学意义(P<0.05)。用药14 d后,两组血清NSE、S-100B蛋白、血清MMP-9水平均低于用药前,且观察组低于对照组,差异有统计学意义(P<0.05)。用药14d后,两组NIHSS评分均低于用药前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论银杏叶提取物联合胞磷胆碱钠胶囊治疗脑梗死效果理想,可控制机体炎症反应,调节血清NSE、S-100B蛋白及MMP-9水平,延缓病情进展,促进神经功能修复,有利于患者尽早康复。

关键词：脑梗死银杏叶提取物胞磷胆碱钠胶囊神经功能

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Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis

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National Science Review 2022年第7期9卷 17-31页

作者： Yujuan Jin Qiqi Zhao Weikang Zhu yan Feng Tian Xiao Peng Zhang Liyan Jiang Yingyong Hou Chenchen Guo Hsinyi Huang Yabin Chen Xinyuan Tong Jiayu Cao Fei Li Xueliang Zhu Jun Qin Dong Gao Xin-Yuan Liu Hua Zhang Luonan Chen Roman K.Thomas Kwok-kin Wong Lei Zhang Yong Wang Liang Hu Hongbin Ji State Key Laboratory of Cell Biology Chinese Academy of Sciences Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Center for Excellence in Mathematical Sciences National Center for Mathematics and Interdisciplinary Sciences Key Laboratory of ManagementDecision and Information SystemHua Loo-Keng Center for Mathematical Sciences Academy of Mathematics and Systems ScienceChinese Academy of Sciences Shenzhen Key Laboratory of Translational Medicine of Tumor Department of Cell Biology and Genetics Shenzhen University Health Sciences Center Shanghai Pulmonary Hospital Tongji University Shanghai Chest Hospital Shanghai Jiaotong University Zhongshan Hospital Fudan University Department of Pathology School of Basic Medical Sciences Fudan University School of Life Science and Technology Shanghai Tech University CAS Key Laboratory of Tissue Microenvironment and Tumor CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Nutrition and Health SciencesChinese Academy of Sciences Laura and Isaac Perlmutter Cancer Center New York University Langone Medical Center School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Department of Translational Genomics Center of Integrated Oncology Cologne-BonnMedical FacultyUniversity of Cologne Department of Pathology University Hospital Cologne

Small-cell lung cancer(SCLC) is a recalcitrant cancer characterized by high ***,the exact cell type contributing to metastasis remains *** a Rb1L/L/Trp53L/Lmouse model,we identify the NCAMhiCD44lo/-subpopulation as the SCLC metastasizing cell(SMC),which is progressively transitioned from the non-metastasizing NCAMloCD44hicell(non-SMC).Integrative chromatin accessibility and gene expression profiling studies reveal the important role of the SWI/SNF complex,and knockout of its central component,Brgl,significantly inhibits such phenotypic transition and ***,TAZ is silenced by the SWI/SNF complex during SCLC malignant progression,and its knockdown promotes SMC transition and ***,ectopic TAZ expression reversely drives SMC-to-non-SMC transition and alleviates ***-cell RNA-se quencing analyses identify SMC as the dominant subpopulation in human SCLC metastasis,and immunostaining data show a positive correlation between TAZ and patient *** data uncover high SCLC plasticity and identify TAZ as the key mole cular switch in orchestrating SCLC phenotypic transition and metastasis.

关键词： small cell lung cancer SWI/SNF complex TAZ phenotypic transition metastasis

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PACT targeting is a novel viral strategy of innate immune evasion

PACT targeting is a novel viral strategy of innate immune ev...

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第九届全国免疫学学术大会

作者： Chi-Ping Chan Pak-Yin Lui Sin-Yee Kitty Fung kin-Hang Kok Dong-yan Jin Departments of Biochemistry and Microbiology The University of Hong Kong

Innate immunity is the first-line host defense against viral infection.A potent innate interferon response is triggered when viral nucleic acids are sensed by cytoplasmic sensors RIG-I and *** recent findings indicate that optimal activation of RIG-I and MDA5 requires double stranded RNA(dsRNA)-binding protein ***

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Decolorization of azo dyes by a salt-tolerant Staphylococcus cohnii strain isolated from textile wastewater

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Frontiers of Environmental Science & Engineering 2012年第6期6卷 806-814页

作者： Bin yan Cuihong DU Meilan XU Wenchao LIAO Department of Environmental Engineering Xiamen University of TechnologyXiamen 361024China School of Biotechnology Engineering Jimei UniversityXiamen 361021China

The salt-tolerant Staphylococcus cohnii strain, isolated from textile wastewater, has been found effective on decolorizing several kinds of azo dyes with different structures. The optimal conditions for azo dye acid red B （ARB） decolorization by S. cohnii were determined to be pH= 7.0 and 30℃. The decolorization efficiency increased with the increase of the salinity concentration, and around 90% of ARB （100mg.L-1） could be decolorized in 24 h when the salinity concentration was up to 50 g-L 1. Moreover, the strain could still decolorize 19% of ARB in 24 h even when the NaC1 concentration was increased to 150 g. L1. Meanwhile, the dependence of the specific decolorization rate by S. cohnii on the ARB concentration could be described with Michaelis-Menten kinetics （kin = 585.7mg·L-1, Vmax = t09.8mg-g cell ·h ^-1）. The addition of quinone redox mediator, named 2-hydroxy-l,4-naphthoquinone and anthraqui- none-2,6-disulfonate, significantly accelerated the deco- lorization performance ofS. cohnii. Furtherly, the activities of azoreductase （0.55 μ*** protein^-***-1） and Nicotineamide adenine dinucleotide-dichlorophenol indophenol （NADH-DCIP） reductase （8.9μ*** ***-1） have been observed in the crude cell extracts of S. cohnii. The decolorization products of ARB were analyzed by HPLC-MS, and the results indicated the reductive pathway was responsible for azo dye decoloriza- tion by S. cohnii.

关键词： Staphylococcus cohnii decolorization salt,azoreductase Nicotineamide adenine dinucleotide-dichlor-ophenol indophenol (NADH-DCIP) reductase

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从线上到线下: 供应商渠道拓展策略研究

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系统工程理论与实践 2023年第10期43卷 2941-2951页

作者：晏妮娜卢继周龚明文慧黎建强中央财经大学商学院北京100086 香港大学工程学院中国香港999077 陕西师范大学国际商学院西安710119

许多曾经专注于线上销售的企业纷纷考虑向线下拓展,其可能的拓展策略包括:不开设线下渠道、线下直销、线下分销.通过构建斯塔克伯格博弈模型,研究一个仅通过电商平台线上销售的供应商从线上渠道向线下渠道拓展的策略,并提出在不同线上... 详细信息

许多曾经专注于线上销售的企业纷纷考虑向线下拓展,其可能的拓展策略包括:不开设线下渠道、线下直销、线下分销.通过构建斯塔克伯格博弈模型,研究一个仅通过电商平台线上销售的供应商从线上渠道向线下渠道拓展的策略,并提出在不同线上销售模式、不同消费者渠道偏好及不同渠道销售成本下,供应商的最优线下渠道拓展策略及定价决策.研究发现:无论何种情况下,供应商都应拓展线下渠道.但现有的线上销售模式会对线下拓展策略产生决定性影响.若现有线上销售模式为直销,则供应商最优策略总是线下直销;若现有线上销售模式为分销,当线上渠道销售成本较高或线上、线下渠道销售成本均较低时,供应商最优策略是线下直销;当线上销售成本较低而线下销售成本较高时,供应商最优策略是线下分销.

关键词：供应链渠道结构定价主从博弈

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Provisioning QoS Guarantee by Multipath Routing and Reservation in Ad Hoc Networks

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Journal of Computer Science & Technology 2004年第2期19卷 128-137页

作者： yan-TaiShu Guang-HongWang LeiWang OliverW.W.yang Yong-JieFan DepartmentofComputerScience TianjinUniversityTianjin300072P.R.China BellLabsResearchChina Beijing100080P.R.China SchoolofInformationTechnologyandEngineering UniversityofOttawaOttawaOntarioKIN6N5Canada

In this paper, a QoS multipath source routing protocol (QoS-MSR) is proposedfor ad hoc networks. It can collect QoS information through route discovery mechanism of multipathsource routing (MSR) and establish QoS route with reserved bandwidth. In order to reserve bandwidthefficiently, a bandwidth reservation approach called the multipath bandwidth splitting reservation(MBSR) is presented, under which the overall bandwidth request is split into several smallerbandwidth requests among multiple paths. In simulations, the authors introduce Insignia, an in-bindsignaling system that supports QoS in ad hoc networks, and extend it to multipath Insignia(M-Insignia) with QoS-MSR and MBSR. The results show that QoS-MSR routing protocol with the MBSRalgorithm can improve the call admission ratio of QoS traffic, the packet delivery ratio, and theend-to-end delay of both best-effort traffic and QoS traffic. Therefore, QoS-MSR with MBSR is anefficient mechanism that supports QoS for ad hoc networks.

关键词： ad hoc network quality of service (QoS) multipath source routing bandwidthreservation

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