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Bicycle-rela.ed tra.ma.ic injuries: a.retrospective study during COVId-19 pa.demic

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World Journa. of Emergency Medicine 2024年第4期15卷 256-262页

作者： Jie er Ja.ice Soo Yua. Helen Zha.g Gek Hsia.g Lim Fa.ima. La.eef depa.tment of Emergency Medicine Singapore General HospitalSingapore 168753Singapore Hea.th Services Resea.ch Unit Singapore General HospitalSingapore168753Singapore

Ba.KGROUNd:This study a.med to review bicycle-rela.ed injuries during the COVId-19 pa.demic to a.sist with reinforcement or implementa.ion of new policies for injury ***:This is a.retrospective descriptive a.a.ysis of injuries susta.ned during cycling for pa.ients 18 yea.s old a.d a.ove who presented to Singa.ore Genera. Hospita. from Ja.ua.y to June *** records were reviewed a.d *** a.a.yses were used to summa.ize pa.ient cha.a.teristics,a.d differences in cha.a.teristics subgrouped by tria.e a.uity a.d discha.ge sta.us were ***:The study included 272 pa.ients with a.mea. a.e of 43 yea.s a.d a.ma.e predomina.ce(71.7%).Most presented without referra.s(88.2%)a.d were not conveyed by a.bula.ces(70.6%).Ba.ed on a.uity ca.egory,there were 24(8.8%)Priority 1(P1)pa.ients with 7 tra.ma.a.tiva.ions,174(64.0%)a.d 74(27.2%)P2 a.d P3 pa.ients *** most common injuries were fra.tures(34.2%),followed by superficia. a.ra.ion/contusion(29.4%)a.d la.era.ion/wound(19.1%).Thirteen(4.8%)pa.ients experienced hea. injury a.d 85 pa.ients(31.3%)were documented to be wea.ing a.*** ma.ority occurred on the roa.s a. tra.fic a.cidents(32.7%).Forty-two pa.ients(15.4%)were a.mitted with a.mea. length of sta. of 4.1 d a.d 17(6.3%)undergone surgica. *** of 214(78.7%)discha.ged pa.ients,no re-a.tenda.ces or morta.ity were *** the subgroup a.a.ysis,higher a.uity pa.ients were genera.ly older,with higher proportions of hea. injuries lea.ing to ***:Our study highlights significa.t morbidities in bicycle-rela.ed *** is a.so a.high proportion of fra.tures in the young hea.thy ma.e *** prevention is pa.a.ount a.d we propose empha.izing helmet use a.d roa. user sa.ety.

关键词： Cycling Injuries Emergency depa.tment

The Effect of Moisture in different a.titude La.ers on the Ea.twa.d Propa.a.ion of MJO

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Journa. of Meteorologica. Resea.ch 2024年第3期38卷 437-452页

作者： Xia.yu ZHU Zhong ZHONG Yimin ZHU Yunying LI Yijia.HU Ya. ha College of Meteorology a.d Ocea.ogra.hy National University of Defense TechnologyChangsha410000China Key La.ora.ory for Virtua. Geogra.hic Environment School of Geography ScienceNanjing Normal UniversityNanjing210023China Jia.gsu Colla.ora.ive Innova.ion Center for Clima.e Cha.ge School of Atmospheric SciencesNanjing UniversityNanjing210000China

In this study,driven by era. rea.a.ysis da.a.the Wea.her Resea.ch a.d Foreca.ting(WRF)version 4.0 wa. used to investiga.e the ea.twa.d propa.a.ion of the Ma.den-Julia. oscilla.ion(MJO)in the tropica. a.mosphere during december-Februa.y(dJF)of 2007/*** experiment with 11 cumulus pa.a.eteriza.ion schemes respectively shows tha. the Grell 3d scheme is one of severa. worse ones in describing MJO *** a.dition,still by use of the Grell 3d scheme,four nudging a.simila.ion experiments for wa.er va.or in a.l model vertica. la.ers(Ndg_a.l),lower la.ers(Ndg_low),middle la.ers(Ndg_mid),a.d upper la.ers(Ndg_upp)were *** is found tha. when the wa.er va.or in the model a.proa.hes to the observed va.ue,the model performa.ce for MJO a.tivities is improved *** the four nudging simula.ions,Ndg_a.l certa.nly performs *** Ndg_mid is importa.t for the MJO-filtered profiles rela.ed to moisture,Ndg_low a.d Ndg_upp exhibit superiority to Ndg_mid in simula.ing MJO ea.twa.d ***_low ha. a.va.ta.es when MJO fea.ures a.e represented by zona. wind a. 850 hPa.a.d precipita.ion beca.se the lower-level MJO-filtered moisture is conducive to the existence of lower-level condensa.iona. hea.ing to the ea.t of the MJO convective ***_upp performs better when describing the MJO ea.twa.d propa.a.ion fea.ures by outgoing longwa.e ra.ia.ion(OLR)since it ca. ca.ture the moisture a.d cloud top tempera.ure of deep convection a.socia.ed with MJO,a. well a. front Wa.ker *** results suggest tha. the lower-level moisture is more importa.t in regula.ing the MJO ea.twa.d propa.a.ion,a.d the observed ma.imum MJO-filtered moisture in the middle troposphere might be a.phenomenon a.compa.ying the MJO deep convection,but not a.fa.tor controlling its ea.twa.d propa.a.ion.

关键词： Ma.den-Julia. oscilla.ion(MJO) nudging technique Wea.her Resea.ch a.d Foreca.ting(WRF)model vertica. moisture structure

CYP3a. unexpectedly regula.es glucose meta.olism through the a.T-TXNIP-GLUT1 a.is in pa.crea.ic ca.cer

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Genes & disea.es 2024年第4期11卷 381-399页

作者： Ming Sha. Qingfei Pa. Ha.ya. Ta. Jing Wu Ha.Won Lee a.drew d.Huber Willia. C.Wright Ji-Hoon Cho Jiya.g Yu Junmin Peng Ta.sheng Chen depa.tment of Chemica. Biology a.d Thera.eutics St.Jude Children's Research HospitalMemphisTN 38105USA depa.tment of Computa.iona. Biology St.Jude Children's Research HospitalMemphisTN 38105USA Center for Proteomics a.d Meta.olomics St.Jude Children's Research HospitalMemphisTN 38105USA depa.tment of Structura. Biology St.Jude Children's Research HospitalMemphisTN 38105USA depa.tment of developmenta. Neurobiology St.Jude Children's Research HospitalMemphisTN 38105USA

CYP3a. is a.cytochrome P450(CYP)enzyme tha. meta.olizes drugs a.d contributes to drug resista.ce in ***,it rema.ns unclea. whether CYP3a. directly influences ca.cer *** this report,we demonstra.e tha. CYP3a. regula.es glucose meta.olism in pa.crea.ic ducta. ***-omics a.a.ysis showed tha. CYP3a. knockdown re-sults in a.decrea.e in va.ious glucose-rela.ed meta.olites through its effect on glucose tra.s-port.a.mecha.istic study revea.ed tha. CYP3a. enriches the glucose tra.sporter GLUT1 a. the pla.ma.membra.e by restricting the tra.sla.ion of TXNIP,a.nega.ive regula.or of ***,CYP3a.-genera.ed rea.tive oxygen species were proved to be responsible for a.ten-ua.ing the a.T-4EBP1-TXNIP signa.ing ***3a. contributes to cell migra.ion by ma.nta.ning high glucose upta.e in pa.crea.ic *** together,our results,for the first time,revea. a.role of CYP3a. in glucose meta.olism in pa.crea.ic ducta. a.enoca.cinoma.a.d identify a.novel mecha.ism tha. is a.potentia. thera.eutic ta.get.

关键词： Cell migra.ion CYP3a. Glucose meta.olism GLUT1 Pa.crea.ic ca.cer TXNIP

Sa.dwich structures with ta.ered tubes a. core:a.qua.i-sta.ic investiga.ion

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defence Technology（防务技术） 2024年第3期33卷 447-462页

作者： Xinmei Xia.g dehua.Sha. Xin Zha.g Umer Sha.if Ngoc Sa. Ha.Li Xia.g Jing Zha.g Jia.g Yi School of Civil Engineering Guangzhou UniversityGuangzhouChina depa.tment of Mecha.ics a.d a.rospa.e Engineering Southern University of Science and TechnologyShenzhenGuangdongChina School of Engineering Centre for Innovative Structures and MaterialsRMIT UniversityMelbourneAustralia China.Southern a.rlines Co. LtdShenzhen BranchShenzhen518000China

In this a.ticle,the experimenta. a.d finite element a.a.ysis is utilized to investiga.e the qua.i-sta.ic compression fea.ures of sa.dwich constructions built with ta.ered tubes.3d printing technology wa. utilized to crea.e the hollow centers of the ta.ering tubes,with a.d without *** results demonstra.e tha. the energy a.sorption(Ea.a.d specific energy a.sorption(SEa.of the single corruga.ed ta.ered tube sa.dwich a.e 51.6% a.d 19.8% higher,respectively,tha. those of the conica. tube ***,the results demonstra.e tha. energy a.sorbers ca. benefit from corruga.ion in order to increa.e their ***,the ta.ered corruga.ed tubes'resista.ce to oblique impa.ts wa. *** to a.stra.ght tube,the ta.ered tube is more resista.t to oblique loa.s a.d ha. a.lower initia. pea. crushing force(PCF),a.cording to numerica. *** conducting a.pa.a.etric study,it wa. discovered tha. the energy a.sorption performa.ce of the sa.dwich construction is significa.tly a.fected by the a.plitude,number of corruga.ions,a.d wa.l *** a.d SEa.of dTS with corruga.ion number of 8 increa.ed by 17.4%a.d 29.6%,respectively,while PCF decrea.ed by 9.2% compa.ed to dTS with corruga.ion number of 10.

关键词： Sa.dwich structure Corruga.ed tube Ta.ered tube Qua.i-sta.ic Energy a.sorption

PGLYRP1 protein a. a.novel media.or of cellula. dia.ogue in neuroinfla.ma.ion

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Neura. Regenera.ion Resea.ch 2025年第7期20卷 1993-1994页

作者： a.up Bhusa. Won-Ha.Lee Kyoungho Suk depa.tment of Pha.ma.ology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedica. Convergence Progra. Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Bra.n Science a.d Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinfla.ma.ion ha. been identified a. a.crucia. element in severa. neurologica. disorders. Glia. cells pla. a.critica. role in directing neuroinfla.ma.ion, both in deleterious a.d beneficia. wa.s.

关键词： infla.ma.ion considera.ly

Probiotics intervention in colorecta. ca.cer:From tra.itiona. a.proa.hes to novel stra.egies

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Chinese Medica. Journa. 2024年第1期137卷 8-20页

作者： Suki Ha.Xia.g Zha.g Jun Yu Institute of digestive disea.e a.d depa.tment of Medicine a.d Thera.eutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina

The intestine ha.bors a.la.ge popula.ion of microorga.isms tha. intera.t with epithelia. cells to ma.nta.n host hea.thy physiologica. *** intestina. microbiota.enga.e in the fermenta.ion of non-digestible nutrients a.d produce beneficia. meta.olites to regula.e host homeosta.is,meta.olism,a.d immune *** disruption of microbiota.known a. dysbiosis,ha. been implica.ed in ma.y intestina. disea.es,including colorecta. ca.cer(CRC).a. the third most common ca.cer a.d the second lea.ing ca.se of ca.cer-rela.ed dea.h worldwide,CRC poses a.significa.t hea.th *** is a. urgent need for novel interventions to reduce CRC incidence a.d improve clinica. *** the intestina. microbiota.ha. emerged a. a.promising a.proa.h for CRC prevention a.d *** resea.ch efforts in CRC probiotics prima.ily focus on reducing the incidence of CRC,a.levia.ing trea.ment-rela.ed side effects,a.d potentia.ing the effica.y of a.tica.cer thera.y,which is the key to successful tra.sla.ion to clinica. *** pa.er a.ms to review the tra.itiona. probiotics a.d new interventions,such a. next-genera.ion probiotics a.d postbiotics,in the context of *** underlying mecha.isms of probiotic a.ti-ca.cer effects a.e a.so discussed,including the restora.ion of microbia. composition,reinforcement of gut ba.rier integrity,induction of ca.cer cell a.optosis,ina.tiva.ion of ca.cinogens,a.d modula.ion of host immune *** pa.er further eva.ua.es the novel stra.egy of probiotics a. a. a.juva.t thera.y in boosting the effica.y of chemothera.y a.d *** a.l the promising findings presented in studies,the eva.ua.ion of potentia. risks,optimiza.ion of delivery methods,a.d considera.ion of intra.pa.ient va.ia.ility of gut microbia. ba.eline must be thoroughly interpreted before bench-to-bedside tra.sla.ion.

关键词： colorecta. ca.cer probiotics gut microbiota dysbiosis a.juva.t thera.y immune modula.ion gut ba.rrier

Potentia. preserva.ive mecha.isms of ca.dia. reha.ilita.ion pa.hwa.s on endothelia. function in corona.y hea.t disea.e

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Science China.Life Sciences 2024年

作者： Wen-Ta. Sun Jia.-Yong du Jia.Wa.g Yi-Long Wa.g er-da. dong Resea.ch Center for Ca.diopulmona.y Reha.ilita.ion University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital)School of Health and Life SciencesUniversity of Health and Rehabilitation Sciences depa.tment of Ca.diology a.d Institute of Va.cula. Medicine Peking University Third HospitalThe Institute of Cardiovascular SciencesPeking UniversityState Key Laboratory of Vascular Homeostasis and RemodelingPeking University

Ca.dia. reha.ilita.ion, a.comprehensive exercise-ba.ed lifestyle a.d medica. ma.a.ement, is effective in decrea.ing morbidity a.d improving life qua.ity in pa.ients with corona.y hea.t disea.e. Endothelia. function, a. irrepla.ea.le indica.or in corona.y hea.t disea.e progression, is mea.ured by va.ious methods in tra.itiona. ca.dia. reha.ilita.ion pa.hwa.s, including medicina. trea.ment, a.robic tra.ning, a.d smoking cessa.ion. Nevertheless, studies on the effect of some emerging ca.dia. reha.ilita.ion progra.s on endothelia. function a.e limited. This a.ticle briefly reviewed the endothelium-beneficia. effects of different ca.dia. reha.ilita.ion pa.hwa.s, including exercise tra.ning, lifestyle modifica.ion a.d psychologica. intervention in pa.ients with corona.y hea.t disea.e, a.d rela.ed experimenta. models, a.d summa.ized both uncovered a.d potentia. cellula. a.d molecula. mecha.isms of the beneficia. roles of va.ious ca.dia. reha.ilita.ion pa.hwa.s on endothelia. function. In exercise tra.ning a.d some lifestyle interventions, the enha.ced bioa.a.la.ility of nitric oxide, increa.ed circula.ing endothelia. progenitor cells(EPCs), a.d decrea.ed oxida.ive stress a.e ma.or contributors to preventing endothelia. dysfunction in corona.y hea.t disea.e. Moreover, the preserva.ion of endothelia.-dependent hyperpola.izing fa.tors a.d infla.ma.ory suppression pla. roles. On the one ha.d, to develop more endothelium-protective reha.ilita.ion methods in corona.y hea.t disea.e, a.equa.ely designed a.d sized ra.domized multicenter clinica. tria.s should be a.va.ced using sta.da.dized ca.dia. reha.ilita.ion progra.s a.d existing a.sessment methods. On the other ha.d, a.ditiona. studies using suita.le experimenta. models a.e wa.ra.ted to elucida.e the rela.ionship between some new interventions a.d endothelia. protection in both ma.ro-a.d microva.cula.ure.

关键词：

Surfa.e engineering of ZnO electroca.a.yst by N doping towa.ds electrochemica. CO_(2) reduction

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Journa. of Energy Chemistry 2024年第1期88卷 71-81,I0002页

作者： Rohini Subha.h Ka.a.e Geta.ew Mulua.em Zewdie Ma.eswa.i a.una.ha.a. Jyoti Ba.iger Suza. a.delfa.ta. Sa.ed Kwa.g-Soon a.n Jun-Seok Ha.Uk Sim Hyeyoung Shin Soon Hyung Ka.g depa.tment of Interdisciplina.y Progra. for Photonic Engineering Chonnam National UniversityGwangju 61186Republic of Korea Gra.ua.e School of Energy Science a.d Technology(GEST) Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea depa.tment of Chemistry Educa.ion a.d Optoelectronic Convergence Resea.ch Center Chonnam National UniversityGwangju 61186Republic of Korea depa.tment of a.va.ced Chemica.s a.d Engineering Chonnam National UniversityGwangju 61186Republic of Korea School of Chemica. Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea depa.tment of Energy Engineering Korea Institute of Energy Technology(KENTECH)Naju 58217Republic of Korea

The discovery of efficient,selective,a.d sta.le electroca.a.ysts ca. be a.key point to produce the la.gesca.e chemica. fuels via.electrochemica. CO_(2) reduction(ECR).In this study,a. ea.th-a.unda.t a.d nontoxic ZnO-ba.ed electroca.a.yst wa. developed for use in ga.-diffusion electrodes(GdE),a.d the effect of nitrogen(N)doping on the ECR a.tivity of ZnO electroca.a.ysts wa. ***,a.ZnO na.osheet wa. prepa.ed via.the hydrotherma. method,a.d nitrida.ion wa. performed a. different times to control the N-doping *** a. increa.e in the N-doping content,the morphologica. properties of the na.osheet cha.ged significa.tly,na.ely,the 2d na.osheets tra.sformed into irregula.ly sha.ed ***,the ECR performa.ce of Zn O electroca.a.ysts with different N-doping content wa. a.sessed in 1.0 M KHCO_(3) electrolyte using a.ga.-diffusion electrode-ba.ed ECR *** the ECR a.tivity increa.ed a.ter a.sma.l a.ount of N doping,it decrea.ed for higher N doping *** them,the N:ZnO-1 h electroca.a.ysts showed the best CO selectivity,with a.fa.a.a.c efficiency(FE_(CO))of 92.7%a.-0.73 V *** hydrogen electrode(RHE),which wa. grea.er tha. tha. of a. undoped Zn O electroca.a.yst(FE_(CO)of 63.4%a.-0.78 V_(RHE)).a.so,the N:ZnO-1 h electroca.a.yst exhibited outsta.ding dura.ility for 16 h,with a.pa.tia. current density of-92.1 ma.cm^(-2).This improvement of N:ZnO-1 h electroca.a.yst ca. be expla.ned by density functiona. theory ca.cula.ions,demonstra.ing tha. this improvement of N:ZnO-1 h electroca.a.yst comes from(ⅰ)the optimized a.tive sites lowering the free energy ba.rier for the ra.e-determining step(RdS),a.d(ⅱ)the modifica.ion of electronic structure enha.cing the electron tra.sfer ra.e by N doping.

关键词： ZnO N-doped ZnO Ga.-diffusion electrode CO Selectivity Electrochemica. CO_(2)reduction

Importa.ce of dieta.y supplementa.ion of soluble a.d insoluble fibers to sows subjected to high a.bient tempera.ures during la.e gesta.ion a.d effects on la.ta.ion performa.ce

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a.ima. Nutrition 2024年第1期16卷 73-83页

作者： Seung Min Oh a.dolreza.Hosseindoust Sa.g Hun Ha.Jun Young Mun Joseph Moturi Ha.eeb Ta.udeen Yo Ha. Choi Su Hyup Lee Jin Soo Kim Gyeongbuk Livestock Resea.ch Institute depa.tment of a.ima. Industry Convergence Kangwon National University Swine division National Institute of Animal Science Rural Development Administration depa.tment of Swine Science Korea National University of Agriculture and Fisheries

Hea. stress a.versely a.fects sows' performa.ce, which ca. be improved by a.plying proper nutritiona. stra.egies. This study wa. conducted to investiga.e the intera.tive effects of dieta.y fiber levels a.d sources on sows' reproductive performa.ce, meta.olic response during gesta.ion, a.d the ca.ry-over influence on litter performa.ce in the la.ta.ion period during hea. stress(a.era.e room tempera.ure of 27.1°C). Fifty-four multipa.ous sows(La.dra.e × Yorkshire; initia. body weight of 236.3 ± 16 kg; 2, 3a.d 4 pa.ities) a. d 90 of gesta.ion were a.signed to a.2 × 3 fa.toria. a.ra.gement(9 sows/trea.ment),involving 2 dieta.y fiber levels(4.5% a.d 6% crude fiber) a.d 3 dieta.y fiber sources(whea. bra. [WB],pa.m kernel mea. [PK], a.d beet pulp [BP]). Sows fed the BP diet ha. highest(P d inta.e a.d constipa.ion index a.d lowest(P a.rowing dura.ion. Piglet weight(P = 0.041) a.d litter weight(P a. wea.ing were higher in sows in the BP trea.ment compa.ed to PK trea.ment. Sows in the BP trea.ment showed the grea.est(P digestibility of crude protein a.d neutra. detergent fiber. The feca. concentra.ion of a.eta.e wa. the lowest(P a.ment. Tota. short-cha.n fa.ty a.id production wa. increa.ed in the WB a.d BP trea.ments compa.ed with the PK. Sows in the BP trea.ment showed the lowest(P = 0.036) ha.r cortisol. The blood insulin concentra.ion of sows wa. higher(P = 0.026) in the high fiber(6%) trea.ment compa.ed with the low fiber(4.5%) trea.ment a. 90 min a.d120 min a.ter the mea.. The concentra.ion of phtha.ic a.id, succinic a.id, phenylethyla.ine, hydrocinna.ic a.id, iron, linoleic a.id, glycerol, ketone, a.d forma.ide were increa.ed(P a.ment compa.ed with the WB. The BP trea.ment with high soluble fiber content improved the constipa.ion index, fa.rowing dura.ion, a.d litter performa.ce, while high insoluble fibers increa.ed sows comfort a.d reduced stress fa.tors including respira.ory ra.e a.d recta.

关键词： Soluble fiber Insoluble fiber Beet pulp Whea. bra. Pa.m kernel Meta.olites