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Unique case of oligoastrocytoma with recurrence and grade progression:Exhibiting differential expression of high mobility group-A1 and human telomerase reverse transcriptase

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World Journal of Clinical Cases 2016年第9期4卷 296-301页

作者： Puneet Gandhi richa khare Kavita Niraj Nitin Garg Sandeep K Sorte Hanni Gulwani Department of Research Bhopal Memorial Hospital and Research Centre Department of Neurosurgery Bhopal Memorial Hospital and Research Centre and Bansal Hospital Department of Pathology Bhopal Memorial Hospital and Research Centre

Mixed gliomas, primarily oligoastrocytomas, account for about 5%-10% of all gliomas. Distinguishing oligoastrocytoma based on histological features alone has limitations in predicting the exact biological behavior, necessitating ancillary markers for greater specificity. In this case report, human telomerase reverse transcriptase(hT ERT) and high mobility group-A1(HMGA1); markers of proliferation and stemness, have been quantitatively analyzed in formalin-fixed paraffin-embedded tissue samples of a 34 years old patient with oligoastrocytoma. Customized florescence-based immunohistochemistry protocol with enhanced sensitivity and specificity is used in the study. The patient presented with a history of generalized seizures and his magnetic resonance imaging scans revealed infiltrative ill-defined mass lesion with calcified foci within the left frontal white matter, suggestive of glioma. He was surgically treated at our center for four consecutive clinical events. Histopathologically, the tumor was identified as oligoastrocytoma-grade Ⅱ followed by two recurrence events and final progression to grade Ⅲ. Overall survival of the patient without adjuvant therapy was more than 9 years. Glial fibrillary acidic protein, p53, Ki-67, nuclear atypia index, pre-operative neutrophillymphocyte ratio, are the other parameters assessed. Findings suggest that hT ERT and HMGA1 are linked to tumor recurrence and progression. Established markers can assist in defining precise histopathological grade in conjuction with conventional markers in clinical setup.

关键词： Human telomerase reverse transcriptase High mobility group-A1 Oligoastrocytoma Recurrence Tumor grade

A systematic review on the aboveground biomass and carbon stocks of Indian forest ecosystems

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Ecological Processes 2018年第1期7卷 165-176页

作者： Onkar Salunkhe P.K.khare richa Kumari M.L.Khan Laboratory of Ecology Department of BotanyDr.Hari Singh Gour UniversitySagarMadhya Pradesh 470003India

Background:Tropical forests play a crucial role as source and sink in global carbon *** and other anthropogenic activities have led to degradation of forest land,and ultimately,it results in loss of biodiversity and increases concentration of CO_(2) in ***,there is urgent need to estimate regional and national level carbon stock for making forest-based policies and strategies for mitigation of CO_(2).Patchy and sporadic information is available on biomass and carbon stock of Indian *** paper presents a systematic review and comprehensive account of studies conducted in different forest types in ***:There are six major forest types found in India consisting of 15 groups and other subgroups with peculiar *** used by researchers for biomass/carbon stock estimation are destructive,nondestructive,tree inventories data,species-specific biomass estimation,and remote *** of estimates are based on nondestructive allometric equation *** showed positive correlation between tree species,diameter at breast height,and biomass/carbon ***-and medium-sized growing trees,invasive species,mixed forest,Agroforestry,and Agrosilviculture also play an important role in atmospheric carbon *** results of diverse forest carbon stock studies are broadly categorized in North,Central,and Southern *** review will be helpful for developing conservation policies and decision to increase carbon stock and also REDD+program for particular forest ***:The systematic literature review was carried out to gather and summarize information from different studies conducted on forest ecosystems and quantification methods used for biomass estimation and carbon stock in different forests types and states of *** general,great variability occurs in aboveground biomass and carbon stock on account of climatic and geographic *** obtain good and accurate

关键词： Tropical forests Aboveground biomass Carbon stock

Multilevel Threshold Based Image Denoising in Curvelet Domain

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Journal of Computer Science & Technology 2010年第3期25卷 632-640页

作者： Nguyen Thanh Binh Ashish khare Department of Electronics and Communication University of Allahabad

In this paper, we propose a multilevel thresholding technique for noise removal in curvelet transform domain which uses cycle-spinning. Most of uncorrelated noise gets removed by thresholding curvelet coefficients at lowest level, while correlated noise gets removed by only a fraction at lower levels, so we used multilevel thresholding on curvelet coefficients. The threshold in the proposed method depends on the variance of curvelet coefficients, the mean and the median of absolute curvelet coefficients at a particular level which makes it adaptive in nature. Results obtained for 2-D images demonstrate an improved performance over other recent related methods available in literature.

关键词： curvelet transform denoising multilevel thresholding cycle-spinning

Machine vision for drill string slip status detection

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Petroleum Research 2022年第1期7卷 115-122页

作者： Sunil Kumar khare Dept.of Petroleum Engineering and Earth Sciences University of Petroleum and Energy StudiesDehradunUK248007India

Slip status of drill string is system generated binary value computed by comparison of sensor generated real time hook load value with a minimum threshold value of hook load stored in measurement *** research article describes a novel method of slip status detection by machine vision technology which helps overcome the constraints of slip status detection with legacy measurement *** also helps improve the real time drilling data quality and optimize and automate drilling operations.A method to detect drill string slip status with high-resolution digital camera installed on mast near rig floor is described along with backend vision processing and communication modules,which generate binary values of slip *** binary values are transferred in real time to drilling measurement system of rig to compute other drilling parameters like bit depth,hole depth and stand *** method includes deploying active optical sensors at the rig floor,obtaining 1-D,2-D,or 3D image data,and processing it to obtain the status of drill *** measurement of slip status by machine vision helps reduce non-productive time(NPT)by reliable real time surveillance of drilling operations.

关键词： Oil and gas Machine vision Camera Slip-status Rig Drilling Rotary table NPT Drilling fluid Drill pipe

Entropy of Quantum Dynamical Systems and Sufficient Families in Orthomodular Lattices with Bayessian State

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Communications in Theoretical Physics 2008年第9期50卷 551-556页

作者： Mona khare Shraddha Roy Department of Mathematics University of AllahabadAllahabad211 001India Allahabad Mathematical Society 10C.S.P.Singh MargAllahabad211 001India

The purpose of the present paper is to study the entropy hs（Ф） of a quantum dynamical systems Ф = （ L, s, Ф）, where s is a bayessian state on an orthomodular lattice L. Having introduced the notion of entropy hs（ Ф, A） of partition A of a Boolean algebra B with respect to a state s and a state preserving homomorphism Ф, we prove a few results on that, define the entropy of a dynamical system hs（Ф）, and show its invariance. The concept of sufficient families is also given and we establish that hs （Ф） comes out to be equal to the supremum of hs （Ф,A）, where A varies over any sufficient family. The present theory has then been extended to the quantum dynamical system （ L, s, Ф）, which as an effect of the theory of commutators and Bell inequalities can equivalently be replaced by the dynamical system （B, s0, Ф）, where B is a Boolean algebra and so is a state on B.

关键词： orthomodular lattices quantum logic valuation isomorphism partitions entropy quantum dynamical systems sufficient families

Modeling of finite-size droplets and particles in multiphase flows

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Chinese Journal of Aeronautics 2015年第4期28卷 974-982页

作者： Prashant khare Shanwu Wang Vigor Yang School of Aerospace Engineering Georgia Institute of Technology

The conventional point-particle approach for treating the dispersed phase in a continuous flowfield is extended by taking into account the effect of finite particle size, using a Gaussian interpolation from Lagrangian points to the Eulerian *** inter-phase exchange terms in the conservation equations are distributed over the volume encompassing the particle size, as opposed to the Dirac delta function generally used in the point-particle *** proposed approach is benchmarked against three different flow configurations in a numerical framework based on large eddy simulation（LES） turbulence ***, the flow over a circular cylinder is simulated for a Reynolds number of 3900 at 1 atm *** show good agreement with experimental data for the mean streamwise velocity and the vortex shedding frequency in the wake *** calculated flowfield exhibits correct physics, which the conventional point-particle approach fails to *** second case deals with diesel jet injection in quiescent environment over a pressure range of 1.1–5.0 *** calculated jet penetration depth closely matches *** decreases with increasing chamber pressure, due to enhanced drag force in a denser fluid ***, water and acetone jet injection normal to air crossflow is studied at1 *** calculated jet penetration and Sauter mean diameter of liquid droplets compare very well with measurements.

关键词： Droplets Finite-size effects Large eddy simulation Multiphase flow Particle-laden flow

Temperature-dependent structural,morphological and optical properties of chemical bath-deposited CdS films

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Rare Metals 2021年第3期40卷 701-707页

作者： Tarkeshwar Sinha Devjyoti Lilhare Ayush khare Department of Physics National Institute of TechnologyRaipur 492010India

Cadmium sulfide(CdS) films were grown on top of the fluorine-doped tin oxide(FTO) coated glass substrates at four different bath temperatures by chemical bath deposition(CBD) technique.X-ray diffraction(XRD),ultraviolet-visible(UV-Vis) spectrometry,energy-dispersive X-ray spectroscopy(EDX),field emission scanning electron microscope(FESEM),photoluminescence(PL)and Fourier-transform infrared(FTIR) analyses were employed to examine the morphological and optical properties of deposited *** studies confirmed the cubic crystalline nature of the deposited films which improved with increase in deposition temperature,and EDX along with FESEM study showed that the films were smooth and uniform with appropriate chemical ***-gap values of the CBD CdS films calculated by UV-Vis spectrometry were found to be in the range of2.32-2.39 eV.A strong blue band and a weak green band were observed in PL emission spectra.C-S,Cd-S and SC-N vibrations were found by FTIR spectral analysis.

关键词： CdS Thin films CBD Bath temperature Photoluminescence

Enhanced thermoelectric figure of merit at near room temperature in n-type binary silver telluride nanoparticles

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Journal of Materiomics 2023年第2期9卷 310-317页

作者： Amish Kumar Gautam Neeraj khare Department of Physics Indian Institute of Technology DelhiHauz KhasNew Delhi110016India

In the present study,we have synthesized Ag2Te nanoparticles using the hydrothermal method and showed significant improvement in the thermoelectric properties compared to the bulk Ag2Te ***2Te nanoparticles showed the highest figure of merit(zT)of 1.37 at 373 K,which is the highest zT reported for this undoped *** high zT in Ag2Te nanoparticles is mainly due to about~2 times higher electrical conductivity(1967 S/cm)and subsequently~2 times lower thermal conductivity(0.53 W/(m$K))as compared to the bulk Ag2Te *** higher electrical conductivity in Ag2Te nanoparticles can be accredited for two reasons(i)better mobility of the charge carrier and(ii)increased carrier *** low thermal conductivity is associated with the enhanced scattering of phonons at the interface of the Ag2Te nanoparticles.

关键词： Silver telluride Nanoparticles Thermoelectrics Figure of merit

Proteomics approaches for early detection and targeted therapy of hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2017年第1期9卷 1-3页

作者： Tripti khare Sharad khare Jamal A Ibdah Division of Gastroenterology and Hepatology Department of Internal Medicine University of Missouri Harry S.Truman Memorial Veterans’ Hospital

Hepatocellular carcinoma(HCC) is one of the leading causes of cancer related mortality worldwide. HCC incidences have increased worldwide though more prevalent in Asia and Africa. Hepatitis B virus and hepatitis C virus infections are mostly responsible of increased number of HCC cases. Biomarkers can help early detection and improve treatment regimen in patients as advanced stage is chemo-refractive with limited treatment options. Potential of proteomics in finding new biomarkers for early detection has been explored more recently. Future developments in this area rely on how efficiently we manage vast amount of data generated by these techniques and speed up the clinical trials to improve patient care.

关键词： Proteomics Cancer Biomarker Hepatocellular carcinoma