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Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

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Intelligent Control and Automation 2012年第3期3卷 278-283页

作者： László rich.rd Tóth Lajos Nagy Ferenc Szeifert Department of Process Engineering University of Pannonia Veszprém Hungary

To reach an acceptable controller strategy and tuning it is important to state what is considered “good”. To do so one can set up a closed-loop specification or formulate an optimal control problem. It is an interesting question, if the two can be equivalent or not. In this article two controller strategies, model predictive control (mPC) and constrained direct inversion (CDI) are compared in controlling the model of a pilot-scale water heater. Simulation experiments show that the two methods are similar, if the manipulator movements are not punished much in mPC, and they act practically the same when a filtered reference signal is applied. Even if the same model is used, it is still important to choose tuning parameters appropriately to achieve similar results in both strategies. CDI uses an analytic approach, while mPC uses numeric optimization, thus CDI is more computationally efficient, and can be used either as a standalone controller or to supplement numeric optimization.

关键词： model Predictive Control Inverse Control Objective Function Closed-Loop Specification Heat Transfer

Pulsed Electrochemical Deposited Nano-Iron for Water Treatment

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American Journal of Analytical Chemistry 2017年第3期8卷 171-179页

作者： éva Fazakas má tyá s-Kará csony Zsuzsanna richá rd Bak Lajos K. Varga Bay Zoltá n Nonprofit Ltd. for Applied Research Budapest Hungary Wigner Research Center for Physics Hungarian Academy of Sciences Budapest Hungary

The application of nanotechnology in drinking water treatment and pollution cleanup is promising, as demonstrated by a number of field-based (pilot and full scale) and bench scale studies. In recent years, the use of zero-valent iron (ZVI) for the treatment of toxic contaminants in groundwater and wastewater has received wide attention and encouraging treatment efficiencies have been documented. In this review, nanoscale iron was prepared by pulse electrodeposition of nano iron by chemical reduction of iron chloride and iron sulfate. Our research focuses on iron nanoparticles preparation and its use for aqueous Cr(VI) reduction. The Cr(VI) reduction by the nFe0 prepared by electrochemical and blasting method at neutral pH were carried. The results show that blasting-nFe0 show lower reaction than the electrochemical-nFe0. It is because the blasting-nFe0 surface contains more Fe2O3 than the other one.

关键词： Nano Iron Electrodeposition Blasting Chromium(VI) Reduction

An acoustofluidic scanning nanoscope using enhanced image stacking and processing

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microsystems & Nanoengineering 2022年第4期8卷 191-198页

作者： Geonsoo Jin Joseph rich Jianping Xia Albert JHe Chenglong Zhao Tony Jun Huang Thomas Lord Department of mechanical Engineering and material Science Duke UniversityDurhamNC 27708USA Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Department of Physics University of Dayton300 College ParkDaytonOH 45469USA Department of Electro-Optics and Photonics University of Dayton300 College ParkDaytonOH 45469USA

Nanoscale optical resolution with a large field of view is a critical feature for many research and industry areas,such as semiconductor fabrication,biomedical imaging,and nanoscale material *** scanning microscopes have been developed to resolve the inverse relationship between the resolution and field of view;however,those scanning microscopes still rely upon fluorescence labeling and complex optical *** overcome these limitations,we developed a dual-camera acoustofluidic nanoscope with a seamless image merging algorithm(alphablending process).This design allows us to precisely image both the sample and the microspheres simultaneously and accurately track the particle path and ***,the number of images required to capture the entire field of view(200×200μm)by using our acoustofluidic scanning nanoscope is reduced by 55-fold compared with previous ***,the image quality is also greatly improved by applying an alpha-blending imaging technique,which is critical for accurately depicting and identifying nanoscale objects or *** dual-camera acoustofluidic nanoscope paves the way for enhanced nanoimaging with high resolution and a large field of view.

关键词： image overcome stacking

Promise and pitfalls of modeling grassland soil moisture in a free-air CO_(2) enrichment experiment(BioCON)using the SHAW model

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Pedosphere 2021年第5期31卷 783-795页

作者： Raquel H.FLINKER m.Bayani CArdENAS Todd G.CALDWELL Gerald N.FLERCHINGER Roy rich Peter B.REICH Department of Geological Sciences The University of Texas at AustinAustin 78712(USA) Bureau of Economic Geology The University of Texas at AustinAustin 78713(USA) Agricultural Research Service United States Department of AgricultureBoise 83712(USA) Smithsonian Environmental Research Center Edgewater 20137(USA) Department of Forest Resources University of MinnesotaSt.Paul 55108(USA) Hawkesbury Institute for the Environment Western Sydney UniversitySydney 2753(Australia)

Free-air carbon dioxide(CO_(2))enrichment(FACE)experiments provide an opportunity to test models of heat and water flow under novel,controlled situations and eventually allow use of these models for hypothesis *** study assesses whether the United States Department of Agriculture SHAW(Simultaneous Heat and Water)numerical model of vertical one-dimensional soil water flow across the soil-plant-atmosphere continuum is able to adequately represent and explain the effects of increasing atmospheric CO_(2) on soil moisture dynamics in temperate *** in a FACE experiment,the Bio CON(Biodiversity,CO_(2),and Nitrogen)experiment,in minnesota,USA,were compared with results of vertical soil moisture *** scenarios represented by different plots were assessed:bare,vegetated with ambient CO_(2),and similarly vegetated with high CO_(2).From the simulations,the bare plot soil was generally the wettest,followed by a drier high-CO_(2) vegetated plot,and the ambient CO_(2) plot was the *** SHAW simulations adequately reproduced the expected behavior and showed that vegetation and atmospheric CO_(2) concentration significantly affected soil moisture *** differences in modeled soil moisture amongst the plots were largely due to transpiration,which was low with high CO_(2).However,the modeled soil moisture only modestly reproduced the ***,while SHAW is able to replicate and help broadly explain soil moisture dynamics in a FACE experiment,its application for point-and time-specific simulations of soil moisture needs further *** typical design of a FACE experiment makes the experimental observations challenging to model with a one-dimensional distributed *** addition,FACE instrumentation and monitoring will need improvement in order to be a useful platform for robust model *** after this can we recommend that models such as SHAW are adequate for process interpretation of datasets from FACE exp

关键词： carbon dioxide FACE experiment soil water flow vadose zone vegetation

Contemporary outcomes of patients undergoing robotic-assisted radical cystectomy:A comparative analysis between intracorporeal ileal conduit and neobladder urinary diversions

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Asian Journal of Urology 2023年第4期10卷 446-452页

作者： Jordan m.rich Shivaram Cumarasamy Daniel Ranti Etienne Lavallee Kyrollis Attalla John P.Sfakianos Nikhil Waingankar Peter N.Wiklund Reza mehrazin Department of Urology Icahn School of Medicine at Mount SinaiNew YorkNYUSA Department of Urology Karolinska University HospitalSolnaSweden

Objective We aimed to compare perioperative and oncologic outcomes for patients undergoing robotic-assisted radical cystectomy(RARC)with intracorporeal ileal conduit(IC)and neobladder(NB)urinary *** Patients undergoing RARC with intracorporeal urinary diversion between January 2017 and January 2022 at the Icahn School of medicine at mount Sinai,New York,NY,USA were *** demographics,clinical characteristics,perioperative,and oncologic outcomes were *** was estimated with Kaplan-meier *** Of 261 patients(206[78.9%]male),190(72.8%)received IC while 71(27.2%)received NB *** age was greater in the IC group(71[interquartile range,IQR 65-78]years vs.64[IQR 59-67]years,pmI was 26.6(IQR 23.2-30.4)kg/m^(2).IC group was more likely to have prior abdominal or pelvic radiation(15.8%vs.2.8%,p=0.014).American Association of Anesthesiologists scores were comparable between *** IC group had a higher proportion of patients with pathological tumor stage 2(pT2)tumors(34[17.9%]vs.10[14.1%],p=0.008)and pathological node stages pN2-N3(28[14.7%]vs.3[4.2%],pmedian operative time(272[IQR 246-306]min vs.341[IQR 303-378]min,pmated blood loss(250[150-500]mL vs.325[200-575]mL,p=0.002).Thirty-and 90-day complication rates were 44.4%and 50.2%,respectively,and comparable between ***-Dindo grades 3-5 complications occurred in 27(10.3%)and 34(13.0%)patients within 30 and 90 days,respectively,with comparable rates between *** follow-up was 324(IQR 167-552)days,and comparable between ***-meier estimate for overall survival at 24 months was 89%for the IC cohort and 93%for the NB cohort(hazard ratio 1.23,95%confidence interval 1.05-2.42,p=0.02).Kaplan-meier estimate for recurrence-free survival at 24 months was 74%for IC and 87%for NB(hazard ratio 1.81,95%confidence interval 0.82-4.04,p=0.10).Conclusion Patients undergoing intracorporeal IC urinary

关键词： Robotic Radical cystectomy Intracorporeal Ileal conduit Neobladder Urinary diversion Oncologic outcome

Upper Lillooet River Hydroelectric Project： The Challenges of Constructing a Power Tunnel for Run-of-River Hydro Projects in mountainous British Columbia

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Engineering 2018年第2期4卷 96-102页

作者： Nichole Boultbee Oliver Robson Serge moalli rich Humphries Colder Associates Ltd. Squamish British Columbia VSB OB4 Canada Innergex Renewable Energy Inc. Vancouver British Columbia VCE 4E6 Canada EBC Inc. North Vancouver British Columbia V7L OBS Canada

The Upper Lillooet River Hydroelectric Project （ULHP） is a run-of-river power generation scheme located near Pemberton, British Columbia, Canada, consisting of two separate hydroelectric facilities （HEFs） with a combined capacity of 106.7 mW. These HEFs are owned by the Upper Lillooet River Power Limited Partnership and the Boulder Creek Power Limited Partnership, and civil and tunnel construction was completed by CRT-ebc. The Upper Lillooet River HEF includes the excavation ofa 6 m wide by 5.5 m high and approximately 2500 m long tunnel along the Upper Lillooet River Valley. The project is in a moun- tainous area; severe restrictions imposed by weather conditions and the presence of sensitive wildlife species constrained the site operations in order to limit environmental impacts. The site is adjacent to the mount meager Volcanic Complex, the most recently active volcano in Western Canada. Tunneling conditions were very challenging, including a section through deposits associated with the most recent eruption from mount meager Volcanic Complex （-2360 years before the present）. This tunnel section included welded breccia and unconsolidated deposits composed of loose pumice, organics （that represent an old forest floor）, and till, before entering the underlying tonalite bedrock. The construction of this section of the tunnel required cover grouting, umbrella support, and excavation with a combination of road header, hydraulic hammer, and drilling-and-blasting method. This paper provides an overview of the project, a summary of the key design and construction schedule challenges, and a description of the successful excavation of the tunnel through deposits associated with the recent volcanic activity.

关键词： Run-of-river hydro project Power tunnel Umbrella support Canopy tubes Volcanic depositsPumiceRoadheader Environmental constraints

Optimization of mycelial growth of Xylaria papulis Lloyd(Xylariaceae)in indigenous liquid culture conditions,science city of muñoz,Nueva Ecija,Philippines

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Studies in Fungi 2022年第1期7卷 176-182页

作者： mark Kevin S.Lopez Sofronio P.Kalaw rich milton R.Dulay Angeles m.De Leon Renato G.Reyes Biology Department College of Arts and SciencesDon Mariano Marcos Memorial State University–North La Union Campus/SapilangBacnotanLa Union Philippines 2515 Center for Tropical mushroom Research and Development Department of Biological SciencesCollege of ScienceCentral Luzon State University/Science City of MuñozNueva EcijaPhilippines 3120

The search for potential and inexhaustible sources of bioactive compounds with great functional activities is imperative for potential drug leads in treating various human *** this regard,this study investigated the optimum liquid medium and physical culture conditions for the mycelial growth of *** Lloyd for nutraceutical *** greatest mycelial biomass was achieved in PSB liquid medium among the indigenous media evaluated,such as potato sucrose broth(PSB),corn meal broth(CmB),rice bran broth(RBB),and coconut water(CW).In terms of pH,*** Lloyd was observed to grow in a wide range of pH(5.0−8.5),but the best mycelial growth was observed at pH *** temperature of 28℃,lighted(137 lux),and static conditions were the other optimum physical culture conditions for mycelial growth of *** Lloyd.

关键词： culture liquid optimum

Pituitary carcinoma: Two case reports and review of literature

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World Journal of Clinical Oncology 2020年第2期11卷 91-102页

作者： Lai Xu Karam Khaddour Jie Chen Keith m rich rich.rd J Perrin Jian Li Campian Divisions of Hematology and Oncology Department of MedicineWashington University School of MedicineSt.LouisMO 63110United States Department of Pathology and Immunology Washington University School of MedicineSt.LouisMO 63110United States Department of Neurological Surgery Washington University School of MedicineSt.LouisMO 63110United States

BACKGROUND Pituitary carcinoma is a rare type of malignancy that can be very difficult to diagnose and *** cases were diagnosed at *** in diagnosis often adversely impact patients’*** with prompt diagnosis,treatment decisions remain challenging in the absence of randomized controlled *** SUmmARY We report two cases of pituitary carcinoma in men with a history of pituitary *** the first case,a 55-year-old man was initially diagnosed with pituitary *** underwent subtotal debulking of the tumor followed by adjuvant ***,he developed relapsed disease and multifocal intracranial metastases and a diagnosis of pituitary carcinoma was *** passed away despite several lines of systemic therapies including temozolomide,lomustine and *** 52-year-old man was diagnosed with atypical pituitary adenoma with presentation of sudden onset of vision loss in the right *** had recurrent pituitary carcinoma with spinal metastases,treated with surgery,radiation and *** Pituitary carcinoma is a rare neoplasm with poor prognosis that is difficult to diagnose and *** small number of cases restricts our ability to design randomized clinical *** is largely driven by retrospective studies and case *** molecular biomarkers and comprehensive genomic profiling could help in decisions about diagnosis and management of pituitary carcinoma.

关键词： Pituitary carcinoma Diagnosis Treatment Pituitary adenoma Temozolomide Case report