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A national longitudinal cohort study of factors contributing to UK medical students’mental ill-health symptoms

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General Psychiatry 2023年第2期36卷 92-105页

作者： Asta Medisauskaite Milou E W M Silkens Antonia rich Medical School UCLLondonUK Department of Health Services Research and Management City University of LondonLondonUK

Background The mental health of current medical students is predictive of their mental health as future *** prevalence of anxiety,depression and burnout is high among medical students,but less is known about the occurrence of other mental ill-health symptoms,such as eating or personality disorders,and factors contributing to mental ***(1)To explore the prevalence of various mental ill-health symptoms in medical students and(2)to investigate what medical school factors and students’attitudes contribute to these mental ill-health *** Between November 2020 and May 2021,medical students from nine geographically spread medical schools in the UK participated by completing online questionnaires at two points in time,approximately 3 months *** Of the 792 participants who filled in the questionnaire at baseline,over half experienced medium to high somatic symptoms(50.8%;402)and drank alcohol at hazardous levels(62.4%;494).Adjusted longitudinal data analysis of 407 students who completed the follow-up questionnaire demonstrated that less supportive educational climates that were more competitive and less centralised around the students,lower feelings of belongingness,greater stigma towards mental ill-health and lower intentions to seek help for mental ill-health,all contributed to students’mental ill-health *** Medical students experience a high prevalence of various mental ill-health *** study suggests that medical school factors and students’attitudes towards mental ill-health are significantly associated with students’mental health.

关键词： filled doctor competitive

Acoustofluidics for simultaneous nanopartide-based drug loading and exosome encapsulation

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Microsystems & Nanoengineering 2022年第2期8卷 149-159页

作者： Zeyu Wang Joseph rich.Nanjing Hao Yuyang Gu Chuyi Chen Shujie Yang Peiran Zhang Tony Jun Huang Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA

Nanocarrier and exosome encapsulation has been found to significantly increase the efficacy of targeted drug delivery while also minimizing unwanted side ***,the development of exosome-encapsulated drug nanocarriers is limited by low drug loading efficiencies and/or complex,time-consuming drug loading ***,we have developed an acoustofluidic device that simultaneously performs both drug loading and exosome *** synergistically leveraging the acoustic radiation force,acoustic microstreaming,and shear stresses in a rotating droplet,the concentration,and fusion of exosomes,drugs,and porous silica nanoparticles is *** final product consists of drug-loaded silica nanocarriers that are encased within an exosomal *** drug loading efficiency is significantly improved,with nearly 30%of the free drug(e.g.,doxorubicin)molecules loaded into the ***,this acoustofluidic drug loading system circumvents the need for complex chemical modification,allowing drug loading and encapsulation to be completed within a matter of *** exosome-encapsulated nanocarriers exhibit excellent efficiency in intracellular transport and are capable of significantly inhibiting tumor cell *** utilizing physical forces to rapidly generate hybrid nanocarriers,this acoustofluidic drug loading platform wields the potential to significantly impact innovation in both drug delivery research and applications.

关键词： exosome loading simultaneous

SURVIVAL TRENDS IN CHILDHOOD HEMATOLOGICAL MALIGNANCIES

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International Journal of Biomathematics 2012年第6期5卷 95-103页

作者： STEPHANIE rich.SHIHAB ALI GEOFFREY W. CALKINS JAMES S. MICHAELSON Laboratory of Quantitative Medicine Massachusetts General Hospital 65 Landsdowne Street Suite 200Cambridge Massachusetts 02139 USA Laboratory of Quantitative Medicine and Departments of Surgery and Pathology Massachusetts General Hospital 65 Landsdowne Street Suite 200Cambridge Massachusetts 02139 USA

Survival of patients with childhood hematological malignancies has increased markedly in the past decades. To examine the finescale details of how this progress has occurred, we carried out KaplanMeier causespecific survival analysis using the Surveillance Epi demiology and End Results （SEER） dataset for patients with childhood hematologi cal malignancies Hodgkin＇s Lymphoma, NonHodgkin＇s Lymphoma, Lymphoblastic Leukemia and Myeloid Leukemia diagnosed in five eras： 1983-1987; 1988-1992; 1993-1997; 1998-2002 and 2003-2007. We generated KaplanMeier estimates of survival for each of the first 24 years after diagnosis. These figures agree with previously reported five and tenyear values and attest to the remarkable increase in survival that has occurred over the past three decades of medical progress. The trend towards progres sively increasing survival shows no sign of slowing, suggesting that we may expect further increases in survival in the years ahead. Most of the increase in survival for childhood hematological malignancies has occurred by reducing the risk of death in the first two years after diagnosis. This may be largely explained by the fact that this is the time period when patients are at highest risk of death.

关键词： Childhood hematological malignancies survival trends.

Atrial fibrillation in the elderly

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Journal of Geriatric Cardiology 2005年第2期2卷 68-73页

作者： Roger Kerzner Michael W. rich Cardiovascular Division

Atrial fibrillation (AF) is an extremely common condition in the elderly, with increasing prevalence around the world as the population ages. AF may be associated with serious health consequences, including stroke, heart failure, and decreased quality of life, so that careful management of AF by geriatric health care providers is required. With careful attention to anticoagulation therapy, and prudent use of medications and invasive procedures to minimize symptoms, many of the adverse health consequences of AF can be prevented.

关键词： atrial fibrillation antithrombotic rhythm control rate control elderly

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Role of antispasmodics in the treatment of irritable bowel syndrome

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World Journal of Gastroenterology 2014年第20期20卷 6031-6043页

作者： Anita Annaházi rich.rd Róka András Rosztóczy Tibor Wittmann First Department of Medicine University of Szeged 6720 Szeged Hungary

Irritable bowel syndrome (IBS) is a long-lasting, relapsing disorder characterized by abdominal pain/discomfort and altered bowel habits. Intestinal motility impairment and visceral hypersensitivity are the key factors among its multifactorial pathogenesis, both of which require effective treatment. Voltage-gated calcium channels mediate smooth muscle contraction and endocrine secretion and play important roles in neuronal transmission. Antispasmodics are a group of drugs that have been used in the treatment of IBS for decades. Alverine citrate, a spasmolytic, decreases the sensitivity of smooth muscle contractile proteins to calcium, and it is a selective 5-HT1A receptor antagonist. Alverine, in combination with simethicone, has been demonstrated to effectively reduce abdominal pain and discomfort in a large placebo-controlled trial. Mebeverine is a musculotropic agent that potently blocks intestinal peristalsis. Non-placebo-controlled trials have shown positive effects of mebeverine in IBS regarding symptom control; nevertheless, in recent placebo-controlled studies, mebeverine did not exhibit superiority over placebo. Otilonium bromide is poorly absorbed from the GI tract, where it acts locally as an L-type calcium channel blocker, an antimuscarinic and a tachykinin NK2 receptor antagonist. Otilonium has effectively reduced pain and improved defecation alterations in placebo-controlled trials in IBS patients. Pinaverium bromide is also an L-type calcium channel blocker that acts locally in the GI tract. Pinaverium improves motility disorders and consequently reduces stool problems in IBS patients. Phloroglucinol and trimethylphloroglucinol are non-specific antispasmodics that reduced pain in IBS patients in a placebo-controlled trial. Antispasmodics have excellent safety profiles. T-type calcium channel blockers can abolish visceral hypersensitivity in animal models, which makes them potential candidates for the development of novel therapeutic agents

关键词： Irritable bowel syndrome Motility Treatment Calcium channel blockers Spasmolytics

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数字切割机设计,美学和技术的完美融合

工业设计 2024年第5期 19-19页

作者： Design Engineering Zürich.GmbH,Zurich.Switzerland Design Engineering Zürich.GmbH

来源:https://***/zh/project/zuend-q-32-32-d-63812这款数字切割机由碳纤维增强塑料制成,不仅重量轻,而且非常坚固,实现了美学和技术的完美结合。精确的几何布局让切割机保持了优雅的外观,外壳侧面在视觉上构成了机器的外观框架,而全... 详细信息

来源:https://***/zh/project/zuend-q-32-32-d-63812这款数字切割机由碳纤维增强塑料制成,不仅重量轻,而且非常坚固,实现了美学和技术的完美结合。精确的几何布局让切割机保持了优雅的外观,外壳侧面在视觉上构成了机器的外观框架,而全自动换刀器则突出了其动态外观。操作元件和触摸屏的布置不仅符合人体工学,而且在视觉上也很吸引人。

关键词：人体工学碳纤维增强塑料切割机自动换刀触摸屏几何布局美学完美融合

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Dynamics of the coronavirus disease 2019(COVID-19)epidemic in Wuhan City,Hubei Province and China:a second derivative analysis of the cumulative daily diagnosed cases during the first 85 days

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Global Health Journal 2021年第1期5卷 4-11页

作者： Bin Yu Xinguang Chen Shannan rich.Qiqing Mo Hong Yan Department of Epidemiology University of FloridaGainesvilleFL 32610USA Deparment of Surgery School of MedicineDuke UniversityDurhamNC 27710USA Department of Social Medicine and Health Promotion School of Public HealthGuangxi Medical UniversityNanningGuangxi 530021China Department of Preventive Medicine School of Health SciencesWuhan UniversityWuhanHubei 430072China

Background:Controlling the coronavirus disease 2019(COVID-19)epidemic requires information beyond new and cumulative *** study aims to conduct an in-depth analysis by geographic strata:Wuhan City(hereafter referred to as Wuhan)only,Hubei Province(hereafter referred to as Hubei)excluding Wuhan,and China excluding ***:Daily cumulative confirmed COVID-19 cases between December 8,2019(the date of symptom onset based on patients'recall during the investigation),and March 1,2020,from official sources and published studies were *** second derivative model was used for information *** analysis was conducted separately for the three ***:A total of 80026 diagnosed COVID-19 cases were reported during the first 85 days of the epidemic,with 49315 cases from Wuhan,17788 from Hubei excluding Wuhan,and 12923 from China excluding *** results indicate that the COVID-19 epidemic consists of an Acceleration,a Deceleration,and a Stabilization Phase in all three geographic strata,plus a Silent Attack Phase for Wuhan *** the reported incubation period of 14 days,effects of the massive anti-epidemic actions were revealed by both the Acceleration and Deceleration *** Acceleration Phase signaled the effect of the intervention to detect the infected;the Deceleration Phase signaled the declines in new infections after the infected were detected,treated and ***:Findings of the study provide new evidence to better monitor the epidemic,evaluate its response to intervention,and predict the trend *** addition to re-evaluating the control of the COVID-19 epidemic in China,this study provided a model for monitoring outbreaks of COVID-19 in different countries across the world.

关键词： Coronavirus disease 2019(COVID-19) First derivative Second derivative China Hubei Province Wuhan City

Heart failure in the elderly:a ***

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Journal of Geriatric Cardiology 2006年第4期3卷 246-247页

作者： Michael W.rich Washington University School of Medicine St.Louis MO 63110USA

　　Heart failure (HF) affects 5 million Americans, of whom three-fourths are over age 65 and half are over age 75.1 HF is currently the leading cause of hospitalization among older adults in the U.S., and it is the m... 详细信息

关键词： HF Heart failure in the elderly

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“假磨楔式”：一个概念的发展历史(英文)

古脊椎动物学报 2010年第4期48卷 336-347页

作者： Thomas H．rich.PatriciaVICKERS-rich 澳大利亚维多利亚博物馆墨尔本3001 澳大利亚莫纳什大学地球科学学院克莱顿3128

大多数情况下古生物学是事后解释的科学,也就是说,在大多数情况下它的中心任务是解释存在的资料。古生物学成为预测科学的一个罕见的实例见诸于"假磨楔式"这个概念的发展历史中。根据一个假磨楔式哺乳动物的单个齿骨上的下臼齿结构,推... 详细信息

大多数情况下古生物学是事后解释的科学,也就是说,在大多数情况下它的中心任务是解释存在的资料。古生物学成为预测科学的一个罕见的实例见诸于"假磨楔式"这个概念的发展历史中。根据一个假磨楔式哺乳动物的单个齿骨上的下臼齿结构,推测出当时尚不知道的上臼齿结构。随后,被认为很可能属于假磨楔式哺乳动物的单个上臼齿以及更晚的一件具有咬合在一起的上下臼齿的标本的发现证实了最初的假设。磨楔式臼齿结构作为哺乳动物历史中一个关键的创新结构,本身相当复杂。假磨楔式概念的被接受在认识磨楔式臼齿结构方面具有重要意义,这个结构可能发生不止一次。"假磨楔式"这个术语最初提出之后,随着它的使用,一些后来的研究者的用法严重偏离了它的本义。这一术语既被用来描述并不以原始定义的假磨楔式方式咬合的柱齿兽类牙齿,也被用于描述明显属于原始定义的磨楔式而不是假磨楔式牙齿。结果是古生物学界对其定义的理解变得更不准确,这个概念的实用性因此大大削弱。所以,回归最初的定义是合适的。

关键词：中生代哺乳动物进化平行演化磨楔式

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