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Irreversible electroporation for the management of pancreatic cancer: Current data and future directions

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World Journal of Gastroenterology 2023年第2期29卷 223-231页

作者： Stavros Spiliopoulos Lazaros Reppas Dimitrios Filippiadis Antonella Delvecchio Maria Conticchio Riccar do Memeo riccardo Inchingolo Second Department of Radiology School of MedicineNational and Kapodistrian University of AthensAthens 12461AttikiGreece Unit of Hepato-Pancreatic-Biliary Surgery “F.Miulli”Regional General HospitalAcquaviva delle Fonti 70021BariItaly Interventional Radiology Unit “F.Miulli”Regional General HospitalAcquaviva delle Fonti 70021Italy

Pancreatic cancer is currently the seventh leading cause of cancer death(4.5%of all cancer deaths)while 80%-90%of the patients suffer from unresectable disease at the time of *** remains poor,with a mean survival up to 15 mo following systemic ***-regional thermal ablative techniques are rarely implemented due to the increased risk of thermal injury to the adjacent structures,which can lead to severe adverse *** electroporation,a promising novel non-thermal ablative modality,has been recently introduced in clinical practice for the management of inoperable pancreatic cancer as a safer and more effective loco-regional treatment *** and initial clinical data are *** review will focus on the basic principles of IRE technology,currently available data,and future directions.

关键词： Pancreatic cancer Interventional oncology Irreversible electroporation Ablation Loco-regional treatment Image-guided treatment

Awake robotic liver surgery:A case report

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2954-2961页

作者： Antonella Delvecchio Gaetano Pavone Maria Conticchio Claudia Piacente Miriam Varvara Valentina Ferraro Matteo Stasi Annachiara Casella Rosalinda Filippo Michele Tedeschi Carmine Pullano riccardo Inchingolo Vito Delmonte riccardo Memeo Unit of Hepato-Pancreatic-Biliary Surgery “F.Miulli”Regional General HospitalBari 70021Italy Unit of Anesthesia and Perioperative Medicine “F.Miulli”Regional General HospitalBari 70021Italy Villa Pia Hospital Rome 00151Italy Unit of Interventional Radiology “F.Miulli”Regional General HospitalBari 70021Italy

BACKGROUND In recent years,minimally invasive liver resection has become a standard of care for liver *** the need to treat increasingly fragile patients,general anesthesia is sometimes avoided due to respiratory ***,surgical treatment with curative intent is abandoned in favor of a less invasive and less radical *** anesthesia has been shown to reduce respiratory complications,especially in elderly patients with pre-existing lung *** SUMMARY A 77-year-old man with hepatitis-C-virus-related chronic liver disease underwent robotic liver resection for hepatocellular *** patient was suffering from hypertension,diabetes and chronic obstructive pulmonary *** National Surgical Quality Improvement Program score for developing pneumonia was 9.2%.We planned a combined spinal–epidural anesthesia with conscious sedation to avoid general *** modification of the standard surgical technique was *** were stable and bleeding was *** postoperative course was *** Robotic surgery in locoregional anesthesia with conscious sedation could be considered a safe and suitable approach in specialized centers and in selected patients.

关键词： Robotic surgery Awake surgery Liver resection Frail patient Locoregional anesthesia Conscious sedation Case report

Navigated liver surgery:State of the art and future perspectives

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Hepatobiliary & Pancreatic Diseases International 2022年第3期21卷 226-233页

作者： Paschalis Gavriilidis Bjørn Edwin Egidijus Pelanis Ernest Hidalgo Nicola de’Angelis riccardo Memeo Luca Aldrighetti Robert P Sutcliffe Department of Hepato-Pancreato-Biliary and Liver Transplant Surgery Queen Elizabeth University Hospitals Birmingham NHS Foundation TrustB152THUK The Intervention Centre and Department of HPB Surgery Oslo University Hospital and Faculty of MedicineUniversity of OsloOsloNorway Department of Hepato-Pancreatico-Biliary Surgery and Transplantation Hospital Universitari Vall d’HebronBarcelonaSpain Department of Digestive Surgery University Hospital Henri Mondor(AP-HP)94010 Creteil and University of Paris EstCreteilFrance Department of Hepatobiliary and Pancreatic Surgery Miulli HospitalAcquaviva delle FontiBari 70021Italy Division of Hepatobiliary Surgery San Raffaele HospitalVia Olgettina 60Milan 20132Italy

Background:In recent years,the development of digital imaging technology has had a significant influence in liver *** ability to obtain a 3-dimensional(3D)visualization of the liver anatomy has provided surgery with virtual reality of simulation 3D computer models,3D printing models and more recently holograms and augmented reality(when virtual reality knowledge is superimposed onto reality).In addition,the utilization of real-time fluorescent imaging techniques based on indocyanine green(ICG)uptake allows clinicians to precisely delineate the liver anatomy and/or tumors within the parenchyma,applying the knowledge obtained preoperatively through digital *** combination of both has transformed the abstract thinking until now based on 2D imaging into a 3D preoperative conception(virtual reality),enhanced with real-time visualization of the fluorescent liver structures,effectively facilitating intraoperative navigated liver surgery(augmented reality).Data sources:A literature search was performed from inception until January 2021 in MEDLINE(Pub Med),Embase,Cochrane library and database for systematic reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)***:Fifty-one pertinent articles were retrieved and *** different types of digital imaging technologies and the real-time navigated liver surgery were estimated and ***:ICG fluorescent imaging techniques can contribute essentially to the real-time definition of liver segments;as a result,precise hepatic resection can be guided by the presence of ***,3D models can help essentially to further advancing of precision in hepatic surgery by permitting estimation of liver volume and functional liver remnant,delineation of resection lines along the liver segments and evaluation of tumor *** liver transplantation and especially in living donor liver transplantation(LDLT),3D printed models of the donor’s live

关键词： Navigated Hepatic surgery 3D Computer assistance Image guidance Image guided surgery Indocyanine green 3D print Visual simulation Virtual reality Augmented reality Real-time navigated liver surgery

Intelligent design:stablecoins(in)stability and collateral during market turbulence

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Financial Innovation 2023年第1期9卷 2454-2476页

作者： riccardo De Blasis Luca Galati Alexander Webb Robert I.Webb Department of Management Marche Polytechnic UniversityVia Lodovico Menicucci 660121 AnconaANItaly School of Business University of WollongongNorthfields Ave2522 WollongongNSWAustralia Derivatives Markets Research Centre Rozetta Institute55 Harrington St2000 SydneyNSWAustralia Department of Economics University of MoliseVia Francesco De Sanctis86100 CampobassoCBItaly McIntire School of Commerce University of Virginia140 Hospital Drive22903 CharlottesvilleVAUSA

How does stablecoin design affect market behavior during turbulent periods?Stable-coins attempt to maintain a“stable”peg to the US dollar,but do so with widely varying structural *** spectacular collapse of the TerraUSD(UST)stablecoin and the linked Terra(LUNA)token in May 2022 precipitated a series of reactions across major stablecoins,with some experiencing a fall in value and others gaining *** a Baba,Engle,Kraft and Kroner(1990)(BEKK)model,we examine the reaction to this exogenous shock and find significant contagion effects from the UST collapse,likely partially due to herding behavior among *** test the varying reactions among stablecoins and find that stablecoin design differences affect the direction,magnitude,and duration of the response to *** discuss the implications for stablecoin developers,exchanges,traders,and regulators.

关键词： Stablecoins Herding Information cascades Volatility spillovers Market crashes Financial contagion

Investigation of typical residential block typologies and their impact on pedestrianlevel microclimate in summers in Nanjing, China

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Frontiers of Architectural Research 2022年第2期11卷 278-296页

作者： Mingjie Zhang Wei You Qin Qin Dandan Peng Youpei Hu Zhi Gao riccardo Buccolieri School of Architecture and Urban Planning Nanjing UniversityNanjing 210093China Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali Laboratory of MicrometeorologyUniversity of Salento73100LecceItaly

The morphology of urban residential blocks in China,which is strictly affected by regulations,can potentially improve or deteriorate *** paper first proposes a framework for identifying typical residential block typologies using Nanjing as an example.A thorough investigation,consisting of 114 samples,was conducted,and 18 typical residential block typologies were ***,3D non-isothermal numerical simulations were performed on the hottest days of summer using the *** effect of morphological indices on the microclimate at the pedestrian level was explored using statistical methods and a novel graphic method named *** results revealed a strong correlation between the urban heat island intensity(UHII),mean radiation temperature,and universal thermal climate index(UTCI)and floor area ratio(FAR),as well as between wind velocity(U)and building coverage ratio(BCR).A significant increase in FAR(by approximately 1.0)can result in a low UTCI that was driven by MRT and shading ***-floor blocks,with FAR between 1.8 and 2.1,had a better overall thermal environment(except for lower U)than that of 11-floor *** considering a similar BCR,blocks with slab-type buildings tended to have a U that was higher by approximately 30%.

关键词： Chinese residential blocks Morphological indices Urban heat island Outdoor thermal comfort Microclimate simulation ENVI-met

CFD Study of Ejector Flow Behavior in a Blast Furnace Gas Galvanizing Plant

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Journal of Thermal Science 2015年第1期24卷 58-66页

作者： Giorgio Besagni riccardo Mereu Fabio Inzoli Politecnico di Milano Department of EnergyVia Lambruschini 4 Milan 20156 Italy

In recent years, there has been a growing interest toward Blast Furnace Gas(BFG) as a low-grade energy source for industrial furnaces. This paper considers the revamping of a galvanic plant furnace converted to BFG from natural gas. In the design of the new system, the ejector on the exhaust line is a critical component. This paper studies the flow behavior of the ejector using a Computational Fluid Dynamics(CFD) analysis. The CFD model is based on a 3D representation of the ejector, using air and exhaust gases as working fluids. This paper is divided in three parts. In the first part, the galvanic plant used as case study is presented and discussed, in the second part the CFD approach is outlined, and in the third part the CFD approach is validated using experimental data and the numerical results are presented and discussed. Different Reynolds-Averaged Navier–Stokes(RANS) turbulence models(k-ω SST and k-ε Realizable) are evaluated in terms of convergence capability and accuracy in predicting the pressure drop along the ejector. Suggestions for future optimization of the system are also provided.

关键词： CFD模型高炉煤气流动行为计算流体力学方法锌厂热镀弹射天然气转化

Effect of acoustic field on C02 desorption in a fluidized bed of fine activated carbon

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Particuology 2015年第6期13卷 8-15页

作者： Federica Raganati Paola Ammendola riccardo Chirone Department of Chemical Engineering Materials and Industrial Production University of Naples Federico II P. le V. Tecchio 80 80125 Napoli Italy Istituto di Ricerche sulla Combustione CNR P. le K Tecchio 80 80125 Napoli Italy

Adsorption using solid sorbents has the potential to complement or replace current absorption technol- ogy, because of its low energy requirements. Among the commercially available adsorbent materials, attention is focused on activated carbons because they are easily regenerable by reason of their low heat of adsorption. These sorbents are generally available in the form of fine powders. Sound-assisted fluidization can process large amounts of fine powders, promoting and enhancing CO2 capture on fine sorbents, because it maximizes gas-solid contact. Temperature swing adsorption （TSA）, consisting of inducing sor- bent regeneration and CO2 recovery by appropriate temperature increase and gas purge, is one of the most promising techniques. This study investigates the CO2 desorption process by TSA in a sound-assisted flu- idized bed of fine activated carbon. Desorption tests were performed under ordinary and sound-assisted fluidization conditions to assess the capability of sound to promote and enhance the desorption efficiency in terms of CO2 recovery, CO2 purity, and desorption time. The results show that the application of sound results in higher desorption rates, CO2 recovery and purity. Regular and stable desorption profiles can be obtained under sound-assisted fluidization conditions. This stability makes it possible to successfully realize a cyclic adsorption/desorption process.

关键词： Temperature swing adsorption Sound-assisted fluidization CO2 capture Activated carbons Fine powders

Scaling Notebooks as Re-configurable Cloud Workflows

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Data Intelligence 2022年第2期4卷 409-425页

作者： Yuandou Wang Spiros Koulouzis riccardo Bianchi Na Li Yifang Shi Joris Timmermans W.Daniel Kissling Zhiming Zhao Multiscale Networked Systems Informatics InstituteUniversity of Amsterdam1098XH AmsterdamThe Netherlands Life Watch ERIC Virtual Lab&InnovationCenter(VLIC)Science Park 9041098XH AmsterdamThe Netherlands Institute for Biodiversity and Ecosystem Dynamics(IBED) 1098xH AmsterdamThe Netherlands

Literate computing environments,such as the Jupyter(i.e.,Jupyter Notebooks,JupyterLab,and JupyterHub),have been widely used in scientific studies;they allow users to interactively develop scientific code,test algorithms,and describe the scientific narratives of the experiments in an integrated *** scale up scientific analyses,many implemented Jupyter environment architectures encapsulate the whole Jupyter notebooks as reproducible units and autoscale them on dedicated remote infrastructures(e.g.,highperformance computing and cloud computing environments).The existing solutions are stl limited in many ways,e.g.,1)the workflow(or pipeline)is implicit in a notebook,and some steps can be generically used by different code and executed in parallel,but because of the tight cell structure,all steps in the Jupyter notebook have to be executed sequentially and lack of the flexibility of reusing the core code fragments,and 2)there are performance bottlenecks that need to improve the parallelism and scalability when handling extensive input data and complex *** this work,we focus on how to manage the workflow in a notebook *** 1)encapsulate the reusable cells as RESTful services and containerize them as portal components,2)provide a composition tool for describing workflow logic of those reusable components,and 3)automate the execution on remote cloud ***,we validate the solution's usability via a use case from the Ecology and Earth Science domain,illustrating the processing of massive Light Detection and Ranging(LiDAR)*** demonstration and analysis show that our method is feasible,but that it needs further improvement,especially on integrating distributed workflow scheduling,automatic deployment,and execution to develop as a mature approach.

关键词： Scientific experiments Jupyter Notebooks Workflow management Ecosystem structure data products Cloud Scalability

Defective autophagy and Alzheimer’s disease: is calcium the key?

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Neural Regeneration Research 2019年第12期14卷 2081-2082页

作者： riccardo Filadi Paola Pizzo Department of Biomedical Sciences University of Padua and Neuroscience Institute-Italian National Research Council (CNR)

Presenilins and autophagy: Presenilin 1 (PS1) and presenilin 2 (PS2) are homologous, multi-pass transmembrane proteins endowed with pleiotropic functions, ranging from the regulation of membrane trafficking to cell differentiation. Their catalytic activity within the γ-secretase complex, an aspartyl-protease responsible for the intramembrane cleavage of several different type I transmembrane proteins, has been intensively studied in the context of Alzheimer’s disease (AD). Indeed, tens of autosomal dominant mutations in the PSEN1 and PSEN2 genes (encoding PS1 and PS2, respectively) have been associated with the rare familial forms of AD (FAD).

关键词： Alzheimer is cell tens has PS1 PS2