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Randomized Trial Comparing Cyclophosphamide, Methotrexate, and 5-Fluorouracil (CMF) Regimen with Rotational CMFEV Regimen (E=Epirubicin, V=Vincristine) as Adjuvant Chemotherapy in Moderate Risk Operable Breast Carcinoma

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Journal of Cancer Therapy 2011年第3期2卷 342-353页

作者： Giorgio Cocconi Corrado Boni Maurizio Tonato Rodolfo Passalacqua Mariantonietta Colozza Anna M. Mosconi Giancarlo Bisagni Ermanno Rondini Lina Rodinò Amalia Carpi Francesco Di Costanzo Mauro Brugia Giuseppe Attardo Luigi Acito riccardo rossetti Maria Bella Roberta Camisa Francesco Cardinale Beatrice Dozin 不详

Objectives: The CMFEV (cyclophosphamide, methotrexate, 5-fluorouracil, epirubicin, vincristine) regimen is an innovative schedule, designed by our Group, aimed at administering five partially or totally no cross-resistant cytotoxic agents in breast carcinoma. It was randomly compared to CMF (cyclophosphamide, methotrexate, 5-fluorouracil) as primary treatment in operable disease and demonstrated a short-term significant increase in clinical complete response rate and a long-term significant locoregional relapse-free survival in premenopausal patients. So, it seemed worth comparing this regimen with CMF as adjuvant chemotherapy in moderate risk operable breast carcinoma. Methods: Four hundred and eighty-nine patients with stage I or II moderate risk breast carcinoma were randomized to receive CMF or CMFEV regimen for 6 cycles after surgery. Main end points were overall survival (OS), invasive disease-free survival (IDFS) and recurrence-free interval (RFI), as estimated by Kaplan-Meier analyses and log-rank tests. Results: At a median observation time of 7.3 years (range 5.4 months-10.3 years), no significant differences in OS and IDFS were observed between the two arms. Deaths from breast carcinoma were more frequent with CMF (58.5%) than with CMFEV regimen (41.7%) as well as recurrences from breast carcinoma (58.8% with CMF and 41.2% with CMFEV). These differences were not statistically significant. Conclusion: CMFEV appears more effective than CMF in preventing recurrences from primary disease in patients with moderate risk stage I-II breast carcinoma. The lack of statistical significance of the observed differences was probably due to the limited number of patients enrolled which rendered the study underpowdered.

关键词： Breast Carcinoma Adjuvant Chemotherapy CMF Regimen Epirubicin Vincristine Second Malignancy

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The occlusal plane in the facial context:inter-operator repeatability of a new three-dimensional method

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International Journal of Oral Science 2012年第1期4卷 34-37页

作者： riccardo Rosati Alberto rossetti Marcio De Menezes Virgilio F Ferrario Chiarella Sforza Department of Human Morphology Universita` degli Studi di MilanoMilano 20133Italy

The repeatability of a non-invasive digital protocol proposed to evaluate the three-dimensional（3D） position of the occlusal plane in the face is assessed.Dental virtual models and soft tissue facial morphology of 20 adult subjects were digitally integrated using a 3D stereophotogrammetric imaging system.The digital 3D coordinates of facial and dental landmarks were obtained by two different operators.Camper＇s（facial） and occlusal（dental） planes were individuated,and their 3D relationships were measured.The repeatability of the protocol was investigated and showed no significant differences in repeated digitizations.The angle between occlusal and Camper＇s planes was smaller than 26 in the frontal and horizontal projections.In the sagittal projection,the angle was observed to be,on average,4.9 6.The determined occlusal plane pitch,roll and yaw values show good agreement with previously published data obtained by different protocols.The current non-invasive method was repeatable,without inter-operator differences and can facilitate assessment of healthy subjects.

关键词： healthy subjects occlusal plane stereophotogrammetry three-dimensional analysis

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Is Burn-Out the Main Issue？ Impact of Aggressiveness and Depression in Burn-Out Among Operators in Oncology

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Psychology Research 2017年第9期7卷 509-514页

作者： Romeo Marco Anna Vespa Maria Velia Giulietti riccardo Giampieri Tania Meletani Ilaria Fiordoliva Mafia Giuditta Baleani Sofia Formentini Rossana Berardi Universita Politecnica delle Marche Ancona Italy Fondazione rossetti Fedecostante Ancona Italy INRCA-IRCCS-National Institute of Science and Health for Aging Ancona Italy Universita Politecnica delle Marche Ancona Italy

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