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Selective internal radiation therapy segmentectomy:A new minimally invasive curative option for primary liver malignancies?

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World Journal of Gastroenterology 2024年第18期30卷 2379-2386页

作者： riccardo Inchingolo Francesco Cortese Antonio Rosario Pisani Fabrizio Acquafredda Roberto Calbi riccardo Memeo Fotis Anagnostopoulos Stavros Spiliopoulos Unit of Interventional Radiology “F.Miulli”Regional General HospitalBari 70021Italy Interdisciplinary Department of Medicine Section of Nuclear MedicineUniversity of Bari“Aldo Moro”Bari 70121Italy Department of Radiology General Regional Hospital“F.Miulli”Acquaviva delle Fonti 70021Italy Unit of Hepato-Pancreatic-Biliary Surgery “F.Miulli”Regional General HospitalBari 70021Italy The Second Radiology Department National and Kapodistrian University of AthensChaidari Athens 12461Greece

Transarterial radioembolization or selective internal radiation therapy(SIRT)has emerged as a minimally invasive approach for the treatment of tumors.This percutaneous technique involves the local,intra-arterial delivery of radioactive microspheres directly into the tumor.Historically employed as a palliative measure for liver malignancies,SIRT has gained traction over the past decade as a potential curative option,mirroring the increasing role of radiation segmentectomy.The latest update of the BCLC hepatocellular carcinoma guidelines recognizes SIRT as an effective treatment modality comparable to other local ablative methods,particularly well-suited for patients where surgical resection or ablation is not feasible.Radiation segmentectomy is a more selective approach,aiming to deliver high-dose radiation to one to three specific hepatic segments,while minimizing damage to surrounding healthy tissue.Future research efforts in radiation segmentectomy should prioritize optimizing radiation dosimetry and refining the technique for super-selective administration of radiospheres within the designated hepatic segments.

关键词： Transarterial radioembolization Selective internal radiation therapy Radiation segmentectomy Hepatocellular carcinoma Primary liver malignancies Personalised dosimetry

A Methodology for Vulnerability Assessment of Cultural Heritage in Extreme Climate Changes

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International Journal of Disaster Risk Science 2024年第3期15卷 404-420页

作者： riccardo Cacciotti Alessandro Sardella Milo? Drdácky Alessandra Bonazza Institute of Theoretical and Applied Mechanics Czech Academy of Sciences Institute of Atmospheric Sciences and Climate National Research Council of Italy Department of Environmental and Prevention Sciences University of Ferrara Istituto Superiore per la Protezione e la Ricerca Ambientale

Vulnerability evaluation plays a key role in risk assessment and reduction and is essential for defining strategies for climate change adaptation and mitigation. In dealing with the safeguarding of cultural heritage at risk, we are still far from adopting and applying an agreed methodology for vulnerability assessment. With the aim to support practitioners, heritage managers,and policy and decision makers to undertake actions that address the protection of cultural heritage at risk, the methodology set up in the framework of the Interreg Central Europe STRENCH is illustrated and discussed here. Based on three major requirements(susceptibility, exposure, and resilience) and a continuous consultation with local stakeholders, the proposed methodology is applicable for evaluating the vulnerability of built heritage and cultural landscape exposed to hydrometeorological hazards, such as heavy rains, floods, and droughts. The results obtained through its validation on 15 case studies from seven Central European regions are shown to underline the strengths and limitations of the methodological approach.Iterative consultation with local stakeholders was fundamental for the definition of the criteria/subcriteria and related values for the assessment of the requirements. Application to further sites in other contexts would surely contribute to strengthening the reliability of the methodological approach.

关键词： Built and natural heritage Exposure Heritage vulnerability Resilience Risk management Susceptibility

Deer antler stem cell niche: An interesting perspective

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World Journal of Stem Cells 2024年第5期16卷 479-485页

作者： Claudia Cavallini Elena Olivi riccardo Tassinari Chiara Zannini Gregorio Ragazzini Martina Marcuzzi Valentina Taglioli Carlo Ventura National Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems-Eldor LabBologna 40128Italy Eldor Lab Bologna 40128Italy Department of Medical and Surgical Sciences(DIMEC) University of BolognaBologna 40138Italy

In recent years,there has been considerable exploration into methods aimed at enhancing the regenerative capacity of transplanted and/or tissue-resident cells.Biomaterials,in particular,have garnered significant interest for their potential to serve as natural scaffolds for cells.In this editorial,we provide commentary on the study by Wang et al,in a recently published issue of World J Stem Cells,which investigates the use of a decellularized xenogeneic extracellular matrix(ECM)derived from antler stem cells for repairing osteochondral defects in rat knee joints.Our focus lies specifically on the crucial role of biological scaffolds as a strategy for augmenting stem cell potential and regenerative capabilities,thanks to the establishment of a favorable microenvironment(niche).Stem cell differen-tiation heavily depends on exposure to intrinsic properties of the ECM,including its chemical and protein composition,as well as the mechanical forces it can generate.Collectively,these physicochemical cues contribute to a bio-instructive signaling environment that offers tissue-specific guidance for achieving effective repair and regeneration.The interest in mechanobiology,often conceptualized as a form of“structural memory”,is steadily gaining more validation and momen-tum,especially in light of findings such as these.

关键词： Extracellular matrix Antler stem cells Stem cell niche Regenerative medicine Decellularized scaffolds Cell memory

The use of green infrastructure and irrigation in the mitigation of urban heat in a desert city

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Building Simulation 2024年第5期17卷 679-694页

作者： Kai Gao Shamila Haddad riccardo Paolini Jie Feng Muzahim Altheeb Abdulrahman Al Mogirah Abdullatif Bin Moammar Mattheos Santamouris School of Built Environment Faculty of ArtsDesign and ArchitectureUniversity of New South WalesSydneyNSW 2052Australia Royal Commission of Riyadh City RiyadhSaudi Arabia Institute of Future Cities Chinese University of Hong KongHong KongChina Department of Building Environment and Energy Engineering The Hong Kong Polytechnic UniversityHong KongChina

Severe urban heat,a prevalent climate change consequence,endangers city residents globally.Vegetation-based mitigation strategies are commonly employed to address this issue.However,the Middle East and North Africa are under investigated in terms of heat mitigation,despite being one of the regions most vulnerable to climate change.This study assesses the feasibility and climatic implications of wide-scale implementation of green infrastructure(GI)for heat mitigation in Riyadh,Saudi Arabia—a representative desert city characterized by low vegetation coverage,severe summer heat,and drought.Weather research forecasting model(WRF)is used to simulate GI cooling measures in Riyadh’s summer condition,including measures of increasing vegetation coverage up to 60%,considering irrigation and vegetation types(tall/short).In Riyadh,without irrigation,increasing GI fails to cool the city and can even lead to warming(0.1 to 0.3℃).Despite irrigation,Riyadh’s overall GI cooling effect is 50% lower than GI cooling expectations based on literature meta-analyses,in terms of average peak hour temperature reduction.The study highlights that increased irrigation substantially raises the rate of direct soil evaporation,reducing the proportion of irrigation water used for transpiration and thus diminishing efficiency.Concurrently,water resource management must be tailored to these specific considerations.

关键词： green infrastructure evapotranspiration cooling desert city irrigation urban overheating

Transurethral prostate surgery in prostate cancer patients: A population-based comparative analysis of complication and mortality rates

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Asian Journal of Urology 2024年第1期11卷 48-54页

作者： Michele Marchioni Giulia Primiceri Alessandro Veccia Marta Di Nicola Umberto Carbonara Fabio Crocerossa Ugo Falagario Ambra Rizzoli riccardo Autorino Luigi Schips Laboratory of Biostatistics Department of MedicalOral and Biotechnological Sciences“G.d'Annunzio”University of ChietiChietiItaly Urology Unit Department of MedicalOral and Biotechnological Sciences“G.d'Annunzio”University of ChietiChietiItaly Division of Urology VCU HealthRichmondVAUSA

Objective:Prostate cancer(PCa)patients might experience lower urinary tract symptoms as those diagnosed with benign prostatic hyperplasia(BPH).Some of them might be treated for their lower urinary tract symptoms instead of PCa.We aimed to test the effect of PCa versus BPH on surgical outcomes after transurethral prostate surgery,namely complication and mortality rates.Methods:Within the American College of Surgeons National Surgical Quality Improvement Program database(2011-2016),we identified patients who underwent transurethral resection of the prostate,photoselective vaporization,or laser enucleation.Patients were stratified according to postoperative diagnosis(PCa vs.BPH).Univariable and multivariable logistic regression models evaluated the predictors of perioperative morbidity and mortality.A formal test of interaction between diagnosis and surgical technique used was performed.Results:Overall,34542 patients were included.Of all,2008(5.8%)had a diagnosis of PCa.The multivariable logistic regression model failed to show statistically significant higher rates of postoperative complications in PCa patients(odds ratio:0.9,95%confidence interval:0.7-1.1;p=0.252).Moreover,similar rates of perioperative mortality(p=0.255),major acute cardiovascular events(p=0.581),transfusions(p=0.933),and length of stay of more than or equal to 30 days(p=0.174)were found.Additionally,all tests failed to show an interaction between post-operative diagnosis and surgical technique used.Conclusion:Patients diagnosed with PCa do not experience higher perioperative morbidity or mortality after transurethral prostate surgery when compared to their BPH counterparts.Moreover,the diagnosis seems to not influence surgical technique outcomes.

关键词： Prostatecancer Transurethral surgery of the prostate Prostate surgery Population-based analysis Benign prostatic hyperplasia Lasersurgery

Modeling of recrystallization behaviour of AA6XXX aluminum alloy profile during extrusion process

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Transactions of Nonferrous Metals Society of China 2024年

作者： Marco Negozio Antonio Segatori riccardo Pelaccia Barbara Reggiani Sara Di Donato Lorenzo Donati DIN Department of Industrial Engineering – University of Bologna University of Parma-Department of Engineering and Architecture Parco Area delle Scienze Hydro Innovation and Technology InterMech-MO.RE – University of Modena and Reggio Emilia DISMI Department of Sciences and Methods for Engineering University of Modena and Reggio Emilia

An innovative approach was introduced for the development of a AA6063 recrystallization model. This method incorporated a regression-based technique for the determination of material constants and introduced novel equations for assessing the grain size evolution. Calibration and validation of this methodology involved a combination of experimentally acquired microstructural data from the extrusion of three different AA6063 profiles and results from the simulation using the Qform Extrusion UK finite element code. The outcomes proved the agreement between experimental findings and numerical prediction of the microstructural evolution. The trend of the grain size variation based on different process parameters has been accurately simulated， both after dynamic and static recrystallization， with an error rate of less than 25% in almost the whole sampling computations.

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难民危机下的儿童安全游乐空间

景观设计学（中英文） 2020年第2期8卷 144-149页

作者：里卡尔多·卢卡·康迪 Catalytic Action非盈利设计工作室

本文回顾了CatalyticAction设计工作室为寄居于黎巴嫩的叙利亚难民儿童建造"微笑游乐场"这一特殊空间的整个过程,旨在探索如何通过建筑应对脆弱社区所面临的挑战,并改善现有的人道主义实践。文章首先介绍了叙利亚难民危机,以及这一背景... 详细信息

本文回顾了CatalyticAction设计工作室为寄居于黎巴嫩的叙利亚难民儿童建造"微笑游乐场"这一特殊空间的整个过程,旨在探索如何通过建筑应对脆弱社区所面临的挑战,并改善现有的人道主义实践。文章首先介绍了叙利亚难民危机,以及这一背景与微笑游乐场设计理念的关联,随后探讨了游乐场建造过程中的社区参与模式,以及项目期待传达的设计价值观,包括使用本地材料和本地劳动力以振兴当地经济。最后,文章介绍了近年来CatalyticAction设计工作室针对难民儿童的其他项目。通过5年多的社区合作与在地实践,设计团队证明了游乐空间对于提升弱势群体福祉的重要作用,在制定应急响应方案时应对此予以更多重视。

关键词：儿童难民游乐场设计叙利亚黎巴嫩

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Absolute Wall Thickness Measurement of Conducting Plates Using Pulsed Eddy Currents

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Journal of Electromagnetic Analysis and Applications 2024年第3期16卷 25-41页

作者： Victor-O. de Haan riccardo Scottini BonPhysics Research and Investigations BV Puttershoek Netherlands

The method using pulsed eddy currents to determine the thickness of a conduction plate is extended to enable the simultaneous measurement of the plate thickness and material properties. For optimal performance, a probe must be designed depending on the thickness range that should be accessible. The need for a calibration of the material properties of a conducting plate to enable the measurement of its thickness has been removed. All that is needed is a probe with known dimensions and suitable hardware to create a current pulse and measure a transient magnetic induction.

关键词： Pulsed Eddy Currents Wall Thickness Absolute and Relative Measurements

Laser-optimized Pt-Y alloy nanoparticles embedded in Pt-Y oxide matrix for high stability and ORR electrocatalytic activity

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Journal of Energy Chemistry 2024年第5期92卷 508-520页

作者： riccardo Brandiele Andrea Guadagnini Mattia Parnigotto Federico Pini Vito Coviello Denis Badocco Paolo Pastore Gian Andrea Rizzi Andrea Vittadini Daniel Forrer Vincenzo Amendola Christian Durante Department of Chemical Sciences University of PaduaVia Marzolo 135131 PadovaItaly Istituto di Chimica della Materia Condensata e di Tecnologie per l’Energia ICMATE-CNR via Marzolo 1 I-35131 PadovaItaly

The development of active yet stable catalysts for oxygen reduction reaction(ORR)is still a major issue for the extensive permeation of fuel cells into everyday technology.While nanostructured Pt catalysts are to date the best available systems in terms of activity,the same is not true for stability,particularly under operating conditions.In this work,Pt_(Х)Y alloy nanoparticles are proposed as active and durable electrocatalysts for ORR.Pt_(Х)Y nanoalloys are synthesized and further optimized by laser ablation in liquid followed by laser fragmentation in liquid.The novel integrated laser-assisted methodology succeeded in producing Pt_(Х)Y nanoparticles with the ideal size(1000 A g^(-1).At the same time,the nanoalloys are embedded in a fine Pt oxide matrix,which allows a greater stability of the catalyst than the commercial Pt reference,as directly verified on a gas diffusion electrode.

关键词： Electrocatalysis GDE ORR Pt_(2)Y Pt_(3)Y LAL LFL Oxide support Pto Nanoalloys

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