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Developmental hemostasis in the neonatal period

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World Journal of Pediatrics 2022年第1期18卷 7-15页

作者： Vicente Rey y Formoso ricardo Barreto Mota Henrique Soares Neonatology Department(Reference Center for Congenital Heart Diseases) São João University Hospital CenterAlameda Prof.Hernâni Monteiro4200-319PortoPortugal Faculty of Medicine Porto UniversityPortoPortugal

Background The hemostatic system is complex and evolves continuously since gestation and well into the adult years,in a process known as“developmental hemostasis.”Data sources A comprehensive review was performed after an extensive literature search on PubMed/MEDLINE concerning developmental hemostasis during the neonatal *** cross references were also *** Although part of a system,each component of the hemostatic system evolves differently,with many displaying both quantitative and qualitative age-related *** leads to drastic disparities between the coagulation system of neonates and both other children’s and adults’,while still maintaining a generally balanced and physiological *** motives behind this process remain to be fully elucidated but may be,at least in part,related to non-hemostatic *** Knowledge regarding“developmental hemostasis”is essential for everyone caring for newborns or even children in general and in this review,we describe each hemostatic system component’s neonatal characteristics and age-related progression as well as explore some of the possible physiological motives behind the process.

关键词： Coagulation factors Developmental hemostasis Hemostasis Newborn Platelets

Studying Formability Limits By Combining Conventional and Incremental Sheet Forming Process

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Chinese Journal of Mechanical Engineering 2021年第4期34卷 78-89页

作者： Fabio Andre Lora Daniel Fritzen ricardo Alves de Sousa Lirio Schaffer Department of Materials Engineering Federal University of Recôncavo da BahiaCampus CETENSFeira de SantanaBahia 44085-132Brazil SATC Uni-versity CriciumaBrazil Center of Mechanical Technology and Automation Department of Mechanical EngineeringUniversity of Aveiro3810-193 AveiroPortugal Federal University of Rio Grande do Sul Porto AlegreBrazil

In this work it is assessed the potential of combining conventional and incremental sheet forming processes in a same sheet of *** so-called hybrid forming approach is performed through the manufacture of a pre-forming by conventional forming,followed by incremental sheet *** main objective is analyzing strain *** pre-forming induced in the conventional forming stage will determine the strain paths,directly influencing the strains produced by the incremental *** conduct the study,in the conventional processes,strains were imposed in three different ways with distinct true *** the incremental stage,the pyramid strategy was adopted with different wall *** the experiments,the true strains and the final geometries were *** simulation was also employed for the sake of comparison and correlation with the measured *** could be observed that single-stretch pre-strain was directly proportional to the maximum incremental strains achieved,whereas samples subjected to biaxial pre-strain influenced the formability according to the degree of pre-strain ***-strain driven by the prior deep-drawing operation did not result,in this particular geometry,in increased formability.

关键词： Hybrid forming process Incremental sheet forming Strain paths Numerical simulation

Introducing System Identification Strategy into Model Predictive Control

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Journal of Systems Science & Complexity 2020年第5期33卷 1402-1421页

作者： WANG Jianhong ricardo A.Ramirez-Mendoza JoRGE de J Lozoya Santos School of Electronic Engineering and Automation Jiangri University of Science and TechnologyGanzhou343000China School of Engineering and Sciences Tecnologico de MonterreyMonterreyAve.Eugenio Garza Sada 2501MonterreyN.L.64849Merico

As system identification theory and model predictive control are belonged to two different research fields separately,so one gap exists between these two *** alleviate this gap between them,one new idea proposed in this paper is to introduce system identification theory into model predictive *** the most important element in model predictive control is the prediction of the output value for a nonlinear system,then the problem of deriving the prediction of the output value can be achieved by system identification *** specifically,a Bayesian approach is applied for the nonparametric estimation by modeling the prediction as realizations of zero mean random *** comparing this kind of prediction corresponding to this Bayesian approach and the former direct weight optimization identification for nonlinear system,the authors see that if the unknown weights are chosen appropriately,these two approaches are equivalent to each *** on the obtained prediction of the output value,the authors substitute this prediction of the output value into one cost function of model predictive control,and then a quadratic programming problem with inequality constraints is *** to solve this quadratic programming problem,a detailed process about how to derive its dual form is *** the dual problem has a simple constraint set,it is amenable to the use of the common Gauss-Seidel algorithm,whose convergence can be shown ***,one simulation example confirms the proposed theoretical results.

关键词： Equivalence model predictive control nonparametric estimation system identification

Metabolism and metabolomics of ketamine:a toxicological approach

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Forensic Sciences Research 2017年第1期2卷 2-10页

作者： ricardo Jorge Dinis-oliveira Department of Sciences IINFACTS–Institute of Research and Advanced Training in Health Sciences and TechnologiesUniversity Institute of Health Sciences(IUCS)CESPUCRLGandraPortugal Department of Biological Sciences UCIBIOREQUIMTELaboratory of ToxicologyFaculty of PharmacyUniversity of PortoPortoPortugal Department of Public Health and Forensic Sciences and Medical EducationFaculty of MedicineUniversity of PortoPortoPortugal

Ketamine is a phencyclidine derivative and a non-competitive antagonist of N-methyl-D-aspartate(NMDA)receptor for which glutamate is the full *** produces a functional dissociation between the thalamocortical and limbic systems,a state that has been termed as dissociative *** variability in the pharmacokinetics and pharmacodynamics between individuals that can affect dose-response and toxicological profile has been *** review aims to discuss pharmacokinetics of ketamine,namely focusing on all major and minor,active and inactive *** ketamine optical isomers undergo hepatic biotransformation through the cytochrome P450,specially involving the isoenzymes 3A4 and *** is first N-demethylated to active metabolite *** minor pathways have been described,namely hydroxylation of the cyclohexanone ring of ketamine and norketamine,and further conjugation with glucuronic acid to increase renal *** recently,metabolomics data evidenced the alteration of several biological pathways after ketamine administration such as glycolysis,tricarboxylic acid cycle,amino acids metabolism and mitochondrial b-oxidation of fatty *** is expected that knowing the metabolism and metabolomics of ketamine may provide further insights aiming to better characterize ketamine from a clinical and forensic perspective.

关键词： Forensic science forensic toxicology ketamine metabolism metabolomics toxicity

Harmonic Polynomials Via Differentiation

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Analysis in Theory and Applications 2018年第4期34卷 336-347页

作者： ricardo Estrada Department of Mathematics Louisiana State University

It is well-known that if p is a homogeneous polynomial of degree k in n variables, p ∈ P;, then the ordinary derivative p（）(r;) has the form A;Y（x）r;where A;is a constant and where Y is a harmonic homogeneous polynomial of degree k, Y ∈ H;, actually the projection of p onto H;. Here we study the distributional derivative p（）(r;) and show that the ordinary part is still a multiple of Y, but that the delta part is independent of Y, that is, it depends only on p-Y. We also show that the exponent 2-n is special in the sense that the corresponding results for p（）(r;)do not hold if α≠2-n. Furthermore, we establish that harmonic polynomials appear as multiples of r;when p（） is applied to harmonic multipoles of the form Y’（x）r;for some Y ∈H;.

关键词： Harmonic functions harmonic polynomials distributions multipoles

Modeling egg development of the pest Clavipalpus ursinus （Coleoptera： Melolonthidae） using a temperature-dependent approach

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Insect Science 2012年第6期19卷 657-665页

作者： Andrea Escobar Rodrigo Gil Carlos ricardo Bojaca Jaime Jimenez Facultad de Ciencias Naturales e Ingenieria Departamento de Ciencias Basicas Universidad de Bogota Jorge Tadeo Lozano Bogota Direccion Tecnica de Sanidad Vegetal Instituto Colombiano Agropecuario Bogota Colombia

Predicting the population dynamics of insects in natural conditions is es- sential for their management or preservation, and temperature-dependent development models contribute to achieving this. In this research the effects of temperature and soil moisture content on egg development and hatching of Clavipalpus ursinus （Blanchard） were evaluated. The eggs were exposed to seven temperature treatments with averages of 7.2, 13.0, 15.5, 19.7, 20.6, 22.0 and 25.3~C, in combination with three soil moisture contents of 40%, 60% and 80%. A linear and two non-linear （Lactin and Briere） models were evaluated in order to determine the thermal requirements of this developmental stage. Temperature affected significantly the time of development and egg hatching, while no significant effect was observed for moisture content. Thermal requirements were set as： 7.2℃ for lower developmental threshold, 20.6℃ for optimum developmental threshold, 25.3℃ for maximum temperature and 344.83 degree-days for the thermal constant. The linear model described satisfactorily egg development at intermediate temperatures; nev- ertheless, a slightly better fit of the observed data was obtained with the Lactin model. Egg development took place inside a narrow range of temperatures. Consequently, an increment of soil temperature could generate a negative impact on the population size of this species or changes in its biological parameters.

关键词： egg development pests soil moisture thermal requirements

Entrepreneurship and Unemployment Cycles： A Delay Differential Equation Approach

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2013年第2期8卷 288-292页

作者： Joao ricardo Faria MPA Program University of Texas at E1 Paso E1 Paso TX 79968-0703 USA

This paper is an application of delay differential equations to entrepreneurship and unemployment. It shows that the results of empirical studies can be replicated through a simple DDE. The paper also carries out a comparative study between a solution of a DDE and the observation of cyclic behaviors. The calculated delay （and growth rate） of the entrepreneurship DDE for the US and Spain is 1.25 years （1.25）, for Ireland is 1.75 years （0.89）, and for the UK is 2 years （0.78）. The delay （and growth rate） of the unemployment DDE for the US and Ireland is 1.5 years （1.04）, for Spain is 2 years （0.78）, and for the UK is 2.5 years （0.62）.

关键词： new firms employment creation cycles delay differential equations

Induced pluripotent stem cells from Huntington's disease patients:a promising approach to define and correct disease-related alterations

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Neural Regeneration Research 2019年第5期14卷 769-770页

作者： Azra Fatima ricardo Gutiérrez-Garcia David Vilchez Institute for Genetics and Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases(CECAD) University of Cologne

Adult somatic cells such as skin or blood cells from either health donors or patients can be reprogrammed into induced pluripotent stem cells(iPSCs).Given their unlimited self-renewal and differentiation capacities,iPSCs are an invaluable resource to generate terminally differentiated ***,iPSCs can facilitate the study of human diseases and drug screening,holding great promise for regenerative *** significant advantage of iPSC disease-modeling is that normal and mutant proteins are expressed at endogenous *** addition,subtle phenotypes and the effects of genetic background variations can be assessed by comparison between iPSC lines obtained from different patients and healthy donors as well as isogenic lines,in which disease-related mutations are corrected.

关键词： Adult somatic cells skin or blood cells Huntington’s disease patients

outcome of varicocele repair in men with nonobstructive azoospermia： systematic review and meta-analysis

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Asian Journal of Andrology 2016年第2期18卷 246-253,J0005,J0006页

作者： Sandro C Esteves ricardo Miyaoka Matheus Roque Ashok Agarwal ANDRoFERT Center for Male Reproduction Av. Dr. Heitor Penteado 1464 Campinas SP 13075-460 Brazil oRLGEN Center for Reproductive MedicineRio de Janeiro Aw Rodolfo de Amoedo 140 Rio de Janeiro RJ 22620-330 Brazil American Center for Reproductive Medicine 10681. Carnegie Avenue X-11Cleveland OH 44195 USA.

The objective of this systemic review was to evaluate the benefit of repairing clinical varicocele in infertile men with nonobstructive azoospermia （NoA）. The surgically obtained sperm retrieval rate （SRR） and pregnancy rates following assisted reproductive technology （ART） with the use of retrieved testicular sperm were the primary outcomes. The secondary outcomes included the presence of viable sperm in postoperative ejaculate to avoid the testicular sperm retrieval and pregnancy rates （both assisted and unassisted） using postoperative ejaculated sperm. An electronic search to collect the data was performed using the MEDLINE and EMBASE databases until April 2015. Eighteen studies were included in this systematic review and accounted for 468 patients who were diagnosed with NoA and varicocele. These patients were subjected to either surgical varicocele repair or percutaneous embolization. Three controlled studies evaluating sperm retrieval outcomes indicated that in patients who underwent varicocelectomy, SRR increased compared to those without varicocele repair （oR： 2,65; 95% Cl. 1.69-4.14; P 〈 0.001）. Although pregnancy rates with the use of testicular sperm favored the varicocelectomy group, results were not statistically significant （clinical pregnancy rate oR： 2.07; 95% CI： 0.92-4.65; P = 0.08; live birth rate oR： 2.19; 95% CI： 0.99-4.83; P = 0.05）. The remaining fifteen studies reported postoperative semen analysis results. In 43.9% of the patients （range： 20.8%-55.0%）, sperm were found in postoperative ejaculates. Pregnancy rates for unassisted and assisted （after IVF/ICSI） were 13.6% and 18.9% in the group of men with sperm in postoperative ejaculates, respectively. our findings indicate that varicocelectomy in patients with NoA and clinical varicocele is associated with improved SRR. In addition, approximately 44% of the treated men will have enough sperm in the ejaculate to avoid sperm retrieval. Limited data on pregnancy outcomes with both postoperative

关键词： azoospermia male infertility meta-analysis sperm retrieval systematic review varicocele varicocelectomy