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One image is worth more than a thousand words:producing an atlas of medical signs for teaching clinical and forensic toxicology

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Forensic Sciences Research 2022年第4期7卷 815-822页

作者： ricardo Jorge Dinis-Oliveira TOXRUN-Toxicology Research Unit University Institute of Health SciencesAdvanced Polytechnic and University Cooperative(CESPU)CRLGandraPortugal Department of Public Health and Forensic Sciences and Medical EducationFaculty of MedicineUniversity of PortoPortoPortugal UCIBIO-REQUIMTE Laboratory of ToxicologyDepartment of Biological SciencesFaculty of PharmacyUniversity of PortoPortoPortugal

Clinical and forensic toxicology are critically involved in the acquisition of basic skills to correctly suspect intoxication,collect biological and non-biological materials for toxicological analysis,comprehend the complexities inherent to laboratory activity,and understand the fundamentals of toxicokinetics and toxicodynamics that underlie the interpretation of *** works presents a pedagogical innovation proposal for the teaching of clinical and forensic toxicology based on a compilation of more than 3000 cases where the image was fulcra for *** experience in this article follows the model practiced in bachelors,masters,and PhD degrees,as well as in other continuing training courses,where we are teaching toxicology for more than 15 *** these levels of education are considered fundamental to the sound development of this *** approach aims also to offer strength to the intervention of the true toxicologist in all the toxicological phases,besides the classic analytical ***,it is impossible to provide effective clinical and forensic toxicological interpretations without a proper and broad education,and not thinking exclusively in terms of laboratory *** the future,it will be interesting to evaluate knowledge retention and to propose a database of videos of signs related to intoxications.

关键词： Forensic sciences clinical and forensic toxicology teaching learning signs of exposure pre-analytical phase

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Human Interaction Dynamics for Its Use in Mobile Robotics:Impedance Control for Leader-follower Formation

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IEEE/CAA Journal of Automatica Sinica 2017年第4期4卷 696-703页

作者： Daniel Herrera Flavio Roberti Marcos Toibero ricardo Carelli Instituto de Automatica Universidad Nacional de San Juan-CONICET IEEE

A complete characterization of the behavior in human-robot interactions(HRI) includes both: the behavioral dynamics and the control laws that characterize how the behavior is regulated with the perception data. In this way, this work proposes a leader-follower coordinate control based on an impedance control that allows to establish a dynamic relation between social forces and motion error. For this, a scheme is presented to identify the impedance based on fictitious social forces, which are described by distance-based potential *** part of the validation procedure, we present an experimental comparison to select the better of two different fictitious force structures. The criteria are determined by two qualities: least impedance errors during the validation procedure and least parameter variance during the recursive estimation ***, with the best fictitious force and its identified impedance,an impedance control is designed for a mobile robot Pioneer 3AT,which is programmed to follow a human in a structured *** to results, and under the hypothesis that moving like humans will be acceptable by humans, it is believed that the proposed control improves the social acceptance of the robot for this kind of interaction.

关键词： Human modeling human-machine interaction impedance control robot dynamics social robotics

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Sap flow rates of Minquartia guianensis in central Amazonia during the prolonged dry season of 2015–2016

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Journal of Forestry Research 2021年第5期32卷 2067-2076页

作者： Saul A.Antezana-Vera ricardo A.Marenco Botany Graduate Program Instituto Nacional de Pesquisas da Amazônia-INPAAvenida AndréAraújo2936ManausAM 69067-375Brazil Tree Ecophysiology LaboratoryInstituto Nacional de Pesquisas da Amazônia-INPAAvenida AndréAraújo2936ManausAM 69067-375Brazil

Minquartia guianensis *** a slow-growing species with several *** the juvenile state,it is well-adapted to low light conditions of the forest ***,it is still unknown how climate variability affects transpiration of this species,particularly under drought *** this study,we aimed to assess the effect of climatic variability on sap flow rates(SFR).SFR and radial growth were measured in six trees(14-50 cm diameter)in 2015 and ***(precipitation,irradiance,relative humidity and temperature)and soil water content(SWC)data were also *** tended to increase in the dry season,with a negative relationship between SFR and SWC and precipitation(p<0.001),while there was a positive association between radial growth and monthly precipitation(p=0.004).Irradiance and temperature were the environmental factors more closely correlated with SFR during daytime(p<0.001),whereas relative humidity and vapor pressure deficit were the most important factors at night(p<0.001).Although negative SFR were sometimes recorded at night,the mean nocturnal sap flow was positive and across trees the nighttime sap flow accounted for 12.5%of the total daily sap *** transpiration during the dry season suggests that the root system of Minquartia was able to extract water from deep soil *** results widen our understanding of the ecophysiology of Amazonian trees under drought and provide further insight into the potential effect of the forecasted decline in precipitation in the Amazon region.

关键词： Reverse sap flow Soil water content Transpiration Tree growth

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Analysis of the testimonial evidence of Portugal's first major forensic case:part Ⅱ

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Forensic Sciences Research 2020年第4期5卷 266-285页

作者： ricardo Jorge Dinis-Oliveira Department of Public Health and Forensic Sciences and Medical EducationFaculty of MedicineUniversity of PortoPortoPortugal IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies Department of SciencesUniversity Institute of Health Sciences(IUCS)Advanced Polytechnic and University Cooperative(CESPU)CRLGandraPortugal UCIBIO-REQUIMTE Laboratory of Toxicology

The crime possibly perpetrated by a doctor named Vicente Urbino de Freitas in 1890 is one of the most famous cases of poisoning,and it had echoes in the Portuguese and foreign press for several *** prestigious doctor was convicted of the fatal poisoning of his *** also attempted the homicide of two nieces and their mother-in-law,who only escaped because they obstinately refused to comply with the"therapeutics"prescribed by the family *** motive of the crime should have been Vicente Urbino de Freitas'ambition to receive the family inheritance of his wife,the daughter of the well-known mer-chant Jose Antonio Sampaio of Flores Street in *** Urbino de Freitas was con-victed but doubt about his guilt persists for more than a *** second work aimed to collect and analyse all the relevant and contradictory testimonial evidence of the prosecu-tion and defence *** case represents an odd historical record obtained through more than 12years of research on the first major significant Portuguese forensic *** and unprecedented testimonial evidence and photographs were obtained from different countries and then repaired,since these also provide an important historical record of the medical photography.

关键词： History of legal medicine forensic sciences forensic toxicology Vicente Urbino de Freitas Mário Guilherme Augusto de Sampaio testimonial evidence Flores Street

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Predatory journals and meetings in forensic sciences:what every expert needs to know about this“parasitic”publishing model

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Forensic Sciences Research 2021年第3期6卷 303-309页

作者： ricardo Jorge Dinis-Oliveira ToXrUn-Toxicology research Unit University institute of health sciences(iUc)CESPUCRLGandraPortugal Department of Public health and Forensic sciences and Medical educationFaculty of MedicineUniversity of PortoPortoPortugal UCIBIO REQUIMETLaboratory of ToxicologyDepartment of Biological sciencesFaculty of PharmacyUniversity of PortoPortoPortugal

The emergence of the internet has transformed all areas of *** includes the universe of scientific publications,with several publishers now exclusively focusing on the electronic format and open access model while expanding to a megajournal *** this context,the pandemic of predatory open access journals(POAJs)and meetings are of grave concern to the academic and research *** new shift within academia produces a variety of new victims;namely,the authors *** turn,scientific knowledge is often discredited,with the public placing less trust in *** more than ever,performing research with integrity and selecting a journal in which to publish requires close attention and ***“predatory movement”has developed increasingly sophisticated techniques for misleading people into believing what seem to be credible professional layouts and legitimate *** such as the Jeffrey Beall’s list,the Cabell’s Scholarly Analytics and *** offer some guidance to uncover the“parasitic”intervention of predatory journals and meetings,but specific education in this field is sorely *** work aims to review the main characteristics of predatory journals and meetings and to analyze this topic in the context of forensic and legal medicine research.

关键词： Forensic sciences predatory open access journals predatory meetings Jeffrey Beall’s list research integrity peer review scientific publishing

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Analysis of the autopsy,toxicological,and psychiatric reports of Portugal’s first major forensic case:partⅢ

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Forensic Sciences Research 2021年第4期6卷 250-272页

作者： ricardo Jorge Dinis-Oliveira Department of Public health and Forensic sciences and Medical educationFaculty of MedicineUniversity of PortoPortoPortugal IINFACTS-Institute of research and advanced Training in health sciences and Technologies Department of sciencesUniversity institute of health sciences(IUCS)advanced Polytechnic and University cooperative(CESPU)CRLGandraPortugal UCIBIO-REQUIMTE Laboratory of ToxicologyDepartment of Biological sciencesFaculty of PharmacyUniversity of PortoPortoPortugal

This work presents an odd historical record obtained through more than 14 years of research regarding one of the first major european forensic *** presumed homicide of Mário Guilherme Augusto de Sampaio in 1890 was allegedly perpetrated by his uncle,the prestigious doctor vicente Urbino de *** famous poisoning had international repercussions for decades,with the participation of several forensic experts that made the history of forensic sciences,namely forensic toxicology and *** third work aims to collect,restore,and analyse all the forensic evidence,particularly from the autopsy,toxicological,and psychiatric forensic *** regarding the life of vicente Urbino de Freitas during his exile in Brazil were also recovered,along with a vast and outstanding assortment of forensic medicine photographs from the 19th century.

关键词： Forensic sciences forensic reports alkaloids history of legal medicine Flores Street vicente Urbino de Freitas JoséAntónio de Sampaio Junior Mário Guilherme Augusto de Sampaio

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Leaf water potential and gas exchange of eucalypt clonal seedlings to leaf solar protectant

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Journal of Forestry Research 2019年第1期30卷 57-64页

作者： Talita Miranda Teixeira Xavier José Eduardo Macedo Pezzopane ricardo Miguel Penchel José ricardo Macedo Pezzopane Departamento de Ciências Florestais e da Madeira Universidade Federal do Espírito Santo Fibria Celulose S.A Rodovia General Euryale Jesus Zerbini Embrapa Pecuária Sudeste

This experiment was carried out in acclimatized greenhouses with seedlings of two hybrid clones of Eucalyptus urophylla×Eucalyptus grandis. A sunscreen protector consisting of 62.5% calcium carbonate was sprayed on the seedlings at weekly intervals. Water stress was induced by suspending irrigation until the soil reached 30% available water and water was then replaced so that it returned to field capacity. Gas exchange and leaf water status were measured after 50 days. The experiment was set up in a 4×2 factorial randomized block design in four distinct environments:(1) temperatures less than 21.2℃ and vapor pressure deficit of 0.15 kPa;(2) intermediate temperatures of 24.2℃ and vapor pressure deficit of 0.69 kPa;(3) high temperatures of 27.0℃ and high vapor pressure deficit of 1.4 kPa; and,(4) high temperature of 27.0℃ and vapor pressure deficit below 1.10 kPa. Two leaf sun protector treatments were used, with five replications each. High atmospheric demand acted as a stress factor for the seedlings during the initial growth *** of leaf sunscreen protector provided beneficial effects in maintaining optimum water status and gas exchanges of the plants under water stress.

关键词： Eucalyptus urophylla×Eucalyptus grandis Calcium carbonate Water stress Atmospheric demand

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Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism

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Translational Neurodegeneration 2017年第1期6卷 310-323页

作者： Rafael Lazo-Gomez ricardo Tapia División de Neurociencias Instituto de Fisiología CelularUniversidad Nacional Autónoma de MéxicoCircuito exterior s/nCiudad UniversitariaCoyoacán04510 Ciudad de MéxicoMexico

Background:Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron *** therapeutic strategies are an unmet need for these ***,such as quercetin and resveratrol,are plant-derived compounds that activate sirtuins(SIRTs)and have shown promising results in some models of neuronal death,although their effects have been scarcely tested in models of motor neuron ***:In this work we investigated the effects of quercetin and resveratrol in an in vivo model of excitotoxic motor neuron death induced by the chronic infusion ofα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AMPA)into the rat spinal cord *** and resveratrol were co-infused with AMPA and motor behavior and muscle strength were assessed daily for up to ten ***,animals were fixed and lumbar spinal cord tissue was analyzed by histological and immunocytological ***:We found that the chronic infusion of AMPA[1 mM]caused a progressive motor neuron degeneration,accompanied by astrogliosis and microgliosis,and motor deficits and paralysis of the rear *** infusion ameliorated AMPA-induced paralysis,rescued motor neurons,and prevented both astrogliosis and microgliosis,and these protective effects were prevented by EX527,a very selective SIRT1 *** contrast,neither resveratrol nor EX527 alone improved motor behavior deficits or reduced motor neuron degeneration,albeit both reduced ***:These results suggest that quercetin exerts its beneficial effects through a SIRT1-mediated mechanism,and thus SIRT1 plays an important role in excitotoxic neurodegeneration and therefore its pharmacological modulation might provide opportunities for therapy in motor neuron disorders.

关键词： Motor neuron disorder Quercetin Resveratrol Sirtuin Excitotoxicity

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Reduction of the Regularization Error of the Method of Regularized Stokeslets for a Rigid Object Immersed in a Three-Dimensional Stokes Flow

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Communications in Computational Physics 2014年第1期15卷 126-152页

作者： Hoang-Ngan Nguyen ricardo Cortez Center for Computational Science Tulane University6823 St.Charles AveNew OrleansLouisiana70118USA.

We focus on the problem of evaluating the velocity field outside a solid object moving in an incompressible Stokes flow using the boundary integral *** points near the boundary,the integral is nearly singular,and accurate computation of the velocity is not *** way to overcome this problem is to regularize the integral *** method of regularized Stokeslet(MRS)is a systematic way to regularize the kernel in this *** a specific blob function which is widely used,the error of the MRS is only of first order with respect to the blob *** prove that this is the case for radial blob functions with decay propertyφ(r)=O(r−3−α)when r→∞for some constantα>*** then find a class of blob functions for which the leading local error term can be removed to get second and third order errors with respect to blob *** the addition of these terms might give a flow field that is not divergence free,we introduce a modification of these terms to make the divergence of the corrected flow field close to zero while keeping the desired ***,these dominant terms are explicitly expressed in terms of blob function and so the computation time is negligible.

关键词： Stokes flow regularized Stokeslet boundary integral equation nearly singular integral.

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Understanding how MSCs reverse radiation-induced fibrosis:HGF ***-B1

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Plastic and Aesthetic Research 2023年第1期10卷 28-45页

作者： ricardo Luis Rodriguez Department of plastic surgery CosmeticsurgLuthervilleMD 21093USA

Radiation induced fibrosis(RIF)can be understood as a form of chronic radiation-induced bystander effect(RIBE).It is a fibrotic process different than acute radiation syndrome(ARS),which is an inflammatory process that has different mediators and effector *** is triggered by Reactive Oxygen Species(ROS)activation of the matrixembedded L-TGF-β***-βacts by directing cellular processes that culminate in a fibrotic *** include epithelial and endothelial mesenchymal transition(EMT and EnMT),G1 phase growth arrest,stimulation of fibrosis,and apoptosis,characterized by hypocellularity with a predominance of fibrocytes and myofibroblasts,fibrosis,and variable loss of tissue *** grafting is the only clinically available tool to reverse *** reversal of RIF is mediated by the mesenchymal stem cells(MSCs)embedded in the stromal vascular fraction(SVF)adipose *** mechanism of action is the release of HGF(hepatocyte growth factor)by the MSCs into the surrounding RIF *** HGF initiates a“mitotic growth program”that reprograms cell *** changes include EMT and EnMT,stimulation of cell proliferation and morphogenesis,anti-apoptosis,downregulation of TGF-β,dissolution of fibrosis,and cell ***“mitotic growth program”culminates in tissue regeneration and reversal of RIF.

关键词： HGF TGF-β RIF radiation-induced fibrosis fat grafting MSC

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