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Intestinal inflammation and the microbiota:Beyond diversity

World Journal of Gastroenterology 2022年第26期28卷 3274-3278页

作者： Gabriela Gama Freire alberca Naiane Samira Souza Cardoso Rosa Liliana Solis-Castro Viviane Nakano ricardo wesley alberca Department of Microbiology Institute of Biomedical SciencesUniversity of São PauloSão Paulo 05508-000Brazil Departamento Académico de Biología Bioquímica Facultad de Ciencias de la SaludUniversidad Nacional de TumbesPampa Grande 24000TumbesPeru Laboratorio de Dermatologia e Imunodeficiencias Departamento de DermatologiaFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 01246-903Brazil

The recent manuscript entitled“Relationship between clinical features and intestinal microbiota in Chinese patients with ulcerative colitis”reported a difference in the intestinal microbiota of patients with ulcerative colitis according to the severity of the *** influence of the intestinal microbiota on the development and progress of gastrointestinal disorders is well *** the diversity in the microbiome,the presence of virulence factors and toxins by commensal bacteria may affect an extensive variety of cellular processes,contributing to the induction of a proinflammatory environment.

关键词： Inflammation Microbiota Toxins Intestinal Ulcerative Colitis Cancer

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Role of vitamin D deficiency and comorbidities in COVID-19

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World Journal of Virology 2022年第1期11卷 85-89页

作者： Gabriela Gama Freire alberca ricardo wesley alberca Department of Microbiology Institute of Biomedical Sciences-University of São PauloSão Paulo 04307-100Brazil Laboratorio de Dermatologia e Imunodeficiencias(LIM-56) Departamento de DermatologiaFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 04307-100Brazil

Recent manuscripts described the incidence of vitamin D hypovitaminosis in coronavirus disease 2019(COVID-19)*** D deficiency is also common in patients with comorbidities that are associated with a poor COVID-19 *** ... 详细信息

关键词： COVID-19 SARS-CoV-2 Comorbidities Vitamin D

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SARS-CoV-2 infection in liver transplant recipients:A complex relationship

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World Journal of Gastroenterology 2021年第44期27卷 7734-7738页

作者： ricardo wesley alberca Gil Benard Gabriela Gama Freire alberca Maria Notomi Sato Laboratorio de Dermatologia e Imunodeficiencias(LIM-56) Departamento de Dermatologia e Institute de Medicina TropicalFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 01246-903Brazil Laboratorio de Dermatologia e Imunodeficiencias(LIM-56) Departamento de DermatologiaFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 01246-903Brazil

The recent manuscript reviewed investigations involving liver damage in coronavirus disease 2019(COVID-19)patients,and COVID-19 in patients with previous chronic hepatological diseases,such as patients with liver *** literature presents several conflicting results concerning the anti-SARS-CoV-2 response in patients with solid organ transplants,in liver transplant ***,we would like to humbly state a few points for consideration involving liver transplant recipients and COVID-19,such as the time since transplantation,comorbidities,and immunosuppressive regimens.

关键词： COVID-19 SARS-CoV-2 Liver transplant Immunosuppression Infection Comorbidities

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Coronavirus disease-2019 and the intestinal tract:An overview

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World Journal of Gastroenterology 2021年第13期27卷 1255-1266页

作者： Gabriela Gama Freire alberca Rosa Liliana Solis-Castro Maria Edith Solis-Castro ricardo wesley alberca Department of Microbiology Institute of Biomedical Sciences-University of São PauloSão Paulo 05508-000Brazil Departamento Académico de Biología Bioquímica Facultad de Ciencias de la SaludUniversidad Nacional de TumbesPampa Grande 24000TumbesPeru Departamento Académico de Medicina Humana Facultad de Ciencias de la SaludUniversidad Nacional de TumbesPampa Grande 24000TumbesPeru Laboratorio de Dermatologia e Imunodeficiencias(LIM-56) Departamento de DermatologiaFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 01246-903Brazil

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) infection can progress to a severe respiratory and systemic disease named coronavirus disease–2019(COVID-19). The most common symptoms are fever and respiratory discomfort. Nevertheless, gastrointestinal infections have been reported, with symptoms such as diarrhea, nausea, vomiting, abdominal pain, and lack of appetite. Importantly, SARS-CoV-2 can remain positive in fecal samples after nasopharyngeal clearance. After gastrointestinal SARS-CoV-2 infection and other viral gastrointestinal infections, some patients may develop alterations in the gastrointestinal microbiota. In addition, some COVID-19 patients may receive antibiotics, which may also disturb gastrointestinal homeostasis. In summary, the gastrointestinal system, gut microbiome, and gut-lung axis may represent an important role in the development, severity, and treatment of COVID-19. Therefore, in this review, we explore the current pieces of evidence of COVID-19 gastrointestinal manifestations, possible implications, and interventions.

关键词： COVID-19 SARS-CoV-2 Gastrointestinal Microbiota Antibiotics

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