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Dysregulated microRNAs in type 2 diabetes and breast cancer:Potential associated molecular mechanisms

World Journal of Diabetes 2024年第6期15卷 1187-1198页

作者： Alex Cleber Improta-Caria Filipe Ferrari João Lucas Penteado Gomes Paloma Brasilio Villalta Úrsula Paula RenóSoci ricardo stein Edilamar M Oliveira Laboratory of Biochemistry and Molecular Biology of the Exercise Physical Education and Sport SchoolUniversity of São PauloSão Paulo 05508-030Brazil Graduate Program in Cardiology and Cardiovascular Sciences Federal University of Rio Grande do SulHospital de Clínicas de Porto AlegrePorto Alegre 90035003Brazil Laboratory of Metabolic Disorders(Labdime) School of Applied SciencesUniversity of Campinas-UNICAMPCampinas 13484-350Brazil Departments of Internal Medicine Molecular Pharmacology and PhysiologyCenter for Regenerative MedicineUSF Health Heart InstituteMorsani College of MedicineUniversity of South FloridaTampaFL 33602United States

Type 2 diabetes(T2D)is a multifaceted and heterogeneous syndrome associated with complications such as hypertension,coronary artery disease,and notably,breast cancer(BC).The connection between T2D and BC is established through processes that involve insulin resistance,inflammation and other factors.Despite this comprehension the specific cellular and molecular mechanisms linking T2D to BC,especially through microRNAs(miRNAs),remain elusive.miRNAs are regulators of gene expression at the post-transcriptional level and have the function of regulating target genes by modulating various signaling pathways and biological processes.However,the signaling pathways and biological processes regulated by miRNAs that are associated with T2D and BC have not yet been elucidated.This review aims to identify dysregulated miRNAs in both T2D and BC,exploring potential signaling pathways and biological processes that collectively contribute to the development of BC.

关键词： Type 2 diabetes Breast cancer MicroRNAs Molecular mechanisms

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Interpolation of Vector Measures

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Acta Mathematica Sinica,English Series 2011年第1期27卷 119-134页

作者： ricardo del CAMPO Antonio FERNANDEZ Fernando MAYORAL Francisco NARANJO Enrique A. SANCHEZ-PEREZ Dpto. Matemdtica Aplicada I Universidad de SevillaEUITA Ctra. de Utrera Kin. 1 41013 Sevilla Spain Dpto. Matemdtica Aplicada II Universidad de Sevilla Escuela Tdcnica Superior de Ingenieros Camino de los Descubrimientos s/n 41092 Sevilla Spain Instituto Universitario de Matemdtica Pura y Aplicada Universidad Politdcnica de Valencia Camino de Vera s/n 46022 Valencia Spain

Let （Ω, ∑） be a measurable space and mo ： E→ Xo and m1 ： E → X1 be positive vector measures with values in the Banach KSthe function spaces Xo and X1. If 0 〈 a 〈 1, we define a X01-ax1a new vector measure [m0, m]a with values in the Calderdn lattice interpolation space and we analyze the space of integrable functions with respect to measure [m0, m1]a in order to prove suitable extensions of the classical stein Weiss formulas that hold for the complex interpolation of LP-spaces. Since each p-convex order continuous Kothe function space with weak order unit can be represented as a space of p-integrable functions with respect to a vector measure, we provide in this way a technique to obtain representations of the corresponding complex interpolation spaces. As applications, we provide a Riesz-Thorin theorem for spaces of p-integrable functions with respect to vector measures and a formula for representing the interpolation of the injective tensor product of such spaces.

关键词： Interpolation Banach function space vector measure

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