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npj Computational Materials 2023年第1期9卷 1023-1038页

作者： Dongil Shin Ryan Alberdi ricardo A.Lebensohn Rémi Dingreville Center for Integrated Nanotechnologies Sandia National LaboratoriesAlbuquerqueNM 87185USA Simulation Modeling Sciences Sandia National LaboratoriesAlbuquerqueNM 87185USA Theoretical Division Los Alamos National LaboratoryLos AlamosNM 87845USA

Recent developments integrating micromechanics and neural networks offer promising paths for rapid predictions of the response of heterogeneous materials with similar accuracy as direct numerical *** deep material network is one such approaches,featuring a multi-layer network and micromechanics building blocks trained on anisotropic linear elastic *** trained,the network acts as a reduced-order model,which can extrapolate the material’s behavior to more general constitutive laws,including nonlinear behaviors,without the need to be ***,current training methods initialize network parameters randomly,incurring inevitable training and calibration ***,we introduce a way to visualize the network parameters as an analogous unit cell and use this visualization to“quilt”patches of shallower networks to initialize deeper networks for a recursive training *** result is an improvement in the accuracy and calibration performance of the network and an intuitive visual representation of the network for better explainability.

关键词： networks Deep network

Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation

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Neural Regeneration Research 2020年第3期15卷 407-415页

作者： Heather R.Lucas ricardo D.Fernández Department of Chemistry Virginia Commonwealth University

N-acetylatedα-synuclein(αSyn)has long been established as an intrinsically disordered protein associated with a dysfunctional role in Parkinson’s *** recent years,a physiologically relevant,higher order conformation has been identified as a helical tetramer that is tailored by buried hydrophobic interactions and is distinctively aggregation *** canonical mechanism by which the tetramer assembles remains *** novel biochemical approaches,computational methods,pioneering purification platforms,and powerful imaging techniques continue to develop,puzzling information that once sparked debate as to the veracity of the tetramer has now shed light upon this new counterpart inαSyn *** magnetic resonance and computational studies on multimericαSyn structure have revealed that the protein folding propensity is controlled by small energy barriers that enable large scale ***,familial mutations ablate tetramerization and reconfigure polymorphic *** this review,we will discuss the dynamic landscape ofαSyn quaternary structure with a focus on the tetrameric conformation.

关键词： alpha-synuclein amyloid fibrils intrinsically disordered protein multimer N-acetylation oligomer Parkinson’s disease protein folding protein structure tetramer

Developmental hemostasis in the neonatal period

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World Journal of Pediatrics 2022年第1期18卷 7-15页

作者： Vicente Rey y Formoso ricardo Barreto Mota Henrique Soares Neonatology Department(Reference Center for Congenital Heart Diseases) São João University Hospital CenterAlameda Prof.Hernâni Monteiro4200-319PortoPortugal Faculty of Medicine Porto UniversityPortoPortugal

Background The hemostatic system is complex and evolves continuously since gestation and well into the adult years,in a process known as“developmental hemostasis.”Data sources A comprehensive review was performed after an extensive literature search on PubMed/MEDLINE concerning developmental hemostasis during the neonatal *** cross references were also *** Although part of a system,each component of the hemostatic system evolves differently,with many displaying both quantitative and qualitative age-related *** leads to drastic disparities between the coagulation system of neonates and both other children’s and adults’,while still maintaining a generally balanced and physiological *** motives behind this process remain to be fully elucidated but may be,at least in part,related to non-hemostatic *** Knowledge regarding“developmental hemostasis”is essential for everyone caring for newborns or even children in general and in this review,we describe each hemostatic system component’s neonatal characteristics and age-related progression as well as explore some of the possible physiological motives behind the process.

关键词： Coagulation factors Developmental hemostasis Hemostasis Newborn Platelets

Updates in penile prosthesis infections

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Asian Journal of Andrology 2020年第1期22卷 28-33页

作者： Amanda R Swanton ricardo M Munarriz Martin S Gross Department of Surgery Section of UrologyDartmouth-Hitchcock Medical CenterLebanonNH 03766USA Department of Urology Boston Medical CenterBostonMA02118USA

Inflatable penile prostheses are an important tool in the treatment of medically refractory erectile *** of the major complications associated with these prostheses is infections,which ultimately require device explanation and placement of a new *** the past several decades,significant work has been done to reduce infection rates and optimize treatment strategies to reduce patient *** article reviews the current state of knowledge surrounding penile prosthesis infections,with attention to the evidence for methods to prevent infection and best practices for device reimplantation.

关键词： erectile dysfunction infection penile prosthesis

Studying Formability Limits By Combining Conventional and Incremental Sheet Forming Process

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Chinese Journal of Mechanical Engineering 2021年第4期34卷 78-89页

作者： Fabio Andre Lora Daniel Fritzen ricardo Alves de Sousa Lirio Schaffer Department of Materials Engineering Federal University of Recôncavo da BahiaCampus CETENSFeira de SantanaBahia 44085-132Brazil SATC Uni-versity CriciumaBrazil Center of Mechanical Technology and Automation Department of Mechanical EngineeringUniversity of Aveiro3810-193 AveiroPortugal Federal University of Rio Grande do Sul Porto AlegreBrazil

In this work it is assessed the potential of combining conventional and incremental sheet forming processes in a same sheet of *** so-called hybrid forming approach is performed through the manufacture of a pre-forming by conventional forming,followed by incremental sheet *** main objective is analyzing strain *** pre-forming induced in the conventional forming stage will determine the strain paths,directly influencing the strains produced by the incremental *** conduct the study,in the conventional processes,strains were imposed in three different ways with distinct true *** the incremental stage,the pyramid strategy was adopted with different wall *** the experiments,the true strains and the final geometries were *** simulation was also employed for the sake of comparison and correlation with the measured *** could be observed that single-stretch pre-strain was directly proportional to the maximum incremental strains achieved,whereas samples subjected to biaxial pre-strain influenced the formability according to the degree of pre-strain ***-strain driven by the prior deep-drawing operation did not result,in this particular geometry,in increased formability.

关键词： Hybrid forming process Incremental sheet forming Strain paths Numerical simulation

Scotogenic dark symmetry as a residual subgroup of Standard Model symmetries

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Chinese Physics C 2020年第8期44卷 108-114页

作者： Salvador Centelles Chuliá ricardo Cepedello Eduardo Peinado Rahul Srivastava AHEP Group Institut de Física Corpuscular-CSIC-Universitat de ValènciaParc Científic de Paterna.C/Catedrático JoséBeltrán2 E-46980 Paterna(Valencia)-SPAIN Instituto de Física Universidad Nacional Autónoma de MéxicoA.P.20-364Ciudad de México 01000México Department of Physics Indian Institute of Science Education and Research-BhopalBhopal Bypass RoadBhauriBhopalIndia

We demonstrate that a scotogenic dark symmetry can be obtained as a residual subgroup of the global U(1)B−L symmetry already present in the Standard *** addition,we propose a general framework in which the U(1)B−L symmetry is spontaneously broken into an even Z2n subgroup,setting the general conditions for neutrinos to be Majorana and for dark matter stability to exist in terms of the residual *** an example,under this general framework,we build a class of simple models where,in a scotogenic manner,the dark matter candidate is the lightest particle running inside the mass loop of a *** global U(1)B−L symmetry in our framework,being anomaly free,can also be gauged in a straightforward manner leading to a richer phenomenology.

关键词： neutrino masses dark matter symmetries scotogenic

Metabolism and metabolomics of ketamine:a toxicological approach

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Forensic Sciences Research 2017年第1期2卷 2-10页

作者： ricardo Jorge Dinis-Oliveira Department of Sciences IINFACTS–Institute of Research and Advanced Training in Health Sciences and TechnologiesUniversity Institute of Health Sciences(IUCS)CESPUCRLGandraPortugal Department of Biological Sciences UCIBIOREQUIMTELaboratory of ToxicologyFaculty of PharmacyUniversity of PortoPortoPortugal Department of Public Health and Forensic Sciences and Medical EducationFaculty of MedicineUniversity of PortoPortoPortugal

Ketamine is a phencyclidine derivative and a non-competitive antagonist of N-methyl-D-aspartate(NMDA)receptor for which glutamate is the full *** produces a functional dissociation between the thalamocortical and limbic systems,a state that has been termed as dissociative *** variability in the pharmacokinetics and pharmacodynamics between individuals that can affect dose-response and toxicological profile has been *** review aims to discuss pharmacokinetics of ketamine,namely focusing on all major and minor,active and inactive *** ketamine optical isomers undergo hepatic biotransformation through the cytochrome P450,specially involving the isoenzymes 3A4 and *** is first N-demethylated to active metabolite *** minor pathways have been described,namely hydroxylation of the cyclohexanone ring of ketamine and norketamine,and further conjugation with glucuronic acid to increase renal *** recently,metabolomics data evidenced the alteration of several biological pathways after ketamine administration such as glycolysis,tricarboxylic acid cycle,amino acids metabolism and mitochondrial b-oxidation of fatty *** is expected that knowing the metabolism and metabolomics of ketamine may provide further insights aiming to better characterize ketamine from a clinical and forensic perspective.

关键词： Forensic science forensic toxicology ketamine metabolism metabolomics toxicity

Behavior and Viability of Blueberry Seeds through Germination and Tetrazolium Test

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Advances in Bioscience and Biotechnology 2016年第1期7卷 11-18页

作者： Ana Paula de Azevedo Pasqualini Jessé Neves dos santos ricardo Antonio Ayub Paraná Federal University Curitiba Brazil Ponta Grossa State University Ponta Grossa Brazil Phytotchny and Phytosanitary Department Ponta Grossa State University Ponta Grossa Brazil

Knowing the physiology of seeds and the elements that influence their germination is fundamental aspects in seminiferous propagation;important techniques are used to obtain genetic variability and development of new cultivars of blueberry. The aim of this study is to evaluate the germination behavior, as well as viability levels, through germination tests and tetrazolium, of Vaccinium ashei Reade seed cultivars Briteblue and Climax. Seeds treated or not with 5 M potassium hydroxide (KOH) were submitted to the germination test, on substrates, filter paper (SP) or solid culture medium with half of the salt concentration (MS/2), at temperatures of 10°C ± 2°C or 25°C ± 2°C. The maximum germination percentage of blueberry seeds was 40%. Both temperatures and substrates caused seed germination in the tested cultivars, and pretreatment with 5 M KOH for 5 minutes inhibited germination. Yet, the tetrazolium test, based on coloration of tissue, allowed the establishment of different levels of viability.

关键词： Vaccinium ashei Reade Germination Behavior Dormancy

Clinical and radiographic features of Hutchinson-Gilford progeria syndrome: A case report

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World Journal of Clinical Cases 2014年第3期2卷 67-71页

作者： Daniel Berretta Alves Juliana Melo Silva Tatiany Oliveira Menezes Rosely santos Cavaleiro Fabrício Mesquita Tuji Marcio Ajudarte Lopes Alexandre Augusto Zaia ricardo Della Coletta Department of Radiology Esperanca Institute of Higher Learning Santarém-Pará 68040-100 Brazil Department of Endodontics Federal University of Pará Belém-Pará 66055-240 Brazil Department of Dentistry for Patients with Special Needs Federal University of Pará Belém-Pará 66055-240 Brazil Department of Oral and Maxillofacial Pathology Federal University of Pará Belém-Pará 66055-240 Brazil Department of Oral Diagnosis School of Dentistry State University of Campinas Piracicaba-Sao Paulo 13083-970 Brazil Department of Restorative Dentistry School of Dentistry State University of Campinas Piracicaba-Sao Paulo 13083-970 Brazil

Hutchinson-Gilford progeria syndrome(HGPS) is a rare dysmorphic syndrome characterized by several features of premature aging with clinical involvement of the skin, bones, and cardiovascular system. HGPS has an estimated incidence of one in four million to one in eight million births. The main clinical features of HGPS include short stature, craniofacial dimorphism, alopecia, bone fragility, and cardiovascular disorders. The most frequent cause of death is myocardial infarction at a mean age of 13 years old. Dental manifestations include delayed development and eruption of teeth, discoloration, crowding and rotation of teeth, and displaced teeth. Cone beam computed tomography images revealed the absence of the sphenoid, frontal, and maxillary sinus, flattening of the condyles and glenoid fossa, and bilateral hypoplasia of the mandibular condyles. The disease is caused by mutations in lamin A/C(LMNA). Here, we present a case report of an 11-year-old boy with classical features of HGPS, which was caused by a de novo germ-line mutation(C1824T, G608G) in exon 11 of the LMNA gene. Some uncommon HGPS-associated features in our patient, such as alterations in the facial sinuses and hypoplasia of the condyles, contributed to the expansion of the phenotypic spectrum of this syndrome from a dentomaxillofacial perspective.

关键词： Cone beam computed tomography LMNA mutation Craniofacial anomalies Temporomandibular joint

Induced pluripotent stem cells from Huntington's disease patients:a promising approach to define and correct disease-related alterations

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Neural Regeneration Research 2019年第5期14卷 769-770页

作者： Azra Fatima ricardo Gutiérrez-Garcia David Vilchez Institute for Genetics and Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases(CECAD) University of Cologne

Adult somatic cells such as skin or blood cells from either health donors or patients can be reprogrammed into induced pluripotent stem cells(iPSCs).Given their unlimited self-renewal and differentiation capacities,iPSCs are an invaluable resource to generate terminally differentiated ***,iPSCs can facilitate the study of human diseases and drug screening,holding great promise for regenerative *** significant advantage of iPSC disease-modeling is that normal and mutant proteins are expressed at endogenous *** addition,subtle phenotypes and the effects of genetic background variations can be assessed by comparison between iPSC lines obtained from different patients and healthy donors as well as isogenic lines,in which disease-related mutations are corrected.

关键词： Adult somatic cells skin or blood cells Huntington’s disease patients