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Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism

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Translational Neurodegeneration 2017年第1期6卷 310-323页

作者： Rafael Lazo-Gomez ricardo Tapia División de Neurociencias Instituto de Fisiología CelularUniversidad Nacional Autónoma de MéxicoCircuito exterior s/nCiudad UniversitariaCoyoacán04510 Ciudad de MéxicoMexico

Background:Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron *** therapeutic strategies are an unmet need for these ***,such as quercetin and resveratrol,are plant-derived compounds that activate sirtuins(SIRTs)and have shown promising results in some models of neuronal death,although their effects have been scarcely tested in models of motor neuron ***:In this work we investigated the effects of quercetin and resveratrol in an in vivo model of excitotoxic motor neuron death induced by the chronic infusion ofα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AMPA)into the rat spinal cord *** and resveratrol were co-infused with AMPA and motor behavior and muscle strength were assessed daily for up to ten ***,animals were fixed and lumbar spinal cord tissue was analyzed by histological and immunocytological ***:We found that the chronic infusion of AMPA[1 mM]caused a progressive motor neuron degeneration,accompanied by astrogliosis and microgliosis,and motor deficits and paralysis of the rear *** infusion ameliorated AMPA-induced paralysis,rescued motor neurons,and prevented both astrogliosis and microgliosis,and these protective effects were prevented by EX527,a very selective SIRT1 *** contrast,neither resveratrol nor EX527 alone improved motor behavior deficits or reduced motor neuron degeneration,albeit both reduced ***:These results suggest that quercetin exerts its beneficial effects through a SIRT1-mediated mechanism,and thus SIRT1 plays an important role in excitotoxic neurodegeneration and therefore its pharmacological modulation might provide opportunities for therapy in motor neuron disorders.

关键词： Motor neuron disorder Quercetin Resveratrol Sirtuin Excitotoxicity

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Reduction of the Regularization Error of the Method of Regularized Stokeslets for a Rigid Object Immersed in a Three-Dimensional Stokes Flow

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Communications in Computational Physics 2014年第1期15卷 126-152页

作者： Hoang-Ngan Nguyen ricardo Cortez Center for Computational Science Tulane University6823 St.Charles AveNew OrleansLouisiana70118USA.

We focus on the problem of evaluating the velocity field outside a solid object moving in an incompressible Stokes flow using the boundary integral *** points near the boundary,the integral is nearly singular,and accurate computation of the velocity is not *** way to overcome this problem is to regularize the integral *** method of regularized Stokeslet(MRS)is a systematic way to regularize the kernel in this *** a specific blob function which is widely used,the error of the MRS is only of first order with respect to the blob *** prove that this is the case for radial blob functions with decay propertyφ(r)=O(r−3−α)when r→∞for some constantα>*** then find a class of blob functions for which the leading local error term can be removed to get second and third order errors with respect to blob *** the addition of these terms might give a flow field that is not divergence free,we introduce a modification of these terms to make the divergence of the corrected flow field close to zero while keeping the desired ***,these dominant terms are explicitly expressed in terms of blob function and so the computation time is negligible.

关键词： Stokes flow regularized Stokeslet boundary integral equation nearly singular integral.

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Considerations for the Conduction and Interpretation of FAIRness Evaluations

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Data Intelligence 2020年第1期2卷 285-292页

作者： ricardo de Miranda Azevedo Michel Dumontier Institute of Data Science Maastricht UniversityUniversiteitssingel 60Maastricht 6229 ERThe Netherlands

The FAIR principles were received with broad acceptance in several scientific ***,there is still some degree of uncertainty on how they should be *** self-report questionnaires have been proposed to assess the implementation of the FAIR ***,the FAIRmetrics group released 14,general-purpose maturity for representing ***,these metrics were conducted as open-answer ***,these metrics have been implemented into a software that can automatically harvest metadata from metadata providers and generate a principle-specific FAIRness *** so many different approaches for FAIRness evaluations,we believe that further clarification on their limitations and advantages,as well as on their interpretation and interplay should be considered.

关键词： FAIR metrics FAIR principles FAIR data FAIRness Implementation Maturity indicators Scientific community

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Overview of boosting options for future downsized engines

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Science China(Technological Sciences) 2011年第2期54卷 318-331页

作者： ricardo Martinez-Botas APOSTOLOS Pesiridis YANG MingYang Imperial College London Exhibition Road London SW7 2AZ UK Tsinghua University Beijing 100084 China

Driven by a demand for better fuel economy and increasingly stringent emissions regulations over a wide range of customers and applications,engine manufacturers have turned towards engine downsizing as the most potent enabler to meet these *** boosting systems becoming ever more numerous as the technical solutions to complex boosting requirements of the internal combustion engine increase,it is time for an overview of available and under development boosting technologies and systems and for a discussion of their relevance to downsizing *** presented analysis shows that there are no standard solutions for all the different applications as the trends indicate a rising complexity to meet with the extreme boosting requirements predicted for the remainder of the *** trends include variable geometry,a shift from single to two(or more)stages,extensive actuation for bypassing exhaust flows,exhaust flow regulation and pulsating exhaust energy recovery, severe electrification and an extensive effort downstream from the turbine to capture waste heat after the principal turbo- charger/supercharger system.

关键词： engine downsizing boosting technologies boosting system

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Proteomic profile of seminal plasma in adolescents and adults with treated and untreated varicocele

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Asian Journal of Andrology 2016年第2期18卷 194-201,J0003页

作者： Mariana Camargo Paula Intasqui ricardo Pimenta Bertolla Department of Surgery Division of Urology Human Reproduction Section Sao Paulo Federal University R. Embau 231 04039-060 Sao Paulo Brazil Sao Paulo Hospital Sao Paulo Brazil.

Varicocele, the most important treatable cause of male infertility, is present in 15% of adult males, 35% of men with primary infertility, and 80% of men with secondary infertility. On the other hand, 80% of these men will not present infertility. Therefore, there is a need to differentiate a varicocele that is exerting a deleterious effect that is treatable from a ＂silent＂ varicocele. Despite the growing evidence of the cellular effects of varicocele, its underlying molecular mechanisms are still eluding. Proteomics has become a promising area to determine the reproductive biology of semen as well as to improve diagnosis of male infertility. This review aims to discuss the state-of-art in seminal plasma proteomics in patients with varicocele to discuss the challenges in undertaking these studies, as well as the future outlook derived from the growing body of evidence on the seminal proteome.

关键词： male infertility proteomics seminal plasma varicocele varicocelectomy

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Neuroprotective therapy for retinal neurodegenerative diseases by stem cell secretome

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Neural Regeneration Research 2021年第1期16卷 117-118页

作者： ricardo Usategui-Martín Ivan Fernandez-Bueno Instituto Universitario de Oftalmobiología Aplicada(IOBA) Retina GroupUniversidad de ValladolidValladolidSpain Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León Red Temática de Investigación Cooperativa en SaludOftaredInstituto de Salud Carlos IIIValladolidSpain

Retinal neurodegenerative diseases like agerelated macular degeneration,glaucoma,diabetic retinopathy or retinitis pigmentosa are the most frequent causes of incurable low vision and blindness *** had been estimated that the prevalence of these diseases varies between 1/750 and 1/5000 depending on the region,the level of consanguinity or ethnicity(Na et al.,2017).The functional and structural complexity of the retina makes it susceptible to multiple types of pathogenic damage.

关键词： diseases protective degenerative

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Constrained Fractional Variational Problems of Variable Order

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IEEE/CAA Journal of Automatica Sinica 2017年第1期4卷 80-88页

作者： Dina Tavares ricardo Almeida Delfim F.M.Torres Department of Mathematics Polytechnic Institute of Leiria Department of Mathematics University of Aveiro

Isoperimetric problems consist in minimizing or maximizing a cost functional subject to an integral *** this work, we present two fractional isoperimetric problems where the Lagrangian depends on a combined Caputo derivative of variable fractional order and we present a new variational problem subject to a holonomic constraint. We establish necessary optimality conditions in order to determine the minimizers of the fractional problems. The terminal point in the cost integral,as well as the terminal state, are considered to be free, and we obtain corresponding natural boundary conditions.

关键词： Fractional calculus fractional calculus of variations holonomic constraints isoperimetric constraints optimization variable fractional order

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Modeling considerations in seismic assessment of RC bridges using state-of-practice structural analysis software tools

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Frontiers of Structural and Civil Engineering 2018年第1期12卷 109-124页

作者： ricardo MONTEIRO Miguel ARAUJO Raimundo DELGADO Mario o MARQUES School of Advanced Studies IUSS Pavia Italy Department of Civil Engineering Faculty of Engineering University of Porto Portugal

The increasing awareness of the general society toward the seismic safety of structures has led to more restrictive performance requirements hence, many times, to the need of using new and more accurate methods of analysis of structures. Among these, nonlinear static procedures are becoming, evermore, the preferred choice of the majority of design codes, as an alternative to complete nonlinear time-history analysis for seismic design and assessment of structures. The many available software tools should therefore be evaluated and well understood, in order to be easily and soundly employed by the practitioners. The study presented herein intends to contribute to this need by providing further insight with respect to the use of commonly employed structural analysis software tools in nonlinear analysis of bridge structures. A comparison between different nonlinear modeling assumptions is presented, together with the comparison with real experimental results. Furthermore, alternative adaptive pushover procedures are proposed and applied to a case study bridge, based on a generic plastic hinge model. The adopted structural analysis program proved to be accurate, yielding reliable estimates, both in terms of local plastic hinge behavior and global structural behavior.

关键词： nonlinear analysis pushover RC bridges structural modelling software

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Expansion Planning for Renewable Integration in Power System of Regions with Very High Solar Irradiation

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Journal of Modern Power Systems and Clean Energy 2021年第3期9卷 485-494页

作者： Musfer Alraddadi Antonio J.Conejo ricardo M.Lima the Department of Electrical and Computer Engineering The Ohio State UniversityColumbusOH 43210USA the Department of Integrated Systems Engineering and the Department of Electrical and Computer Engineering The Ohio State UniversityColumbusOH 43210USA King Abdullah University of Science and Technology Thuwal 23955-6900Kingdom of Saudi Arabia

In this paper,we address the long-term generation and transmission expansion planning for power systems of regions with very high solar *** target the power systems that currently rely mainly on thermal generators and that aim to adopt high shares of renewable *** propose a stochastic programming model with expansion alternatives including transmission lines,solar power plants(photovoltaic and concentrated solar),wind farms,energy storage,and flexible combined cycle gas *** model represents the longterm uncertainty to characterize the demand growth,and the short-term uncertainty to characterize daily solar,wind,and demand *** use the Saudi Arabian power system to illustrate the functioning of the proposed model for several cases with different renewable integration *** results show that a strong dependence on solar power for high shares of renewable sources requires high generation capacity and storage to meet the night demand.

关键词： Generation and transmission expansion planning uncertainty solar power wind power

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A Novel Iterative Velocity Control Algorithm and Its FPGA Implementation Based on Trigonometric Function

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Chinese Journal of Electronics 2019年第2期28卷 237-245页

作者： WEN Quangang LIANG Yanchun Adriano Tavares ricardo Teixeira WU Chunguo Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education College of Computer Science and Technology Jilin University Zhuhai Laboratory of Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education Zhuhai College of Jilin University Department of Industrial Electronics University of Minho Campus de Azurm

The servo motor’s flexible acceleration/deceleration(acc/dec) control is an emerging research topic in the automation field. A velocity control algorithm based on trigonometric function is proposed in this *** required parameters, it transforms trigonometric calculations into elementary mathematical operations and calculates the velocity controlling values iteratively, which could avoid trigonometric calculation and reduce the computation time. Experimental results show that the proposed algorithm is suitable for implementation on field programmable gate arrays and achieves a flexible controlling, enhancing both the equipment’s stability and reliability. It is promising to significantly improve the high-speed computerized numerical control equipment’s controlling accuracy, without a huge hardware resource consumption.

关键词： Acceleration Velocity control Algorithm design and analysis Field programmable gate arrays Servomotors

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