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Epidemiological shift and geographical heterogeneity in the burden of leptospirosis in China

Infectious Diseases of Poverty 2018年第1期7卷 552-565页

作者： Pandji Wibawa Dhewantara Abdullah AMamun Wen-Yi Zhang Wen-Wu Yin Fan Ding Danhuai Guo Wenbiao Hu Federico Costa Albert Icksang Ko ricardo jsoares magalhaes Spatial Epidemiology Laboratory School of Veterinary ScienceThe University of QueenslandGattonQLD 4343Australia National Institute of Health Research and Development(NIHRD) Ministry of Health of IndonesiaUnit of Vector-borne Diseases ControlPangandaranWest Java 46396Indonesia Institute for Social Science Research The University of QueenslandIndooroopillyQLD 4068Australia Center for Disease Surveillance and Research Institute of Disease Control and Prevention of PLABeijing 100071People’s Republic of China Chinese Center for Disease Control and Prevention Beijing 102206People’s Republic of China Scientific Data Center Computer Network Information CenterChinese Academy of SciencesBeijing 100190People’s Republic of China School of Public Health and Social Work Queensland University of TechnologyKelvin GroveQLD 4059Australia Instituto Gonçalo Moniz Fundação Oswaldo CruzMinistério da SaúdeSalvadorBA 40296-710Brazil Instituto da Saúde Coletiva Federal University of Bahia(UFBA)SalvadorBA 40110-040Brazil Department of Epidemiology of Microbial Diseases Yale School of Public HealthNew HavenCT 06520USA Children’s Health and Environment Program Child Health Research CentreThe University of QueenslandSouth BrisbaneQLD 4101Australia

Background:Leptospirosis morbidity and mortality rates in China have decreased since the *** analyses of the spatiotemporal and demographic changes occurring in the last decade and its implication on estimates of disease burden are required to inform intervention *** this study,we quantified the epidemiological shift and geographical heterogeneity in the burden of leptospirosis during 2005-2015 in ***:We used reported leptospirosis case data from 1st January 2005 to 31st of December 2015 that routinely collected by the China Information System for Disease Control and Prevention(CISDCP)to analyze the epidemiological trend and estimate the burden in terms of disability-adjusted life-years(DALYs)over space,time,and demographical ***:A total of 7763 cases were reported during *** which,2403(31%)cases were the laboratoryconfirmed *** 2005,the notified incidence rate was gradually decreased(P0.05).During 2005-2015,we estimated a total of 10313 DALYs were lost due to leptospirosis comprising a total of 1804 years-lived with disability(YLDs)and 8509 years-life lost(YLLs).Males had the highest burden of disease(7149 DALYs)compared to females(3164 DALYs).The highest burden estimate was attributed to younger individuals aged 10-19 years who lived in southern provinces of *** 2005-2015,this age group contributed to approximately 3078 DALYs corresponding to 30%of the total DALYs lost in ***,our analysis indicated a declining trend in burden estimates(P<0.001)since 2005 and remained relatively low during *** burden estimates have been identified in the endemic regions where infections principally *** of the changes in DALY estimates were driven by changes in ***:In the last 11-years,the burden estimates of leptospirosis have shown a declining trend across the country;however,leptospirosis should not be neglected as it re

关键词： Leptospirosis Epidemiology Burden China DALY Spatiotemporal trends

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Epigenomic mediation after adverse childhood experiences:a systematic review and meta-analysis

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Forensic Sciences Research 2021年第2期6卷 103-114页

作者： Inês Neves ricardo Jorge Dinis-Oliveira Teresa magalhaes Department of Public Health and Forensic Sciences and Medical EducationFaculty of MedicineUniversity of PortoPortoPortugal IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies Department of SciencesUniversity Institute of Health Sciences(IUCS)CESPUCRLGandraPortugal UCIBIO REQUIMTELaboratory of ToxicologyDepartment of Biological SciencesFaculty of PharmacyUniversity of PortoPortoPortugal

Epigenetic mechanisms are potential mediators of the physiological response to abuse by altering the genetic predisposition of the cellular response to the environment,leading to changes in the regulation of multiple organ *** study was established to review the epigenetic mechanisms associated with childhood abuse as well as the long-term deter-minants that these epigenetic changes may have on future *** retrospectively ana-lysed the effect of exposure to adverse childhood experiences(ACEs,specifically those relating to childhood maltreatment)between the ages of 0 and 16years on the human epi-genome,as well as possible clinical *** meeting inclusion and exclusion crite-ria,36 articles were included in this systematic *** of these studies did not find a relationship between childhood maltreatment and DNA *** the remaining 28 studies,nine were genome-wide association studies,whereas the rest were candidate gene studies,mainly studying effects on neuroendocrine,serotoninergic and immunoregulatory ***-analysis of correlation coefficients from candidate gene studies estimated an association of childhood adversity and DNA methylation variation at r=0.291(P<0.0001),and meta-analysis of two epigenome-wide association studies(EWASs)identified 44 differen-tially methylated CpG *** conclusion,childhood maltreatment may mediate epigenetic mechanisms through DNA methylation,thereby affecting physiological responses and con-ferring a predisposition to an increased risk for psychopathology and forensic *** evidence for somatic illnesses is not yet available.

关键词： Forensic sciences forensic genetics child abuse DNA methylation epigenetics meta-analysis mental illness HPA axis

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Guidelines for Collection of Biological Samples for Clinical and Forensic Toxicological Analysis

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Forensic Sciences Research 2016年第1期1卷 42-51页

作者： ricardo Jorge Dinis-Oliveira Duarte Nuno Vieira Teresa magalhaes Department of Legal Medicine and Forensic Sciences Faculty of MedicineUniversity of PortoPortoPortugal Department of Sciences IINFACTS–Institute of Research and Advanced Training in Health Sciences and TechnologiesUniversity Institute of Health Sciences(IUCS)CESPUCRLGandraPortugal UCIBIO-REQUIMTE Laboratory of ToxicologyDepartment of Biological SciencesFaculty of PharmacyUniversity of PortoPortoPortugal Faculty of Medicine University of CoimbraPortoPortugal

This article aims to review general procedures for sampling of routinely collected as well as on alternative samples that may provide additional information regarding *** approaches may be applied whenever sample collection for clinical and forensic toxicology is required and should be considered as general guidelines that must be adapted to each specific *** is expected that this article will help toxicologists and other forensic experts to accomplish their mission,since the toxicological result is first influenced by the quality and quantity of the sample available for *** guidelines were approved by the European Council of Legal Medicine.

关键词： Forensic science forensic toxicology samples collection guidelines kits and labelling storage and preservation

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Application of Finite Elements Method for Structural Analysis in a Coffee Harvester

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Engineering（科研） 2014年第3期6卷 138-147页

作者： Evandro Pereira da Silva Fabio Moreira da Silva ricardo Rodrigues magalhaes Department of Engineering University of LavrasLavrasBrazil

Stress concentration and large displacements are usual problems in the components of the structure of agricultural machinery such harvesters coffee, and that finite element method (FEM) can be a tool to minimize its effects. The goal of this paper is to get results of stresses and displacements of a coffee harvester structure by using FEM for static simulation. The main parts of the coffee harvester analyzed were: engine frame, body right and left sides, front and rear end, main beam, coffee reservoir, wheels and fuel tank. Two different design concepts of a coffee harvester machine were analyzed (structure with rear wheels aligned and misaligned) and the results were compared. It was observed that the model with rear wheels misaligned showed maximum displacement lower than the model with rear wheels aligned. Although higher stress was found in the rear wheels misaligned, it was observed that average stresses for the misaligned wheels design were lower in most structural components analyzed. Based on FEM results, the coffee harvester machine with misaligned rear wheels was built and subjected to operational tests without showing any structural failure.

关键词： Finite Elements Method Stress Concentration Static Simulation Coffee Harvester

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Distribution of and associated factors for dengue burden in the state of Odisha,India during 2010-2016

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Infectious Diseases of Poverty 2019年第3期8卷 72-81页

作者： Subhashisa Swain Minakshi Bhatt Sanghamitra Pati ricardo J.Soares magalhaes Indian Institute of Public Heaith-Bhubaneswar Public Health Foundation of IndiaBhubaneswarOdishaIndia Regional Medical Research Center Indian Council of Medical ResearchBhubaneswarOdishaIndia School of Medicine University of NottinghamNottinghamUK UQ Spatial Epidemiology Laboratory School of Veterinary ScienceThe University of QueenslandGattonQLD 4343Australia UQ Child Health Research Centre Children’s Health and Environment ProgramThe University of QueenslandSouth BrisbaneQLD 4101Australia

This study is aimed to estimate the epidemiological burden of dengue in Odisha,India using the disability adjusted life year(DALY)methods and to explore the associated factors in the year *** the period of 2010-2016,27772 cases(68.4%male)were reported in the *** age(years)of male and female was 31.63 and 33.82,*** district wise disability adjusted life years(DALY)per 100000 people was higher in the year 2016(0.45)and mean DALY lost per person was highest in the year 2015(34.90 years).Adjusted regression model indicates,every unit increase in humidity and population density increases DALY by 1.05 and 1.02 units ***,unit change in sex ratio(females per 1000 males)and forest coverage increases the DALY by 0.98 *** results indicate geographical variation of DALY in Odisha,which is associated with population density,humidity and forest *** identified between standard incidence and DALY maps suggests,latter can be used to present disease burden more *** prevalence among young males suggests the need of strengthening the targeted prevention and control measures.

关键词： Disability adjusted life year Dengue Burden Distribution India

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Synthesis and Characterization of Poly(D,L-Lactide-co-Glycolide) Copolymer

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Journal of Biomaterials and Nanobiotechnology 2012年第2期3卷 208-225页

作者： Cynthia D’Avila Carvalho Erbetta ricardo José Alves Jarbas magalhaes Resende Roberto Fernando de Souza Freitas ricardo Geraldo de Sousa Polymer Science and Technology Laboratory Chemical Engineering DepartmentSchool of EngineeringFederal University of Minas GeraisBelo HorizonteBrazil Pharmaceutical Products Department Pharmacy SchoolFederal University of Minas GeraisBelo HorizonteBrazil Chemical Department Exact Sciences InstituteFederal University of Minas GeraisBelo HorizonteBrazil

The copolymer poly(D,L-lactide-co-glycolide) is one of the most interesting polymers for medical applications. This interest is justified by the fact that it is bioreabsorbable, biocompatible and non-toxic, while its degradation kinetics can be modified by the copolymerization ratio of the monomers. In this study, copolymers were synthesised at 175?C by opening the rings of the cyclic dimers of the D,L-lactide and glycolide monomers in the presence of stannous octoate initiator and lauryl alcohol co-initiator. The application of vacuum to the reaction medium, coupled with adequate stirring, is essential for obtaining good results. The following analytical techniques were used to characterise the synthesised copolymers: Differential Scanning Calorimetry (DSC), Thermogravimetry (TG), Nuclear Magnetic Resonance Spectroscopy (NMR) and Fourier Transform Infrared Spectroscopy (FTIR). Both the input monomers and the reaction products were analysed. Important characteristics, such as melting temperature, glass transition temperature, thermal stability, chemical composition and the ratio of the monomers in the synthesised copolymer, were obtained from these analyses. These results helped to infer the absence of residual monomers in the synthesised copolymers.

关键词： PLGA Synthesis Characterization DSC TG NMR FTIR

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Linear Stapler in Total Laryngectomy

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第6期3卷 354-358页

作者： Carolina Durao Sofia Decq Motta Ana Hebe ricardo Pacheco Pedro Montalvao Miguel magalhaes Otolaryngology Department Hospital Prof.Doutor Fernando FonsecaAmadoraPortugal Otolaryngology Department Portuguese Oncology Institute of LisbonFrancisco GentilPortugal

Introduction: Stapler application for pharyngeal closure after total laryngectomy allows rapid watertight closure. We intend to report the experience of the Portuguese Oncology Institute of Lisbon, Francisco Gentil (IPOLFG). Material and Methods: Retrospective study of patients submitted to total laryngectomy using linear stapler device treated in IPOLFG from 2005 to 2010. Results: 108 patients were studied. The majority of patients were male, aged from 60 to 69 years old, and had smoking and alcohol habits. The average length of hospital stay was 13.1 days. Post-operative complications occurred as follows: wound infection in 6.5%, cervical hematoma in 4.6% and pharyngocutaneous fistula in 11.1% of cases. Conclusions: The mechanical suture of the pharynx in total laryngectomy is a simple and quick method. It does not increase the incidence of post-operative complications. It seems to be a very safe method, as long as its limits regarding the location and extent of tumour are respected.

关键词： Pharyngeal Closure Total Laryngectomy Linear Stapler

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The Importance of the Three-Dimensional Image in the Early Diagnosis of Cementoblastoma

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Open Journal of Radiology 2012年第1期2卷 10-13页

作者： Tania Mara Pimenta Amaral Claudia Silami de magalhaes Allyson Nogueira ricardo Alves Mesquita Joao Batista de Freitas Maria Cassia Ferreira Aguiar Department of Oral Pathology and Surgery School of Dentistry Universidade Federal de Minas Gerais Belo Horizonte Brazil Department of Restorative Dentistry School of Dentistry Universidade Federal de Minas Gerais Belo Horizonte Brazil

The cementoblastoma is a very rare odontogenic neoplasm characterised by the formation of cementum-like tissue in connection with the root of a tooth. An 18-year-old boy was referred to the Clinic of Oral Pathology of the School of Dentistry, Universidade Federal de Minas Gerais, Brazil, complaining of an irradiating, itching pain from the region of the lower right first molar. He reported that the symptoms began three months prior, with a gradual increase in intensity during this period. The pain episodes were of short duration, with characteristics of toothache originating from the pulp. Upon intra-oral clinical examination, an open bite and slight increase in volume at the buccal alveolar region of the lower right first molar was observed. He also reported palpation and percussion pain symptoms in this region. Electrical, heat and cold pulp vitality tests were performed, and the tooth was vital. Periapical and panoramic radiographs showed radiolucent images with diffuse, poorly defined borders at the mesial root periapex extending to the interradicular region suggesting an inflammatory periapical lesion. In this early presentation, the three-dimensional image was fundamental to the final diagnosis of cementoblastoma.

关键词： Cementoblastoma Cone Beam CT Dental Radiography

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Atelosteogenesis Type 2/Diastrophic Dysplasia Phenotypic Spectrum: From Prenatal to Preimplantation Genetic Diagnosis

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Open Journal of Obstetrics and Gynecology 2014年第7期4卷 399-404页

作者： Eduardo P.Mattos José Antonio A.magalhaes Lauréane Mittaz-Crettol ricardo Azambuja Lilian Okada Denise P.Cavalcanti Juliana Cuzzi Mariangela Badalotti Rafaella Petracco Alvaro Petracco Lavinia Schüler-Faccini Maria Teresa V.Sanseverino Department of Genetics Federal University of Rio Grande do SulPorto AlegreBrazil Medical Genetics Service Hospital de Clínicas de Porto AlegrePorto AlegreBrazil School of Medicine Federal University of Rio Grande do SulPorto AlegreBrazil Division of Molecular Pediatrics Lausanne University HospitalLausanneSwitzerland Fertilitat Clínica de Reproducao Porto AlegreBrazil Skeletal Dysplasia Group Medical Genetics DepartmentFaculty of MedicineState University of CampinasCampinasBrazil Genesis Genetics Diagnosis Sao PauloBrazil

Atelosteogenesis type II (AO2) and diastrophic dysplasia (DTD) are two recessively inherited, severe skeletal dysplasias caused by mutations in the SLC26A2 gene. AO2 is an invariably lethal condition, while DTD patients may reach adult life, although both diseases have overlapping diagnostic features. Here we report a patient with an intermediate phenotype between AO2 and DTD and present the successful application of preimplantation genetic diagnosis (PGD) in this situation. Sequencing of SLC26A2 alleles in the infant identified two compound heterozygous mutations, ***178Ter and ***279Trp, of paternal and maternal origin, respectively. At request from the parents, PGD was developed by haplotype mapping of parental SLC26A2 alleles in eleven five-day embryos. Transference to the mother was attempted twice, finally resulting in pregnancy and delivery of a healthy baby. This exemplifies the utility of PGD for inherited lethal conditions with a significant risk of recurrence, and highlights the importance of accurate diagnosis of skeletal dysplasias with prenatal manifestation.

关键词： Atelosteogenesis Type 2 Diastrophic Dysplasia Preimplantation Genetic Diagnosis Prenatal Diagnosis Skeletal Dysplasia

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2012年宁夏H5N1亚型高致病性禽流感疫情回顾性调查

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中国动物检疫 2014年第9期31卷 57-61页

作者：刘华雷王晓亮 ricardo J Soares Magalh?es 李知新周小燕王静静赵云玲郑东霞 David Castellan 黄保续王志亮中国动物卫生与流行病学中心山东青岛266032 宁夏动物疾病预防控制中心宁夏银川750011 联合国粮食及农业组织跨界动物疫病应急中心中国办公室北京100600 联合国粮食及农业组织亚太区域办公室跨界动物疫病应急中心

[目的 ]2012年4月,宁夏当地报告蛋鸡发生疑似H5N1亚型高致病性禽流感(HPAI)疫情。为解本次疫情的流行病学特征、分析导致疫情发生的风险因素,在疫情发生后我们与当地兽医有关部门联合开展了回顾性暴发调查。[方法 ]以发生疫情的固原市... 详细信息

[目的 ]2012年4月,宁夏当地报告蛋鸡发生疑似H5N1亚型高致病性禽流感(HPAI)疫情。为解本次疫情的流行病学特征、分析导致疫情发生的风险因素,在疫情发生后我们与当地兽医有关部门联合开展了回顾性暴发调查。[方法 ]以发生疫情的固原市头营镇所有的87个蛋鸡养殖场作为研究对象,采用问卷调查和抽样检测相结合的方式。对发病场采集病鸡的病料样品采用反转录-聚合酶链式反应(RT-PCR)或病毒分离来检测H5N1亚型禽流感病毒。采用多元回顾分析对疫情发生的风险因素进行研究,通过半方差图分析来证实发病场的聚集性分布。[结果 ]调查表明:H5N1疫情在头营镇分布广泛,其中有45户养殖场H5N1病毒RT-PCR呈阳性,其中4个养殖场病毒分离呈阳性。多变量模型分析表明:对废弃物不进行无害化处理(调整后的比值比OR为2.7,95%置信区间=1.20-8.30)和在疫情发生前一个月内有外来人员来访(调整后的比值比=5.5,95%置信区间=1.97-15.64)等两个因素可能与本次高致病性禽流感疫情有关。[结论 ]因此,频繁的人员流动和没有对废弃物进行无害化处理可增加感染发生的风险。为预防H5N1亚型HPAI感染的发生,应加强生物安全管理措施,包括限制外来人员来访和强化废弃物无害化处理等。

关键词：高致病性禽流感 H5N1 暴发调查

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