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MicroRNAs expression dynamics reveal post-transcriptional mechanisms regulating seed development in Phaseolus vulgaris L.

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Horticulture Research 2021年第1期8卷 195-211页

作者： jose ricardo Parreira Michela Cappuccio Alma Balestrazzi Pedro Fevereiro Susana de Sousa Araujo Instituto de Tecnologia Quimica e Biologica Antonio Xavier Universidade Nova de LisboaAvenida da Republica2780-157 OeirasPortugal Department of Biology and Biotechnology“L.Spallanzani” University of Paviavia Ferrata 927100 PaviaItaly InnovPlantProtect Collaborative Laboratory Estrada de Gil Vaz7351-901 ElvasPortugal Present address:Association BLC3-Technology and Innovation Campus Centre Bio R&D UnitRua Nossa Senhora da Conceicao 2Lagares da Beira3405-155 Oliveira do HospitalPortugal

The knowledge on post-transcriptional regulation mechanisms implicated in seed development(SD)is still limited,particularly in one of the most consumed grain legumes,Phaseolus vulgaris *** explore for the first time the miRNA expression dynamics in *** developing ***-two known and 39 new miRNAs were found expressed in *** developing *** of the miRNAs identified were more abundant at 10 and 40 days after anthesis,suggesting that late embryogenesis/early filling and desiccation were SD stages in which miRNA action is more *** analysis and target prediction identified targets for 77 expressed *** several known miRNAs were predicted to target HD-ZIP,ARF,SPL,and NF-Y transcription factors families,most of the predicted targets for new miRNAs encode for functional ***-targets expression profiles evidenced that these miRNAs could tune distinct seed developmental *** more accumulated at early SD stages were implicated in regulating the end of embryogenesis,postponing the seed maturation program,storage compound synthesis and *** more accumulated at late SD stages could be implicated in seed quiescence,desiccation tolerance,and longevity with still uncovered roles in *** miRNAs herein described represent novel *** resources with potential application in future biotechnological approaches to modulate the expression of genes implicated in legume seed traits with impact in horticultural production systems.

关键词： mechanisms dynamics regulating

New environmental factors related to diabetes risk in humans:Emerging bisphenols used in synthesis of plastics

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World journal of Diabetes 2023年第8期14卷 1301-1313页

作者： Rafael Moreno-Gómez-Toledano María Delgado-Marín Alberto Cook-Calvete Claudia González-Cucharero Nunzio Alcharani Beatriz jiménez-Guirado Ignacio Hernandez Rafael Ramirez-Carracedo Laura Tesoro Laura Botana Sandra Sánchez-esteban javier Diez-Mata jose Luis Zamorano ricardo j.Bosch Carlos Zaragoza Marta Saura Universidad de Alcalá Department of Biological Systems/PhysiologyAlcaláde Henares 28871Spain Cardiology Department University Hospital Ramón y CajalMadrid 28034Spain Laboratory of Cardiovascular Pathophysiology Joint Translational Research UnitUniversity Francisco de Vitoria School of MedicineMadrid 28034Spain Instituto Ramón y Cajal de Investigación Sanitaria-IRYCIS Madrid 28034Spain

BACKGROUND Diabetes mellitus(DM)is one of the largest global health emergencies of the 21st *** recent years,its connection with environmental pollutants,such as bisphenol A(BPA),has been demonstrated;consequently,new structurally similar molecules are used to replace BPA in the plastics industry(BPS,BPF and BPAF).AIM To carry out a systematic review to allow coherent evaluation of the state of the ***,a meta-analysis was performed to unify the existing quantitative *** Firstly,a systematic review was carried out,using the terms“(bisphenol)AND(Diabetes OR Hyperglycemia)”,to maximize the number of ***,three authors analyzed the set of ***,a meta-analysis was performed for each BP,using RevMan *** addition,funnel plots were developed to study publication *** The systematic analysis of the literature revealed 13 recent articles(2017–2023)related to the study *** qualitative analysis showed interesting data linking diabetes to the three most widely used substitute BPs in the industry:BPS,BPF and ***,the meta-analysis determined a positive relationship with BPS,BPF and BPAF,which was only statistically significant with *** There is a need to apply the precautionary principle,regulating the use of new ***,replacing BPA with BPS,BPF or BPAF is unlikely to protect the population from potential health risks,such as DM.

关键词： Bisphenol S Bisphenol F Bisphenol AF Diabetes mellitus Systematic review Meta-analysis

Changes in Mangrove Epifaunal Assemblages Caused by Forest Logging during Hunting of the Neotropical Cormorant (<i>Phalacrocorax brasilianus</i>) on the Colombian Pacific Coast

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Open journal of Marine Science 2012年第4期2卷 150-156页

作者： Carlos Andrés Satizabal R. jaime ricardo Cantera Kintz Paula Cristina Sierra-Correa Marine and Coastal Research Institute (INVEMAR) Cerro Punta Betín Santa Marta Colombia Universidad del Valle Ecology of Estuaries and Mangroves Research Group (ECOMANGLARES) Cali Colombia

Although the importance of mangroves is clearly recognized around the world, these ecosystems are being strongly altered by the logging of their forests for multiple purposes. The Colombian Pacific coast is not an exception to this situation, and apart from the traditional logging of wood, the hunting of the Neotropical Cormorant or Pato-cuervo (Phalacrocorax brasilianus), an activity largely unknown but widespread in the region, is also causing the logging of great extensions of mangroves. The aim of this research was to determine if the assemblages of mollusks and crustaceans of these mangroves are being affected by the hunting of the cormorant. To answer this question, quantitative samplings were realized in four transects in logged and unlogged mangrove areas on the southwestern coast of the Colombian Pacific and diversity, equitability and dominance of macrofaunal assemblages of mangroves were calculated. The data show that although significant differences between diversity indices were not found, there were important differences in equitability (total j’: 0.55 in T1, 0.77 in T2, 0.46 in T3 and 0.65 in T4), specific dominance, and composition of species (T1: 11 species, T2: 13, T3: 9 and T4: 11) between logged and unlogged areas. Based on these results, although forest structure and interstitial salinity were different among transects, we conclude that the present practice of exploitation of the Neotropical Cormorant is affecting the epifaunal populations of mangroves, causing changes in the composition and dominance of species.

关键词： Mangrove Mollusks Crustaceans Neotropical Cormorant Colombian Pacific

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地面坡度对喷灌均匀度的影响

灌溉排水 1993年第1期12卷 52-55页

作者： A.A.soares L.S.Willardson j.Keller 崔天怀陕西省地下水工作队

地面坡度对喷灌的均匀度影响很大。作者通过野外试验对此作了定量研究,提出了一个不同地面坡度和竖管倾斜度时模拟喷灌水量的模型。虽然该模型是针对无风情况下坡度为0°时的单喷头而提出的,但是实验表明它同样适用于坡地。另外作者还... 详细信息

地面坡度对喷灌的均匀度影响很大。作者通过野外试验对此作了定量研究,提出了一个不同地面坡度和竖管倾斜度时模拟喷灌水量的模型。虽然该模型是针对无风情况下坡度为0°时的单喷头而提出的,但是实验表明它同样适用于坡地。另外作者还对竖管倾斜度、喷射仰角、地面坡度对喷灌水量分布均匀度的影响作了研究,重点探讨了两种喷灌布置形式(其水量分布曲线类似于克里斯琴森的B型和E型)的情况。结果表明,竖管与地面保持垂直时,可以获得最佳喷洒均匀度,且对土壤侵蚀最小。对陡坡地,喷射仰角较大时,喷灌均匀度较好,但同时受风的影响也增大。

关键词：喷灌均匀度地面坡度

The Phytochemical Profile and Photoprotective Potential of Bark and Leaves of Erythrina velutina Willd.—A Medicinal Species from the Caatinga Region of Brazil

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journal of Biosciences and Medicines 2023年第12期11卷 325-342页

作者： Bruno de Almeida Andrade Allan jonathan Chernichiarro Corrêa Ana Klarissa soares Gomes Patrícia Maria da Silva Neri Cruz Aline Michaele de Saint-George Albuquerque Cheron Valerium Thijan Nobre de Almeidae Castro Décio Henrique Araújo Salvadôr de Mello Cláudia Sampaio de Andrade Lima ricardo Yara Elba Lúcia Cavalcanti de Amorim Department of Pharmaceutical Sciences Federal University of Pernambuco Recife Brazil Pharmacy Course Mauricio de Nassau University Center Recife Brazil Department of Biophysics Federal University of Pernambuco Recife Brazil Departament of Biomedical Engineering Federal University of Pernambuco Recife Brazil

The use of medicinal plants as therapeutic and economic resources has been on the rise in recent years. In Brazil, however, increasing doubt is being cast on the quality of these products, owing to the prevalence of adulteration and fraud. Solar radiation can cause serious damage to human skin, as a result, mostly, of ultraviolet light, which is a cause of skin cancer. Photoprotective substances are capable of absorbing, reflecting, or refracting ultraviolet radiation and thus protecting skin from exposure to sunlight. The present study aimed to characterize samples and examine the phytochemical profile and photoprotective potential of bark and leaves of Erythrina velutina Willd. The samples underwent five extraction methods using 80% ethanol. The phenolic content was measured using spectrophotometry. Antioxidant activity was examined using the DPPH and the photoprotective properties of the plant extracts were assessed using the method developed by Mansur. There was a quantitative difference in some groups of metabolites, with higher levels of tannin in the bark and of flavonoids in the leaves. The latter showed greater DPPH free radical scavenging capacity than the bark, although higher levels of SPF were obtained from the bark, with no statistically significant differences between methods. The results indicate that Erythrina velutina Willd. has potential as a photoprotector.

关键词： Phytochemical Caatinga Phytochemistry Sun Protection Factor (SPF)

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平面心肌灌注成像评价急性胸痛患者的价值

世界核心医学期刊文摘（心脏病学分册） 2005年第5期1卷 44-45页

作者： Yamada A.T. soares jr. j. Meneghetti j.C. 郝广华 Heart Institute (InCor) Univ. of S. Paulo Medical School Av. Dr. Eneas Carvalho A. S. ao Paulo Brazil

Background: Rest single-photon emission computed tomographic(SPECT) perfusion imaging identifies acute myocardial ischemia in patients with chest pain in the emergency department; however, the costs are high and radioisotopic services are usually not available 24 h a day. Planar imaging through a portable gamma camera may be useful in this setting. However, planar imaging might be associated with less predictive values in comparison with a gated SPECT imaging. We sought to evaluate rest planar myocardial perfusion imaging for evaluation and triage of patients with suspected acute cardiac ischemia. Methods: Patients within 6 h of chest pain onset and nondiagnostic electrocardiograms(ECGs) underwent planar myocardial perfusion imaging. Studies showing perfusion defects were considered suggestive of acute coronary syndromes. The results of planar scintigraphy were compared with the clinical diagnosis and outcomes. All patients were followed up and monitored for the occurrence of major cardiac events 120 days after hospital discharge. Results: 71 patients underwent scintigraphy. Twenty-one(30%) patients had acute coronary syndromes, 15(21%) had major cardiac events(8 had myocardial infarction and 7 underwent myocardial revascularization). Planar scintigraphy demonstrated perfusion defects in 21 patients, 16 (76%) patients with acute coronary syndromes, 12(80%) patients who had major cardiac events and in 7(88%) patients with myocardial infarction. The negative predictive value of planar scintigraphy was 90%for diagnosis of acute coronary syndromes and 94%for detecting major cardiac events. Conclusion: Early planar myocardial perfusion imaging allowed rapid and accurate risk stratification of emergency departments patients with possible myocardial ischemia and nondiagnostic ECGs.

关键词：急性胸痛灌注成像灌注缺损心脏事件急性心肌缺血急诊科阴性预测值门控检查费用风险度

蜂胶对致癌物诱导金仓鼠舌黏膜反应的影响(英文)

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中西医结合学报 2012年第12期10卷 1443-1450页

作者： ricardo Lopes-Rocha Poliana Ribeiro Barroso Alexandre soares Santos Nádia Lages Lima Fernanda Oliveira Ferreira Flaviana Dornela Verli Department of Dentistry Federal University of Vales do Jequitinhonha e Mucuri Department of Pharmacy Federal University of Vales do Jequitinhonha e Mucuri Department of Basic Sciences Federal University of Vales do Jequitinhonha e Mucuri

目的:研究9,10-二甲基-1,2-苯并蒽(9,10-dimethyl-1,2-benzanthracene,DMBA)以及蜂胶乙醇提取物(ethanol extract of propolis,EPE)对金仓鼠舌黏膜组织反应的影响。方法:60只金仓鼠按实验周期被随机分为两大组,每组再被分为EPE组、蜂胶水提取物(aqueous propolis extract,APE)组和DMBA组(n=20)。测定实验鼠舌黏膜的临床和组织学改变,包括面积、容积的临床改变,鳞状上皮组织的结构和细胞学变化,并测量鳞状细胞癌组织学上的改变区域。结果:各组在第13周和第20周所测定的实验结果不存在显著差异。在第13周,EPE组出现1例单一鳞状细胞癌;在第20周,EPE组的鳞状细胞癌的发生率最高,但与其他组比较差异无统计学意义。结论:蜂胶乙醇提取物对舌黏膜组织的影响以及其致癌机制还有待研究。

关键词：蜂胶致癌性试验 9,10-二甲基-1,2-苯并蒽化学预防金仓鼠

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家,j次方

缤纷 2011年第8期 72-79页

作者： ricardo espinosa 菲比 BBLAB

"我要一座大房子,有很大的落地窗户,阳光洒在地板上,也温暖了我的被子……"位于西班牙瓦伦西亚鲁卡福尔特的j house超额满足了这个基本要求。

关键词：西班牙风格建筑外立面空间层次西亚拓扑阳光建筑学院设计师空间感基本要求

Gold Nanoparticle and Berberine Entrapped into Hydrogel Matrix as Drug Delivery System

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journal of Biomaterials and Nanobiotechnology 2015年第1期6卷 53-63页

作者： Camila Rufino Souza Henrique R. Oliveira Wagner M. Pinheiro Lubhandwa S. Biswaro ricardo B. Azevedo Anderson j. Gomes Claure N. Lunardi Laboratory of Nanobiotechnology Faculty of Ceilandia University of Brasilia Brasilia Brazil Institute of Biological Sciences University of Brasilia Brasilia Brazil

In this study the novel hydrogel loaded with gold nanoparticle (AuNP) enhanced the berberine (BS) release when compared with other formulations of hydrogel. Hydrogels are hydrophilic polymer networks having the capacity to absorb water, ranging from about twenty to thousand times their dry weight. BS is a natural product, a quaternary ammonium salt from the group of isoquinoline alkaloids found in medicinal plants as Berberis Vulgaris. BS has some activity against dysentery, hypertension, inflammation, and liver disease in China and japan. In this work, BS was used as a model drug to study its association with different types of hydrogel composites of polyvinyl alcohol (BS-PVA 10%);gellan gum (BS-GG 2%), gellan gum-PVA crosslinked with cysteine (cys) (BSGG2%PVA2%cys) and gellan gum-PVA cosslinked with cysteine associated with gold nanoparticles (AuNP-BSGG2%PVA2%cys). Several parameters such as fraction of retained water (Wf), hydration percentage (%H), Swelling (DSw) and time course profile (t = 100%) (TC) were evaluated for all preparations. The results showed that the AuNP-BS-GG2%PVA2%cys was able to retain more water and swelling than the other preparations. The time course of release of the BS to the medium was greater for AuNP-BS-GG2%PVA2%cys making it a candidate to drug delivery studies in biological assays. Also Scanning Electron Microscopy (SEM) images of the surface of these hydrogel were performed. Furthermore, crosslink of the resulting hydrogels were investigated by Fourier Transform Infrared Spectroscopy (FTIR) and differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Thus, briefly, the aim of this work was to study three composition of hydrogel loaded with BS and its composition in relation to addition to AuNP and evaluate its profile for further drug delivery application using the Surface Plasmonic Resonance (SPR) as a tool improving the drug release in the new hydrogel.

关键词： Hydrogel Berberine Drug Delivery AuNPs