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Neural Regeneration Research 2019年第5期14卷 769-770页

作者： Azra Fatima ricardo gutiérrez-garcia David Vilchez Institute for Genetics and Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases(CECAD) University of Cologne

Adult somatic cells such as skin or blood cells from either health donors or patients can be reprogrammed into induced pluripotent stem cells(iPSCs).Given their unlimited self-renewal and differentiation capacities,iPSCs are an invaluable resource to generate terminally differentiated ***,iPSCs can facilitate the study of human diseases and drug screening,holding great promise for regenerative *** significant advantage of iPSC disease-modeling is that normal and mutant proteins are expressed at endogenous *** addition,subtle phenotypes and the effects of genetic background variations can be assessed by comparison between iPSC lines obtained from different patients and healthy donors as well as isogenic lines,in which disease-related mutations are corrected.

关键词： Adult somatic cells skin or blood cells Huntington’s disease patients

Validity of automated refraction after segmented refractive multifocal intraocular lens implantation

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1728-1733页

作者： Cesar Albarran-Diego Gonzalo Munoz Stephanie Rohrweck Satiago garcia-Lazaro Jose ricardo Albero Clinica Baviera Castellon Castellon de la Plana 12001 Spain Optics Optometry and Vision Sciences Department University of Valencia Burjassot 46100 Spain

AIM： To evaluate the clinical utility of automated refraction（AR） and keratometry（KR） compared with subjective or manifest refraction（MR） after cataract or refractive lens exchange surgery with implantation of Lentis Mplus X（Oculentis GmbH） refractive multifocal intraocular lens（IOL）.METHODS： Eighty-six eyes implanted with the Lentis Mplus X multifocal IOL were included. MR was performed in all patients followed by three consecutive AR measurements using the Topcon KR-8000 autorefractor. Assessment of repeatability of consecutive AR before and after dilation with phenylephrine 10%, and comparison of the AR and KR with MR using vector analysis were performed at 3 mo ***： Analysis showed excellent repeatability of the AR measurements. Linear regression of AR versus MR showed good correlation for sphere and spherical equivalent, whereas the correlation for astigmatism was low. The mean difference AR-MR was-1.28±0.29 diopters（D） for sphere. Astigmatism showed better correlation between KR and MR. CONCLUSION： We suggest AR sphere plus 1.25 D and the KR cylinder as the starting point for MR in eyes with a Lentis Mplus X multifocal IOL. If AR measurements are equal to MR, decentration of the IOL should be suspected.

关键词： autorefraction vector analysis agreement multifocal intraocular lenses

Neuroprotective measures in children with traumatic brain injury

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World Journal of Critical Care Medicine 2016年第1期5卷 36-46页

作者： Shruti Agrawal ricardo garcia Branco Department of Paediatric Intensive Care Cambridge University Hospitals NHS Foundation Trust

Traumatic brain injury(TBI) is a major cause of death and disability in children. Severe TBI is a leading cause of death and often leads to life changing disabilities in survivors. The modern management of severe TBI in children on intensivecare unit focuses on preventing secondary brain injury to improve outcome. Standard neuroprotective measures are based on management of intracranial pressure(ICP) and cerebral perfusion pressure(CPP) to optimize the cerebral blood flow and oxygenation, with the intention to avoid and minimise secondary brain injury. In this article, we review the current trends in management of severe TBI in children, detailing the general and specific measures followed to achieve the desired ICP and CPP goals. We discuss the often limited evidence for these therapeutic interventions in children, extrapolation of data from adults, and current recommendation from paediatric guidelines. We also review the recent advances in understanding the intracranial physiology and neuroprotective therapies, the current research focus on advanced and multi-modal neuromonitoring, and potential new therapeutic and prognostic targets.

关键词： Paediatrics Intracranial pressure Traumatic brain injury Neuroprotection Paediatric critical care Advanced neuromonitoring

Pneumo-CT assessing response to neoadjuvant therapy in esophageal cancer: Imaging-pathological correlation

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World Journal of Gastrointestinal Oncology 2013年第12期5卷 222-229页

作者： Marina Ulla Ernestina Gentile Ezequiel Levy Yeyati Maria L Diez Demetrio Cavadas ricardo D garcia-Monaco Pablo R Ros Department of Radiology Hospital Italiano de Buenos Aires

Pneumo-computed tomography (PnCT) is a technique primarily developed and used to study stenotic lesions of the esophagus, gastroesophageal junction and stom-ach for pre-surgical planning. It helps to define both upper and lower borders of neoplasms located in the aforementioned areas. It achieves maximum lumen distension with CO2 highlighting thickened areas of the esophageal wall, thus allowing an accurate quantifica-tion of their extents. Although there are other alterna-tives for distension (oral contrast agents, water and ef-fervescent granules), they may be suboptimal. Patients with locally advanced esophageal cancer have a dismal prognosis despite surgical resection. Therefore, neo-adjuvant treatment strategies using radiation therapy and chemotherapy were developed to improve sur-vival. Neoadjuvant therapy improves esophageal tumor prognosis in a substantial proportion of patients, and the use of imaging techniques is mandatory to detect their response. PnCT combined with virtual endoscopy and multiplanar reconstruction enhances morphologic details in esophageal cancer, and thus would allow animproved assessment of response to neoadjuvant treat-ment. Therefore, more information could be provided to assess the efficacy of pre-surgical treatment. We de-scribe the potential use of PnCT to assess the response to neoadjuvant therapy in esophageal cancer with an imaging pathologic correlation.

关键词： Esophagus Cancer 64-multidetector com-puted tomography Neoadjuvant treatment Assess-ment response

Minimally invasive surgery and transsulcal parafascicular approach in the evacuation of intracerebral haemorrhage

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Stroke & Vascular Neurology 2020年第1期5卷 40-49页

作者： Lina Marenco-Hillembrand Paola Suarez-Meade Henry Ruiz garcia ricardo Murguia-Fuentes Erik H Middlebrooks Lindsey Kangas W David Freeman Kaisorn L Chaichana Neurological Surgery Mayo ClinicJacksonvilleFloridaUSA Radiology Neurological SurgeryMayo ClinicJacksonvilleFloridaUSA

Intracerebral haemorrhage(ICH)describes haemorrhage into the brain parenchyma that may result in a decline of the patient’s neurological *** is a common cause of morbidity and mortality *** surgical treatment for ICH has remained controversial as clinical trials have failed to demonstrate substantial improvement in patient outcome and ***,promising mechanical and pharmacological minimally invasive surgery(MIS)techniques for the treatment of ICH have been *** was designed with the objective of reducing morbidity due to complications of surgical *** MIS includes the use of tubular retractors and small diameter instruments for ICH *** methods consist of catheter placement inside the haematoma cavity for the passive drainage of the haematoma over the course of several *** of the most favourable approaches for MIS is the use of natural corridors for reaching the lesion,such as the transsulcal parafascicular *** approach provides an anatomical dissection of the subjacent white matter tracts,causing the least amount of damage while evacuating the haematoma.A detailed description of the currently known MIS techniques and devices is presented in this *** attention is given to the transsulcal parafascicular approach,which has particular benefits to provide a less traumatic MIS with promising overall patient outcome.

关键词： approach surgery cavity

Analytical/Numerical Modelling of Two Parallel Robots as Laser Calibration Instruments Controlled by Classical/Intelligent Schemes

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Journal of Control Science and Engineering 2015年第2期3卷 64-78页

作者： ricardo Zavala-Yoe ricardo A. Ramirez-Mendoza Daniel Chaparro-Altamirano JavierRuiz-garcia Tecnologico de Monterrey Escuela de lngenieriay Ciencias Calle del Puente 222 Ejidos de Huipulco 14380 Mexico City Computer Science Department Columbia University New York USA

Industrial metrology deals with measurements in production environment. It concerns calibration procedures as well as control of measurement processes. Measuring devices have been evolving from manual theodolites, electronic theodolites, robotic total stations, to a relatively new kind of laser-based systems known as laser trackers. Laser trackers are 3D coordinate measuring devices that accurately measure large （and relatively distant） objects by computing spatial coordinates of optical targets held against those objects. In addition, laser trackers are used to align truthfully large mechanical parts. However, such aligning can be done in moving parts, for instance during robot calibration in a welding line. In this case, serial robots are controlled in order to keep a prescribed trajectory to accomplish its task properly. Nevertheless, in spite of a good control algorithm design, as time goes by, deviations appear and a calibration process is necessary. It is well known that laser tracker systems are produced by very well established enterprises but their laser products may result expensive for some （small） industries. We offer two parallel robot-based laser tracker systems models whose implementation would result cheaper than sophisticated laser devices and takes advantage of the parallel robot bondages as accuracy and high payload. The types of parallel robots evaluated were 3-SPS-1-S and 6-PUS. Modelling of the parallel robots was done by analytical and numerical techniques. The latter includes classical and artificial intelligence-based algorithms. The control performance was evaluated between classical and intelligent controllers.

关键词： Parallel robots laser calibration classical and al-controllers.

Physico-Chemical Features and Catalytic Activity of ZrO2-MoO3

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材料科学与工程（中英文版） 2010年第9期4卷 1-9页

作者： Hernandez Juan garcia Luz Cortez Luz garcia ricardo Handy Brent Cairdenas Maria Cueto Arturo Instituto Politecnico Nacional Escuela Superior de Ingenieria Textil Av. lnstituto Politecnico Nacional S/N Edificio # 8 Col. Linda Vista Mexico D.F. 07738. Mexico Instituto Tecnologico de Cd. Madero Division de Estudios de Posgrado e Investigacion Cd. Madero Tam. 89440 Mexico CIEP Facultad de Ciencias Qulmicas Universidad Aut6noma de San Luis Potosi San Luis Potosl 78210 Mdxico Universidad Autonoma Metropolitana-Azcapotzalco Av. San Pablo #180 Col. Reynosa Tamaulipas Delegacin Azcapotzalco Mexico D.F. 02200 oMexico

Endovascular treatment of paravisceral mycotic aneurysm: Chimmeny endovascular sealing the end of de road

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World Journal of Cardiology 2017年第7期9卷 629-633页

作者： Martin Rabellino Pedro N Moltini Vanesa G Di Caro Jose G Chas ricardo Marenchino ricardo D garcia-Monaco Department of Interventional Radiology Hospital Italiano de Buenos Aires Department of Cardio-vascular Surgery Hospital Italiano de Buenos Aires

Open surgery is the elective treatment for mycotic aneurysms of the aorta. This surgery consists of resection of the aneurysm, debridement and revascularization with an in situ or extra-anatomic bypass. Even when surgery has been successful, the morbimortality is raised and the endovascular treatment has become an alternative for specific patients. When mycotic aneurysms involved the visceral arteries, more complex techniques are necessary such as fenestrated endovascular aortic repair or chimmeny endovascular aortic repair and the most frequent complications of this are endoleaks and oclussion the visceral arteries. We present a case of a pacient with a paravisceral abdominal mycotic aneurysms that was result with 2 chimney technique(in the right renal and superior mesenteric arteries) and a single Nellix EVAS(Endologix, Irvine, Calif) of 12 cm long without evidence of endoleaks in the follow-up.

关键词： Mycototic aneurysms Edovascular repair Aorta Endoleaks Para visceral aneurysms

Fine mapping of genomic regions associated with female fertility in Nellore beef cattle based on sequence variants from segregating sires

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Journal of Animal Science and Biotechnology 2020年第2期11卷 303-315页

作者： Gerson A.Oliveira Júnior Daniel J.A.Santos Aline S.M.Cesar Solomon A.Boison ricardo V.Ventura Bruno C.Perez JoséF.garcia JoséBento S.Ferraz Dorian J.Garrick Department of Veterinary Medicine University of São Paulo(USP)Faculty of Animal Science and Food EngineerPirassunungaSPBrazil Department of Animal Bioscience Center for Genetic Improvement of LivestockUniversity of GuelphGuelphONCanada Department of Animal and Avian Sciences University of MarylandCollege ParkMarylandUSA Department of Animal Science University of São Paulo(USP)PiracicabaSPBrazil Department of Sustainable Agricultural Systems University of Natural Resources and Life SciencesViennaAustria Department of Animal Nutrition and Production School of Veterinary Medicine and Animal ScienceUniversity of São Paulo(USP)PirassunungaBrazil Department of Support Production and Animal HealthSchool of Veterinary MedicineSão Paulo State University(Unesp)AraçatubaSPBrazil School of Agriculture Massey UniversityRuakura Ag CentreHamiltonNew Zealand

Background:Impaired fertility in cattle limits the efficiency of livestock production *** the genetic architecture of fertility traits would facilitate their improvement by *** this study,we characterized SNP chip haplotypes at QTL blocks then used whole-genome sequencing to fine map genomic regions associated with reproduction in a population of Nellore(Bos indicus)***:The dataset comprised of 1337 heifers genotyped using a GeneSeek®Genomic Profiler panel(74677 SNPs),representing the daughters from 78 *** performing marker quality control,64800 SNPs were *** carried by each sire at six previously identified QTL on BTAs 5,14 and 18 for heifer pregnancy and BTAs 8,11 and 22 for antral follicle count were constructed using findhap *** significance of the contrasts between the effects of every two paternally-inherited haplotype alleles were used to identify sires that were heterozygous at each ***-genome sequencing data localized to the haplotypes from six sires and 20 other ancestors were used to identify sequence variants that were concordant with the haplotype *** analyses were applied to these variants using KEGG and MeSH ***:A total of six(BTA 5),six(BTA 14)and five(BTA 18)sires were heterozygous for heifer pregnancy QTL whereas six(BTA 8),fourteen(BTA 11),and five(BTA 22)sires were heterozygous for number of antral follicles’*** to inadequate representation of many haplotype alleles in the sequenced animals,fine mapping analysis could only be reliably performed for the QTL on BTA 5 and 14,which had 641 and 3733 concordant candidate sequence variants,*** KEGG“Circadian rhythm”and“Neurotrophin signaling pathway”were significantly associated with the genes in the QTL on BTA 5 whereas 32 MeSH terms were associated with the QTL on BTA *** the concordant sequence variants,0.2%and 0.3%were classified as missense variants for BTAs 5 and 14,respe

关键词： Antral follicles Causal variants Haplotype Heifer pregnancy WGS

Distribution and Relation of Primes with Tesla Numbers 3, 6, and 9

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1021-1027页

作者： Javier Mendoza-Navarrete Huetzin Perez Ismael Ojeda Victor Verdugo Gabriel Luna Sandoval ricardo Jimenez garcia Jaime Alvarez Departametno de Matemá ticas CBTis 256 DGETI Cabo San Lucas M&#233xico DCI Departamento de Fisica Mé dica Universidad de Guanajuato Leon M&#233xico Divisió n de Ingenieria en Sistemas Computacionales Tecnol&#243gico Nacional de M&#233xico ITES Los Cabos Cabo San Lucas M&#233xico Departamento de Ingenieria Industrial en Manufactura Universidad Estatal de Sonora Navojoa M&#233xico Departamento de Elé ctrica-Electr&#243nica Tecnol&#243gico Nacional de M&#233xico Campus Mexicali Mexicali M&#233xico Guanajuato M&#233xico

This work presents a different approach to twin primes, an approach from the perspective of the Tesla numbers and gives a refresh and new observation of twin primes that could lead us to an answer to the Twin Prime Conjecture problem. We expose a peculiar relation between twin primes and the generation of prime numbers with Tesla numbers. Tesla numbers seem to be present in so many domains like time, vibration and frequency [1], and the space between twin primes is not the exception. Let us say that twin primes are more than just prime numbers plus 2 or minus 2, and Tesla numbers are more involved with twin primes than we think, and hopefully, this approach give us a better understanding of the distribution of the twin pairs.

关键词： Tesla Numbers Prime Number Twin Prime Numbers Twin Pair