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The Role of CD4+ and CD8+ T-Cells during Angiostrongylus vasorum Infection in Dogs

Open Journal of Animal Sciences 2014年第5期4卷 285-290页

作者： Thales Augusto Barcante Lis Ribeiro do Valle Antonelli Kenneth Gollob Thiago Pasqua Narciso Silvio Divino de Oliveira Junior Vitor Marcio Ribeiro ricardo Toshio fujiwara Ana Paula Peconick Debora Negrao-Correa Walter dos Santos Lima Joziana Muniz de Paiva Barcante Laboratorio de Biologia Parasitaria(BIOPAR) Departamento de Medicina VeterinariaSetor PreventivaUniversidade Federal de Lavras(UFLA)LavrasBrazil Instituto de Ciencias Biologicas Universidade Federal de Minas GeraisBelo HorizonteBrazil Programa de Pos-graduacao em Ciencias Veterinarias Departamento de Medicina VeterinariaUniversidade Federal de Lavras(UFLA)LavrasBrazil

A determinant factor in the pathology of canine angiostrongylosis seems to be related to the location of the parasite in the definitive host. Their presence inside the arteries and its branches, promoting mechanical and metabolic action on the wall of the vessels, may alter its homeostasis. Bronchoalveolar lavage (BAL) is a procedure that retrieves cells and other elements from de lungs for evaluation, and helps in the diagnosis of many pulmonary diseases. The aim of this study was to evaluate CD4+/CD8+ lymphocyte profile during the infection by Angiostrongylus vasorum, using cells retrieved using BAL. The identification of subpopulations of T lymphocytes by evaluating the co-expression of CD4 and CD8 receptor proteins has shown that despite the increase in both populations, there was a predominance of CD4+ T-cells, instead of CD8+ T-cells. These increases of CD4+ T-cells associated with the increase of the ratio between CD4+/CD8+ suggest polarization of a Th2 response. However, the immune cells, signaling factors, and cytokines that mediate such immunity and how and where they act within the body remain largely undefined during angiostrongylosis.

关键词： Citometria Angiostrongyliasis Brochoalveolar Lavage

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Development and Evaluation of the Human Hookworm Vaccine

Development and Evaluation of the Human Hookworm Vaccine

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2005年寄生虫学国际学术研讨会暨中国动物学会寄生虫专业委员会第十次学术研讨会

作者： Peter Hotez Jeffrey Bethony Maria Elena Bottazzi Simon Brooker Rodrigo Correa-Oliveira Ciro de Quadros Vehid Deumic ricardo fujiwara Gaddam Goud Alex Loukas Susana Mendez Aaron Miles Jordan Plieskatt Laura Rodrigues Philip Russell Peter Smith Kari Stoever Michael Whitham The George Washington University USA London School of Hygiene and Tropical Medicine UK FIOCRUZ Brazil Sabin Vaccine Institute USA Queensland Institute of Medical Research Australia

Human hookworm infection is one of the most common infections of humans and a leading cause of anemia and malnutrition. Approximately 700 million people are infected in rural areas of developing countries, with the largest numbers of cases occurring in Sub-Saharan Africa, Southeast Asia, and tropical regions of the Americas. Widespread use of benzimidazole anthelminthic drugs (BZAs) has not controlled hookworm because of variable efficacy of BZAs, high rates of post-treatment re-infection, and the diminishing efficacy of BZAs with frequent and periodic use. There is concern about emerging BZA resistance. In order to accelerate the global control of hookworm, a public private partnership known as the Human Hookworm Vaccine

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