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p53 promote. AKT and SP1-de.e.de.t me.abolism through the.pe.tose.phosphate.pathway that inhibits apoptosis in re.ponse.to Nutlin-3a

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Journal of Mole.ular Ce.l Biology 2018年第4期10卷 331-340页

作者： Te.t Le. Duan ricardo e. perez Ling Che. Lothar A. Blatte. Carl G. Maki De.artme.t of Ce.l & Mole.ular Me.icine Rush University Medical Center Chicago IL 60612 USA De.artme.t of Laboratory Me.icine Shiyan Taihe Hospital College of Biomedical Engineering Hubei University of Medicine Shiyan 442000 China De.artme.t of Physiology & Biophysics Rush University Medical Center Chicago IL 60612 USA

Nutlin-3a is a MDM2 antagonist and pre.linical drug that activate. p53. Ce.ls with MDM2 ge.e.amplification are.e.pe.ially prone.to Nutlin-3a-induce. apoptosis, though the.basis for this is uncle.r. Glucose.me.abolism can inhibit apoptosis in re.ponse.to Nutlin-3a through me.hanisms that are.incomple.e.y unde.stood. Glucose.me.abolism through the.pe.tose.phosphate.pathway （PPP） produce. NADPH that can prote.t ce.ls from pote.tially le.hal re.ctive.oxyge. spe.ie. （ROS）. We.compare. apoptosis and glucose.me.abolism in cance. ce.ls with and without MDM2 ge.e.amplification tre.te. with Nutlin-3a. Apoptosis in MDM2-amplifie. ce.ls was associate. with a re.uction in glycolysis and the.PPP, re.uce. NADPH, incre.se. ROS, and de.le.ion of the.transcription factor SP1, which normally promote. PPP ge.e.e.pre.sion. In contrast, glycolysis and the.PPP we.e.maintaine. or incre.se. in MDM2 non-amplifie. ce.ls tre.te. with Nutlin-3a. This was de.e.de.t on p53-me.iate. AKT activation and was associate. with mainte.ance.of SP1 and continue. e.pre.sion of PPP ge.e.. Knockdown or inhibition of AKT, SP1, or the.PPP se.sitize. MDM2-non-amplifie. ce.ls to apoptosis. The.data indicate.that p53 promote. AKT and SP1-de.e.de.t activation of the.PPP that prote.ts ce.ls from Nutlin-3a-induce. apoptosis. The.e.findings provide.insight into how glucose.me.abolism re.uce. Nutlin-3a-induce. apoptosis, and also provide.a me.hanism for the.he.ghte.e. se.sitivity of MDM2-amplifie. ce.ls to apoptosis in re.ponse.to Nutlin-3a.

关键词： Nutlin p53 MDM2 SP1 glycolysis pe.tose.phosphate.pathway

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A Syste.atic Re.ie. of Compute. Vision Te.hnique. for Quality Control in e.d-of-Line.Visual Inspe.tion of Ante.na Parts

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Compute.s, Mate.ials & Continua 2024年第8期80卷 2387-2421页

作者： Zia Ullah Lin Qi e.J.Solte.ro Pire. Arsénio Re.s ricardo Rodrigue. Nune. School of e.e.trical and Information e.gine.ring Zhengzhou UniversityZhengzhou450001China School of Scie.ce.and Te.hnology Universidade de Trás-os-Montes e Alto DouroVila Real5000-801Portugal

The.rapid e.olution of wire.e.s communication te.hnologie. has unde.score. the.critical role.of ante.nas in e.suring se.mle.s *** de.e.ts,ranging from manufacturing impe.fe.tions to e.vironme.tal we.r,pose.significant challe.ge. to the.re.iability and pe.formance.of communication *** re.ie. pape. navigate. the.landscape.of ante.na de.e.t de.e.tion,e.phasizing the.ne.d for a nuance. unde.standing of various de.e.t type. and the.associate. challe.ge. in visual *** re.ie. pape. se.ve. as a valuable.re.ource.for re.e.rche.s,e.gine.rs,and practitione.s e.gage. in the.de.ign and mainte.ance.of communication *** insights pre.e.te. he.e.pave.the.way for e.hance. re.iability in ante.na syste.s through targe.e. de.e.t de.e.tion *** this study,a compre.e.sive.lite.ature.analysis on compute. vision algorithms that are.e.ploye. in e.d-of-line.visual inspe.tion of ante.na parts is *** PRISMA principle. will be.followe. throughout the.re.ie.,and its goals are.to provide.a summary of re.e.t re.e.rch,ide.tify re.e.ant compute. vision te.hnique.,and e.aluate.how e.fe.tive.the.e.te.hnique. are.in discove.ing de.e.ts during *** contains article. from scholarly journals as we.l as pape.s pre.e.te. at confe.e.ce. up until June.*** re.e.rch utilize. se.rch phrase. that we.e.re.e.ant,and pape.s we.e.chose. base. on whe.he. or not the. me. ce.tain inclusion and e.clusion *** this study,se.e.al diffe.e.t compute. vision approache.,such as fe.ture.e.traction and de.e.t classification,are.broke. down and ***,the.r applicability and pe.formance.are.*** re.ie. highlights the.significance.of utilizing a wide.varie.y of datase.s and me.sure.e.t *** findings of this study add to the.e.isting body of knowle.ge.and point re.e.rche.s in the.dire.tion of promising ne. are.s of inve.tigation,such as re.l-time.inspe.tion syste.s and multispe.tral *** re.ie.,on its whole.of

关键词： Compute. vision e.d-of-line.visual inspe.tion of ante.na parts machine.le.rning algorithms image.proce.sing te.hnique. de.p le.rning mode.s

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Targe.ing e.ide.mal growth factor re.e.tor signaling to facilitate.cortical injury re.air?

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Ne.ral Re.e.e.ation Re.e.rch 2024年第5期19卷 935-936页

作者： ricardo Góme.-Oliva Pe.ro Nune.-Abade. Carme. Castro Áre. de.Fisiología Facultad de Medicina Universidad de CádizCadizSpain Instituto de.Inve.tigación e.Innovación e. Biome.icina de.Cádiz CadizSpain De.artame.to de.Fisiología Facultad de FarmaciaUniversidad de SevillaSevilleSpain

The.e.iste.ce.of ne.ral ste. ce.ls(NSC)in spe.ific are.s of the.adult mammalian brain le.ds to the.ge.e.ation of ne. ne.rons involve. in home.static *** is the.case.of the.NSC of the.subve.tricular zone.SVZ)that produce. olfactory bulb(OB)*** ne.rons inte.rate.into circuits to modulate.se.sory information and participate.in olfactory proce.sing(Bragado Alonso e. al.,2019).A se.ie. of hie.archical e.e.ts ne.d to take.place.to produce.OB ne.rons from NSC of the.***,the.activation of quie.ce.t NSC is ne.e.sary to produce.inte.me.iate.transit amplifying proge.itors(TAP),which will ge.e.ate.*** latte. are.ce.ls that maintain a prolife.ative.phe.otype.while.in an immature.***,once.the. initiate.migration toward the.OB,the. progre.sive.y unde.go the.r diffe.e.tiation into ne.rons(Kje.l e. al.,2020).

关键词： ve.tricular maintain

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Spatial and te.poral patte.ns of fore.t fire. in the.Ce.tral Monte.re.ationships with re.ional climate

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e.ological Proce.se. 2024年第01期13卷 66-79页

作者： Pablo e.ge.io Villagra e.ica Ce.ca Le.ndro Manue. Alvare. Silvia De.gado ricardo Villalba Instituto Arge.tino de.Nivología Glaciología y Cie.cias Ambie.tale.–CONICe.-CCT Me.doza Facultad de.Cie.cias Agrarias Unive.sidad Nacional de.Cuyo

Background Natural and anthropoge.ic wildfire. burn large.are.s of arid and se.i-arid fore.ts with significant socio-e.onomic and e.vironme.tal impacts. Fire.re.ime. are.controlle. by climate. ve.e.ation type. and anthropoge.ic factors such as ignition source. and human-induce. disturbance.. Proje.tions of climate.and land-use.change.sugge.t that the.e.controlling factors will change. alte.ing fire.re.ime. in the.ne.r future. In the.southe.n Ce.tral Monte. Me.doza, Arge.tina, the.factors that modulate.the.fire.te.poral and spatial variability are.poorly unde.stood. We.re.onstructe. the.fire.history of southe.st of Me.doza from 1984 to 2023 and inve.tigate. the.re.ationships be.we.n fire.e.te.t and climate.variability at se.sonal and inte.annual scale.. Burne. are.s we.e.de.e.mine. using Google.e.rth e.gine.by proce.sing Landsat 5-TM, Landsat 7-e.M+, and Landsat 8-OLI-TIRS se.sor *** The.re.ion e.hibite. high spatial and te.poral variability in fire.occurre.ce. be.ng a mosaic of are.s with diffe.e.t fire.historie. and re.ove.y time.. Be.we.n 1985 and 2023, fire.re.urre.ce.range. from site. unburne. to site. with up to 14 fire.. The.occurre.ce.of large.fire. was strongly favore. by a combination of a ye.r with abundant spring–e.rly summe. pre.ipitation, which favors fue. accumulation, followe. by a ye.r of low spring–e.rly summe. pre.ipitation. Pre.ipitation and burnt are. showe. a ve.y pronounce. 6–7 ye.r cycle. sugge.ting a dominant climatic control on fire.*** Fire.distribution in southe.ste.n Me.doza fore.ts is not homoge.e.us, re.ulting in a mosaic of patche. with diffe.e.t fire.historie.. This he.e.oge.e.ty may be.re.ate. to ve.e.ation patte.ns and land use. The.te.poral variability of fire. is strongly influe.ce. by climate.variability, which would promote.fue. production and subse.ue.t drying. Large.fire. are.conce.trate. in pe.iods of high inte.annual pre.ipitation variability. Climate.change.sce.arios pre.ict an incre.se.in te.

关键词： Fire.re.urre.ce Fire.mapping Re.ove.y time Climate Dry fore.t Wildfire

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Litte. production and le.f nutrie.t conce.tration and re.obilization in re.ponse.to climate.se.sonality in the.ce.tral Amazon

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Journal of Fore.try Re.e.rch 2024年第3期35卷 131-141页

作者： ricardo Antonio Mare.co Saul Alfre.o Ante.ana-Ve.a Danie.a Pe.e.ra Dias Luiz Antonio Candido Instituto Nacional de.Pe.quisas da Amazonia Coordenagao de Uso da Terra e Mudanca ClimaticaAv.Andre Araujo 2936ManausAM69067-375Brazil Programa de.pos-Graduagao e. Agricultura no Tropico Umido Instituto Nacional de Pesquisas da Amazonia-INPAManausAMBrazil Unidade.Acade.ica de.Cie.cias Agrarias Universidade Federal de JataiBR 364km 195JataiGO 75801-615Brazil

Litte.fall is the.large.t source.of nutrie.ts to for-e.t soils of tropical ***,variability in lit-te.fall production,nutrie.t re.obilization,and change. in le.f nutrie.t conce.tration with climate.se.sonality re.ain large.y unknown for the.ce.tral *** study me.s-ure. litte.fall production,le.f nutrie.t re.obilization,and le.f are. inde. on a fore.t plate.u in the.ce.tral *** was me.sure. at monthly inte.vals during 2014,while.nitroge.,phosphorus,potassium,calcium and mag-ne.ium conce.trations of le.f litte. and canopy le.ve. we.e.me.sure. in the.dry and rainy se.sons,and re.obilization rate. *** are. inde. was also re.orde. in the.dry and rainy *** litte.fall varie. from 33.2(in the.rainy se.son)to 87.6 g m^(-2) in the.dry se.son,while.le.f are. inde. incre.se. slightly in the.rainy *** se.sonality had no e.fe.t on conce.trations of nitroge.,calcium,and magne.ium,whe.e.s phosphorous and potassium re.ponde. to rainfall se.sonality *** phosphorous incre.se.,potassium de.re.se. during the.dry *** se.sons,nitroge.,potassium,and phosphorous de.re.se. in le.f litte.;calcium incre.se. in le.f litte.,while.magne.ium re.aine. unaffe.te. with le.f ***,the.five.nutrie.ts had similar re.obilization rate. ove. the.*** abse.ce.of climate.se.sonality on nutrie.t re.obilization sugge.ts that the.curre.t le.gth of the.dry se.son doe. not alte. nutrie.t re.obilization rate. but this may change.as dry pe.iods be.ome.more.prolonge. in the.future.due.to climate.change.

关键词： Throughfall Nutrie.t cycling Climatic se.sonality Le.f mass pe. are.

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Distribution and Re.ation of Prime. with Te.la Numbe.s 3, 6, and 9

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Journal of Applie. Mathe.atics and Physics 2024年第4期12卷 1021-1027页

作者： Javie. Me.doza-Navarre.e.Hue.zin perez Ismae. Oje.a Victor Ve.dugo Gabrie. Luna Sandoval ricardo Jime.e. Garcia Jaime.Alvare. De.artame.no de.Mate.á ticas CBTis 256 DGETI Cabo San Lucas M&#233xico DCI De.artame.to de.Fisica Mé dica Universidad de Guanajuato Leon M&#233xico Divisió n de Ingenieria en Sistemas Computacionales Tecnol&#243gico Nacional de M&#233xico ITES Los Cabos Cabo San Lucas M&#233xico De.artame.to de.Inge.ie.ia Industrial e. Manufactura Universidad Estatal de Sonora Navojoa M&#233xico De.artame.to de.e.é ctrica-Electr&#243nica Tecnol&#243gico Nacional de M&#233xico Campus Mexicali Mexicali M&#233xico Guanajuato M&#233xico

This work pre.e.ts a diffe.e.t approach to twin prime., an approach from the.pe.spe.tive.of the.Te.la numbe.s and give. a re.re.h and ne. obse.vation of twin prime. that could le.d us to an answe. to the.Twin Prime.Conje.ture.proble.. We.e.pose.a pe.uliar re.ation be.we.n twin prime. and the.ge.e.ation of prime.numbe.s with Te.la numbe.s. Te.la numbe.s se.m to be.pre.e.t in so many domains like.time. vibration and fre.ue.cy [1], and the.space.be.we.n twin prime. is not the.e.ce.tion. Le. us say that twin prime. are.more.than just prime.numbe.s plus 2 or minus 2, and Te.la numbe.s are.more.involve. with twin prime. than we.think, and hope.ully, this approach give.us a be.te. unde.standing of the.distribution of the.twin pairs.

关键词： Te.la Numbe.s Prime.Numbe. Twin Prime.Numbe.s Twin Pair

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e.fe.t of re.istance.training volume.on body adiposity,me.abolic risk,and inflammation in postme.opausal and olde. fe.ale.:Syste.atic re.ie. and me.a-analysis of randomize. controlle. trials

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Journal of Sport and He.lth Scie.ce 2024年第2期13卷 145-159页

作者： Paulo ricardo Prado Nune. Pame.a Castro-e.Souza Anse.mo Alve. de.Olive.ra Bruno de.Fre.tas Camilo Gislaine.Cristina-Souza Lucio Marque. Vie.ra-Souza Marce.o Augusto da Silva Carne.ro De.artme.t of Body and Human Move.e.t Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Unive.sity Ce.te. of Planalto de.Araxa(UNIARAXA) 38180-129 AraxaMGBrazil Physical Activity Health and Ageing Research Group(GPASE)Minas Gerais State University(UEMG)37902-092 PassosMGBrazil e.e.cise.and Nutrition Re.e.rch Group(GPe.) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Sport Scie.ce. and Physical e.e.cise.Study and Re.e.rch Group(Ge.Ce.X) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Me.abolism Nutrition and Exercise LaboratoryPhysical Education and Sport CenterLondrina State University(UEL)86050-070 LondrinaPRBrazil Postgraduate.Program in Physical e.ucation Federal University of Sergipe(UFS)49107-230 Sao CristovaoSEBrazil

Purpose.This me.a-analytical study aime. to e.plore.the.e.fe.ts of re.istance.training(RT) volume.on body adiposity,me.abolic risk,and inflammation in postme.opausal and olde. ***:A syste.atic se.rch was pe.forme. for randomize. controlle. trials in PubMe.,Scopus,We. of Scie.ce.and *** controlle. trials with postme.opausal and olde. fe.ale. that compare. RT e.fe.ts on body adiposity,me.abolic risk,and inflammation with a control group(CG) we.e.*** re.ie.e.s se.e.te. the.studie.,e.tracte. the.data,and pe.forme. the.risk of bias and ce.tainty of the.e.ide.ce.Grading of Re.omme.dations,Asse.sme.t,De.e.opme.t,and e.aluation(GRADe.) *** body and abdominal adiposity,blood lipids,glucose.and C-re.ctive.prote.n we.e.include. for me.a-analysis.A random-e.fe.ts mode.,standardize. me.n diffe.e.ce.He.ge.’ g),and 95% confide.ce.inte.val(95%CI) we.e.use. for ***:Twe.ty randomize. controlle. trials(ove.all risk of bias:some.conce.ns;GRADe.low to ve.y low) with ove.we.ght/obe.e.postme.opausal and olde. fe.ale. we.e.*** groups we.e.divide. into low-volume.RT(LVRT,~44 se.s/we.k) and high-volume.RT(HVRT,~77 se.s/we.k).Both RT groups pre.e.te. improve. body adiposity,me.abolic risk,and inflammation whe. compare. to ***,HVRT de.onstrate. highe. e.fe.t size. than LVRT for glucose.HVRT=-1.19;95%CI:-1.63 to-0.74;LVRT=-0.78;95%CI:-1.15 to-0.41) and C-re.ctive.prote.n(HVRT=-1.00;95%CI:-1.32 to-0.67;LVRT=-0.34;95%CI,-0.63 to-0.04)) whe. compare. to ***:Compare. to CG,HVRT protocols e.icit gre.te. improve.e.ts in me.abolic risk and inflammation outcome. than LVRT in ove.we.ght/obe.e.postme.opausal and olde. fe.ale..

关键词： C-re.ctive.prote.n Fat mass Lipid profile Me.opause Stre.gth training

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e.ficie.t re.oval of the.re.alcitrant me.amizole.contaminant from drinking wate. by using a CaLaCoO_(9) pe.ovskite.supporte. on re.ycle. polye.hyle.e

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Journal of e.vironme.tal Scie.ce. 2024年第2期136卷 56-67页

作者： e.ne.to Valade.-Re.te.ia Christian perez-Carrasco Dulce.Yolotzin Me.ina-Ve.azque. Vice.te.Rodrigue.-Gonzale. Jorge.Oliva CONACYT-División de.Mate.iale. Avanzados Instituto Potosino de Investigación Científica y Tecnológica A.C.San Luis PotosíSLP 78216México División de.Cie.cias Básicas e.Inge.ie.ía Universidad Autónoma Metropolitana AzcapotzalcoCol.Reynosa-TamaulipasC.P.MéxicoDF 02200México

Me.amizole.MZ)is a wide.y use. anti-inflammatory *** to its common use.this contaminant is found in se.age.and *** orde. to re.uce.the.contamination produce. by the.MZ,we.fabricate. in this work a photocatalytic composite.using re.ycle. polye.hyle.e.RPe.and the.CaLaCoO_(9)(LCCO)*** nanoparticle. had a microplate.like.morphology and size. of 1.4–5.5μm according to the.analysis of *** photocatalytic prope.tie. of the.LCCO powde.s we.e.e.aluate. unde. ultraviole.-visible.UV-Vis)irradiation and found a re.oval e.ficie.cy of 96%.Whe. the.RPe.LCCO composite.was e.ploye. for the.photocatalytic de.radation of MZ,a maximum de.radation of 92.5%was *** influe.ce.of the.pH on the.photocatalytic activity was also studie. and found that an initial pH=3 produce. a total de.radation of MZ afte. 240 min of UV-Vis ***,thre. re.se.cycle. we.e.carrie. out for the.pure.LCCO powde.s and for the.RPe.LCCO composite. and found that the.maximum loss of de.radation was 5%.Furthe.more.scave.ge. e.pe.ime.ts de.onstrate. that the.supe. oxide.and hydroxyl radicals are.forme. during the.photocatalytic re.ction and we.e.re.ponsible.for the.de.radation of ***,the.X-ray photoe.e.tron-spe.troscopy and Raman analysis de.onstrate. the.formation of de.e.ts(oxyge. vacancie.),those.one. de.aye. the.e.e.tron-hole.re.ombination,which in turn,e.hance. the.de.radation of the.***,the.studie. pe.forme. in this work prove. that composite. made.with re.ycle. plastics and LCCO pe.ovskite. are.a low-cost and fe.sible.alte.native.for the.cle.ning of wate. source. pollute. with pharmace.tical compounds.

关键词： Photocatalysis Me.amizole Pharmace.tical contaminant UV-Vis irradiation Pe.ovskite

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The.Nikola Te.la Constant and Its Re.ation to the.Circumfe.e.ce.Inscribe. in a Square

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Journal of Applie. Mathe.atics and Physics 2024年第1期12卷 277-283页

作者： Javie. Me.doza Navarre.e.José Ismae. Oje.a Campaña Hue.zin perez Gabrie. Luna-Sandoval Victor Ve.dugo ricardo Jiméne. Garcia De.artame.to de.Mate.áticas CBTis 256 DGETI Cabo San Lucas México División de.Inge.ie.ía e. Siste.as Computacionale. Tecnológico Nacional de México/ITES de Los Cabos Cabo San Lucas México DCI De.artame.to de.Física Médica Universidad de Guanajuato León México De.artame.to de.Inge.ie.ía Industrial e. Manufactura Universidad Estatal de Sonora Navojoa México De.artame.to de.e.éctrica-e.e.trónica Tecnológico Nacional de México Campus Mexicali Mexicali México

This re.e.rch work re.ate. the.surface.of a square.and the.are. circumscribe. by a circle. re.ulting in a value.calle. Nikola Te.la constant. This constant starts with the.calculation of the.are.s of the.square.and the.inscribe. circle. giving a ratio of 9/40 and from which a re.idual are. of the.are. proportions of the.ge.me.ric figure. de.cribe. is obtaine.. Plotting smooth curve., particularly those.in round shape., can be.re.re.e.te. e.ficie.tly with the.use.of Nikola Te.la constant, re.ucing comple. mathe.atical calculus.

关键词： Te.la Numbe.s Prime.Numbe. Circle Binary Are.

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Quasiline.r e.liptic proble.s with e.pone.tial growth via the.Ne.ari manifold me.hod: e.iste.ce.of nonne.ative.and nodal solutions

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Acta Mathe.atica Sinica,e.glish Se.ie. 2024年

作者： Giovany FIGUe.Re.O Sandra More.ra ricardo Ruviaro Addre.s De.artame.to de.Mate.atica Universidade de Brasilia De.artame.to de.Mate.atica e.Informatica Universidade Estadual do Maranhao De.artame.to de.Mate.atica Universidade de Brasilia

In this pape. we.will be.conce.ne. with the.proble. -Δu-1/2Δ(a（x）u2)u+V（x）u=f（u）,x∈R2，whe.e.V is a pote.tial continuous and f : R → R is a supe.line.r continuous function with e.pone.tial subcritical or e.pone.tial critical growth. We.use.as a main tool the.Ne.ari manifold me.hod in orde. to show e.iste.ce.of nonne.ative.solutions and e.iste.ce.of nodal solutions. Our re.ults comple.e.t the.classical re.ult of solutions for quasiline.r Schrodinge. e.uations via the.Ne.ari me.hod due.to Jia-quan Liu, Ya-qi Wang and Zhi-Qiang Wang in the.se.se.that in this article.we.are.conside.ing nonline.rity of the.e.pone.tial type.

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