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The Impact of Chronic Pelvic Pain in Women

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International Journal of Clinical Medicine 2013年第10期4卷 421-427页

作者： Adriana Peterson Mariano Salata Romao ricardo Gorayeb Gustavo Salata Romao Omero Benedicto Poli-Neto Antonio Alberto nogueira Department of Gynecology and Obstetrics School of Medicine of Ribeirao PretoUniversity of Sao PauloRibeirao PretoSPBra-zil Department of Neurosciences and Behavioral Sciences School of Medicine of Ribeirao PretoUniversity of Sao PauloRibeirao PretoSPBrazil Federal University of Sao Carlos SPBrazil Department the Surgery and Anatomy University HospitalFaculty of Medicine of Ribeirao PretoUniversity of São PauloRibeirao PretoSPBrazil Department of the Surgery and Anatomy Uni-versity HospitalFaculty of Medicine of Ribeirao PretoUniversity of Sao PauloRibeirao PretoSPBrazil.

Chronic pelvic pain (CPP) is a prevalent condition with a significant impact on the personal, social, professional and marital life of women. It is a complex condition that may have no specific causal diagnosis or may be associated with multiple diagnoses, frequently involving treatment failure. The definition of health care strategies fundamentally depends on the way women live with this condition. Thus, the objective of the present study is to learn how women with CPP experience their diagnosis and the meaning they attribute to it. A qualitative study was conducted by interviewing a focus group of 11 women. The content of the interviews was recorded and fully transcribed, and the speeches were interpreted by Bardin’s content analysis. The topics most frequently dealt with in the interview were diagnosis, beginning of pain, worsening and improving factors, marital and interpersonal relationships, interference with daily activities, association with emotional aspects, and perspectives for the future. It could be perceived how much these women need to be better heard and how much the association between psychic and physical questions must be visualized by the professionals who provide care for them. The approach used by professionals from different areas, when properly structured, can minimize the problem of the division of a sick person into separate parts. Psychological care is very important, especially in relation to the discovery of more effective strategies for living with pain.

关键词： Lived Experience Chronic Pelvic Pain Qualitative Method Women’s Health

Bone Marrow Transplant Long-Term Survivors’ Satisfaction with Quality of Life: Comparison with a Control Group

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Open Journal of Medical Psychology 2014年第5期3卷 337-347页

作者： Maribel Pelaez Doro José Zanis Neto Denise carvalho Julita Maria Pelaez Vaneuza Funke ricardo Pasquini International Society for Quality of Life Research (ISOQOL) Milwaukee USA

Purpose: To evaluate the global quality of life (QoL) of survivors with 10-year or more post-transplant, and to identify risk factors that interfere with well-being. Methods: This is a prospective analytic transversal study with 214 survivors of Bone Marrow Transplant (BMT) and 264 healthy people identified among blood donors, treated as the control group, of both sexes, 18 years or older. The protocol includes a demographic-socioeconomic questionnaire, World Health Organization Quality of Life (WHOQOL) and the Karnofsky Performance Status Scale. Results: 53.7% of the survivor group members are satisfied with their QoL. A similar result can be found in the control group (54.2%). Chronological maturity, anxiety, sexual difficulty, and being a provider are factors that interfere negatively in the QoL of male survivors. In female survivors, the risk factors are anxiety, low educational level, not having a stable partner, being a provider, and not being Caucasian. Conclusions: Survivors are as satisfied with their QoL as the control group. QoL is understood as a perceptive process composed of objective (functional and relational capacity) and subjective phenomenon (perceptive composition).

关键词： Quality of Life Bone Marrow Transplantation Long-Term Survivors Control Group Resilience

Impact of Chronic Pelvic Pain on Female Sexual Function

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International Journal of Clinical Medicine 2013年第3期4卷 178-182页

作者： Adriana Peterson Mariano Salata Romao ricardo Gorayeb Gustavo Salata Romao Omero Benedicto Poli-Neto Antonio Alberto nogueira Department of Neurosciences and Behavioral Sciences School of MedicineUniversity of Sao PauloSao PauloBrazil Department of Gynecology and Obstetrics School of MedicineUniversity of Sao PauloSao PauloBrazil Federal University of Sao Carlos Sao CarlosBrazil Department of Surgery and Anatomy University HospitalFaculty of Medicine of Ribeirao PretoUniversity of São PauloRibeirao PretoBrazil

The objective of the present study was to determine the prevalence of sexual dysfunction and depression in women with chronic pelvic pain (CPP). A case-control study was conducted on 66 women, 36 of them with CPP and 30 without this diagnosis. Depression was evaluated using the Beck Depression Inventory (BDI) and sexual dysfunction was evaluated using the Female Sexual Function Index (FSFI). Data were analyzed statistically by the Mann-Whitney test, Fisher exact test, chisquare test, and Spearman correlation test. Regarding sociodemographic data, no significant differences were detected between populations with respect to the variables studied (age, schooling, number of children, income, salary, and marital status), indicating group homogeneity and thus increasing the reliability of the data. A cut-off of 26.55 points was used to calculate the total score for sexual function. In the group of women with CPP, 94.4% were at high risk for sexual dysfunction. Comparison of FSFI scores showed that the domains of sexual function, such as orgasm, lubrication and pain differed significantly between women with and without CPPP. Correlations were detected between the following items: orgasm × age (r = -0.01904), orgasm × number of children (r =-0. 00947), orgasm × body mass index (BMI) (r =-0.00 955), relationship × age (r = 0.03952), income × relationship (r =-0.014680), relationship × number of children (r =-0.03623), depression × relationship (r =-0.16091), desire × age (r = -0.45255), desire × number of children (r = -0.01824), lubrication × excitement (r = 0.04198), and lubrication × BMI (r = -0.01608). The prevalence of depression detected in the present study was 38.9% among women with pain and 3.3% among control women. It was observed that women with CPP suffer a negative interference regarding sexual function compared to controls. Thus, it can be seen that a specific approach related to sexuality is extremely important within the context of women with CPP. Depression

关键词： Chronic Pelvic Pain Sexual Function Depression Women

Co-Inoculation of Soybean with Bradyrhizobium and Azospirillum Promotes Early Nodulation

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American Journal of Plant Sciences 2015年第10期6卷 1641-1649页

作者： Amaral Machaculeha Chibeba Maria de Fátima Guimaraes Osmar Rodrigues Brito Marco Antonio nogueira ricardo Silva Araujo Mariangela Hungria Department of Agronomy Universidade Estadual de Londrina(UEL)LondrinaBrazil Embrapa Soja LondrinaBrazil Total Biotecnologia Indústria e Comércio Ltda CuritibaBrazil

Soybean inoculation with elite strains of Bradyrhizobium to improve nodulation, N2 fixation, and grain yield is well established worldwide. However, when grown in soils where N is deficient, soybean undergoes an initial phase of N starvation that may last up to 20 days after seedling germination due to the lack of synchronism between the phase when seed N reserves are exhausted and the moment when plants begin to benefit from the nitrogen fixed by the bacteria. Practices that promote early nodulation may play a key role in reducing the N starvation period. Azospirillum is a plant growth promoting rhizobacteria (PGPR) that can stimulate root hair formation and root growth, creating more sites for early root infection and nodule formation by N2-fixing Bradyrhizobium spp. In this study, the effects of co-inoculating soybeans with Bradyrhizobium spp. and Azospirillum brasilense on nodulation precocity and N2 fixation were evaluated under greenhouse and field conditions. Nodule number and dry weight, as well as plant and root dry weight and N accumulated in shoots at 15, 18, 21, 24 and 30 days after emergence (DAE) were evaluated in response to inoculation with Bradyrhizobium spp. alone or when co-inoculated with Azospirillum sp. In the greenhouse, co-inoculated plants nodulated precociously as indicated by a significant increase (p Azospirillum helps plants to overcome environmental stresses.

关键词： Biological Nitrogen Fixation Inoculation Soybean Symbiosis

Prognosis of Patients with Acute Coronary Syndromes and Bleeding—The Importance of Routine Use of a Bleeding Risk Score

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World Journal of Cardiovascular Diseases 2015年第12期5卷 327-334页

作者： Alexandre de Matos Soeiro ricardo Cesar Campos Devezae Silva Aline Siqueira Bossa Cindel nogueira Zullino Tatiana de carvalho Andreucci Torres Leal Maria Carolina Feres de Almeida Soeiro Carlos V. Serrano Jr. Múcio Tavares Oliveira Jr. Emergency Unit-Heart Institute University of Sao Paulo Medical School Sao Paulo Brazil

Introduction: Recent studies showed relation between mortality and bleeding in acute coronary syndromes. Objective: The objective is to analyze the prognosis of patients with acute coronary syndromes with or without in-hospital major and/or minor bleedings. Methods: This was a pro-spective data bank analysis study with 546 patients (39 with bleeding (group I) and 507 without bleeding (group II)) with acute coronary syndromes included between May 2010 and May 2013. Besides, Mehran bleeding risk score was calculated to all patients. The primary endpoint was all causes of in-hospital death and combined events. Comparison between groups was made by Anova and Q-square. Multivariate analysis was determined by logistic regression and was considered significant when p p = 0.005) and combined events (35.9% vs 11.4%, p < 0.001). The same results were observed in multivariate and long-term analysis. Con-clusions: Almost half of patients with acute coronary syndromes had higher risk of bleeding, and that with major or minor bleedings had greater deaths and combined events.

关键词： Unstable Angina Bleeding Acute Myocardial Infarction

Schistosoma mansoni Infection in Holochilus sciureus Shows Sex-Related Differences in Parasitological Patterns

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Open Journal of Animal Sciences 2019年第2期9卷 173-182页

作者： Guilherme Silva Miranda Joao Gustavo Mendes Rodrigues Maria Gabriela Sampaio Lira Ranielly Araujo nogueira Gleycka Cristine carvalho Gomes Neuton Silva-Souza Department of Parasitology Institute of Biological SciencesFederal University of Minas GeraisBelo HorizonteBrazil Teaching Department Federal Institute of MaranhaoSao Raimundo das MangabeirasBrazil Department of Pathology Centre for Biological and Health SciencesFederal University of MaranhaoSao LuisBrazil Department of Chemistry and Biology Laboratory of Human ParasitologyState University of MaranhaoSao LuisBrazil

Due to the different parasitological patterns found between sexes in human populations and in different biological models during Schistosoma mansoni infection, we proposed to investigate such differences using Holochilus sciureus rodent, besides confirming whether this rodent is suitable for experimental infections. In this sense, males and females of H. sciureus were infected with 200 cercariae from a human strain of S. mansoni. The number of eggs per gram of feces (epg) and the worms were quantified, besides histopathological analysis. Thus, it was shown that females have fewer epg, as well as a longer prepatent period. On the other hand, males had a lower recovery rate of adult worms. The histopathological analysis did not show differences between the sexes. Thus, we suggest that infection in H. sciureus females provides a favorable environment for the development of adult worms, despite impairing the parasite fecundity. In addition, H. sciureus may be an excellent biological model for S. mansoni experimental infections.

关键词： Biological Model Females Males Schistosomiasis Wild Reservoir

Response Proliferative Capacity of Undifferentiated Stem Cells of Obtained Human Adult Dental Follicle

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Stem Cell Discovery 2014年第4期4卷 125-137页

作者： Larissa Kim Higashi de carvalho Aline Vieira Pinheiro de Araujo Manuela Garcia Laveli da Silva Rosa Andréa nogueira Laiso Durvanei Augusto Maria Faculty of Medicine University of Sao Paulo Sao Paulo Brazil Laboratory of Biochemistry and Biophysics Butantan Institute Sao Paulo Brazil

Objective: The aim of this study was correlation proliferative activity, markers express stem cells, and lipid peroxides of undifferentiated stem cells of human adult dental follicle (DF) following culture. Methods: For this study, we used 8 samples from DF of impacted third molars to maintain culture conditions and evaluated the growth curve, cell viability, production of lipid peroxidation, cell cycle phases, and proliferative index during 25 days of culture. Results: Cells after culture showed characteristics of fibroblast-like type following 25th day of culture. The results of lipid peroxidation showed that stem cells in culture produce 13 nmoles/ml malondialdehyde at the start of culture, increasing until the 12th day and then began a decline that lasted until the 25th day. We revealed that DFSCs presented a significantly higher percentage of cells in S + G2/M phases by the 15th day of culture compared with cells at the start of culture. Cell surface markers revealed that cell lines were negative for HLA-DR and positive for CD90, CD44, and CD105. The expression of p21 protein, involved in the regulation of the cell cycle, showed a significant increase from the 15th to 25th day of culture. Results of cell division rates show a significant increase between the 6th and 15th day of culture. Conclusions: We conclude that the culture remained stable during the 25 days of culture, presenting the markers of stem cells and markers of control, progression, and cell proliferation that there was an increased production of lipid peroxides between the 6th and 12th days;this increase is related to the increased numbers of cells that also occurs during this period. Then, there is a significantly decline in the production of lipid peroxides and the number of cells, which is accompanied by an increase in cell unviability.

关键词： Follicle Dental Stem Cells Lipid Peroxidation Cell Cycle Proliferation

The Importance of the Three-Dimensional Image in the Early Diagnosis of Cementoblastoma

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Open Journal of Radiology 2012年第1期2卷 10-13页

作者： Tania Mara Pimenta Amaral Claudia Silami de Magalhaes Allyson nogueira ricardo Alves Mesquita Joao Batista de Freitas Maria Cassia Ferreira Aguiar Department of Oral Pathology and Surgery School of Dentistry Universidade Federal de Minas Gerais Belo Horizonte Brazil Department of Restorative Dentistry School of Dentistry Universidade Federal de Minas Gerais Belo Horizonte Brazil

The cementoblastoma is a very rare odontogenic neoplasm characterised by the formation of cementum-like tissue in connection with the root of a tooth. An 18-year-old boy was referred to the Clinic of Oral Pathology of the School of Dentistry, Universidade Federal de Minas Gerais, Brazil, complaining of an irradiating, itching pain from the region of the lower right first molar. He reported that the symptoms began three months prior, with a gradual increase in intensity during this period. The pain episodes were of short duration, with characteristics of toothache originating from the pulp. Upon intra-oral clinical examination, an open bite and slight increase in volume at the buccal alveolar region of the lower right first molar was observed. He also reported palpation and percussion pain symptoms in this region. Electrical, heat and cold pulp vitality tests were performed, and the tooth was vital. Periapical and panoramic radiographs showed radiolucent images with diffuse, poorly defined borders at the mesial root periapex extending to the interradicular region suggesting an inflammatory periapical lesion. In this early presentation, the three-dimensional image was fundamental to the final diagnosis of cementoblastoma.

关键词： Cementoblastoma Cone Beam CT Dental Radiography

Social media in cardiology:Reasons to learn how to use it

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World Journal of Cardiology 2019年第10期11卷 217-220页

作者： Rafael Vidal-Perez Jose Juan Gómez de Diego Julia Grapsa ricardo Fontes-carvalho Jose Ramon Gonzalez-Juanatey Heart Failure Unit Cardiology DepartmentHospital Clinico Universitario de SantiagoSantiago de Compostela 15706A CorunaSpain Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares SpainSantiago de Compostela 15706A CorunaSpain Cardiovascular Institute Hospital Universitario San CarlosMadrid 28040Spain Cardiology Department St Bartholomew HospitalBarts Health TrustLondon EC1A 7BEUnited Kingdom Cardiology Department Centro Hospitalar GaiaUniversity of PortoPorto 4434-502Portugal

Social media has changed the way we learn,educate,and interact with our *** dynamic nature of social media and their immediate availability through our portable devices(smartphones,tablets,smartwatches,etc.)is quickly transforming the way we participate in *** scope of these digital tools is broad as they deal with many different aspects:Teaching and learning,case discussion,congresses coverage,peer to peer interaction,research are examples worth *** scientific societies considered more innovative,are promoting these tools between their *** new concepts need to be known by the cardiologists to stay updated,as countless information is moving rapidly through these *** summarize the main reasons why learning how to use these tools to be part of the conversation is essential for the cardiologist in training or fully stablished.

关键词： Social media Cardiology Congress Learning Teaching Interaction Cardiovascular diseases Impact Factor Portable devices Smartphone Tablet