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Hypothalamic circuits and aging:keeping the circadian clock updated

Neural Regeneration Research 2024年第9期19卷 1919-1928页

作者： Rosa Vázquez-Lizarraga Lucia Mendoza-Viveros Carolina Cid-Castro Sareni Ruiz-Montoya Erick Carreño-Vázquez ricardo orozco-Solis Instituto Nacional de Medicina Genómica(INMEGEN) México CityMéxico Centro de Investigacíon sobre el Envejecimiento Centro de Investigacíon y de Estudios Avanzados(CIE-CINVESTAV)México CityMéxico Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México UNAMMéxico CityMéxico

Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of *** on aged animal models have unveiled a progressive discoordination at multiple regulatory levels,including transcriptional,translational,and post-translational processes,resulting from cellular stress and circadian *** circadian clock emerges as a key regulator,sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes,such as stem-cell function,cellular stress responses,and inter-tissue communication,which become disrupted during *** the crucial role of hypothalamic circuits in regulating organismal physiology,metabolic control,sleep homeostasis,and circadian rhythms,and their dependence on these processes,strategies aimed at enhancing hypothalamic and circadian function,including pharmacological and non-pharmacological approaches,offer systemic benefits for healthy *** brain-directed drug administration represents a promising avenue for effectively targeting specific brain regions,like the hypothalamus,while reducing side effects associated with systemic drug delivery,thereby presenting new therapeutic possibilities for diverse age-related conditions.

关键词： aging astrocytes cellular stress responses circadian clock hypothalamus intranasal drug administration metabolic control nutrient sensor SIRT1 sleep homeostasis

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Prefrontal and Accumbal Electric Activity during Auditory Stimulation in Virgin Female Rats: Changes Related to the Estrous Cycle

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Journal of Behavioral and Brain Science 2013年第6期3卷 454-462页

作者： Marisela Hernández-González Diego Radberto Chapa García Abascal Miguel ángel Guevara ricardo alonso romero orozco Mayra Linné Almanza Sepúlveda Leopoldo Eduardo Flores Mancilla Facultad de Medicina Universidad Autónoma de Zacatecas Unidad Académica de Medicina Humana y Ciencias de la Salud Zacatecas México Instituto de Neurociencias Universidad de Guadalajara Guadalajara México

The estrous cycle is a physiological process modulated by hormonal changes associated, in turn, with alterations of the attraction or sensitivity with which females perceive different sensory stimuli. Auditory stimuli play an important role in the social interaction of several mammals, including their sexual behavior and the mother-young relationship. Since the prefrontal cortex (PFC) and nucleus accumbens (Acc) had been associated with the processing and assignation of the incentive value of stimuli, this study was designed to analyze whether electroencephalographic (EEG) activity in the PFC and Acc was modified during the two antagonist phases of the estrous cycle (proestrus-estrus and diestrus) when female rats heard sound recordings with different types of cries emitted by other rats. EEGs were recorded in eight female virgin Wistar rats, 80-100 days old, bilaterally implanted in the PFC and Acc during an awake-quiet state, in three conditions: when hearing 1) cries of pups;2) cries of adult male rats;and, 3) cries of adult female rats. The cries were recorded from pups (2-10 days old) and male and female adult rats after gentle prodding by a human hand. Each auditory stimulus (which included vocalizations up to 22 kHz) was randomly played back through a speaker placed near the female rats. Only upon perceiving the cries of male rats did the females in the proestrus-estrous phase show a lower relative power in the 14-30 Hz band in the Acc and an increased inter-prefrontal correlation in the 8-13 Hz band. It is probable that these EEG changes are associated with the lower activation or non-anxious state that the female rat presents specifically during the proestrus-estrous phase in response to the alarm cries of adult male rats.

关键词： Auditory Stimulation EEG Accumbens Prefrontal Cortex Estrous Cycle Rats

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Targeting epidermal growth factor receptor signaling to facilitate cortical injury repair?

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Neural Regeneration Research 2024年第5期19卷 935-936页

作者： ricardo Gómez-Oliva Pedro Nunez-Abades Carmen Castro Área de Fisiología Facultad de Medicina Universidad de CádizCadizSpain Instituto de Investigación e Innovación en Biomedicina de Cádiz CadizSpain Departamento de Fisiología Facultad de FarmaciaUniversidad de SevillaSevilleSpain

The existence of neural stem cells(NSC)in specific areas of the adult mammalian brain leads to the generation of new neurons involved in homeostatic *** is the case of the NSC of the subventricular zone(SVZ)that produces olfactory bulb(OB)*** neurons integrate into circuits to modulate sensory information and participate in olfactory processing(Bragado alonso et al.,2019).A series of hierarchical events need to take place to produce OB neurons from NSC of the ***,the activation of quiescent NSC is necessary to produce intermediate transit amplifying progenitors(TAP),which will generate *** latter are cells that maintain a proliferative phenotype while in an immature ***,once they initiate migration toward the OB,they progressively undergo their differentiation into neurons(Kjell et al.,2020).

关键词： ventricular maintain

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Post-transplant biliary complications using liver grafts from deceased donors older than 70 years:Retrospective case-control study

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世界胃肠外科杂志:英文版(电子版) 2023年第8期15卷 1615-1628页

作者： Carlos Jimenez-romero Iago Justo-alonso Pilar del Pozo-Elso Alberto Marcacuzco-Quinto Cristina Martín-Arriscado-Arroba Alejandro Manrique-Municio Jorge Calvo-Pulido Alvaro García-Sesma ricardo San Román Oscar Caso-Maestro Unit of HPB Surgery and Abdominal Organs Transplantation `12 de Octubre´University HospitalMadrid 28041Spain Clinical Research Unit(I+12) `12 de Octubre´University HospitalMadrid 28041Spain Department of Radiology `12 de Octubre´University HospitalMadrid 28041Spain

BACKGROUND The shortage of liver grafts and subsequent waitlist mortality led us to expand the donor pool using liver grafts from older *** To determine the incidence,outcomes,and risk factors for biliary complications(BC)in liver transplantation(LT)using liver grafts from donors aged>70 *** Between January 1994 and December 31,2019,297 LTs were performed using donors older than 70 *** excluding 47 LT for several reasons,we divided 250 LTs into two groups,namely post-LT BC(n=21)and without BC(n=229).This retrospective case-control study compared both *** Choledocho-choledochostomy without T-tube was the most frequent technique(76.2%in the BC group vs 92.6%in the non-BC group).Twenty-one patients(8.4%)developed BC(13 anastomotic strictures,7 biliary leakages,and 1 nonanastomotic biliary stricture).Nine patients underwent percutaneous balloon dilation and nine required a Rouxen-Y hepaticojejunostomy because of dilation *** incidence of post-LT complications(graft dysfunction,rejection,renal failure,and non-BC reoperations)was similar in both *** were no significant differences in the patient and graft survival between the ***,only three deaths were attributed to *** female donors were protective factors for BC,donor cardiac arrest was a risk *** The incidence of BC was relatively low on using liver grafts>70 *** could be managed in most cases by percutaneous dilation or Roux-en-Y hepaticojejunostomy,without significant differences in the patient or graft survival between the groups.

关键词： Older liver Liver transplant Biliary complications Biliary strictures Septuagenarian donors Octogenarian donors

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Collaborative learning via social computing

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Frontiers of Information Technology & Electronic Engineering 2019年第2期20卷 265-282页

作者： ricardo S.alonso Javier PRIETO óscar GARCíA Juan M.CORCHADO BISITE Research Group University of Salamanca

Educational innovation is a field that has been greatly enriched by using technology in its processes, resulting in a learning model where information comes from numerous sources and collaboration takes place among multiple students. One attractive challenge within educational innovation is the design of collaborative learning activities from the social computing point of view, where collaboration is not limited to student-to-student relationships, but includes student-to-machine interactions. At the same time, there is a great lack of tools that give support to the whole learning process and are not restricted to specific aspects of the educational task. In this paper, we present and evaluate context-aware framework for collaborative learning applications(CAFCLA) as a solution to these problems. CAFCLA is a flexible framework that covers the entire process of developing collaborative learning activities, taking advantage of contextual information and social interactions. Its application in the experimental case study of a collaborative WebQuest within a museum has shown that, among other benefits, the use of social computing improves the learning process, fosters collaboration, enhances relationships, and increases engagement.

关键词： Context-awareness Collaborative learning Social computing Virtual organizations Wireless sensor networks Real time location system

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Perspective on the use of synthetic biology in rudimentary food fermentations

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Systems Microbiology and Biomanufacturing 2023年第1期3卷 150-165页

作者： Alexander da Silva Vale Gilberto Vinícius de Melo Pereira Leonardo Martins Santana Dão Pedro de Carvalho Neto Brigitte Sthepani orozco Colonia Vanete Thomaz Soccol Bruna Leal Maske Carlos ricardo Soccol Department of Bioprocess Engineering and Biotechnology Federal University of Paraná(UFPR)CuritibaPRBrazil Department of Genetics University of São Paulo(USP)Ribeirão PretoSPBrazil Federal Institute of Education Science and Technology of Paraná(IFPR)LondrinaPRBrazil

Rudimentary food fermentation can be defined as a spontaneous process of conversion of food components through enzy-matic action.A great variety of fermented foods are produced using spontaneous approaches;however,cocoa and coffee represent the most important agricultural commodities on international *** a manner to increase the efficiency of these processes,starter cultures have been developed and applied under field *** selection process begins with the recovery of microbial strains from spontaneous fermentation through phenotypic and metabolic ***,mutation-based breeding is used to develop and improve well-adapted starter *** advances in synthetic biology,especially in the last decade,the development of robust cellular fabrications with high fermentative capacity has become easier-largely due to the development of genomic approaches,such as next-generation sequencing techniques,CRISPR-Cas system and bioinformatics *** review brings prospects on the use of synthetic biology to design new robust strains for use in cocoa and coffee fermentations,but which can be extended to other rudimentary *** addition,metabolic traits and target genes(e.g.,UvrA,RecA,GPD1,and GPP2)are proposed as a starting point for the improvement of cocoa and coffee ***,the regulatory and safety requirements for these food crops are *** review aims to stimulate research on the process of fermentation and the associated synthetic biology tools to produce fermented food efficiently and sustainably.

关键词： Coffee fermentation Cocoa fermentation Starter cultures CRISPR-Cas Synthetic promoters

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Quick Review and Technical Approach for Regenerative Peripheral Nerve Interface Surgery

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Modern Plastic Surgery 2023年第4期13卷 126-131页

作者： Obed H Grajeda Chávez Andres Gallardo Castillo Samantha Colchado Mariscal Xunaxi Guadalupe Vázquez orozco Dulce Sánchez Dauth Carlos Javier Mata Quintero Jorge Montalvo Hernández ricardo Palacios Merino Minerva Irene Hernandez Cristian Diaz Solleiro Department of Surgery Pemex Hospital Central Norte Mexico City Mexico

Regenerative peripheral nerve interface RPNI’s surgery was originally designed for prosthetic control. RPNI’s has demonstrated to be an effective tool to prevent neuroma formation by providing free muscle grafts as physiological targets for peripheral nerve ingrowth. Nerve transection injuries can result in painful neuromas that adversely affect patient recovery. This is especially significant following amputation surgeries, but they can also be used in surgeries in which the nerves can be visualized with a noticeable lesion. The first series of patients undergoing RPNI implantation for treatment of symptomatic postamputation neuromas was published in 2016. The series included a report of 46 patients undergoing RPNI. The clinical outcomes of RPNI have been optimistic with a reduction in neuroma pain up to 73% and phantom pain reduction of 53% along the uniformly high patient satisfaction. Since then, studies have been expanded, and knowledge regarding physiology has increased, providing us with new tools for a better understanding and giving these procedures more benefits and applications.

关键词： Component Formatting Style Styling Insert

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Pharmacogenetics of hepatocellular carcinoma and cholangiocarcinoma

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Cancer Drug Resistance 2019年第3期2卷 680-709页

作者： Marta alonso-Peña Anabel Sanchez-Martin Paula Sanchon-Sanchez Meraris Soto-Muñiz ricardo Espinosa-Escudero Jose J.G.Marin Experimental Hepatology and Drug Targeting(HEVEFARM) IBSALUniversity of SalamancaSalamanca 37007Spain Center for the Study of Liver and Gastrointestinal Diseases(CIBERehd).Carlos III National Institute of Health Madrid 28029Spain.

Primary liver cancers constitute the fourth most deadly group of *** poor prognosis is due in part to the pre-existence and/or development,often during treatment,of powerful mechanisms accounting for the poor response of cancer cells to antitumor *** include both impaired gene expression and the appearance of spliced variants,polymorphisms and mutations,affecting the function of genes leading to the reduction in intracellular concentrations of active agents,changes in molecular targets and survival pathways,altered tumor microenvironment and phenotypic *** present review summarizes available information regarding the role of germline and somatic mutations affecting drug transporters,enzymes involved in drug metabolism,organelles and signaling molecules related to liver cancer chemoresistance.A more complete picture of the actual complexity of this problem is urgently needed for carrying out further pharmacogenomic studies aimed to improve the management of patients suffering from hepatocellular carcinoma or cholangiocarcinoma.

关键词： Anticancer drug chemoresistance chemotherapy cholangiocarcinoma germline mutation hepatoma liver cancer somatic mutation

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South American SLR stations monitoring ground displacement caused by the M8.8 Chilean earthquake of 2010

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Chinese Science Bulletin 2011年第8期56卷 738-742页

作者： YIN ZhiQiang HAN YanBen PODESTA ricardo LIU WeiDong PACHECO Ana alonso Ester ACTIS Eloy HUANG DongPing ZHAO LiMin WANG Rui XIA JinChao National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Observatorio Astronomico Felix Aguilar San Juan University San Juan 5400 Argentina

The M8.8 Chilean earthquake of February 27,2010 caused a large surface displacement near its *** Laser Ranging(SLR) station 7405,cooperatively operated by Germany and Chile about 130 km from the epicenter was affected by the *** SLR station,No.7406,operated jointly by the National Astronomical Observatories of the Chinese Academy of Sciences and San Juan University of Argentina,was about 600 km from the *** the observations of these two SLR stations with global SLR station observations,we calculate the geocentric coordinates of the two stations based on *** results show that the coordinates of the two stations have changed by varying ***-7405 moved substantially towards the southwest with displacements of about 3.11,0.52 and 0.49 m in X,Y,Z directions;the corresponding displacements for SLR-7406 are about 0.02,0.03 and 0.02 *** solution,as an independent result derived from SLR observations,could provide an essential external check for other positioning techniques such as GPS.

关键词：地表位移 8级地震 SLR 智利 ITRF2000 GPS定位技术中国科学院国家天文台

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Environmental Issues of a Marine Protected Area in a Tectonic Estuary in the Tropical Eastern Pacific:Uramba(Malaga Bay Colombia):Context,Biodiversity,Threats and Challenges

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Journal of Water Resource and Protection 2013年第11期5卷 1037-1047页

作者： Jaime ricardo Cantera Kintz Edgardo Londono-Cruz Luz Marina Mejia-Ladino Leonardo Herrera-orozco Carlos Andres Satizabal Natalia Uribe-Castaneda Research Group in Estuaries and Mangroves of Colombian Pacific Departamento de BiologiaUniversidad del ValleCaliColombia Research Group in Taxonomy Systematic and Marine EcologyInstituto de Investigaciones Marinas y Costeras“Jose Benito Vives de Andreis”Santa MartaColombia

The environmental protection of tropical marine and coastal areas faces different challenges due to the diversity of aspects related to these areas, which include natural, social and economical issues. Despite these challenges, efforts for the protection of these areas are urgent nowadays because of the dramatical increase of human related threats like habitat destruction and population growth. Malaga Bay (MB) is a tectonic estuarine system located in Panama Bight (central region of the Colombian Pacific coast), which due to its origin shows important environmental characteristics of few sites in the Tropical Eastern Pacific (TEP) match. For these reasons, the government of Colombia declared in 2010, the bay’s marine area as a Marine National Natural Park in order to preserve its unique estuarine marine biodiversity. Despite this measure, MB presents several conditions that make environmental protection a very difficult task. In this paper, we present the geographical context, biodiversity and natural resources, environmental threats, the complexity of economic and social context, and the institutional and legal context of MB, to exemplify the difficulty that the protection of marine areas face in the TEP.

关键词： Protected Marine Areas Resources Conservation Estuaries Tropical Eastern Pacific

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