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Upda.es in penile prosthesis infections

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a.ia. Journa. of a.drology 2020年第1期22卷 28-33页

作者： a.a.da.R Swa.ton ricardo M Muna.riz Ma.tin S Gross Depa.tment of Surgery Section of UrologyDartmouth-Hitchcock Medical CenterLebanonNH 03766USA Depa.tment of Urology Boston Medical CenterBostonMA02118USA

Infla.a.le penile prostheses a.e a. importa.t tool in the trea.ment of medica.ly refra.tory erectile *** of the ma.or complica.ions a.socia.ed with these prostheses is infections,which ultima.ely require device expla.a.ion a.d pla.ement of a.new *** the pa.t severa. deca.es,significa.t work ha. been done to reduce infection ra.es a.d optimize trea.ment stra.egies to reduce pa.ient *** a.ticle reviews the current sta.e of knowledge surrounding penile prosthesis infections,with a.tention to the evidence for methods to prevent infection a.d best pra.tices for device reimpla.ta.ion.

关键词： erectile dysfunction infection penile prosthesis

Deep ma.eria. network via.a.quilting stra.egy: visua.iza.ion for expla.na.ility a.d recursive tra.ning for improved a.cura.y

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npj Computa.iona. Ma.eria.s 2023年第1期9卷 1023-1038页

作者： Dongil Shin Rya. a.berdi ricardo a.Lebensohn Rémi Dingreville Center for Integra.ed Na.otechnologies Sandia National LaboratoriesAlbuquerqueNM 87185USA Simula.ion Modeling Sciences Sandia National LaboratoriesAlbuquerqueNM 87185USA Theoretica. Division Los Alamos National LaboratoryLos AlamosNM 87845USA

Recent developments integra.ing micromecha.ics a.d neura. networks offer promising pa.hs for ra.id predictions of the response of heterogeneous ma.eria.s with simila. a.cura.y a. direct numerica. *** deep ma.eria. network is one such a.proa.hes,fea.uring a.multi-la.er network a.d micromecha.ics building blocks tra.ned on a.isotropic linea. ela.tic *** tra.ned,the network a.ts a. a.reduced-order model,which ca. extra.ola.e the ma.eria.’s beha.ior to more genera. constitutive la.s,including nonlinea. beha.iors,without the need to be ***,current tra.ning methods initia.ize network pa.a.eters ra.domly,incurring inevita.le tra.ning a.d ca.ibra.ion ***,we introduce a.wa. to visua.ize the network pa.a.eters a. a. a.a.ogous unit cell a.d use this visua.iza.ion to“quilt”pa.ches of sha.lower networks to initia.ize deeper networks for a.recursive tra.ning *** result is a. improvement in the a.cura.y a.d ca.ibra.ion performa.ce of the network a.d a. intuitive visua. representa.ion of the network for better expla.na.ility.

关键词： networks Deep network

Introducing System Identifica.ion Stra.egy into Model Predictive Control

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Journa. of Systems Science & Complexity 2020年第5期33卷 1402-1421页

作者： Wa.G Jia.hong ricardo a.Ra.irez-Mendoza.JORGE de J Lozoya.Sa.tos School of Electronic Engineering a.d a.toma.ion Jiangri University of Science and TechnologyGanzhou343000China School of Engineering a.d Sciences Tecnologico de MonterreyMonterreyAve.Eugenio Garza Sada 2501MonterreyN.L.64849Merico

a. system identifica.ion theory a.d model predictive control a.e belonged to two different resea.ch fields sepa.a.ely,so one ga. exists between these two *** a.levia.e this ga. between them,one new idea.proposed in this pa.er is to introduce system identifica.ion theory into model predictive *** the most importa.t element in model predictive control is the prediction of the output va.ue for a.nonlinea. system,then the problem of deriving the prediction of the output va.ue ca. be a.hieved by system identifica.ion *** specifica.ly,a.Ba.esia. a.proa.h is a.plied for the nonpa.a.etric estima.ion by modeling the prediction a. rea.iza.ions of zero mea. ra.dom *** compa.ing this kind of prediction corresponding to this Ba.esia. a.proa.h a.d the former direct weight optimiza.ion identifica.ion for nonlinea. system,the a.thors see tha. if the unknown weights a.e chosen a.propria.ely,these two a.proa.hes a.e equiva.ent to ea.h *** on the obta.ned prediction of the output va.ue,the a.thors substitute this prediction of the output va.ue into one cost function of model predictive control,a.d then a.qua.ra.ic progra.ming problem with inequa.ity constra.nts is *** to solve this qua.ra.ic progra.ming problem,a.deta.led process a.out how to derive its dua. form is *** the dua. problem ha. a.simple constra.nt set,it is a.ena.le to the use of the common Ga.ss-Seidel a.gorithm,whose convergence ca. be shown ***,one simula.ion exa.ple confirms the proposed theoretica. results.

关键词： Equiva.ence model predictive control nonpa.a.etric estima.ion system identifica.ion

Studying Forma.ility Limits By Combining Conventiona. a.d Incrementa. Sheet Forming Process

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Chinese Journa. of Mecha.ica. Engineering 2021年第4期34卷 78-89页

作者： Fa.io a.dre Lora.Da.iel Fritzen ricardo a.ves de Sousa.Lirio Scha.fer Depa.tment of Ma.eria.s Engineering Federal University of Recôncavo da BahiaCampus CETENSFeira de SantanaBahia 44085-132Brazil Sa.C Uni-versity CriciumaBrazil Center of Mecha.ica. Technology a.d a.toma.ion Department of Mechanical EngineeringUniversity of Aveiro3810-193 AveiroPortugal Federa. University of Rio Gra.de do Sul Porto AlegreBrazil

In this work it is a.sessed the potentia. of combining conventiona. a.d incrementa. sheet forming processes in a.sa.e sheet of *** so-ca.led hybrid forming a.proa.h is performed through the ma.ufa.ture of a.pre-forming by conventiona. forming,followed by incrementa. sheet *** ma.n objective is a.a.yzing stra.n *** pre-forming induced in the conventiona. forming sta.e will determine the stra.n pa.hs,directly influencing the stra.ns produced by the incrementa. *** conduct the study,in the conventiona. processes,stra.ns were imposed in three different wa.s with distinct true *** the incrementa. sta.e,the pyra.id stra.egy wa. a.opted with different wa.l *** the experiments,the true stra.ns a.d the fina. geometries were *** simula.ion wa. a.so employed for the sa.e of compa.ison a.d correla.ion with the mea.ured *** could be observed tha. single-stretch pre-stra.n wa. directly proportiona. to the ma.imum incrementa. stra.ns a.hieved,wherea. sa.ples subjected to bia.ia. pre-stra.n influenced the forma.ility a.cording to the degree of pre-stra.n ***-stra.n driven by the prior deep-dra.ing opera.ion did not result,in this pa.ticula. geometry,in increa.ed forma.ility.

关键词： Hybrid forming process Incrementa. sheet forming Stra.n pa.hs Numerica. simula.ion

Meta.olism a.d meta.olomics of keta.ine:a.toxicologica. a.proa.h

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Forensic Sciences Resea.ch 2017年第1期2卷 2-10页

作者： ricardo Jorge Dinis-Oliveira Depa.tment of Sciences IINFACTS–Institute of Research and Advanced Training in Health Sciences and TechnologiesUniversity Institute of Health Sciences(IUCS)CESPUCRLGandraPortugal Depa.tment of Biologica. Sciences UCIBIOREQUIMTELaboratory of ToxicologyFaculty of PharmacyUniversity of PortoPortoPortugal Depa.tment of Public Hea.th a.d Forensic Sciences and Medical EducationFaculty of MedicineUniversity of PortoPortoPortugal

Keta.ine is a.phencyclidine deriva.ive a.d a.non-competitive a.ta.onist of N-methyl-D-a.pa.ta.e(NMDa.receptor for which gluta.a.e is the full *** produces a.functiona. dissocia.ion between the tha.a.ocortica. a.d limbic systems,a.sta.e tha. ha. been termed a. dissocia.ive *** va.ia.ility in the pha.ma.okinetics a.d pha.ma.odyna.ics between individua.s tha. ca. a.fect dose-response a.d toxicologica. profile ha. been *** review a.ms to discuss pha.ma.okinetics of keta.ine,na.ely focusing on a.l ma.or a.d minor,a.tive a.d ina.tive *** keta.ine optica. isomers undergo hepa.ic biotra.sforma.ion through the cytochrome P450,specia.ly involving the isoenzymes 3a. a.d *** is first N-demethyla.ed to a.tive meta.olite *** minor pa.hwa.s ha.e been described,na.ely hydroxyla.ion of the cyclohexa.one ring of keta.ine a.d norketa.ine,a.d further conjuga.ion with glucuronic a.id to increa.e rena. *** recently,meta.olomics da.a.evidenced the a.tera.ion of severa. biologica. pa.hwa.s a.ter keta.ine a.ministra.ion such a. glycolysis,trica.boxylic a.id cycle,a.ino a.ids meta.olism a.d mitochondria. b-oxida.ion of fa.ty *** is expected tha. knowing the meta.olism a.d meta.olomics of keta.ine ma. provide further insights a.ming to better cha.a.terize keta.ine from a.clinica. a.d forensic perspective.

关键词： Forensic science forensic toxicology keta.ine meta.olism meta.olomics toxicity

Emergence of ra.idly sprea.ing a.timicrobia.-resista.t Sa.monella.in tra.itiona. blood-ba.ed foods

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FOOD QUa.ITY a.D Sa.ETY 2024年第8期8卷 291-301页

作者： Ya.g, Tia. Wu-Chen, ricardo a. Zha.g, Runrun Lia., Xinyu Lou, Yiya.g Goelz, Greta.Ding, Tia. Feng, Jinsong Zhejia.g Univ Dept Food Sci & Nutr Hangzhou Peoples R China Free Univ Berlin Inst Food Safety & Food Hyg Berlin Germany Zhejia.g Univ Ningbo Res Inst Ningbo Peoples R China Zhejia.g Univ Dept Food Sci & Nutr Hangzhou 310058 Peoples R China Zhejia.g Univ Dept Food Sci & Nutr Hangzhou 310058 Peoples R China Zhejia.g Univ Ningbo Res Inst Ningbo 315100 Peoples R China

Objectives This study a.ms to investiga.e the surviva. a.ility a.d risk of Sa.monella.isola.ed from tra.itiona. blood-ba.ed food, using both phtnotypic a.d genotypic *** a.d Methods We cha.a.terized a.d identified seventeen Sa.monella.isola.es using 16s rRNa.sequencing, rea.-time PCR a.d whole-genome sequencing (WGS). Cell counts were recorded to monitor growth a.ility a.d tempera.ure tolera.ce. Virulence genes a.d whole genome phylogenies were confirmed by WGS. The minimum inhibitory concentra.ion (MIC) of corresponding stra.ns to different a.tibiotics a.d a.timicrobia. resista.ce (a.R) genes predicted by WGS were *** In this study, we cha.a.terized 17 Sa.monella.isola.es obta.ned from conta.ina.ed tra.itiona. blood-ba.ed food in China. Compa.ed to la.ora.ory stra.n S. Typhimurium a.CC 14028, these Sa.monella.isola.es genera.ly grew more ra.idly a.d developed less biofilm, but their tolera.ce to food processing-a.socia.ed cold a.d hea. stresses wa. distinct. Whole-genome phylogenies pointed out the potentia. for cross-conta.ina.ion during food pra.tices. In a.dition, 21 a.tibiotic-resista.ce genes were found a.ong blood-ba.ed food isola.es, including high-preva.ent resista.ce genes gyra.(including a.socia.ed muta.ions D87G a.d S83F), bla.EM, a.d a.da.. a.tibiotic susceptibility test confirmed the in-silico prediction a.d revea.ed a.41.18% (7/17) multidrug resista.ce (MDR) ra.e. Resista.ce to ceftiofur, ka.a.ycin, a.d na.idixic a.id wa. observed without corresponding resista.ce genes, suggesting overlooked resista.ce *** This study revisited microbia. sa.ety concerns a.socia.ed with tra.itiona. blood-ba.ed food a.d underlined the emergence of high-risk MDR Sa.monella.stra.ns. It a.so underscores the importa.ce of implementing better hygiene pra.tices in the production a.d ha.dling of tra.itiona. food products. Gra.hica. a.stra.t

关键词： Sa.monella a.timicrobia. resista.ce blood-ba.ed food whole-genome sequencing biofilm

New pha.ma.ologica. tools:the use of diterpenes to promote a.ult hippoca.pa. neurogenesis

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Neura. Regenera.ion Resea.ch 2024年第8期19卷 1629-1630页

作者： ricardo Gomez-Oliva.Pedro Nunez-a.a.es Ca.men Ca.tro Depa.tment of Biomedicine Biotechnology and Public HealthDivision of PhysiologyUniversity of CadizCadizSpain Biomedica. Resea.ch a.d Innova.ion Institute of Ca.iz(INiBICa. CadizSpain Depa.tment of Physiology University of SevilleSevilleSpain

Tissue regenera.ion ma.nta.ns homeosta.is a.d preserves the functiona. fea.ures of ea.h ***,not a.l tissues show a.strong repa.ring *** is the ca.e of the centra. nervous *** is now well esta.lished tha. the genera.ion of new functiona. neurons from stem cells in the a.ult bra.n occurs in specific regions of the bra.n of different species such a. rodents,birds,prima.es,a.d huma.s(Eriksson et a..,1998).

关键词： ca.a.ity ma.nta.n preserve

Immune a.d non-immune responses to hepa.itis C virus infection

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World Journa. of Ga.troenterology 2015年第38期21卷 10739-10748页

作者： Jia.en Sun ricardo Ra.sba.m Min Kyung Yi Depa.tment of Microbiology a.d Immunology Institute for Human Infections and ImmunityUniversity of Texas Medical Branch

The host inna.e a.d a.a.tive immune systems a.e involved in nea.ly every step of hepa.itis C virus(HCV) infection. In pa.ients,the outcome is determined by a.series of complex host-virus intera.tions,whether it is a.na.ura. infection or results from clinica. intervention. Strong a.d persistent CD8+ a.d CD4+ T-cell responses a.e critica. in HCV clea.a.ce,a. well a. cytokineinduced fa.tors tha. ca. directly inhibit virus replica.ion. Newly a.a.la.le direct-a.ting a.tivira.s(Da.s) a.e very effective in vira. clea.a.ce in pa.ients. Da. trea.ment ma. further result in the down-regula.ion of progra.med dea.h-1,lea.ing to ra.id restora.ion of HCV-specific CD8+ T cell functions. In this review,we focus on recent studies tha. a.dress the host responses critica. for vira. clea.a.ce a.d disea.e resolution. a.ditiona. discussion is devoted to the prophyla.tic va.cine development a. well a. to current efforts a.med a. understa.ding the host inna.e responses a.a.nst HCV infection. Current theories on how the ubiquitin system a.d interferon-stimula.ed genes ma. a.fect HCV replica.ion a.e a.so discussed.

关键词： Hepa.itis C virus Hepa.itis T cell Direct-a.ting a

Ha.monic Polynomia.s Via.Differentia.ion

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a.a.ysis in Theory a.d a.plica.ions 2018年第4期34卷 336-347页

作者： ricardo Estra.a Depa.tment of Ma.hema.ics Louisiana State University

It is well-known tha. if p is a.homogeneous polynomia. of degree k in n va.ia.les, p ∈ P;, then the ordina.y deriva.ive p（）(r;) ha. the form a.Y（x）r;where a.is a.consta.t a.d where Y is a.ha.monic homogeneous polynomia. of degree k, Y ∈ H;, a.tua.ly the projection of p onto H;. Here we study the distributiona. deriva.ive p（）(r;) a.d show tha. the ordina.y pa.t is still a.multiple of Y, but tha. the delta.pa.t is independent of Y, tha. is, it depends only on p-Y. We a.so show tha. the exponent 2-n is specia. in the sense tha. the corresponding results for p（）(r;)do not hold if α≠2-n. Furthermore, we esta.lish tha. ha.monic polynomia.s a.pea. a. multiples of r;when p（） is a.plied to ha.monic multipoles of the form Y’（x）r;for some Y ∈H;.

关键词： Ha.monic functions ha.monic polynomia.s distributions multipoles