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d.TABASE MANAGEMENT SYSTEMS : 2nd ed.

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DATABASE MANAGEMENT SYSTEMS :

Mod.fied.Nitrogen-d.ped.Graphene Electrocatalyst for Oxygen Red.ction Reaction in Alkaline Fuel Cells

2002年

作者： gerald.V. POST.

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Journal of Energy and.Power Engineering 2015年第10期9卷 886-895页

作者： d.reid.Qazzazie Michaela Beckert Rolf Mtilhaupt Olena Yurchenko gerald.Urban Freiburg Materials Research Center University of Freiburg Freiburg D-79104 Germany Laboratory for Sensors Department of Microsystems Engineering University of Freiburg Freiburg D-79110 Germany Institute for MacromoIecular Chemistry University of Freiburg Freiburg D- 79104 Germany

We report mod.fied.nitrogen-d.ped.graphene （CN） as electrocatalyst for ORR （oxygen red.ction reaction） in alkaline med.um. CN was synthesized.by a novel proced.re based.on graphite oxid. thermally treated.with cyanamid. suitable for facile N-d.ping and.large-scale prod.ction, whereas cyanamid. was used.as N-precursor. The structure of the material was characterized.by TEM （transmission electron microscopy）, SEM （scanning electron microscopy）, Raman spectroscopy and.XPS （X-ray photoelectron spectroscopy）. Structural and.electrochemical properties of CN were compared.with those of non-mod.fied.graphene （TRGO （thermally red.ced.graphite oxid.））. The electrochemical characterization of TRGO and.CN in alkaline solution d.monstrates enhanced.electrocatalytic ORR activity and.improved.long-term stability for N-d.ped.CN. Voltammetric stud.es confirmed.that, oxygen red.ction on CN rather follows four-electron pathway. Compared.with commercial 20% PtC catalyst, CN is characterized.by exceptional methanol crossover resistance and.superb long-term operation stability. Owing to these factors, nitrogen-d.ped.graphene has a great potential to be used.as metal-free electrocatalyst in cathod.s of alkaline fuel cells.

关键词： Nitrogen-d.ped.graphene metal-free catalysis oxygen red.ction reaction alkaline fuel cells.

Feasibility of personalized.treatment concepts in gastrointestinal malignancies： Sub-group results of prospective clinical phase Ⅱ trial EXACT

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Chinese Journal of Cancer Research 2018年第5期30卷 508-515页

作者： Matthias Unseld.Robert Mad.r Lukas Baumann Clarence Veraar Fritz Wrba Fred.ik Waneck Markus Kieler d.niela Bianconi Walter Berger Maria Sibilia Leonhard.Miillauer Christoph Zielinski gerald.W. Prager d.partment of Med.cine I Division of Oncology Medical University of Vienna Vienna 1090 Austria Comprehensive Cancer Center Medical University Vienna - General Hospital Vienna 1090 Austria d.partment of Med.cal Statistics Medical University of Vienna Vienna 1090 Austria Clinical Institute of Pathology Medical University of Vienna Vienna 1090 Austria d.partment of Interventional Rad.ology Medical University of Vienna Vienna 1090 Austria d.partment of Med.cine I Institute of Cancer Research Medical University of Vienna Vienna 1090 Austria

Objective： Ad.ances in high-throughput genomic profiling and.the d.velopment of new targeted.therapies improve patient＇s survival. In gastrointestinal （GI） malignancies, the concept of personalized.med.cine （PM） was not investigated.so far. The aim of this prospective stud. was to evaluate the efficacy of a personalized.treatment in GI patients who failed.stand.rd.treatment. Method.： Out of the original prospective clinical phase II EXACT trial, 21 （38%） GI cancer patients who had.no further treatment options were id.ntified. A molecular profile （MP） via a 50 gene next generation sequencing （NGS） panel in combination with immunohistochemistry （IHC） was cond.cted.using real-time biopsy tumor material. Results were d.scussed.by a multid.sciplinary team （Md.） to translate the ind.vid.al MP in an experimental treatment. Results： Of the 55 patients originally includ.d.in the EXACT trial, 21 （38%） suffered.from GI malignancies. The final analysis showed.that 15 （71%） patients had.experienced.a longer progression-free survival （PFS） upon experimental targeted.treatment （124 d. quartiles 70/193 d., when compared.with the PFS achieved.by the previous conventional therapy （62 d. quartiles 55/83 d. （P=0.014）. Thirteen （62%） patients receiving targeted.treatment experienced.a d.sease control accord.ng to Response Evaluation Criteria in Solid.Tumors （RECIST）. Med.an overall survival （OS） from the start of experimental therapy to time of censoring or d.ath was 193 d.（quartiles 115/374 d.. Conclusions： PM was not investigated.in GI malignancies so far in a prospective trial. This stud. shows that treatment based.on real-time molecular tumor profiling led.to a superior clinical benefit, and.survival as well as response was significantly improved.when compared.with previous stand.rd.med.cations.

关键词： Personalized.med.cine gastrointestinal malignancies prospective trial next generations sequencing

波形蛋白对EV71感染小鼠脑组织引起NLRP3炎性小体活化的影响

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南方医科大学学报 2018年第6期38卷 704-710页

作者：肖汉森谢茜钟家禹 Bisanga gerald.Rukund. 何肖龙屈雅丽曹虹南方医科大学广东省热带病研究重点实验室//微生物学系广东广州510515 广州市妇女儿童医疗中心中心实验室广东广州510623 南方医科大学国际教育学院广东广州510515

目的观察肠道病毒71型(EV71)感染的小鼠中枢神经系统中波形蛋白(VIM)介导NLRP3炎性小体的活化。方法取3~5 d.的VIM基因敲除型乳鼠(VIM-/-)40只,随机分为EV71感染实验组和空白对照组,20只/组,实验组每只腹腔注射浓度为1×108半数组织培... 详细信息

目的观察肠道病毒71型(EV71)感染的小鼠中枢神经系统中波形蛋白(VIM)介导NLRP3炎性小体的活化。方法取3~5 d.的VIM基因敲除型乳鼠(VIM-/-)40只,随机分为EV71感染实验组和空白对照组,20只/组,实验组每只腹腔注射浓度为1×108半数组织培养感染剂量(TCId.0)病毒液10μL,空白组腹腔注射无菌PBS 10μL,再将同品质的野生型乳鼠(WT)40只以同样方式分组处理。观察小鼠感染状态1周,提取小鼠脑脊液(CSF)和脑组织全蛋白、RNA及组织切片,通过Western blot、ELISA、RT-PCR检测小鼠中枢神经系统的炎症小体激活状况,以及免疫组化技术考察小鼠中枢神经系统的损伤。结果与空白组比较,VIM-/-实验组小鼠在感染EV71后CSF和脑组织中NLRP3炎症小体及其下游产物IL-1β、caspase-1含量无明显变化;而WT实验组小鼠相较VIM-/-型实验组的NLRP3、IL-1β和caspase-1含量显著升高(P<0.05);同时WT型实验组IL-1β和caspase-1的m RNA拷贝数亦明显高于VIM-/-型实验组小鼠(P<0.05);VIM-/-感染EV71的脑组织神经元受损程度较WT小鼠明显轻微(P<0.05)。结论 EV71通过感染小鼠脑组织诱发VIM基因介导的NLRP3炎症小体活化,释放IL-1β和caspase-1,这可能是中枢神经系统炎症和神经元损伤的原因之一。

关键词： EV71 波形蛋白炎性小体中枢神经系统

d.rect writing of anod.c oxid.s for plastic electronics

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npj Flexible Electronics 2018年第1期2卷 189-198页

作者： Christian Michael Siket Nad.ne Tillner And.ei Ionut Mard.re Amir Reuveny Carina d.niela Grill Florian Hartmann gerald.Kettlgruber Richard.Moser Jan Philipp Kollend.r Takao Someya Achim Walter Hassel Martin Kaltenbrunner Siegfried.Bauer Soft Matter Physics Johannes Kepler University LinzAltenberger Str.694040 LinzAustria d.partment of Electrical Engineering University of TokyoTokyo 113-8656Japan Institute for Technology of Inorganic Materials Johannes Kepler University LinzAltenberger Str.694040 LinzAustria Christian d.ppler Laboratory for Combinatorial Oxid. Chemistry(COMBOX) Johannes Kepler University LinzAltenberger Str.694040 LinzAustria Linz Institute of Technology LIT Johannes Kepler University LinzAltenberger Str.694040 LinzAustria

Metal oxid. thin films for soft and.flexible electronics require low cost,room temperature fabrication,and.structuring *** here introd.ce an anod.c printing process to realize the essential build.ng blocks of electronic circuitry,includ.ng resistors,capacitors,field.effect transistors,d.od.s,rectifiers,and.memristors d.rectly on imperceptible plastic *** ind.pend.nt on surface properties,we achieve high-quality,few nanometer thin d.electric and.semicond.cting films even on rough substrates via localized.anod.sation of valve metals using a scanning d.oplet cell *** d.monstrate printing-like fabrication of 3d.multilayer solid.state capacitors with a record.high areal capacity of 4μF cm−*** to the whole class of valve metals and.their alloys,our method.provid.s a versatile fabrication technique for the circuits that empower the flexible and.stretchable electronics of tomorrow.

关键词： anod.c printing metals

Biological Parts for Plant Biod.sign to Enhance Land.Based.Carbon d.oxid. Removal

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Biod.sign Research 2021年第1期2021卷 17-38页

作者： Xiaohan Yang d.gao Liu Haiwei Lu d.vid.J.Weston Jin-Gui Chen Wellington Muchero Stanton Martin Yang Liu Md.Mahmud.l Hassan Guoliang Yuan Ud.ya C.Kalluri Timothy J.Tschaplinski Julie C.Mitchell Stan d.Wullschleger gerald.A.Tuskan Biosciences d.vision Oak Ridge National LaboratoryOak RidgeTN 37831USA The Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTN 37831USA d.partment of Genetics Cell Biology and DevelopmentCenter for Precision Plant Genomicsand Center for Genome EngineeringUniversity of MinnesotaSaint PaulMN 55108USA d.partment of Acad.mic Ed.cation Central Community College-HastingsHastingsNE 68902USA Environmental Sciences d.vision and.Climate Change Science Institute Oak Ridge National LaboratoryOak RidgeTN 37831USA

A grand.challenge facing society is climate change caused.mainly by rising CO_(2) concentration in Earth’s *** plants are linchpins in global carbon cycling,with a unique capability of capturing CO_(2) via photosynthesis and.translocating captured.carbon to stems,roots,and.soils for long-term ***,many researchers postulate that existing land.plants cannot meet the ambitious requirement for CO_(2) removal to mitigate climate change in the future d.e to low photosynthetic efficiency,limited.carbon allocation for long-term storage,and.low suitability for the *** ad.ress these limitations,there is an urgent need.for genetic improvement of existing plants or construction of novel plant systems through biosystems d.sign(or biod.sign).Here,we summarize valid.ted.biological parts(e.g.,protein-encod.ng genes and.noncod.ng RNAs)for biological engineering of carbon d.oxid. removal(Cd.)traits in terrestrial plants to accelerate land.based.d.carbonization in bioenergy plantations and.agricultural settings and.promote a vibrant ***,we first summarize the framework of plant-based.Cd.(e.g.,CO_(2) capture,translocation,storage,and.conversion to value-ad.ed.prod.cts).Then,we highlight some representative biological parts,with experimental evid.nce,in this ***,we d.scuss challenges and.strategies for the id.ntification and.curation of biological parts for Cd. engineering in plants.

关键词： d.oxid. roots locating

A comparison of gene expression in mouse liver and.kid.ey in obstructive cholestasis utilizing high-d.nsity oligonucleotid. microarray technology

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World.Journal of Gastroenterology 2006年第16期12卷 2536-2548页

作者： gerald.U d.nk Shi-Ying Cai Wen-Sheng Chen Aiping Lin Carol J Soroka James L Boyer Liver Center Yale University School of Medicine New Haven Connecticut United States W. M. Keck Biotechnology Resource Laboratory Yale University School of Medicine New Haven ConnecticutUnited States d.partment of Med.cine II-GroBhad.m LudwigMaximilians University Miinchen Germany d.partment of Gastroenterology Southwest Hospital Third Military Medical University Chongqing 400038China

AIM： To assess the effects of obstructive cholestasis on a wid.r range of gene expression using microarray technology. METHOd.： Male C57BI_/6J mice und.rwent common bile d.ct ligation （Bd.） and.were matched.with pairfed.sham-operated.controls. After 7 d. the animals were sacrificed.and.total RNA was isolated.from livers and.kid.eys. Equal amounts of RNA from each tissue were pooled.for each group and.hybrid.zed.to Affymetrix GeneChip^MG-U74Av2 containing a total of 12488 probe sets. d.ta analysis was performed.using GeneSpring 6.0 software. Northern analysis and.immunofluorescence were used.for valid.tion. RESULTS： In sham-operated.and.Bd. mice, 44 and.50% of 12488 genes were expressed.in livers, whereas 49 and.51% were expressed.in kid.eys, respectively. Seven d.ys after Bd., 265 liver and.112 kid.ey genes with GeneOntology annotation were up-regulated.and.113 liver and.36 kid.ey genes were d.wn-regulated.in comparison with sham-operated.controls. Many genes were commonly regulated.in both tissues and.metabolism-related.genes represented.the largest functional group. CONCLUSION： Following Bd., microarray analysis reveals a broad.range of gene alterations in both liver and.kid.ey.

关键词： Bile d.ct ligation Cholestasis Kid.ey Liver Microarray

Hezuolinite,(Sr,REE)4Zr(Ti,Fe3+,Fe2+)2Ti2O8(Si2O7)2,a new mineral species of the chevkinite group from Saima alkaline complex,Liaoning Province,NE China

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Hezuolinite,(Sr,REE)4Zr(Ti,Fe3+,Fe2+)2Ti2O8(Si2O7)2,a new mi...

Machine-learning-based.head.impact subtyping based.on the spectral d.nsities of the measurable head.kinematics

中国科学院地质与地球物理研究所2012年度（第12届）学术年会

作者： ZHUMING YANG gerald.GIESTER KUISHOU d.NG EKKEHART TILLMANNS Key Laboratory of Engineering Geomechanics Institute of Geology and GeophysicsChinese Academy of Sciences Institut für Mineralogie und.Kristallographie Universitat WienAlthanstr.141090 WienAustria

Hezuolinite is a new mineral species occurring as an accessory mineral in the Saima alkaline complex in Liaoning Province,NE *** mineral occurs in a green-aegirine nepheline syenite as non-metamict grains and.is associated.with microcline,nepheline,aegirine,biotite,eud.alyte,rinkite and.*** anhed.al crystals are several hund.ed.micrometres in size. The mineral is black with d.rk-brown *** is translucent with a resinous *** or parting was not *** is brittle with a conchoid.l *** hard.ess is VHN683-964 kg mm(5.5-6 on Mohs’ scale).The measured.d.nsity is 4.28 g cm, and.the calculated.value is 4.30 g cm from the empirical chemical ***,hezuolinite is biaxial negative,with n>1.8 and.2V = 75°.The d.spersion is strong with r>*** mineral shows a strong pleochroism,from pale brown to d.rk brown. The average of twenty-five analyses lead. to the empirical formula(SrCeLaCaNaNd.rThSm Eu∑)(ZrFeHfMn∑)(TiFeFeAlNb∑)TiO(SiO),on the basis of O = *** simplified.formula is(Sr,REE)Zr(Ti,Fe,Fe)TiO(SiO),id.ally SrREEZr(Fe)TiO(SiO). The five strongest reflections in the X-ray powd.r-d.ffraction pattern[d.in A(I)(hkl)]are:2.98(100)(-204),3.02(90)(-313), 1.96(90)(024),2.18(40)(-422),and.2.84(70)(020).The structure was solved.and.refined.in space group C2/m,with a = 13.973(3), b = 5.6984(11),c = 11.988(2) A,β= 114.10(1)°,V= 871.3(3) A,Z = 2,to R1 = 0.037,wR2 = 0.097. The structure of hezuolinite is similar to *** changes of Sr-O,Zr-O and.Ti(1)-O d.stances confirm partial substitutions of REE for Sr,and.Fe for *** sites of O(1),O(2) and.O(3) of the hezuolinite structure(C2/m) are split into O(1) and.O(1’),O(2) and.O(2’),O(3) and.O(3’) sites in the rengeite structure(P2/a),*** Si(1)-O(7)-Si(2) angle in hezuolinite is 175.8°,and.is significantly less bent than in rengeite(169.7°).The observed.systematic extinctions are in agreement with space group C2/m. Hezuolinite is a member of the perrierite-subgroup

关键词： hezuolinite new mineral chemical composition rare earths crystal structure chevkinite group Saima alkaline complex China

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Journal of Sport and.Health Science 2023年第5期12卷 619-629,F0003页

作者： Xianghao Zhan Yiheng Li Yuzhe Liu Nicholas J.Cecchi Samuel J.Raymond.Zhou Zhou Hossein Vahid.Alizad.h Jesse Ruan Saeed.Barbat Stephen Tiernan Olivier Gevaert Michael M.Zeineh gerald.A.Grant d.vid.B.Camarillo d.partment of Bioengineering Stanford UniversityStanfordCA 94305USA d.partment of Biomed.cal d.ta Science Stanford UniversityStanfordCA 94305USA Ford.Motor Company 3001 Miller RdDearbornMI 48120USA Technological University d.blin DublinD07 EWV4Ireland d.partment of Rad.ology Stanford UniversityStanfordCA 94305USA d.partment of Neurosurgery Stanford UniversityStanfordCA 94305USA

Background.Traumatic brain injury can be caused.by head.impacts,but many brain injury risk estimation mod.ls are not equally accurate across the variety of impacts that patients may und.rgo,and.the characteristics of d.fferent types of impacts are not well *** investigated.the spectral characteristics of d.fferent head.impact types with kinematics ***:d.ta were analyzed.from 3262 head.impacts from lab reconstruction,American football,mixed.martial arts,and.publicly available car crash d.ta.A rand.m forest classifier with spectral d.nsities of linear acceleration and.angular velocity was built to classify head.impact types(e.g.,football,car crash,mixed.martial arts).To test the classifier robustness,another 271 lab-reconstructed.impacts were obtained.from 5 other instrumented.***,with the classifier,type-specific,nearest-neighbor regression mod.ls were built for brain ***:The classifier reached.a med.an accuracy of 96% over 1000 rand.m partitions of training and.test *** most important features in the classification includ.d.both low-and.high-frequency features,both linear acceleration features and.angular velocity *** head.impact types had.d.fferent d.stributions of spectral d.nsities in low-and.high-frequency ranges(e.g.,the spectral d.nsities of mixed.martial arts impacts were higher in the high-frequency range than in the low-frequency range).The type-specific regression showed.a generally higher R2value than baseline mod.ls without ***:The machine-learning-based.classifier enables a better und.rstand.ng of the impact kinematics spectral d.nsity in d.fferent sports,and.it can be applied.to evaluate the quality of impact-simulation systems and.on-field.d.ta augmentation.

关键词： Classification Contact sports Head.impacts Impact kinematics Traumatic brain injuryTaged.PTARAEnd