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New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis

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Bone Research 2023年第2期11卷 303-315页

作者： Emilie Hascoet Frédéric Blanchard Claudine Blin-Wakkach Jérôme Guicheux Philippe Lesclous Alexandra Cloitre Nantes Université OnirisUniv AngersCHU NantesINSERMRegenerative Medicine and SkeletonRMeSUMR1229F-44000 NantesFrance UniversitéCote d'Azur CNRSLP2M NiceFrance

Rheumatoid arthritis(RA)and periodontitis are chronic inflammatory diseases leading to increased bone *** this inflammatory bone resorption is a major health *** diseases share immunopathogenic similarities and a common inflammatory *** autoimmune response or periodontal infection stimulates certain immune actors,leading in both cases to chronic inflammation that perpetuates bone ***,RA and periodontitis have a strong epidemiological association that could be explained by periodontal microbial *** dysbiosis is believed to be involved in the initiation of RA via three mechanisms.(i)The dissemination of periodontal pathogens triggers systemic inflammation.(ii)Periodontal pathogens can induce the generation of citrullinated neoepitopes,leading to the generation of anti-citrullinated peptide autoantibodies.(iii)Intracellular danger-associated molecular patterns accelerate local and systemic ***,periodontal dysbiosis could promote or sustain bone resorption in distant inflamed ***,in inflammatory conditions,the existence of osteoclasts distinct from“classical osteoclasts”has recently been *** have proinflammatory origins and *** populations of osteoclast precursors have been described in RA,such as classical monocytes,a dendritic cell subtype,and arthritis-associated osteoclastogenic *** aim of this review is to synthesize knowledge on osteoclasts and their precursors in inflammatory conditions,especially in RA and *** attention will be given to recent data related to RA that could be of potential value in periodontitis due to the immunopathogenic similarities between the two *** our understanding of these pathogenic mechanisms should lead to the identification of new therapeutic targets involved in the pathological inflammatory bone resorption associated with these diseases.

关键词： inflammatory osteoclast period

Analyzing Changes in maize Leaves Orientation due to GxExm Using an Automatic method from RGB Images

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Plant Phenomics 2023年第2期5卷 239-252页

作者： mario Serouart Raul Lopez-Lozano Gaëtan Daubige maëva Baumont Brigitte Escale Benoit De Solan Frédéric Baret Arvalis Institut du végétal228route de l’aérodrome-CS 4050984914 Avignon Cedex 9France INRAE Avignon UniversitéUMR EMMAHUMT CAPTE228route de l’aérodrome-CS 4050984914 Avignon Cedex 9France Arvalis Ecophysiology21 Chemin de Pau64121 MontardonFrance

The sowing pattern has an important impact on light interception efficiency in maize by determining the spatial distribution of leaves within the *** orientation is an important architectural trait determining maize canopies light *** studies have indicated how maize genotypes may adapt leaves orientation to avoid mutual shading with neighboring plants as a plastic response to intraspecific *** goal of the present study is 2-fold:firstly,to propose and validate an automatic algorithm(Automatic Leaf Azimuth Estimation from midrib detection[ALAEm])based on leaves midrib detection in vertical red green blue(RGB)images to describe leaves orientation at the canopy level;and secondly,to describe genotypic and environmental differences in leaves orientation in a panel of 5 maize hybrids sowing at 2 densities(6 and 12 plants.m^(−2))and 2 row spacing(0.4 and 0.8 m)over 2 different sites in southern *** ALAEm algorithm was validated against in situ annotations of leaves orientation,showing a satisfactory agreement(root mean square[RmSE]error=0.1,R^(2)=0.35)in the proportion of leaves oriented perpendicular to rows direction across sowing patterns,genotypes,and *** results from ALAEm permitted to identify significant differences in leaves orientation associated to leaves intraspecific *** both experiments,a progressive increase in the proportion of leaves oriented perpendicular to the row is observed when the rectangularity of the sowing pattern increases from 1(6 plants.m^(−2),0.4 m row spacing)towards 8(12 plants.m^(−2),0.8 m row spacing).Significant differences among the 5 cultivars were found,with 2 hybrids exhibiting,systematically,a more plastic behavior with a significantly higher proportion of leaves oriented perpendicularly to avoid overlapping with neighbor plants at high *** in leaves orientation were also found between experiments in a squared sowing pattern(6 plants.m^(−2),0.4 m

关键词： cultivar spacing pattern

比利时高放废物处置库设计及与基岩和工程屏障体系的热–水–力性状的相关研究(英文)

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岩石力学与工程学报 2006年第4期25卷 681-692页

作者：李香绫 Bernier Frédéric Bel Johan Euridice SCK.CEN国家核能研究中心 ONDRAF/NIRAS国家放射性废弃物和多裂隙材料管理局

在比利时,泥岩中地质处置是高放废物最终处置的首选。处置库在高放废物与生物圈之间的多重屏障基础上设计的,而 Boom 泥岩作为基岩的研究已有 20 多年历史。1980 年比利时做出重大决定,建立名为 HADES 的地下研究机构,以研究 Boom 泥岩... 详细信息

在比利时,泥岩中地质处置是高放废物最终处置的首选。处置库在高放废物与生物圈之间的多重屏障基础上设计的,而 Boom 泥岩作为基岩的研究已有 20 多年历史。1980 年比利时做出重大决定,建立名为 HADES 的地下研究机构,以研究 Boom 泥岩在地下 223 m 处的力学性质,并调查和论证处置的可行性,为处置库屏障(天然和人工)提供可靠数据。在 HADES 的众多现场试验中,很多试验用来对基岩和工程屏障体系(包括封口和回填的可行性)的热–水–力性状进行研究,包括 CACTUS,ATLAS,BACCHUS 和 RESEAL 等项目。自 1995 年以来,研究开发计划向大型和示范性试验方向发展。最主要成果是运用工业技术建立地下研究设施(竖井和井巷)可行性得到了验证,且这种工业技术给研究提供一个较好机会,便于进一步认识基岩泥岩(CLIPEX 方案)的水–力性状及了解隧道开挖工程(SELFRAC 课题)对挖掘破坏区的影响。另一个重大成果是成功地实现对一种称为“OPHELE”的预制膨润土(人工屏障材料)加热和水化地面大型试验。下一步工作内容包括实现大尺寸现场加热器试验(PRACLAY 试验),此试验预计于 2006 年开始,并可持续 10 a 之久。据此,首先简要描述比利时高放废物处置库设计,然后回顾 Boom 泥岩和工程屏障体系的热–水–力性状相关试验,最后介绍下一步大规模 PRACLAY 试验。

关键词：高放废弃物贮存设计地下研究设施工程屏障体系热-水-力耦合性态开挖破坏区模型试验大尺寸现场试验

Variability of the Critical Frequency foF2 during minimum and maximum Phases of Solar Cycles 20 and 21: A Comparative Study between American and African Equatorial Regions

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Atmospheric and Climate Sciences 2022年第1期12卷 105-112页

作者： Kaboré m’Bi Diabaté Abidina Ouattara Frédéric Laboratoire de Recherche en Energétique et météorologie de l’Espace (LAREmE) Université Norbert Zongo Koudougou Burkina Faso Laboratoire de matériaux d’Héliophysique et Environnement (LAMHE) Université Nazi Boni Bobo Dioulasso Burkina Faso

The present work is a comparative study between the foF2 variabilities for two equatorial regions (Ouagadougou: lat. 12°21'N;long. 1°30'E, dip. 1.43° in Africa and Huancayo: Lat. 12°S;Long. 75°12'W in America) during solar cycles 20 and 21 minima and maxima phases under geomagnetic extreme conditions (quiet and disturb). Profiles from these two stations are very similar for all the seasons over the solar cycles. However, measured data from Huancayo station are higher than those from Ouagadougou station during

关键词： foF2 Longitudinal Variation Seasonal Variation

Discrete Element modeling of a Subduction Zone with a Seafloor Irregularity and its Impact on the Seismic Cycle

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Acta Geologica Sinica(English Edition) 2022年第3期96卷 776-790页

作者： JIAO Liqing CHAN Chung-Han Luc SCHOLTÈS Aurélia HUBERT-FERRARI Frédéric-Victor DONZÉ Paul TAPPONNIER SinoProbe Center Chinese Academy of Geological SciencesBeijing 100037China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Earthquake-Disaster&Risk Evaluation and management(E-DREam)Center National Central UniversityTaoyuanChina Department of Earth Sciences National Central UniversityTaoyuanChina CNRS IRDOPGCLaboratoire Magma et VolcansUniversitéClermont AuvergneClermont-FerrandFrance Department de Geography Universitéde LiegeLiegeBelgium Institut des Sciences de la Terre UniversitéGrenoble AlpesGrenobleFrance National Institute of Natural Hazards MEMCBeijing 100085China

Seafloor irregularities influence rupture behavior along the subducting slab and in the overriding plate,thus affecting earthquake *** seafloor irregularities increase the likelihood of large earthquakes in a subduction zone remains contested,partially due to focus put either on fault development or on rupture ***,we simulate a subducting slab with a seafloor irregularity and the resulting deformation pattern of the overriding plate using the discrete element *** simulations illustrate the rupture along three major fault systems:megathrust,splay and backthrust *** results show different rupture dimensions of earthquake events varying from tens to ca.140 *** results suggest that the recurrence interval of megathrust events with rupture length of ca.100 km is ca.140 years,which is overall comparable to the paleoseismic records at the mentawai area of the Sumatran *** further propose the coseismic slip amounts decrease and interseismic slip amounts increase from the surface downwards *** conclude that the presence of seafloor irregularities significantly affects rupture events along the slab as well as fault patterns in the overriding plate.

关键词： discrete element modeling subduction zone megathrust splay backthrust faults seamount mentawai

A New member of the Thioredoxin Reductase Family from Early Oxygenic Photosynthetic Organisms

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molecular Plant 2017年第1期10卷 212-215页

作者： Rubén m. Buey Sergio Galindo-trigo Luis López-maury Adrián Velázquez-Campoy José Luis Revuelta F. Javier Florencio José m. de Pereda Peter Schürmann Bob B. Buchanan monica Balsera Department microbiología y Genética Universidad de Salamanca Salamanca 37007 Spain Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA-CSIC) Salamanca 37008 Spain Instituto de Bioquímica Vegetal y Fotosíntesis (CSIC-Universidad de Sevilla) Seville 41092 Spain Institute of Biocomputation and Physics of Complex Systems (BIFI) University of Zaragoza Zaragoza 50018 Spain Instituto de Biología molecular y Celular del Cáncer (CSIC-Universidad de Salamanca) Salamanca 37007 Spain Laboratoire de Biologie moléculaire et Cellulaire Université de Neuchâtel Neuchâtel 2000 Switzerland Department of Plant and microbial Biology University of California Berkeley CA 94720 USA

Dear Editor,Thioredoxins （Trxs） are key components of the redox system that regulates the activity of a spectrum of target proteins through dithiol-disulfide exchange reactions. Trxs are reduced by mem- bers of the Trx reductase （TR） family （Jacquot et al., 2009）. NADP-dependent thioredoxin reductases （NTRs）, the most com-mon type, belong to the family of dimeric pyridine nucleotide disul-fide oxidoreductase flavoproteins that use NADPH as the source of reducing equivalents.

关键词： Thioredoxin Early Organisms

DNP NmR reveals the hidden surface C–C bond growth mechanism over ZnAlO_(x) during syngas conversion

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Journal of Energy Chemistry 2022年第4期31卷 640-644页

作者： Pan Gao Dong Xiao Zhenchao Zhao Subhradip Paul Frédéric Blanc Xiuwen Han Guangjin Hou Xinhe Bao State Key Laboratory of Catalysis National Laboratory for Clean Energy2011-Collaborative Innovation Center of Chemistry for Energy MaterialsDalian Institute of Chemical PhysicsChinese Academy of Sciences457 Zhongshan RoadDalian 116023LiaoningChina DNP mAS NmR Facility Sir Peter Mansfield Imaging CentreUniversity of NottinghamNottingham NG72RDUnited Kingdom Department of Chemistry University of LiverpoolCrown StreetLiverpool L697ZDUnited Kingdom Stephenson Institute for Renewable Energy University of LiverpoolCrown StreetLiverpool L697ZDUnited Kingdom

Direct catalytic transformation of syngas(CO/H_(2)) into high value-added hydrocarbons has been one of the most attractive,yet challenging issues in C1 chemistry. In recent years, the concept of oxide-zeolite(OXZEO) bifunctional catalysis has emerged and spurred renewed enthusiasm in this field [1,2]. This method describes the use of selected oxide-zeolite-based composite catalysts for the direct syngas-to-hydrocarbons conversion.

关键词： zeolite hydrocarbons syngas

Reduced formation of peroxide and radical species stabilises iron-based hybrid catalysts in polymer electrolyte membrane fuel cells

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Journal of Energy Chemistry 2022年第2期31卷 433-438页

作者： Dongyoon Shin Sabita Bhandari marc FTesch Shannon ABonke Frédéric Jaouen Sonia Chabbra Christoph Pratsch Alexander Schnegg Anna K.mechler max Planck Institute for Chemical Energy Conversion Stiftstr.34–3645470 Mülheim an der RuhrGermany ICGm Univ.MontpellierCNRSENSCMMontpellierFrance Fritz Haber Institute of the max Planck Society Department of Inorganic ChemistryFaradayweg 4-614195 BerlinGermany

The incorporation of Pt into an iron-nitrogen-carbon(Fe NC)catalyst for the oxygen reduction reaction(ORR)was recently shown to enhance catalyst stability without Pt directly contributing to the ORR ***,the mechanistic origin of this stabilisation remained *** is established herein with rotating ring disc experiments that the side product,H_(2)O_(2),which is known to damage FeNC catalysts,is suppressed by the presence of *** formation of reactive oxygen species is additionally inhibited,independent of intrinsic H_(2)O_(2) formation,as determined by electron paramagnetic *** electron microscopy identifies an oxidised Fe-rich layer covering the Pt particles,thus explaining the inactivity of the latter towards the *** insights develop understanding of Fe NC degradation mechanisms during ORR catalysis,and crucially establish the required properties of a precious metal free protective catalyst to improve Fe NC stability in acidic media.

关键词： Electrochemistry Fuel cells Oxygen reduction reaction Non-precious metal catalyst Hybrid catalyst Stability

Influence of the operating temperature on the ageing and interfaces of double layer polymer electrolyte solid state Li metal batteries

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Nano Research 2023年第6期16卷 8377-8384页

作者： mikel Arrese-Igor maría martinez-Ibañez Ander Orue Ekaterina Pavlenko Erwan Dumont michel Armand Frédéric Aguesse Pedro López Aranguren Centre for Cooperative Research on Alternative Energies(CIC energiGUNE) Basque Research and Technology Alliance(BRTA)Alava Technology ParkAlbert Einstein 48Vitoria-Gasteiz 01510Spain University of the Basque Country(UPV/EHU) Barrio Sarrienas/nLeioa 48940Spain Saft 111 Boulevard Alfred DaneyBordeaux Cedex 33074France

Solid-state lithium metal batteries(SSLmBs)are considered an auspicious technology to develop high energy density and safe energy storage *** double layer polymer electrolyte(DLPE)is a rational approach for engineering high-performance SSLmBs addressing electrolyte requirements with specifically designed polymers at the positive electrode and as *** this work,SSLmBs were assembled with poly(propylene carbonate)(PPC),offering stability toward oxidation at the positive electrode,and a gel polymer electrolyte with polyethyleneglycol dimethylether(PEGDmE)as separator,offering high ionic conductivity at low temperature and sufficient interfacial stability with Li *** electrochemical properties and performance of cells with LiFePO_(4) and Li[Ni_(0.6)mn_(0.2)Co_(0.2)]O_(2) positive electrodes are thoroughly investigated as function of the operating temperature by using a host of characterization ***-voltage cells with an areal capacity of 0.7 mAh·cm^(−2)cycled at 40℃ exhibit a higher capacity retention than the cells cycled at 70℃.To understand such differences,a three-electrode setup is applied to discriminate anodic processes from cathodic as function of the *** elucidate the ageing and interfacial evolution for DLPE cells with gel polymer electrolytes paving the way for building performance solid state batteries.

关键词： double layer polymer electrolyte solid-state lithium metal battery gel polymer electrolyte high voltage interfacial study