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Preclinical and clinical evidence of the association of colibactinproducing Escherichia coli with anxiety and depression in colon cancer

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World Journal of Gastroenterology 2024年第21期30卷 2817-2826页

作者： Fabien Rondepierre Maëva Meynier Johan Gagniere Vincent Deneuvy Anissa Deneuvy Gwenaelle Roche Elodie Baudu Bruno Pereira richard Bonnet Nicolas Barnich Frédéric Antonio carvalho Denis Pezet Mathilde Bonnet Isabelle Jalenques Service de Psychiatrie de l’Adulte A et Psychologie Médicale CHU Clermont-FerrandClermont-Ferrand 63000France M2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France NeuroDol UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France Department of Digestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biostatistics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France Department of Bacteriology CHU de Clermont-FerrandClermont-Ferrand 63001France Universitéclermont Auvergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

BAcKGROUND The association between the intestinal microbiota and psychiatric disorders is becoming increasingly *** gut microbiota contributes to colorectal carcinogenesis(cRc),as demonstrated with colibactin-producing Escherichia coli(coPEc).AIM To evaluate the association between coPEc prevalence and anxiety-and depressive-like behaviors with both preclinical and clinical *** Patients followed after a cRc surgery and for whom the prevalence of coPEc has been investigated underwent a psychiatric *** were compared according to the coPEc *** parallel c57BL6/J wild type mice and mice with a cRc susceptibility were chronically infected with a coPEc *** behavior was assessed using the Elevated Plus Maze test,the Forced Swimming Test and the Behavior recognition system PhenoTyper®.RESULTS In a limited cohort,all patients with coPEc colonization presented with psychiatric disorders several years before cancer diagnosis,whereas only one patient(17%)without coPEc *** result was confirmed in c57BL6/J wildtype mice and in a cRc susceptibility mouse model(adenomatous polyposis colimultiple intestinal neoplasia/+).Mice exhibited a significant increase in anxiety-and depressive-like behaviors after chronic infection with a coPEc *** This finding provides the first evidence that coPEc infection can induce microbiota-gut-brain axis disturbances in addition to its procarcinogenic properties.

关键词： colorectal cancer colibactin Escherichia coli colibactin-producing Escherichia coli Inflammation Anxiety Depression Behavior

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Alkyl-thiophene-alkyl linkers to construct double-cable conjugated polymers for single-component organic solar cells

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chinese chemical Letters 2024年第1期35卷 542-546页

作者： Wenbin Lai Safakath Karuthedath chengyi Xiao Lei Meng Frédéric Laquai Weiwei Li Yongfang Li Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Beijing Advanced Innovation center for Soft Matter Science and Engineering&State Key Laboratory of Organic-Inorganic composites Beijing University of Chemical TechnologyBeijing 100029China King Abdullah University of Science and Technology(KAUST) KAUST Solar Center(KSC)Physical Sciences and Engineering Division(PSE)Material Science and Engineering Program(MSE)Thuwal 23955-6900Kingdom of Saudi Arabia University of chinese Academy of Sciences Beijing 100049China Institute of Materials Research Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China

In this work,semirigid linkers of the alkyl-thiophene-alkyl structure are developed to construct double-cable *** alkyl units,propyl(c3H6),hexyl(c6H12),and dodecyl(c12H24),are applied as semirigid linkers,yielding three double-cable polymers:PBc6-T,PBc12-T,and PBc24-T,***12-T which uses c6H12-thiophene-c6H12 linkers is found to exhibit the best device efficiency of 5.56%,while PBc6-T and PBc24-T with shorter or longer linkers yield device efficiencies of only 2.65%and 1.09%in single-component organic solar cells(ScOScs).Further studies reveal that PBc12-T exhibits higher crystallinity and improved charge transport,resulting in better *** work provides an approach to construct double-cable conjugated polymers with long alkyl linkers,and it shows the importance of the linker length for the photovoltaic performance of ScOScs.

关键词： Double-cable conjugated polymer Single-component organic solar cell crystallinity Semirigid linkers Alkyl-thiophene-alkyl

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Modeling the Kinetics of Moisture Desorption from Safou Pulp [Dacryodes edulis (G. Don) ***] before the Oil Extraction Step

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Open Journal of Applied Sciences 2024年第8期14卷 2050-2064页

作者： Anicet Frédéric Binaki Feueltgaldah christian Bopoundza Bob Wilfrid Loumouamou Gueko Séraphin Nguié Eliane Thérèse Biassala Thomas Silou Multidisciplinary Food and Nutrition Research Team Regional Center of Excellence in Food and Nutrition Faculty of Science and Technology Marien Ngouabi University Brazzaville Congo Process Engineering Laboratory UNESCO-ENSP Chair Marien Ngouabi University Brazzaville Congo cR2IE Chemistry and Technology Platform Higher School of Cataract Technology (EPrES) Brazzaville Congo

The aim of this work is to model the drying kinetics of Safou pulp with or without endocarp using a phenomenological approach. Oven-drying kinetics at 70˚c, 90˚c and 105˚c were monitored using the curves given by the reduced mass as a function of time, which are modeled according to the Avrami/page, Fick and Peleg models using OringinPro 2018 software. The results showed that parameters k and n of the Avrami/Page model vary very little with fruit size and drying temperature (0.0018 ± 0.0002 k n k (Avrami model/page) were virtually identical, while b (Fick model) and n (Avrami model/page) were virtually identical for the same sample. For the Peleg model, the parameter a, varies from 0.0018 ± 0.0002 to 0.03328 ± 0.0079, with a ratio of 18.6 for all experimental conditions studied. However, with 0.977 R2 χ2 ch ranges from 0.82 ± 0.05 to 1.21 ± 0.02. Thus, drying modeling by these three models can be used to describe and predict the progress of oven-drying of safou pulp.

关键词： Drying Modeling Empirical Models Dacryodes edulis congo Basin

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c1c2 Wiring and Posttraumatic Atlantoaxial Dislocation: An Effective and cheap Surgical Procedure in a Developing country

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Surgical Science 2024年第5期15卷 357-370页

作者： Ibrahim Dao Massimiliano Visocchi Salah Sow John Jabang Ousmane Ouattara Astride Somda Abdoulaye Sanou Elie Dibloni Nassoum Arsène Tossou Narcisse Ouedraogo Frédéric Bako Massadiami Soulama Malick Diallo Patrick Wendpouiré Hamed Dakouré Department of Neurosurgery University Hospital Souro Sanou Nazi Boni University Bobo Dioulasso Burkina Faso High Institute of Health Sciences Nazi Boni University Bobo Dioulasso Burkina Faso Military Hospital colonel Major Tanguet Ouattara Bobo Dioulasso Burkina Faso Institute of Neurosurgery Craniovertebral Junction Surgery Unit School of Medicine Catholic University Rome Italy Department of Radiology and Medical Imaging University Hospital Yalgado Ouedraogo Joseph Ki-Zerbo University Ouagadougou Burkina Faso Department of Neurosurgery (Unit) Edward Francis Small Teaching Hospital Banjul Gambia Department of Neurosurgery University Hospital Yalgado Ouedraogo Joseph Ki-Zerbo University Ouagadougou Burkina Faso Department of Neurosurgery Military Hospital Capitaine Halassane Coulibaly Ouagadougou Burkina Faso Department of Orthopedic Surgery University Hospital Souro Sanou Nazi Boni University Bobo Dioulasso Burkina Faso

Objectives: Atlantoaxial dislocation remains a rare and serious condition with a high preoperative and postoperative morbidity and mortality. Its successful surgical management is still challenging and gratifying for neurosurgeons. Several technics have been described such as wiring, trans articular screwing, c1c2 screwing with plate and screw introduced by Goel et al., and modified by insertion of polyaxially screw and rod many years later by Harms. Unavailability and expensiveness of upper cervical spine instrumentation device led us to c1c2 Wiring resulting in a good outcome. Finally, a quadriplegic patient with a more comfortable financial condition had ordered devices from abroad and benefit for Goel and Harms screwing technique and improved dramatically from ASIA A to ASIA E. Material and methods: This is a retrospective study of patients managed in our department by a same neurosurgeon from January 2019 to April 2024. Results: We defined 6 men and 1 woman with an average age of 33 years. Unrestrained driver in a rollover motor vehicle accident was most common. Only one patient was neurologically intact on admission. Neurovegetative disorders were noticed in one patient. Dislocation was associated to a fracture of the dens in two patients. Three patients have been successfully operated with remarkable outcome, mostly from ASIA A to E. conclusion: c1c2 dislocation is a serious condition and c1c2 Wiring represents an effective and cheaper technic. Therefore, this technic should deserve consideration above all in low incomes countries when screwing devices are not available. Seatbelt should be demanded for motor vehicle drivers and passengers.

关键词： Superior cervical Spine Dislocation Fracture Wiring Screwing Neurovegetative Disorders

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High temperature X-ray diffraction study of the formation of Na_(2)Ti_(3)O_(7) from a mixture of sodium carbonate and titanium oxide

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Journal of Energy chemistry 2022年第2期31卷 210-218页

作者： caroline Piffet Bénédicte Vertruyen Frédéric Hatert Rudi cloots Frédéric Boschini Abdelfattah Mahmoud GREENMAT CESAM Research UnitChemistry DepartmentUniversity of Liège4000 LiègeBelgium Laboratory of Mineralogy Geology Research UnitUniversity of Liège4000 LiègeBelgium

Na2Ti3O7 has attracted much attention in the field of anode materials for Na-ion batteries thanks to its non-toxicity and very low working potential of 0.3 V vs Na0/Na+.Building a clearer picture of its formation from cheap Na_(2)cO_(3) and TiO_(2) starting materials is therefore of obvious ***,we report new insights from an in-situ high temperature X-ray diffraction study conducted from room temperature to 800°c,complemented by ex-situ *** were thereby able to position the previously reported Na_(4)Ti_(5)O_(12) and Na_(2)Ti_(6)O_(13) intermediate phases in a reaction scheme involving three successive steps and temperature *** and/or broadening of a subset of the Na_(2)Ti_(6)O_(13) reflections suggested a combination of intra-layer disorder with the well-established ordering of successive *** in-situ study was carried out on reproducible mixtures of Na_(2)cO_(3) and TiO_(2) in 1:3 molar ratio prepared by spraydrying of mixed aqueous ***-phase Na_(2)Ti_(3)O_(7) was obtained after only 8 h at 800°c in air,instead of a minimum of 20 h for a conventional solid-state route using the same *** analysis revealed~15 mm diameter granules made up from rectangular rods of a fewmm length presenting electrochemical properties in line with *** the absence of grinding or formation of intimate composites with conductive carbon,the specific capacity of 137 m Ah/g at c/5 decreased at higher rates.

关键词： Formation mechanism High temperature XRD Na_(2)Ti_(3)O_(7) Spray-drying synthesis Na-ion batteries

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Aminopeptidase A and dipeptidyl peptidase 4:a pathogenic duo in Alzheimer’s disease?

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Neural Regeneration Research 2022年第10期17卷 2215-2217页

作者： Frédéric checler Audrey Valverde Universitécôte d’Azur INSERMCNRSIPMCteam labelled“Laboratory of Excellence(LABEX)DistAlz”ValbonneFrance

The etiology of Alzheimer’s disease is far from being completely *** approaches have helped in this matter and have greatly supported the view that theβ-amyloid precursor protein(βAPP)could be at the center of gravity of the ***,mutations responsible for autosomal dominant aggressive forms of Alzheimer’s disease(AD)are all harbored by eitherβAPP itself or by its cleaving enzyme presenilins 1/2 referred to asγ-*** was therefore convincing to note that fully independent gene products harboring AD-linked mutations,all concur to modulateβAPP proteolytic *** genetic clues combined with a bulk of anatomical observations and cellular manipulations pointed to the role of amyloid-β(Aβ),the main biochemical component of senile plaques that accumulate at late stages of ***,a series of clinical trials designed to either abolish Aβproduction or neutralize it once produced have consistently failed(checler et al.,2021).

关键词： Alzheimer Aβ senile

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Holographic models of the scalar sector of QcD

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chinese Physics c 2010年第9期34卷 1516-1519页

作者： Frédéric Jugeau TPcSF Institute of High Energy PhysicsChinese Academy of Sciences

We investigate the AdS/QcD duality for the two-point correlation functions of the lowest dimension scalar meson and scalar glueball operators,in the case of the Soft Wall holographic model of *** and decay constants as well as gluon condensates are compared to their QcD *** particular,the role of the boundary conditions for the bulk-to-boundary propagators is emphasized.

关键词： AdS/QcD correspondence holographic models of QcD hadron spectroscopy

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comparative transcriptomics of anadromous and resident brook charr Salvelinus fontinalis before their first salt water transition

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current Zoology 2012年第1期58卷 158-170页

作者： Boulet, Marylène Normandeau, Éric Bougas, Bérénice Audet, céline mboulet@ubishops.ca Bernatchen, Louis IBIS (Institut de Biologie Intégrative et des Systèmes) Université Laval Québec QC G1V 0A6 Canada ISMER Université du Québec à Rimouski Rimouski QC G5L 3A1 Canada

Most salmonid taxa have an anadromous life history strategy, whereby fish migrate to saltwater habitats for a growth period before returning to freshwater habitats for spawning. Moreover, several species are characterized by different life history tactics whereby resident and anadromous forms may occur in genetically differentiated populations within a same species, as well as polymorphism within a population. The molecular mechanisms underlying the physiological differences between anadromous and resident forms during the first transition from freshwater to saltwater environments are only partially understood. Insofar re- search has typically focused on species of the genus Salmo. Here, using a 16,000 cDNA array, we tested the hypothesis that ana- dromous brook charr Salvelinus fontinalis are characterized by differences in their transcriptome relative to resident brook charr before the anadromous fish migration. Families originating from parapatric populations of anadromous and resident charr were reared in controlled environments mimicking natural temperature and photoperiod, and sampled in spring, while still in fresh wa- ter. While anadromous and resident charr showed similar transcriptome profiles in white muscle, they were characterized by striking differences in their gill transcriptome profiles. Genes that were upregulated in the gills of anadromous charr were princi- pally involved in metabolism （mitochondrial electron transport chain, glucose metabolism, and protein synthesis）, development （tissue differentiation） and innate immunity. We discuss the nature of these transcriptomic differences in relation to molecular mechanisms underlying the expression of anadromous and resident life history tactics and suggest that the anadromous charr express some of the molecular processes present in other migratory salmonids [current Zoology 58 （1）： 158-170, 2012].

关键词： Transcriptome Life history tactics Anadromy Migration to salt water Ecotypes Salmohids

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MsFEM à la crouzeix-Raviart for Highly Oscillatory Elliptic Problems

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chinese Annals of Mathematics,Series B 2013年第1期34卷 113-138页

作者： claude LE BRIS Frédéric LEGOLL Alexei LOZINSKI cole Nationale des Ponts et chaussées 6 et 8 avenue Blaise Pascal INRIA Rocquencourt MICMAC project-team Institut de Mathématiques de Toulouse Université Paul Sabatier Laboratoire de Mathématiques cNRS UMR 6623 Université de Franche-Comté

We introduce and analyze a multiscale finite element type method (MsFEM) in the vein of the classical crouzeix-Raviart finite element method that is specifically adapted for highly oscillatory elliptic problems. We il... 详细信息

关键词： Homogenization Finite elements Galerkin methods Highly oscillatoryPDE

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The formation of orthogonal joint systems and cuboidal blocks:New insights gained from flat-lying limestone beds in the region of Havre-Saint-Pierre(Quebec,canada)

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第12期15卷 3079-3093页

作者： Shaocheng Ji Yvéric Rousseau Denis Marcotte Noah John Phillips Département des Génies civil Géologique et des MinesÉcole Polytechnique de MontréalMontréalQuébecH3C 3A7Canada Department of Geology Lakehead UniversityThunder BayOntarioP7B 5E1Canada

Vertical orthogonal joints are a common feature in shallow crustal *** are several competing theories for their formation despite the *** examined the exceptional exposures of orthogonal joints in flat-lying Ordovician limestone beds from the Havre-Saint-Pierre Region in Quebec,canada(north shore of Saint-Lawrence River)to test conceptual models of joint formation in a natural *** the region,the spacing of cross-joints is consistently larger than the spacing of systematic joints by a factor of 1.5 *** joint-spacing-to-bed-thickness ratios(s/t)are much larger in these beds(s/t=4.3 for systematic joints,and 6.4 for cross-joints)than those in higher strained strata along the south shore of the Saint-Lawrence River(s/t=1),highlighting the effect of tectonic strain in decreasing fracture spacing and block *** high values of s/t indicate that cross-joint formation was unlikely caused by a switch from compression to tension once a critical s/t ratio for systematic joints was reached(as hypothesized in previous studies).We proposed a new model for the formation of orthogonal joint systems where the principal stress axes locally switch during the formation of systematic *** presence of ladder-shaped orthogonal joints suggests a state of effective stress withσ_(1)^(∗)≫0>σ_(2)^(∗)>σ_(3)^(∗)and whereσ_(2)^(∗)-σ_(3)^(∗)is within the range of fracture strength variability at the time of *** research provides a new mechanical model for the formation of orthogonal joint systems and cuboidal blocks.

关键词： Plato's cuboids Orthogonal joints Fracture spacing Limestone Layered rock mechanics Appalachian geology

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