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Acta Geologica Sinica(English Edition) 2015年第5期89卷 1429-1439页

作者： WANG Haobo Olesia V.BONDARENKO Frédéric M.B.JACQUES WANG Yuehua ZHOU Zhekun Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences School of Life Science Yunnan University College of Agriculture and Bioscience Dali University University of Chinese Academy of Sciences Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Institute of Biology and Soil Science Far Eastern Branch Russian Academy of Sciences

A new species, Tsuga nanfengensis ***.（Pinaceae）, is described on the basis of lignified fossil wood from the late Miocene of the Xianfeng Basin, central Yunnan, southwestern *** observation of the fossil wood specimens show the following characteristics： distinct growth rings, absence of resin canals, uniseriate bordered pits in the radial wall of tracheids, ray tracheids and piceoid and cupressoid cross-field *** features indicate similarities to the wood of extant Tsuga canadensis, ***, and *** to the fossil record, Tsuga was present in Xundian County during the *** Tsuga is drought intolerant, preferring wet conditions with no extant species growing naturally in Xundian *** presence of Tsuga in the Miocene of Xundian County indicates a humid climate consistent with previous palaeoclimatic reconstructions showing a wetter and probably shorter dry season in the Miocene, relative to the present ***, the change in the local climate such as increasing aridity through the Miocene might explain the local extinction of Tsuga from central Yunnan.

关键词： Tsuga fossil wood palaeoclimate late Miocene Yunnan

Crohn's disease-related'gastrocnemius myalgia syndrome'successfully treated with infliximab:A case report

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World Journal of Gastroenterology 2022年第7期28卷 755-762页

作者： Julien Catherine Hazim Kadhim Frédéric Lambot Claire Liefferinckx Virginie Meurant Lukas Otero Sanchez Institute for Medical Immunology UniversitéLibre de BruxellesGosselies 6041Belgium Department of Internal Medicine C.U.B.Hôpital ErasmeBrussels 1070Belgium NeuroMyopathology Unit(Anatomic Pathology Service)and Reference Center for Neuromuscular Pathology CHU BrugmannUniversitéLibre de BruxellesBrussels 1020Belgium Department of Internal Medicine Centre Hospitalier Universitaire TivoliLa Louvière 7100Belgium Department of Gastroenterology Hepatopancreatology and Digestive OncologyC.U.B.Hôpital ErasmeBrussels 1070Belgium Laboratory of Experimental Gastroenterology UniversitéLibre de BruxellesBrussels 1070Belgium Department of Emergency Medicine Centre Hospitalier Universitaire TivoliLa Louvière 7100Belgium

BACKGROUND Extra-intestinal manifestations in inflammatory bowel diseases(IBD)are frequent and involve virtually all ***,the clinical characteristics and course of inflammatory myopathies in IBD remain poorly described and mostly related to orbital ***,alternative therapeutic strategies in non-responder patients to corticosteroid therapy must still be *** SUMMARY A 33-year-old woman with a history of unclassified colitis presented with acute bilateral calf *** admission,her clinical and biological examinations were ***,magnetic resonance imaging showed bilateral inflammatory changes in gastrocnemius muscles suggestive of *** biopsy confirmed the diagnosis of myositis and demonstrated an inflammatory infiltrate mainly located in the perimysial compartment including lympho-plasmocytic cells with the formation of several granulomatous structures while the endomysium was relatively *** combined clinical,biological and histomyopathological findings were concordant with the diagnosis of‘gastrocnemius myalgia syndrome’(GMS),a rare disorder associated with Crohn’s disease(CD).Ileocolonoscopy confirmed CD diagnosis and systemic corticosteroids(CS)therapy was started,resulting in a rapid clinical *** CS tapering,however,she experienced a relapse of GMS together with a severe active *** was started and allowed a sustained remission of both conditions at the latest follow-up(20 mo).CONCLUSION The GMS represent a rare CD-associated inflammatory myopathy for which anti-tumour necrosis factor-αtherapy might be considered as an effective therapeutic option.

关键词： Crohn’s disease Extra-intestinal manifestation Gastrocnemius myalgia syndrome Granulomatous myositis Anti-tumour necrosis factor-αtherapy Case report

Genotype phenotype classification of hepatocellular adenoma

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World Journal of Gastroenterology 2007年第19期13卷 2649-2654页

作者： Paulette Bioulac-Sage Jean Frédéric Blanc Sandra Rebouissou Charles Balabaud Jessica Zucman-Rossi CHU Bordeaux Hpital Pellegrin Department of Pathology Bordeaux F-33076 France Charles Balabaud Inserm U889 Bordeaux F-33076 GREF Univ Victor Segalen Bordeaux 2 Bordeaux F-33076 France Charles Balabaud CHU Bordeaux Hpital Saint André Department of Hepatology Bordeaux F-33075 France Inserm U674 CEPH Univ Paris 7 Paris F-75010 France CHU Bordeaux Hpital Saint André Department of Hepatology Bordeaux F-33075 France

Studies that compare tumor genotype with phenotype have provided the basis of a new histological/molecular classification of hepatocellular adenomas. Based on two molecular criteria （presence of a TCFI/HNF1α or β-catenin mutation）, and an additional histological criterion （presence or absence of an inflammatory infiltrate）, subgroups of hepatocellular adenoma can be defined and distinguished from focal nodular hyperplasia. Analysis of 96 hepatocellular adenomas performed by a French collaborative network showed that they can be divided into four broad subgroups： the first one is defined by the presence of mutations in TCF1 gene inactivating the hepatocyte nuclear factor 1 （HNF1α）, the second by the presence of β-catenin activating mutations; the category without mutations of HNF1α or β-catenin is further divided into 2 subgroups depending on the presence or absence of inflammation. Therefore, the approach to the diagnosis of problematic benign hepatocytic nodules may be entering a new era directed by new molecular information. It is hoped that immunohistological tools will improve significantly diagnosis of liver biopsy in our ability to distinguish hepatocellular adenoma from focal nodular hyperplasia （FNH）, and to delineate clinically meaningful entities within each group to define the best clinical management. The optimal care of patients with a liver nodule will benefit from the recent knowledge coming from molecular biology and the combined expertise of hepatologists, pathologists, radiologists, and surgeons.

关键词： Hepatocellular adenoma HNF1α mutation β-catenin mutation Inflammatory adenoma Telangiectatic adenoma Maturity-onset diabetes of theyoung Hepatocyte nuclear factor 1 CTNNB1 Focal nodular hyperplasia

From Prototype to Inference:A Pipeline to Apply Deep Learning in Sorghum Panicle Detection

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Plant Phenomics 2023年第1期5卷 94-109页

作者： Chrisbin James Yanyang Gu Andries Potgieter Etienne David Simon Madec Wei Guo Frédéric Baret Anders Eriksson Scott Chapman School of Agriculture and Food Sciences The University of QueenslandBrisbaneAustralia School of Information Technology and Electrical Engineering The University of QueenslandBrisbaneAustralia Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneAustralia Arvalis Institut du VégétalParisFrance Graduate School of Agricultural and Life Sciences The University of TokyoTokyoJapan Institut National de la Recherche Agronomique ParisFrance

Head(panicle)density is a major component in understanding crop yield,especially in crops that produce variable numbers of tillers such as sorghum and *** of panicle density both in plant breeding and in the agronomy scouting of commercial crops typically relies on manual counts observation,which is an inefficient and tedious *** of the easy availability of red–green–blue images,machine learning approaches have been applied to replacing manual ***,much of this research focuses on detection per se in limited testing conditions and does not provide a general protocol to utilize deep-learning-based *** this paper,we provide a comprehensive pipeline from data collection to model deployment in deep-learning-assisted panicle yield estimation for *** pipeline provides a basis from data collection and model training,to model validation and model deployment in commercial *** model training is the foundation of the ***,in natural environments,the deployment dataset is frequently different from the training data(domain shift)causing the model to fail,so a robust model is essential to build a reliable *** we demonstrate our pipeline in a sorghum field,the pipeline can be generalized to other grain *** pipeline provides a high-resolution head density map that can be utilized for diagnosis of agronomic variability within a field,in a pipeline built without commercial software.

关键词： crops breeding utilize

Computational design for 4D printing of topology optimized multi-material active composites

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npj Computational Materials 2023年第1期9卷 2342-2350页

作者： Darshan Athinarayanarao Romaric Prod’hon Dominique Chamoret H.Jerry Qi Mahdi Bodaghi Jean-Claude André Frédéric Demoly ICB UMR 6303 CNRS Univ.Bourgogne Franche-ComtéUTBM90010 BelfortFrance The George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Department of Engineering School of Science and TechnologyNottingham Trent UniversityNottingham NG118NSUK LRGP UMR 7274 CNRS University of LorraineNancyFrance

Recent efforts on design for four-dimensional(4D)printing have considered the spatial arrangement of smart materials and energy *** development of multifunctional structures and their desired mechanical/actuation performances require tackling 4D printing from a multi-material design *** the materials distributions there is an opportunity to increase the spectrum of design concepts with computational *** main goal being to achieve the“best”distribution of material properties in a voxelized structure,a computational framework that consists of a finite element analysis-based evolutionary algorithm is *** fuses the advantages of optimizing both the materials distribution and material layout within a design space via topology optimization to solve the inverse design problem of finding an optimal design to achieve a target shape change by integrating void *** results demonstrate the efficacy of the proposed method in providing a highly capable tool for the design of 4D-printed active composites.

关键词： composites printing topology

Two imprinted genes primed by DEMETER in the central cell and activated by WRKY10 in the endosperm

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Journal of Genetics and Genomics 2024年第8期51卷 855-865页

作者： Ke Yang Yuling Tang Yue Li Wenbin Guo Zhengdao Hu Xuanpeng Wang Frédéric Berger Jing Li College of Life Science and Technology Huazhong Agricultural UniversityWuhanHubei 430070China Sanya Institute of Breeding and Multiplication Hainan UniversitySanyaHainan 572025China School of Tropical Agriculture and Forestry Hainan UniversityHaikouHainan 570228China Hainan Yazhou Bay Seed Laboratory SanyaHainan 572025China Gregor Mendel Institute Austrian Academy of SciencesVienna BioCenter1030 ViennaAustria

The early development of the endosperm is crucial for balancing the allocation of maternal nutrients to *** process is believed to be evolutionarily associated with genomic imprinting,resulting in parentally biased allelic gene *** Fertilization Independent Seed(FIS)genes,the number of imprinted genes involved in early endosperm development and seed size determination remains *** study introduces early endosperm-expressed HAIKU(IKU)downstream Candidate F-box 1(ICF1)and ICF2 as maternally expressed imprinted genes(MEGs)in Arabidopsis *** these genes are also demethylated by DEMETER(DME)in the central cell,their activation differs from the direct DME-mediated activation seen in classical MEGs such as the FIS ***,ICF maternal alleles carry pre-established hypomethylation in their promoters,priming them for activation by the WRKY10 transcription factor in the *** the contrary,paternal alleles are predominantly suppressed by CG ***,we find that ICF genes partially contribute to the small seed size observed in iku *** discovery reveals a two-step regulatory mechanism that highlights the important role of conventional transcription factors in the activation of imprinted genes,which was previously not fully ***,the mechanism provides a new dimension to understand the transcriptional regulation of imprinting in plant reproduction and development.

关键词： Imprinting Epigenetics DNAmethylation Seedsize Endosperm

Discrete Element Modeling of a Subduction Zone with a Seafloor Irregularity and its Impact on the Seismic Cycle

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Acta Geologica Sinica(English Edition) 2022年第3期96卷 776-790页

作者： JIAO Liqing CHAN Chung-Han Luc SCHOLTÈS Aurélia HUBERT-FERRARI Frédéric-Victor DONZÉ Paul TAPPONNIER SinoProbe Center Chinese Academy of Geological SciencesBeijing 100037China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Earthquake-Disaster&Risk Evaluation and Management(E-DREaM)Center National Central UniversityTaoyuanChina Department of Earth Sciences National Central UniversityTaoyuanChina CNRS IRDOPGCLaboratoire Magma et VolcansUniversitéClermont AuvergneClermont-FerrandFrance Department de Geography Universitéde LiegeLiegeBelgium Institut des Sciences de la Terre UniversitéGrenoble AlpesGrenobleFrance National Institute of Natural Hazards MEMCBeijing 100085China

Seafloor irregularities influence rupture behavior along the subducting slab and in the overriding plate,thus affecting earthquake *** seafloor irregularities increase the likelihood of large earthquakes in a subduction zone remains contested,partially due to focus put either on fault development or on rupture ***,we simulate a subducting slab with a seafloor irregularity and the resulting deformation pattern of the overriding plate using the discrete element *** simulations illustrate the rupture along three major fault systems:megathrust,splay and backthrust *** results show different rupture dimensions of earthquake events varying from tens to ca.140 *** results suggest that the recurrence interval of megathrust events with rupture length of ca.100 km is ca.140 years,which is overall comparable to the paleoseismic records at the Mentawai area of the Sumatran *** further propose the coseismic slip amounts decrease and interseismic slip amounts increase from the surface downwards *** conclude that the presence of seafloor irregularities significantly affects rupture events along the slab as well as fault patterns in the overriding plate.

关键词： discrete element modeling subduction zone megathrust splay backthrust faults seamount Mentawai

Kenya's Curling Moment

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ChinAfrica 2022年第4期14卷 48-49页

作者： éric VINCENT FOMO 不详

The East African country is a sports powerhouse, especially in athletics. It is now trying to develop curling An athlete moves forward, focused on his aim, and slides a stone across the ice. The curl is in place. Two other athletes use brooms to furiously wipe the ice against the advancing piece of granite to keep it on course, without touching it, so that it comes to a stop close to the center of the “house,” as the target on the track is called. Curling is a high-intensity sport that needs strategy and focus.

关键词： Curling sports piece

Diplomacy In a Track Suit Sports emerge as a new area for China and Africa to promote exchanges and solidify friendships

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ChinAfrica 2023年第11期15卷 22-23页

作者： éric VINCENT FOMON 不详

The Chinese Ambassador’s Cup tournaments for numerous sports in African countries have been playing a vital role not only in the development of the sport in these countries,but also in the deepening of African people’s bonds with the Chinese *** Zhihong,Chinese ambassador to Mali,reiterated China’s unwavering support in the realms of sports in his speech at the inauguration of the Chinese Ambassador’s Cup football competition in Mali on 8 October.

关键词： deepening African sports

DNP NMR reveals the hidden surface C–C bond growth mechanism over ZnAlO_(x) during syngas conversion

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Journal of Energy Chemistry 2022年第4期31卷 640-644页

作者： Pan Gao Dong Xiao Zhenchao Zhao Subhradip Paul Frédéric Blanc Xiuwen Han Guangjin Hou Xinhe Bao State Key Laboratory of Catalysis National Laboratory for Clean Energy2011-Collaborative Innovation Center of Chemistry for Energy MaterialsDalian Institute of Chemical PhysicsChinese Academy of Sciences457 Zhongshan RoadDalian 116023LiaoningChina DNP MAS NMR Facility Sir Peter Mansfield Imaging CentreUniversity of NottinghamNottingham NG72RDUnited Kingdom Department of Chemistry University of LiverpoolCrown StreetLiverpool L697ZDUnited Kingdom Stephenson Institute for Renewable Energy University of LiverpoolCrown StreetLiverpool L697ZDUnited Kingdom

Direct catalytic transformation of syngas(CO/H_(2)) into high value-added hydrocarbons has been one of the most attractive,yet challenging issues in C1 chemistry. In recent years, the concept of oxide-zeolite(OXZEO) bifunctional catalysis has emerged and spurred renewed enthusiasm in this field [1,2]. This method describes the use of selected oxide-zeolite-based composite catalysts for the direct syngas-to-hydrocarbons conversion.

关键词： zeolite hydrocarbons syngas