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Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease

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Neural Regeneration Research 2021年第6期16卷 1099-1104页

作者： Steven Vetel Laura Foucault-Fruchard Claire Tronel Frédéric Buron Jackie Vergote Sylvie Bodard Sylvain Routier Sophie Sérrière Sylvie Chalon UMR 1253 iBrainUniversitéde ToursInsermToursFrance CHU Tours Service pharmacieToursFrance Institut de Chimie Organique et Analytique ICOAUMR CNRS 7311Universitéd’OrléansOrléansFrance

To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s *** was recently observed in a rodent model of Alzheimer’s disease that the interaction between the α7 subtype of nicotinic acetylcholine receptor(α7-nAChR)and sigma-1 receptor(σ1-R)could exert neuroprotective effects through the modulation of neuroinflammation which is one of the key components of the pathophysiology of Parkinson’s *** this context,the aim of the present study was to assess the effects of the concomitant administration of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide(PHA)543613 as an α7-nAChR agonist and 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate(PRE)-084 as aσ1-R agonist in a well-characterized 6-hydroxydopamine rat model of Parkinson’s *** animals received either vehicle separately or the dual therapy PHA/PRE once a day until day 14 *** no effect was noticed in the amphetamine-induced rotation test,our data has shown that the PHA/PRE treatment induced partial protection of the dopaminergic neurons(15-20%),assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia ***,this dual therapy reduced the degree of glial activation consecutive to the 6-hydroxydopamine lesion,i.e,the 18 kDa translocation protein density and glial fibrillary acidic protein staining in the striatum,and the CD11b and glial fibrillary acidic protein staining in the substantia ***,this study reports for the first time that concomitant activation of α7-nAChR andσ1-R can provide a partial recovery of the nigro-striatal dopaminergic neurons through the modulation of microglial *** study was approved by the Regional Ethics Committee(CEEA Val de Loire n°19)validated this protocol(Authorization N°00434.02)on May 15,2014.

关键词： 6-hydroxydopamine astrocytes microglial activation neurodegeneration neuroinflammation nicotinicα7 receptor Parkinson’s disease PHA 543613 PRE-084 sigma-1 receptor

Dual antibiotic loaded bone cement in patients at high infection risks in arthroplasty: Rationale of use for prophylaxis and scientific evidence

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World Journal of Orthopedics 2021年第3期12卷 119-128页

作者： Christof Ernst Berberich Jérome Josse Frédéric Laurent Tristan Ferry Department of Medical Training Heraeus Medical GmbHWehrheim 612173HessenGermany Institut des Sciences Pharmaceutiques et Biologiques de Lyon(ISPB) International Center for Research in InfectiologyInserm U1111CNRS UMR5308ENS de LyonUCBL1Lyon 69008France Interregional Reference Center for the Management of Complex Osteo-Articular Infections Hospices Civils de LyonLyon 69008France Bacteriology Laboratory Institute of Infectious AgentsCroix-Rousse HospitalHospices Civils de LyonLyon 69008France Infectious and Tropical Diseases Department Croix-Rousse HospitalHospices Civils de LyonLyon 69008France

In view of the demographic changes and projected increase of arthroplasty procedures worldwide,the number of prosthetic joint infection cases will naturally ***,in order to counteract this trend more rigid rules and a stricter implementation of effective preventive strategies is of highest *** the absence of a"miracle weapon"priorities should lie in evidence-based measures including preoperative optimization of patients at higher infection risks,the fulfilment of strict hygiene rules in the operating theatre and an effective antibiotic prophylaxis *** of a"one size fits all"philosophy,it has been proposed to adjust the antibiotic prophylaxis protocol to major infection risks taking into account important patient-and procedure-related risk factors.A stronger focus on the local application mode via use of high dose dual antibioticloaded bone cement in such risk situations may have its advantages and is easy to apply in the *** more potent antimicrobial growth inhibition in vitro and the strong reduction of the prosthetic joint infection rate in risk for infection patients with aid of dual antibiotic-loaded bone cement in clinical studies align with this hypothesis.

关键词： Prosthetic joint infection Antibiotic-loaded bone cement Single low dose antibiotic-loaded bone cement Dual high dose antibiotic-loaded bone cement Antibiotic prophylaxis Risk-for-infection patients

Imaging of hypoxia in human glioblastoma with dynamic 18F-fluoromisonidazole PET

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Cancer Drug Resistance 2019年第1期2卷 131-140页

作者： Redha-Alla Abdo Frédéric Lamare Philippe Fernandez M’hamed Bentourkia Department of Nuclear Medicine and Radiobiology Universitéde SherbrookeSherbrookeQC J1H5N4Canada Service de Médecine Nucléaire Universitéde Bordeaux-IIEPHEBordeaux 33076France

Aim:The purpose of this study was to locate the levels of hypoxia in glioblastoma PET images measured with 18F-fluoromisonidazole in human *** is recognized that tumors with hypoxia are resistant to treatment by radiotherapy and ***:The images were acquired in dynamic mode for 15 min or 30 min and in static mode for two single scans at 2 h and 3 h to allow the accumulation of the radiotracer in the *** images were analyzed at the voxel basis with compartmental analysis(CA)and with the usual tumor-to-blood uptake ratio(TBR).Kmeans algorithm was applied to cluster the levels of hypoxia in the ***:TBR at a threshold of 1.2 at imaging times of 15 min,2 h and 3 h produced images with different ***,the comparison of TBR with the distribution volume obtained with CA had a similarity index of 0.61±***:We found some differences in defining the hypoxic volume within a tumor using *** compartmental analysis allowed discrimination of the tumor hypoxic sub-volumes which can be useful for a better treatment with radiotherapy.

关键词： PET 18F-fluoromisonidazole glioblastoma hypoxia tumor-to-blood uptake ratio compartmental modeling

Reduced formation of peroxide and radical species stabilises iron-based hybrid catalysts in polymer electrolyte membrane fuel cells

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Journal of Energy Chemistry 2022年第2期31卷 433-438页

作者： Dongyoon Shin Sabita Bhandari Marc FTesch Shannon ABonke Frédéric Jaouen Sonia Chabbra Christoph Pratsch Alexander Schnegg Anna K.Mechler Max Planck Institute for Chemical Energy Conversion Stiftstr.34–3645470 Mülheim an der RuhrGermany ICGM Univ.MontpellierCNRSENSCMMontpellierFrance Fritz Haber Institute of the Max Planck Society Department of Inorganic ChemistryFaradayweg 4-614195 BerlinGermany

The incorporation of Pt into an iron-nitrogen-carbon(Fe NC)catalyst for the oxygen reduction reaction(ORR)was recently shown to enhance catalyst stability without Pt directly contributing to the ORR ***,the mechanistic origin of this stabilisation remained *** is established herein with rotating ring disc experiments that the side product,H_(2)O_(2),which is known to damage FeNC catalysts,is suppressed by the presence of *** formation of reactive oxygen species is additionally inhibited,independent of intrinsic H_(2)O_(2) formation,as determined by electron paramagnetic *** electron microscopy identifies an oxidised Fe-rich layer covering the Pt particles,thus explaining the inactivity of the latter towards the *** insights develop understanding of Fe NC degradation mechanisms during ORR catalysis,and crucially establish the required properties of a precious metal free protective catalyst to improve Fe NC stability in acidic media.

关键词： Electrochemistry Fuel cells Oxygen reduction reaction Non-precious metal catalyst Hybrid catalyst Stability

A Double Swath Configuration for Improving Throughput and Accuracy of Trait Estimate from UAV Images

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Plant Phenomics 2021年第1期3卷 378-388页

作者： Wenjuan Li Alexis Comar Marie Weiss Sylvain Jay Gallian Colombeau Raul Lopez-Lozano Simon Madec Frédéric Baret HIPHEN 228 Route de l’Aérodrome84000 AvignonFrance INRAE Avignon UniversitéUMR EMMAH84000 AvignonFrance ARVALIS Institut du Végétal 3 Rue Joseph et Marie Hackin75116 ParisFrance

Multispectral observations from unmanned aerial vehicles(UAVs)are currently used for precision agriculture and crop phenotyping applications to monitor a series of traits allowing the characterization of the vegetation ***,the limited autonomy of UAVs makes the completion of flights difficult when sampling large *** the throughput of data acquisition while not degrading the ground sample distance(GSD)is,therefore,a critical issue to be *** propose here a new image acquisition configuration based on the combination of two focal length(f)optics:an optics with f=4:2 mm is added to the standard f=8 mm(SS:single swath)of the multispectral camera(DS:double swath,double of the standard one).Two flights were completed consecutively in 2018 over a maize field using the AIRPHEN multispectral camera at 52 m *** DS flight plan was designed to get 80%overlap with the 4.2 mm optics,while the SS one was designed to get 80%overlap with the 8 mm *** a result,the time required to cover the same area is halved for the DS as compared to the *** georeferencing accuracy was improved for the DS configuration,particularly for the Z dimension due to the larger view angles available with the small focal length *** to plant height estimates demonstrates that the DS configuration provides similar results as the SS ***,for both the DS and SS configurations,degrading the quality level used to generate the 3D point cloud significantly decreases the plant height estimates.

关键词： optics overlap altitude

Innate and adaptive immune responses toward nanomedicines

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Acta Pharmaceutica Sinica B 2021年第4期11卷 852-870页

作者： Iara Maíra de Oliveira Viana Sabrina Roussel Joan Defrêne Eliana Martins Lima Frédéric Barabé Nicolas Bertrand Laboratory of Pharmaceutical Technology(FarmaTec) Federal University of GoiásGoiás 74605-220Brazil Faculty of Pharmacy UniversitéLaval and CHU de Québec-UniversitéLaval Research CenterQuébec G1V 4G2Canada Department of Medicine Faculty of MedicineUniversitéLaval and CHU de Québec-UniversitéLaval Research CenterQuébec G1V 4G2Canada

Since the commercialization of the frst liposomes used for drug delivery,Doxil/Caelyx® and Myocet®,tremendous progress has been made in understanding interactions between nanomedicines and biological *** work at the interface of engineering and medicine has allowed nanomedicines to deliver therapeutic small molecules and nucleic acids more *** nanomedicines are used in oncology for immunotherapy or to deliver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid complexes(Onpattro®)have paved the way for a variety of therapies beyond *** parallel,the global severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has highlighted the potential of mR NA vaccines to develop immunization strategies at unprecedented *** rationally design therapeutic and vaccines,chemists,materials scientists,and drug delivery experts need to better understand how nanotechnologies interact with the immune *** review presents a comprehensive overview of the innate and adaptative immune systems and emphasizes the intricate mechanisms through which nanomedicines interact with these biological functions.

关键词： Cancer immunotherapy mRNA vaccine Complement activation Macrophage In vivo clearance Anti-PEG antibody Nanoparticle mRNA-1273 BNT162b2 Immunology

CAN 2022:le Sénégal sur le toit de I'Afrique Le Sénegal a deécroché son premier titre de champion d'Afrique face à I'Egypte, le 6 février, au stade d'Olembé à Yaoundé

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中国与非洲（法文版） 2022年第3期14卷 42-43页

作者： Éric VINCENT FOMO 不详

Multiband emission from single β-NaYF_(4)(Yb,Er) nanoparticles at high excitation power densities and comparison to ensemble studies

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Nano Research 2021年第11期14卷 4107-4115页

作者： Florian Frenzel Christian Würth Oleksii Dukhno Frédéric Przybilla Lisa MWiesholler Verena Muhr Thomas Hirsch Yves Mély Ute Resch-Genger Federal Institute for Materials Research and Testing(BAM) Division 1.2 BiophotonicsRichard-Willstaetter-Str.1112489BerlinGermany Laboratory of Biomaging and Pathologies UMR 7021 CNRSUniversity of Strasbourg67000StrasbourgFrance Institute of Analytical Chemistry Chemo-and BiosensorsUniversity of Regensburg93040RegensburgGermany Institut für Physik and IRIS Adlershof Humboldt-Universität zu BerlinNewtonstraße 1512489BerlinGermany

Ensemble and single particle studies of the excitation power density (P)-dependent upconversion luminescence (UCL) of core and core-shell β-NaYF_(4):Yb,Er upconversion nanoparticles (UCNPs) doped with 20% Yb^(3+) and 1% or 3% Er^(^(3+)) performed over a P regime of 6 orders of magnitude reveal an increasing contribution of the emission from high energy Er^(3+) levels at P > 1 kW/cm^(2). This changes the overall emission color from initially green over yellow to white. While initially the green and with increasing P the red emission dominate in ensemble measurements at P < 1 kW/cm^(2), the increasing population of higher Er^(^(3+)) energy levels by multiphotonic processes at higher P in single particle studies results in a multitude of emission bands in the ultraviolet/visible/near infrared (UV/vis/NIR) accompanied by a decreased contribution of the red luminescence. Based upon a thorough analysis of the P-dependence of UCL, the emission bands activated at high P were grouped and assigned to 2–3, 3–4, and 4 photonic processes involving energy transfer (ET), excited-state absorption (ESA), cross-relaxation (CR), back energy transfer (BET), and non-radiative relaxation processes (nRP). This underlines the P-tunability of UCNP brightness and color and highlights the potential of P-dependent measurements for mechanistic studies required to manifest the population pathways of the different Er^(3+) levels.

关键词： upconversion luminescence single nanoparticle study high power excitation emission color luminescence decay kinetics

Influence of the operating temperature on the ageing and interfaces of double layer polymer electrolyte solid state Li metal batteries

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Nano Research 2023年第6期16卷 8377-8384页

作者： Mikel Arrese-Igor María Martinez-Ibañez Ander Orue Ekaterina Pavlenko Erwan Dumont Michel Armand Frédéric Aguesse Pedro López Aranguren Centre for Cooperative Research on Alternative Energies(CIC energiGUNE) Basque Research and Technology Alliance(BRTA)Alava Technology ParkAlbert Einstein 48Vitoria-Gasteiz 01510Spain University of the Basque Country(UPV/EHU) Barrio Sarrienas/nLeioa 48940Spain Saft 111 Boulevard Alfred DaneyBordeaux Cedex 33074France

Solid-state lithium metal batteries(SSLMBs)are considered an auspicious technology to develop high energy density and safe energy storage *** double layer polymer electrolyte(DLPE)is a rational approach for engineering high-performance SSLMBs addressing electrolyte requirements with specifically designed polymers at the positive electrode and as *** this work,SSLMBs were assembled with poly(propylene carbonate)(PPC),offering stability toward oxidation at the positive electrode,and a gel polymer electrolyte with polyethyleneglycol dimethylether(PEGDME)as separator,offering high ionic conductivity at low temperature and sufficient interfacial stability with Li *** electrochemical properties and performance of cells with LiFePO_(4) and Li[Ni_(0.6)Mn_(0.2)Co_(0.2)]O_(2) positive electrodes are thoroughly investigated as function of the operating temperature by using a host of characterization ***-voltage cells with an areal capacity of 0.7 mAh·cm^(−2)cycled at 40℃ exhibit a higher capacity retention than the cells cycled at 70℃.To understand such differences,a three-electrode setup is applied to discriminate anodic processes from cathodic as function of the *** elucidate the ageing and interfacial evolution for DLPE cells with gel polymer electrolytes paving the way for building performance solid state batteries.

关键词： double layer polymer electrolyte solid-state lithium metal battery gel polymer electrolyte high voltage interfacial study