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Risk and predictors of severity and mortality in patients with type 2 diabetes and COVID-19 in Dubai

World Journal of Diabetes 2023年第8期14卷 1259-1270页

作者： Fatheya Alawadi Alaaeldin Bashier Azza Abdulaziz Bin Hussain Nada Al-Hashmi Fawzi Al Tayb Bachet Mohamed Mahmoud Aly Hassanein Marwan abdelrahim Zidan Rania Soued Amar Hassan Khamis Debasmita Mukhopadhyay Fatima Abdul Aya Osama Fatima Sulaiman Muhammad Hamed Farooqi riad abdel latif bayoumi Department of Endocrinology Dubai Academic Health CorporationDubaiUnited Arab Emirates Department of Medical Education and Research Dubai Academic Health CorporationDubaiUnited Arab Emirates Department of Radiology Mediclinic City HospitalDubaiUnited Arab Emirates College of Medicine Mohamed Bin Rashid University of Medicine and Health SciencesDubaiUnited Arab Emirates Dubai Diabetes Center Dubai Academic Health CorporationDubaiUnited Arab Emirates Basic Medical Sciences College of MedicineMohammed Bin Rashid University of Medicine and Health SciencesDubaiUnited Arab Emirates

BACKGROUND Globally,patients with diabetes suffer from increased disease severity and mortality due to coronavirus disease 2019(COVID-19).Old age,high body mass index(BMI),comorbidities,and complications of diabetes are recognized as major risk factors for infection severity and *** To investigate the risk and predictors of higher severity and mortality among inhospital patients with COVID-19 and type 2 diabetes(T2D)during the first wave of the pandemic in Dubai(March–September 2020).METHODS In this cross-sectional nested case-control study,a total of 1083 patients with COVID-19 were *** study included 890 men and 193 *** these,427 had T2D and 656 were *** clinical,radiographic,and laboratory data of the patients with and without T2D were *** predictors of mortality in COVID-19 non-survivors were identified in patients with and without *** T2D patients with COVID-19 were older and had higher BMI than those without *** had higher rates of comorbidities such as hypertension,ischemic heart disease,heart failure,and more life-threatening *** laboratory parameters of disease severity were significantly higher than in those without ***,these patients had a longer hospital stay and a significantly higher mortality *** died from COVID-19 at a rate three times higher than patients *** laboratory and radiographic severity indices in non-survivors were high in patients with and without *** the univariate analysis of the predictors of mortality among all COVID-19 non-survivors,significant associations were identified with old age,increased white blood cell count,lymphopenia,and elevated serum troponin *** multivariate analysis,only lymphopenia was identified as an independent predictor of mortality among T2D *** Patients with COVID-19 and T2D were older with higher BMI,more comorbidities,higher disease severity indices,more severe proinflamma

关键词： Type 2 diabetes COVID-19 Risk factors Mortality United Arab Emirates

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Utility of oral glucose tolerance test in predicting type 2 diabetes following gestational diabetes:Towards personalized care

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World Journal of Diabetes 2021年第10期12卷 1778-1788页

作者： riad abdel latif bayoumi Amar Hassan Khamis Muna A Tahlak Taghrid F Elgergawi Deemah K Harb Komal S Hazari Widad A abdelkareem Aya O Issa Rakeeb Choudhury Mohamed Hassanein Jeyaseelan Lakshmanan Fatheya Alawadi Department of Basic Medical Sciences College of MedicineMohammed Bin Rashid University of Medicine and Health SciencesDubai 123United Arab Emirates Department of Biostatistics HBMDCMohammed Bin Rashid University of Medicine and Health SciencesDubai 123United Arab Emirates Department of Obstetrics and Gynecology Dubai Health AuthorityDubai 123United Arab Emirates Department of Endocrinology Dubai Health AuthorityDubai 123United Arab Emirates Department of Biostatistics Mohammed Bin Rashid University of Medicine and Health SciencesDubai 123United Arab Emirates

BACKGROUND Women with gestational diabetes mellitus(GDM)are at a seven-fold higher risk of developing type 2 diabetes(T2D)within 7-10 years after childbirth,compared with those with normoglycemic *** raised fasting blood glucose(FBG)levels has been said to be the main significant predictor of postpartum progression to T2D,it is difficult to predict who among the women with GDM would develop ***,we conducted a cross-sectional retrospective study to examine the glycemic indices that can predict postnatal T2D in Emirati Arab women with a history of *** To assess how oral glucose tolerance test(OGTT)can identify the distinct GDM pathophysiology and predict possible distinct postnatal T2D *** The glycemic status of a cohort of 4603 pregnant Emirati Arab women,who delivered in 2007 at both latifa Women and Children Hospital and at Dubai Hospital,United Arab Emirates,was assessed retrospectively,using the International Association of Diabetes and Pregnancy Study Groups(IADPSG)*** the total,1231 women were followed up and assessed in *** FBG and/or the 2-h blood glucose(2hrBG)levels after a 75-g glucose load were measured to assess the prevalence of GDM and T2D,according to the IADPSG and American Diabetes Association(ADA)criteria,*** receiver operating characteristic curve for the OGTT was plotted and sensitivity,specificity,and predictive values of FBG and 2hrBG for T2D were *** Considering both FBG and 2hrBG levels,according to the IADPSG criteria,the prevalence of GDM in pregnant Emirati women in 2007 was 1057/4603(23%),while the prevalence of pre-pregnancy T2D among them,based on ADA criteria,was 230/4603(5%).In the subset of women(n=1231)followed up in 2016,the prevalence of GDM in 2007 was 362/1231(29.6%),while the prevalence of prepregnancy T2D was 36/1231(2.9%).Of the 362 pregnant women with GDM in 2007,96/362(26.5%)developed T2D;142/362(39.2%)developed impaired fasting glucose;29/36

关键词： Type 2 diabetes Type 2 diabetes subtypes Oral glucose tolerance test Diabetes Gestational diabetes mellitus subtypes

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Investigation on the mechanical properties of sintered porous copper compacts

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China Particuology 2007年第6期5卷 391-394页

作者： Yasser M.Z. Ahmed Mohamed I. riad Ahmed I. Zaky Mohammed abdel-Aziz Mohamed M.H. Shalabi Central Metallurgical Research and Development Institute CMRDI El-Felzat Street El-Tabbin P.O. Box 87 Helwan Cairo Egypt

In line with recent attention on porous metals having low and medium porosities in the range of 20-50%, this paper studies the effect of porosity on the mechanical properties of sintered copper compacts. Experiments were designed to investigate the effect of porosity, applied stress and sliding velocity on the wear rate of copper compacts, leading to the finding that the effects of both porosity and applied stress of the wear test on the wear rate are approximately similar and higher than that of sliding velocity. The investigation concerning the effect of porosity on compressive strength indicated that the stress-strain curve of high-porosity compact exhibited identifiable ultimate strength points, though low-porosity compact showed distinct stages of elastic plastic behavior.

关键词： Porous copper Wear rate Compressive strength Experimental design technique

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I-131 MIBG Therapy for Advanced Stage III &IV Neuroblastoma

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Journal of Cancer Therapy 2011年第4期2卷 481-489页

作者： Raef riad Magdy Kotb Walid Omar Ahmed Zaher Emad Ebied Alexander Gregory Pitman Hussein abdel Dayem 不详

Radio-labelled MIBG therapy has been tried in the treatment of advanced stage III and IV neuroblastoma in an attempt to improve patients outcome. The use of radiolabelled MIBG to treat neuroblastoma has arisen from the high sensitivity and specificity of in vivo MIBG imaging for detection of primary and metastatic tumours. Although, clinical trials have been performed to determine the role of MIBG therapy, the overall therapeutic strategy of MIBG therapy is not precisely defined. Aim of the work: to determine the impact of MIBG therapy on patients’ outcome especially their quality of life. Patients & methods: 42 paediatri neuroblastoma patients are included in this study, 12 (28.5%) stage III disease and 30 (71.5%) stage IV. I-131 MIBG doses ranged from 100 to 150 mCi with number of courses ranged from 1-8 according to response and toxicity. Results: Group I (stage III): 1/12 patients showed complete response, 5/12 patients had partial response and the other 6 patients remained stable. The 5 years event free survival (EFS) of stage III patients was 46.6% and the overall survival was 75%. Group II (stage IV): 2/30 patients achieved CR, 9/30 patients showed PR to I-131 MIBG and the other 18 remained stable. The 5 years event free survival (EFS) of stage IV patients was 48.2% and the overall survival was 69%. Conclusion: We conclude that 131I-MIBG therapy has favourable therapeutic effects that are translated into an overall improved outcome with good quality of life.

关键词： I-131 MIBG Neuroblastoma Pediatrics

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