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Linking of Environmental and Health Indicators by Neural Networks:Case of Breast Cancer Mortality,Slovak Republic

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Open Journal of Geology 2013年第2期3卷 101-112页

作者： Stanislav Rapant Mária.Letkovicová Veronika Cvecková Andrej Durza Katarína Fajcíková Hana Zach State Geological Institute of D.Stúr BratislavaSlovak Republic Environment a.s.NitraSlovak Republic Faculty of Natural Sciences Comenius UniversityBratislavaSlovak Republic

This study deals with the analysis of relationship between 67 environmental indicators in geological environment and breast cancer mortality in Slovakia. Primary data comprises a database of 67 environmental indicators for groundwater and soils as a mean value for every Slovak municipality and the data on relative mortality from breast cancer for Slovak municipalities (about 2900) collected for the period of 22 years. The training neural network was used as a mathematical model for data analysis. The top 200 networks have identified 12 environmental indicators (8 for soils: pHKCl, carbonates, Ca, Mg, Na, Co, Sr and 4 for groundwater: ba, SiO2, Zn, Fe) with high rate of influence. As the most influential environmental indicator was identified pHKCl in soil that should be within the range of acids, definitely under the neutral point. Most of environmental indicators were unambiguously identified as negative (Mg, Ca, Sr, carbonates, ba, SiO2, Zn and Fe). These indicators should be at the lowest level of their concentration in related geological component. Three environmental indicators, Ce, Na and Co had parabolic function where certain essential concentration levels of these elements are presumed with protective effect on human health. For all influential indicators limit values with respect to the lowest mortality were proposed. The verification of achieved results was performed through regressive model of breast cancer mortality for 12 calculated influential environmental indicators for all municipalities in the Slovak Republic. The revealed difference between real mortality levels and the model values was found for 6 environmental indicators (pHKCl, Mg, Ca, Sr, ba, Zn). Each executed limit has decreased breast cancer mortality for about 0.79 cases per 100,000 inhabitants.

关键词： Neural Network Breast Cancer Mortality Environmental Indicators Soil Groundwater Slovak Republic

Effect of herpesvirus infection on pancreatic duct cell secretion

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World Journal of Gastroenterology 2005年第38期11卷 5997-6002页

作者： Péter Hegyi balázs rdg Zoltán Rakonczai Jr Tamás Takács János Lonovics Annamária.Szabolcs Réka Sári András Tóth Julius G Papp András Varró Mária.K Kovács Mike A Gray barry E Argent Zsolt Boldogki First Department of Medicine Department of Biology Division of Cardiovascular Pharmacology School of Cell and Molecular Biosciences

AIM： To examine the effect of acute infection caused by herpesvirus （pseudorabies virus, PRV） on pancreatic ductal secretion. METHODS： The virulent ba-DupGreen （BDG） and non- virulent Ka-RREp01acgfp （KEG） genetically modified strains of PRV were used in this study and both of them contain the gene for green fluorescent protein （GFP）. Small intra/ interlobular ducts were infected with BDG virus （10^7 PFU/mL for 6 h） or with KEG virus （10^10 PFU/mL for 6 h）, while non-infected ducts were incubated only with the culture media. The ducts were then cultured for a further 18 h. The rate of HCO3 secretion [base efflux -λ（B）] was determined from the buffering capacity of the cells and the initial rate of intracellular acidification （1） after sudden blockage of basolateral base loaders with dihydro-4,4,- diisothiocyanatostilbene-2,2,-disulfonic acid （500 μmol/L） and amiloride （200 μmol/L）, and （2） after alkali loading the ducts by exposure to NH4Cl. All the experiments were performed in HCO3-buffered Ringer solution at 37 ℃ （n = 5 ducts for each experimental condition）. Viral structural proteins were visualized by immunohistochemistry. Virallyencoded GFP and immunofluorescence signals were recorded by a confocal laser scanning microscope.RESULTS： The BDG virus infected the majority of accessible cells of the duct as judged by the appearance of GFP and viral anUgens in the ductal cells. KEG virus caused a similarly high efficiency of infection. After blockage of basolateral base loaders, BDG infection significantly elevated -λB-） 24 h after the infection, compared to the non-infected group. However, KEG infection did not modify -λB-）. After alkali loading the ducts, -λB-） was significantly elevated in the BDG group compared to the control group 24 h after the infection. As we found with the inhibitor stop method, no change was observed in the group KEG compared to the non-infected group. CONCLUSION： Incubation with the BDG or KEG strains of PRV results in an effective i

关键词： Pancreas Hypersecretion Ductal cells Infection Pseudorabies virus

成年鹅口服鹅细小病毒B株不能引进体液免疫反应

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广东畜牧兽医科技 1981年第4期 72-74页

作者： J.Kisary Mária.Kelemen 杜伟贤

两月龄的鹅用强毒鹅细小病毒B株无论是口服还是肌肉注射,均产生中和病毒的抗体,出现病症后短时间排毒。同月龄的鹅用减弱毒株则仅肌肉在射才有体液免疫反应,而经口服则无。

关键词：鹅细小病毒成年鹅肌肉接种抗体 ba 弱毒株体液免疫反应

Risk of gastrointestinal cancer in a symptomatic cohort after a complete colonoscopy:Role of faecal immunochemical test

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World Journal of Gastroenterology 2020年第1期26卷 70-85页

作者： Noel Pin-Vieito María J Iglesias David Remedios Lorena Rodríguez-Alonso Francisco Rodriguez-Moranta Victoria.lvarez-Sánchez Fernando Fernández-bañares Jaume Boadas Eva Martínez-bauer Rafael Campo Luis Bujanda Ángel Ferrandez Virginia Piñol Daniel Rodríguez-Alcalde Jordi Guardiola Joaquín Cubiella Gastroenterology Department Complexo Hospitalario Universitario de OurenseCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd)Ourense 32005Spain Department of Gastroenterology and Hepatology University Hospital of Bellvitge-IDIBELLL'Hospitalet de LlobregatBarcelona 08907Spain.Ciber de Epidemiología y Salud Pública(CIBERESP)Spain Gastroenterology Department Complejo Hospitalario de PontevedraPontevedra 36001Spain Gastroenterology Department Hospital Universitari Mútua de TerrassaCIBERehdTerrassa 08221Spain Gastroenterology Department Consorci Sanitari de TerrassaTerrassa 08221Spain Gastroenterology Department Hospital de SabadellCorporacióSanitària Donostia Hospital Biodonostia InstituteUniversity of the Basque Country UPV/EHUCIBERehdSan Sebastian 20010Spain Servicio de Aparato Digestivo Hospital Clínico UniversitarioIIS AragónUniversity of ZaragozaCIBERehdZaragoza 50009Spain Gastroenterology Department Hospital Dr.Josep TruetaGirona 17007Spain Digestive Disease Section Hospital Universitario de MóstolesMadrid 28935Spain

baCKGROUND Faecal immunochemical test(FIT)has been recommended to assess symptomatic patients for colorectal cancer(CRC)***,some conditions could theoretically favour blood originating in proximal areas of the gastrointestinal tract passing through the colon unmetabolized.A positive FIT result could be related to other gastrointestinal cancers(GIC).AIM To assess the risk of GIC detection and related death in FIT-positive symptomatic patients(threshold 10μg Hb/g faeces)without *** Post hoc cohort analysis performed within two prospective diagnostic test studies evaluating the diagnostic accuracy of different FIT analytical systems for CRC and significant colonic lesion *** patients with gastrointestinal symptoms referred consecutively for colonoscopy from primary and secondary healthcare,underwent a quantitative FIT before undergoing a complete *** without CRC were divided into two groups(positive and negative FIT)using the threshold of 10μg Hb/g of faeces and data from follow-up were retrieved from electronic medical records of the public hospitals involved in the *** determined the cumulative risk of GIC,CRC and upper *** rate(HR)was calculated adjusted by age,sex and presence of significant colonic *** We included 2709 patients without CRC and a complete baseline colonoscopy,730(26.9%)with FIT≥10μgr Hb/*** a mean time of 45.5±20.0 mo,a GIC was detected in 57(2.1%)patients:An upper GIC in 35(1.3%)and a CRC in 14(0.5%).Thirty-six patients(1.3%)died due to GIC:22(0.8%)due to an upper GIC and 9(0.3%)due to ***-positive subjects showed a higher CRC risk(HR 3.8,95%CI:1.2-11.9)with no differences in GIC(HR 1.5,95%CI:0.8-2.7)or upper GIC risk(HR 1.0,95%CI:0.5-2.2).Patients with a positive FIT had only an increased risk of CRC-related death(HR 10.8,95%CI:2.1-57.1)and GIC-related death(HR 2.2,95%CI:1.1-4.3),with no differences in upper GIC-related death(HR 1.4,95%CI:0.6-3.3).An

关键词： Colonoscopy Colorectal cancer Faecal immunochemical test Gastric cancer Gastroesophageal cancer Gastrointestinal cancer Symptoms

窒息新生儿血糖、皮质醇、胰岛素水平变化及其临床意义

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新生儿科杂志 2005年第6期20卷 254-256页

作者：周英陈菲巴雅新疆医科大学第一附属医院新生儿科 830054 新疆建工医院儿科新疆医科大学第一附属医院核医学科

目的观察窒息新生儿血糖(BG)、皮质醇(co)、胰岛素(InS)水平变化,以探讨其临床意思。方法用微量法和放免法检测40例正常新生儿和50例窒息新生儿血糖、皮质醇、胰岛素。结果窒息新生儿脐血BG、InS、Co明显升高,且与窒息严重程度呈... 详细信息

目的观察窒息新生儿血糖(BG)、皮质醇(co)、胰岛素(InS)水平变化,以探讨其临床意思。方法用微量法和放免法检测40例正常新生儿和50例窒息新生儿血糖、皮质醇、胰岛素。结果窒息新生儿脐血BG、InS、Co明显升高,且与窒息严重程度呈正相关(r值分别为0．36、0．31、0．33)。出生3 d BG和Co水平有所降低,而InS水平无降低趋势。重度窒息组与对照组相比,各项水平差异显著(P< 0．01),且窒息组3 d时BG、Co水平与脐血相比有明显差异(P<0．05)。结论应激状态可造成BG、InS、Co升高,随窒息解除、病情缓解,胰岛素抵抗的恢复较血糖和皮质醇恢复慢。在窒息抢救时,尤其是重度窒息儿,应密切监测血糖与激素变化,且慎用糖皮质激素。

关键词：窒息新生儿血糖皮质醇胰岛素

Socio-Environmental Responsibility Policy in Financial Institutions

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Macro Management & Public Policies 2020年第1期2卷 17-27页

作者： Sady Mazzioni Francielle Corazza Cristian baúDal Magro Antonio Zanin Postgraduate Program in Accounting and Administration Universidade Comunitária da Região de Chapecó-ChapecóBrazil

This research intents to analyze the influence of Socio-Environmental Responsibility Policy of Brazilian’s Central bank on financial institutions economic performance listed at the Brazilian stock *** data was collected from diversified sources(websites,explanatory notes,reference form and Economatica®data base)from 2012 up to *** sample,22 financial institutions were considered for data collection and *** results showed that the growth in shareholder’s equity and contingent liabilities have significant differences from the adoption of the Socio-Environmental Responsibility *** six items of corporate governance and six items of risk management,no investigated institution presented all these mechanisms requested by Brazilian’s Central ***’s financial institutions recognized a greater volume of liabilities and expenses after the implementation of such policy,which reduced their net *** research shed some lights in socio-environmental policies regarding corporate governance and risk management ***:to analyze whether the adoption of a socio-environmental responsibility policy influences the performance indicators and the corporate governance and risk management framework of financial institutions listed on the Brazilian stock ***:Data were collected from the period 2012 to 2017,referring to 22 Brazilian financial institutions,which provided information to operationalize the ***:the results showed that,from the performance indicators investigated,the growth in shareholders'equity and contingent liabilities presented significant differences as of the adoption of the socio-environmental responsibility *** items were analyzed,six of which were corporate governance and six of risk management,noting that no investigated institution presented all the mechanisms provided by the Central bank of ***:the evidence suggests that Brazilian financial institutio

关键词： Sustainability Risk management Performance Financial Institution

尿VEGF、ET检测对2型糖尿病患者早期肾脏微血管损伤的诊断价值

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热带医学杂志 2008年第1期8卷 49-51页

作者：张拔山陈丽静赖福娣广东省东莞市人民医院检验科东莞523018

目的探讨尿血管内皮生长因子(VEGF)、内皮素(ET)对2型糖尿病患者早期肾脏微血管损伤的诊断价值。方法按尿微量蛋白排泄率把76例2型糖尿病患者分为无肾病、早期肾病、临床肾病3组。采用放射免疫法(ria.和酶联免疫吸附试验(ELISA)测定尿V... 详细信息

目的探讨尿血管内皮生长因子(VEGF)、内皮素(ET)对2型糖尿病患者早期肾脏微血管损伤的诊断价值。方法按尿微量蛋白排泄率把76例2型糖尿病患者分为无肾病、早期肾病、临床肾病3组。采用放射免疫法(ria.和酶联免疫吸附试验(ELISA)测定尿VEGF、α1-微球蛋白(α1-MG)、β2-微球蛋白(β2-MG)、免疫球蛋白G(IgG)、ET水平。结果2型糖尿病患者尿VEGF、ET与对照组比较差异有统计学意义(t≥2.29,Pba1c)呈正显著相关(r≥0.309),而与空腹血糖(FBG)无明显相关(r≤0.06)。结论VEGF、ET参与糖尿病微血管病变的发生、发展;尿VEGF、ET是诊断2型糖尿病患者早期肾脏微血管损伤的敏感指标,对糖尿病肾病的早期诊断和肾功能损害程度的判断有一定的临床诊断价值。

关键词：血管内皮生长因子内皮素糖尿病肾病

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提高放射免疫分析技术教学质量的改革与实践

山东化工 2020年第14期49卷 178-179页

作者：张奇洲杨英李毓斌巴雅李肖红秦永德新疆医科大学第一附属医院核医学科新疆乌鲁木齐830011 新疆维吾尔自治区人民医院干部保健中心新疆乌鲁木齐830011

放射免疫分析技术是应用核素示踪技术和体外放射分析技术进行机体的功能研究和对体内的微量物质实施超微量分析的一项实用技术。在这章内容的教学中,基本原理、基础知识的系统讲授必不可少,原理分析生动有趣又严谨求实,临床实训课突出... 详细信息

放射免疫分析技术是应用核素示踪技术和体外放射分析技术进行机体的功能研究和对体内的微量物质实施超微量分析的一项实用技术。在这章内容的教学中,基本原理、基础知识的系统讲授必不可少,原理分析生动有趣又严谨求实,临床实训课突出提高学生的动手能力、创新意识和严谨求实的实验精神,懂得误差引入与控制,积极引导学生汲取网络资源,了解前沿。通过教学内容、教学方式等方面的不断改进,提高放射免疫分析教学质量。

关键词：放射免疫分析教学质量改革

甲亢甲低患者肝纤维化指标检测的临床意义分析

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现代生物医学进展 2011年第6期11卷 1152-1154页

作者：巴红珍徐海峰周飞华魏龙晓王俊燕第四军医大学唐都医院核医学科陕西西安710038

目的:探讨甲状腺功能亢进(甲亢)、甲状腺功能减低(甲低)与肝纤维化指标的关系及其可能的机制。方法:采用放射免疫分析法(R1A)检测57例甲亢患者、43例甲低患者、39例甲亢治疗后甲状腺激素正常者和50例健康成人的血清Ⅳ型胶原(1V-C)、Ⅲ... 详细信息

目的:探讨甲状腺功能亢进(甲亢)、甲状腺功能减低(甲低)与肝纤维化指标的关系及其可能的机制。方法:采用放射免疫分析法(R1A)检测57例甲亢患者、43例甲低患者、39例甲亢治疗后甲状腺激素正常者和50例健康成人的血清Ⅳ型胶原(1V-C)、Ⅲ型前胶原(PCⅢ)、透明质酸(HA)、层粘连蛋白(LN)、T3、T4、FT3、FT4、TSH、TGA、TMA含量。结果:甲亢患者组血清中1V-C、PCⅢ含量比正常对照组及甲低患者组显著性增高(P0.05),在甲亢治疗前后无显著性差异(P>0.05)。各项肝纤维化指标与TGA、TMA的阳性率无关。结论:甲亢患者可有不同程度的肝功能损害,血清中甲状腺激素水平增高时,1V-C、PCⅢ水平也增高,在用1V-C、PCⅢ判断肝纤维化时应注意有无甲状腺疾病特别是甲亢。未发现HA、LN含量与甲状腺激素水平的关系。

关键词：甲亢甲低肝纤维化指标