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Assessment of the Anaerobic Speed Reserve during Specific High-Intensity Exercise in Judo Athletes

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Journal of Science in Sport and Exercise 2022年第3期4卷 266-274页

作者： Emerson Franchini Rafael Lima Kons Valéria Leme Gonçalves Panissa Daniele Detanico Martial Arts and Combat Sports Research Group School of Physical Education and SportUniversity of São PauloSão PauloBrazil Biomechanics Laboratory Center of SportsFederal University of Santa CatarinaFlorianópolisSC 88040-900Brazil

Purpose This study aimed to describe self-selected intensity and its relationship to performance during a high-intensity all-out judo protocol,and to verify whether athletes with different anaerobic speed reserve(ASR)perform differently during a high-intensity all-out interval uchi-komi(judo-specific skill).Methods We analyzed the performance of 28 judo athletes as a whole group and divided into groups,according to their *** performed several judo-specific protocols using a specific skill:maximal speed sprint(MSS)and maximal aerobic speed(MAS),and high-intensity intermittent uchi-komi protocol(12×20 s all-out:10 s passive recovery).Results The main results demonstrated a decrease in the number of repetitions and an increase in heart rate across the *** with greater ASR performed a higher number of repetitions,compared to the low ASR group,and they were able to exercise at a higher percentage of the MAS(low ASR=126%;SD=13%;high ASR=152%,SD=l9%)and at a lower percentage of MSS compared to the low ASR group(low ASR=84%,SD=7%;high ASR=76%,SD=11%).However,both groups exercised at a similar percentage of their own ASR during the protocol(low ASR=50%,SD=20%;high ASR=53%,SD=19%).Conclusions Athletes with different ASR seem to set their pace at around 50%of their ASR within an all-out uchi-komi ***,the ASR is useful for predicting performance during high-intensity judo-specific interval exercise intervals.

关键词： Combat sports Rating of perceived exertion Pace All-out exercise

Defective claudin-10 causes a novel variation of HELIX syndrome through compromised tight junction strand assembly

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Genes & Diseases 2022年第5期9卷 1301-1314页

作者： Sebastian Sewerin Jorg Piontek ria Schonauer Sonja Grunewald Angelika Rauch Steffen Neuber Carsten Bergmann Dorothee Gunzel Jan Halbritte Division of Nephrology University of Leipzig Medical CenterLeipzig 04103Germany Clinical Physiology/Nutritional Medicine Charitee Universitatsmedizin BerlinBerlin 12203Germany Division of Dermatology Venereologyand AllergologyUniversity of Leipzig Medical CenterLeipzig 04103Germany Division of Prosthodontics and Materials Science University of Leipzig Medical CenterLeipzig 04103Germany Center for Human Genetics BioscientiaIngelheim 55218Germany f Medizinische Genetik MainzLimbach GeneticsMainz 55128Germany

Formation of claudin-10 based tight junctions(TJs)is paramount to paracellular Na+transport in multiple *** variants in CLDN10 have been linked to HELIX syndrome,a salt-losing tubulopathy with altered handling of divalent cations accompanied by dysfunctional salivary,sweat,and lacrimal ***,we investigate molecular basis and phenotypic consequences of a newly identified homozygous CLDN10 variant that translates into a single amino acid substitution within the fourth transmembrane helix of *** addition to hypohidrosis(H),electrolyte(E)imbalance with impaired urine concentrating ability,and hypolacrimia(L),phenotypic findings include altered salivary electrolyte composition and amelogenesis imperfecta but neither ichthyosis(I)nor xerostomia(X).Employing cellular TJ reconstitution assays,we demonstrate perturbation of cis-and trans-interactions between mutant claudin-10 *** of reconstituted TJ strands show disturbed continuity and reduced abundance in the mutant ***,both major isoforms,claudin-10a and claudin-10b,are differentially affected with claudin-10b showing more severe molecular ***,expression of the mutant in renal epithelial cells with endogenous TJs results in wild-type-like ion selectivity and conductivity,indicating that aberrant claudin-10 is generally capable of forming functional paracellular ***,mutant proteins prove pathogenic by compromising claudin-10 TJ strand *** ex vivo investigations indicate their insertion into TJs to occur in a tissue-specific manner.

关键词： Claudin-10 HELIX syndrome Paracellular transport Salt-losing tubulopathy Tight junction

Post-mortem Microstructural Study of Aluminous Refractory Brick Used in Channels of Blast Furnaces

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China's Refractories 2023年第1期32卷 40-43页

作者： Ana Valéria de Sousa COSTA Belmira Benedita de LIMA-KUHN Antonio Renato BIGANSOLLI Department of Chemical Engineering Technology InstituteFederal Rural University of Rio de JaneiroSeropédica 23851-970Brazil

Aluminous refractory materials with high alumina contents are widely used in the steel industry,and the higher the alumina content,the higher the working *** such as high refractoriness and thermal shock resistance lead these refractory materials to be used as channel linings of blast furnaces,where they are exposed to the attack by slag,molten steel,working cycles and sudden temperature changes between 25℃(room temperature)and 1520℃(the temperature of molten pig iron).In this work,microstructural changes in post-mortem aluminous refractory bricks were investigated by apparent porosity,X-ray diffraction analysis(XRD),Fourier transform infrared spectroscopy(FTIR),scanning electron microscopy,and X-ray dispersion energy spectrometry(SEM/EDS).The results showed an increase in the apparent porosity and the bulk density and the presence of the phases mullite,sillimanite,alumina,and quartz in the post-mortem *** and magnesium were not detected in the microstructure of the post-mortem brick,indicating that slags did not corrode these refractory ***,the microstructural changes that occurred in the post-mortem bricks must be due to thermal *** the X-ray diffraction(XRD)test,mullite,sillimanite,quartz,andα-alumina phases were *** results indicate that the aluminous refractory was obtained from *** infrared spectroscopy(FTIR)it was possible to identify the vibration bands referring to the Si-O and Al-O *** increase in the porosity is a result of cracks caused by work cycles at high temperatures and the temperature gradient to which the refractory was subjected during *** the micrograph it was possible to identify the presence of acicular *** absence of magnesium and calcium in the microanalysis results by energy dispersed X-ray spectrometry(EDS)indicates that there was no infiltration by slag or liquid *** results indicate that the microstructural changes that occurred in t

关键词： aluminous refractories steel industry microstructural blast furnace

Endurance exercise and gut microbiota:A review

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Journal of Sport and Health Science 2017年第2期6卷 179-197页

作者： Núria Mach Dolors Fuster-Botella Health Science Department International Graduate Institute of the Open University of Catalonia (UOC) Barcelona 08035 Spain Animal Genetics and Integrative Biology unit (GABI) INRA AgroParis Tech Univesity of Paris-Saclay Jouy-en-Josas 78350 France

Background: The physiological and biochemical demands of intense exercise elicit both muscle-based and systemic responses. The main adaptations to endurance exercise include the correction of electrolyte imbalance, a decrease in glycogen storage and the increase of oxidative stress, intestinal permeability, muscle damage, and systemic inflammatory response. Adaptations to exercise might be influenced by the gut microbiota, which plays an important role in the production, storage, and expenditure of energy obtained from the diet as well as in inflammation,redox reactions, and hydration ***: A systematic and comprehensive search of electronic databases, including MEDLINE, Scopus, Clinical ***, Science Direct,Springer Link, and EMBASE was done. The search process was completed using the keywords: "endurance", "exercise", "immune response","microbiota", "nutrition", and "probiotics".Results: Reviewed literature supports the hypothesis that intestinal microbiota might be able to provide a measureable, effective marker of an athlete's immune function and that microbial composition analysis might also be sensitive enough to detect exercise-induced stress and metabolic disorders. The review also supports the hypothesis that modifying the microbiota through the use of probiotics could be an important therapeutic tool to improve athletes' overall general health, performance, and energy availability while controlling inflammation and redox ***: The present review provides a comprehensive overview of how gut microbiota may have a key role in controlling the oxidative stress and inflammatory responses as well as improving metabolism and energy expenditure during intense exercise.

关键词：剧烈运动肠道菌群耐力 MEDLINE 炎症反应氧化应激氧化还原反应代谢紊乱

Soil moisture content as a predictor of soil disturbance caused by wheeled forest harvesting machines on soils of the Western Carpathians

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Journal of Forestry Research 2017年第2期28卷 283-289页

作者： Michal Allman Martin Jankovsk Valéria Messingerov Zuzana Allmanov Department of Forest Harvesting Logistics and AmeliorationsFaculty of ForestryTechnical University in ZvolenT.G.Masaryka 24960 53 ZvolenSlovakia

Limiting surface soil disturbance caused by forest harvesting machines is an important task and is influenced by the selection of efficient and reliable predictors of such disturbance. Our objective was to determine whether soil moisture content affects soil load bearing capacity and the formation of ruts. Measurements were conducted in six forest stands where various machines operated. We measured the formation of ruts along skid trails in connection with varying soil moisture content. Soil moisture content was determined through the gravimetric sampling method. Our results showed that severe（rut depth16–25 cm） to very severe disturbance（rut depth [26 cm）occurred in forest stands where the instantaneous soil moisture exceeded its plasticity limits defined through Atterberg limits. Atterberg limits of soil plasticity ranged from 26 to 32 % in individual stands. Regression and correlation analysis confirmed a moderately strong relationship（R = 0.52; p ／ 0.05） between soil moisture content and average rut depth. This confirmed that soil moisture is a suitable and effective predictor of soil disturbance.

关键词： disturbance moisture machines stands plasticity harvesting predictor moderately operated limits

Gut region-specific TNFR expression:TNFR2 is more affected than TNFR1 in duodenal myenteric ganglia of diabetic rats

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World Journal of Diabetes 2023年第1期14卷 48-61页

作者： Bence Pál Barta Benita Onhausz Afnan AL Doghmi Zita Szalai János Balázs Mária Bagyánszki Nikolett Bódi Department of Physiology Anatomy and NeuroscienceUniversity of SzegedSzeged 6726Hungary

BACKGROUND Cytokines are essential in autoimmune inflammatory processes that accompany type 1 *** necrosis factor alpha plays a key role among others in modulating enteric neuroinflammation,however,it has a dual role in cell degeneration or survival depending on different *** general,TNFR1 is believed to trigger apoptosis,while TNFR2 promotes cell *** importance of the neuronal microenvironment has been recently highlighted in gut region-specific diabetic enteric neuropathy,however,the expression and alterations of different TNFRs in the gastrointestinal tract has not been *** To investigate the TNFR1 and TNFR2 expression in myenteric ganglia and their environment in different intestinal segments of diabetic *** Ten weeks after the onset of hyperglycemia,gut segments were taken from the duodenum,ileum and colon of streptozotocin-induced(60 mg/body weight kg i.p.)diabetic(n=17),insulin-treated diabetic(n=15)and sex-and age-matched control(n=15)*** plexus whole-mount preparations were prepared from different gut regions for TNFR1/HuCD or TNFR2/HuCD double-labeling fluorescent ***1 and TNFR2 expression was evaluated by post-embedding immunogold electron microscopy on ultrathin sections of myenteric *** levels were measured by enzyme-linked immunosorbent assay in muscle/myenteric plexus-containing(MUSCLE-MP)tissue homogenates from different gut segments and experimental *** A distinct region-dependent TNFRs expression was detected in *** density of TNFR1-labeling gold particles was lowest,while TNFR2 density was highest in duodenal ganglia and a decreased TNFRs expression from proximal to distal segments was observed in MUSCLE-MP *** diabetics,the TNFR2 density was only significantly altered in the duodenum with decrease in the ganglia(0.32±0.02 vs 0.45±0.04,P<0.05),while no significant changes in TNFR1 density was *** diabetic MUSCLE-MP h

关键词： Tumor necrosis factor alpha receptors Myenteric ganglia Enteric neurons Neuronal environment Diabetes Insulin

Self-rechargeable energizers for sustainability

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eScience 2022年第4期2卷 347-364页

作者： JinKiong Ling ria Kunwar Linlin Li Shengjie Peng Izan Izwan Misnon Mohd Hasbi Ab Rahim Chun-Chen Yang Rajan Jose Center for Advanced Intelligent Materials Universiti Malaysia Pahang26300KuantanPahang Faculty of Industrial Sciences and Technology Universiti Malaysia Pahang26300KuantanPahang College of Material Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing210016 Battery Research Center for Green Energy(BRCGE) Ming Chi University of Technology24301New Taipei City Department of Chemical Engineering Ming Chi University of Technology24301New Taipei City Department of Chemical and Materials Engineering Chang Gung UniversityKwei-shan333Taoyuan

Electrical energy generation and storage have always been complementary to each other but are often disconnected in practical electrical ***,efforts to combine both energy generation and storage into self-powered energizers have demonstrated promising power sources for wearable and implantable *** line with these efforts,achieving self-rechargeability in energy storage from ambient energy is envisioned as a tertiary energy storage(3rd-ES)*** review examines a few of the possible 3rd-ES capable of harvesting ambient energy(photo-,thermo-,piezo-,tribo-,and bio-electrochemical energizers),focusing also on the devices'*** self-rechargeability mechanisms of these devices,which function through modifications of the energizers’constituents,are analyzed,and designs for wearable electronics are also *** challenges for self-rechargeable energizers and avenues for further electrochemical performance enhancement are *** article serves as a one-stop source of information on self-rechargeable energizers,which are anticipated to drive the revolution in 3rd-ES technologies.

关键词： Batteries Supercapacitors Self-powered Textile electronics Yarns

Way back for fructose and liver metabolism:Bench side to molecular insights

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World Journal of Gastroenterology 2012年第45期18卷 6552-6559页

作者： Alba Rebollo Núria Roglans Marta Alegret Juan C Laguna Pharmacology Unit School of PharmacyInstitute of BiomedicineUniversity of Barcelona08028 BarcelonaSpain Biomedical Network Research Centre in Physiopathology of Obesity and Nutrition 08028 BarcelonaSpain

The World Health Organization recommends that the daily intake of added sugars should make up no more than 10% of total *** consumption of sugarsweetened beverages is the main source of added ***,together with glucose,as a component of high fructose corn syrups or as a component of the sucrose molecule,is one of the main sweeteners present in this kind of *** from prospective and intervention studies clearly point to high fructose consumption,mainly in the form of sweetened beverages,as a risk factor for several metabolic diseases in *** incidence of hypertension,nonalcoholic fatty liver disease(NAFLD),dyslipidemia(mainly hypertriglyceridemia),insulin resistance,type 2 diabetes mellitus,obesity,and the cluster of many of these pathologies in the form of metabolic syndrome is higher in human population segments that show high intake of *** and young adults from lowincome families are especially at *** recently reviewed evidence from experimental animals and human data that confirms the deleterious effect of fructose on lipid and glucose *** this present review we update the information generated in the past 2 years about high consumption of fructose-enriched beverages and the occurrence of metabolic disturbances,especially NAFLD,type 2 diabetes mellitus,and metabolic *** have explored recent data from observational and experimental human studies,as well as experimental data from animal and cell ***,using information generated in our laboratory and others,we provide a view of the molecular mechanisms that may be specifically involved in the development of liver lipid and glucose metabolic alterations after fructose consumption in liquid form.

关键词：肝脏脂质糖分子果糖代谢功能 2型糖尿病代谢综合征台式世界卫生组织

Induced pluripotent stem cells for modeling and cell therapy of Parkinson＇s disease

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Neural Regeneration Research 2016年第5期11卷 727-728页

作者： Mária Csobonyeiová Lubos Danisovic Stefan Polák Institute of Histology and Embryology Faculty of Medicine Comenius University in Bratislava Bratislava Slovakia Institute of Medical Biology Genetics and Clinical Genetics Faculty of Medicine Comenius University in Bratislava Bratislava Slovakia

Neurodegenerative disorders include a variety of hereditary or sporadic diseases involving the chronic,progressive loss on neural ***＇s disease（PD）is the second most common neurodegenerative disease,affecting more than 6 million people worldwide（Wan et al.,2015）.Degeneration of nigrostriatal dopamine（DA）neurons is the main pathology in PD.

关键词： INDUCTION IPSCS