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雷珠单抗对新生血管性青光眼患者眼动脉血流动力学、房水血管活性物质和炎性因子表达水平的影响

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四川生理科学杂志 2024年第2期46卷 299-301,390页

作者：袁思佳张相冉王延武郑州市金水区总医院门诊眼科河南郑州450000 濮阳市人民医院眼科河南濮阳457000 郑州大学第二附属医院眼科河南郑州450000

目的:探讨雷珠单抗对新生血管性青光眼(Neovascular glaucoma,NVG)患者眼动脉血流动力学、房水血管活性物质和炎性因子表达水平的影响。方法:选取我院眼科2021年1月至2022年6月期间收治的拟行玻璃体切除术的NVG患者86例作为研究对象,随... 详细信息

目的:探讨雷珠单抗对新生血管性青光眼(Neovascular glaucoma,NVG)患者眼动脉血流动力学、房水血管活性物质和炎性因子表达水平的影响。方法:选取我院眼科2021年1月至2022年6月期间收治的拟行玻璃体切除术的NVG患者86例作为研究对象,随机分为两组(每组43人)。对照组给予玻璃体切除术治疗,观察组在对照组基础上给予玻璃体腔注射雷珠单抗治疗,观察两组患者眼压水平,眼动脉血流动力学情况,房水血管活性物质和炎性因子表达水平以及不良反应发生情况。结果:两组治疗后1 w、治疗后1 m、治疗后3 m眼压均较治疗前降低,且观察组的眼压均较对照组低(Pri)均较治疗前下降,且观察组低于对照组(P<0.05);两组眼收缩期峰值流速(Peak systolic velocity,PSV)、舒张末期流速(End diastolic velocity,EDV)均较治疗前升高,且观察组高于对照组(P<0.05);治疗后两组患者房水内血管内皮生长因子(Vascular endothelial growth factor,VEGF)、白细胞介素-6(Interleukin-6,IL-6)水平均低于治疗前,且观察组较对照组低(P<0.05);两组不良反应发生率对比差异无统计学意义。结论:玻璃体腔注射雷珠单抗用于治疗NVG能够降低眼压,改善眼部动脉血流情况,抑制房水中的VEGF和IL-6表达,不增加不良发应。

关键词：雷珠单抗新生血管性青光眼白细胞介素-6 玻璃体切除术

Experimental investigation on mechanical behaviors of granites after high-temperature exposure

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Journal of Central South University 2022年第4期29卷 1332-1344页

作者： HE Ming YU Li-yuan LIU ri-cheng JIANG Yu-jing LI Zhi-cong wang Xiao-lin State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China School of Engineering Nagasaki UniversityNagasaki 852-8521Japan

To investigate the influence of temperature on the physical,mechanical and acoustic emission characteristics of granites,uniaxial compression test,variable-angle shear test,acoustic emission signal monitoring and the measurement of physical parameters including mass,size and P-wave velocity were carried out on granite samples treated at temperatures T ranging from 25 to 900℃.The results show that the density and P-wave velocity decrease gradually with increasing *** the temperature increases,the peak compressive stress decreases while the peak strain increases,due to the fact that a high temperature induces the escaping of waters within granites,the expanding of mineral grains and the generations of *** the increment of T,both the peak shear stress and the cohesion decrease,whereas the frictional angle *** the compressing and shearing tests,the maximum acoustic emission counts show a decreasing trend when T increases from 25 to 900℃.When T exceeds 573℃,the crystal lattice structure of quartz changes fromα-phase toβ-phase,decreasing the mechanical behavior of granites to a great *** addition,the results also indicate that T=500−600℃ is the critical temperature ramge to characterize the influence of temperature on the physical,mechanical and acoustic emission characteristics of granites.

关键词： high-temperature exposure uniaxial compression variable angle shear acoustic emission scanning electron microscopy

不同剂量麦粒灸对寒湿凝滞型原发性痛经患者子宫动脉血流影响的比较研究

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针刺研究 2024年第7期49卷 760-766页

作者：刘今刘君王雪松李旭欣林杪刘俊亚张细芬高渊博路广通佘延芬河北中医药大学针灸推拿学院石家庄050091 河北省中医针灸优势病症国际联合研究中心石家庄050200

目的:观察不同剂量麦粒灸对寒湿凝滞型原发性痛经(PD)患者子宫动脉血流影响的差异。方法:将60例PD患者随机分3壮组、6壮组和9壮组,每组20例。3组均选取三阴交、地机、血海进行治疗,分别采用3壮、6壮和9壮3种不同剂量的麦粒灸,月经来潮前... 详细信息

目的:观察不同剂量麦粒灸对寒湿凝滞型原发性痛经(PD)患者子宫动脉血流影响的差异。方法:将60例PD患者随机分3壮组、6壮组和9壮组,每组20例。3组均选取三阴交、地机、血海进行治疗,分别采用3壮、6壮和9壮3种不同剂量的麦粒灸,月经来潮前7 d开始治疗3次,共治疗3个月经周期。治疗前后记录患者子宫动脉血流参数指标搏动指数(PI)、阻力指数(ri)、血流比值(S/D);评价治疗前1个月、治疗第1、2、3个月经周期及治疗结束后第1个月经周期的视觉模拟量尺(VAS)评分、Cox痛经症状量表严重程度(CMSS-S)及持续时间(CMSS-T)积分。结果:治疗后9壮组患者的子宫动脉血流PI、ri、S/D值低于本组治疗前及同时点的3壮组和6壮组(P<0.05)。3壮组在第1周期和第2周期VAS评分低于治疗前(P<0.05);6壮组和9壮组各观察时点VAS评分均低于本组治疗前(P<0.05),在治疗第3周期和随访期低于3壮组(P<0.05);9壮组的VAS评分在随访期低于6壮组(P<0.05)。9壮组在治疗第1周期CMSS-T积分较治疗前降低(P<0.05),6壮组、9壮组在治疗第2、3周期及随访期的CMSS-T积分较治疗前降低(P<0.05),6壮组和9壮组的CMSS-T积分在第3周期和随访期低于3壮组(P<0.05),9壮组的CMSS-T积分在随访期低于6壮组(P<0.05);6壮组、9壮组在治疗第2、3周期及随访期CMSS-S积分较治疗前降低(P<0.05),6壮组和9壮组在第3周期和随访期的CMSS-S积分低于3壮组(P<0.05),9壮组的CMSS-S积分在随访期低于6壮组(P<0.05)。结论:麦粒灸治疗原发性痛经具有量效关系,麦粒灸9壮较6壮、3壮在改善PD患者的子宫动脉血流指标和减轻痛经症状等方面更有优势。

关键词：原发性痛经艾灸量寒湿凝滞子宫动脉血流

Influence of cobalt content on microstructure and corrosionperformance of extruded Sn-9Zn solder alloys

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Journal of Central South University 2020年第3期27卷 711-720页

作者： JIANG Shou-li ZHONG Jian-feng LI Jia-yuan wang ri-chu PENG Chao-qun CAI Zhi-yong Nanjing Research Institute of Electronics and Technology Nanjing 210039China School of Materials Science and Engineering Central South UniversityChangsha 410083China Key Laboratory of Electronic Packaging and Advanced Functional Materials Changsha 410083China

The Pb-free solders have attracted a great deal of attention recently due to the environmental *** present work focuses on the effect of cobalt content(0,0.5 and 3.0)on the microstructural characteristics,melting point and corrosion performance of extruded Sn-9Zn solder *** results reveal that the Zn-rich precipitates with spherical or needle-like shape in the Sn-9Zn-xCo alloys are refined remarkably by forming the γ-Co5Zn21 and Co2Sn2Zn Co-contained intermetallic compounds,though the melting point and eutectic reaction temperature decrease *** is suggested that the corrosion property of the extruded Sn-9Zn-xCo alloys is improved significantly by adding the cobalt element,while the content should be controlled *** the corrosion morphology,the influence of cobalt content on the corrosion behavior of the Sn-9Zn-xCo alloys is analyzed in terms of the refined microstructure and the enhanced passive film stability.

关键词： Sn-9Zn solder alloy cobalt addition extrusion microstructure corrosion performance

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改进的两步沉淀法制备高结晶度碱式碳酸铜

当代化工 2024年第5期53卷 1063-1067页

作者：刘博帆孟令臣李浩东段日吴慧玲张思琦袁胜华中石化(大连)石油化工研究院有限公司辽宁大连116045

碱式碳酸铜,化学式为Cu_(2)(OH)_(2)CO_(3),是一种重要的铜盐产品。对两步沉淀法制备碱式碳酸铜的二段反应过程进行了优化调整,结合XRD和SEM等表征手段,对二段反应不同的酸碱液浓度、碱液组分配比、反应温度和老化条件进行了对比实验探... 详细信息

碱式碳酸铜,化学式为Cu_(2)(OH)_(2)CO_(3),是一种重要的铜盐产品。对两步沉淀法制备碱式碳酸铜的二段反应过程进行了优化调整,结合XRD和SEM等表征手段,对二段反应不同的酸碱液浓度、碱液组分配比、反应温度和老化条件进行了对比实验探究,发现在使用较低的酸碱液浓度、碱液中n(Na_(2)CO_(3))∶n(NaOH)=1:2、反应温度选择较低的水浴温度、采取搅拌老化方式的条件下,产品的结晶效果最好。采用改进后的两步沉淀法成功制备出了高结晶度的碱式碳酸铜产品。

关键词：碱式碳酸铜孔雀石两步沉淀法形貌调控反应结晶

Prospective randomized comparison of transumbilical two-port laparoscopic and conventional laparoscopic varicocele ligation

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Asian Journal of Andrology 2017年第1期19卷 34-38页

作者： Guo-Xi Zhang Jan Yang Da-Zhi Long Min Liu Xiao-Feng Zou yuan-Hu yuan ri-Hai Xiao Yi-Jun Xue Xin Zhong Quan-Liang Liu Fo-Lin Liu Bo Jiang Rui-Quan Xu Kun-Lin Xie Department of Urology First Affiliated Hospital of Gannan Medical University Ganzhou 341000 People's Republic of China.

We have established a novel method named transumbilical two-port laparoscopic varicocele ligation （TTLVL） for varicocele, which is still needed to evaluate. In this study, 90 patients with left idiopathic symptomatic varicoceles of grades Ⅱ-Ⅲ according to the Dubin grading system were randomly assigned to TTLVL （n = 45） and conventional laparoscopic varicocele ligation （CLVL）（n = 45）. The demographic, intraoperative, postoperative, and follow-up data were recorded and compared between the two groups. All the procedures in the two groups were completed successfully with no intraoperative complications and no conversions to open surgery. No significant difference was found in the operative time, resuming ambulation, bowel recovery, postoperative hospital stay, and postoperative resolution of scrotal pain between the two groups （P 〉 0.05）. However, the postoperative mean visual analog pain scale scores for TTLVL group were all less at 24 h, 48 h, 72 h, and 7 days postoperatively compared to CLVL （P= 0.001, 0.010, 0.006, and 0.027, respectively）. The mean patient scar assessment questionnaire score in postoperative month 3 was 29.7 for TTLVL group compared with 32.1 for CLVL group （P 〈 0.001）. There was no testicular atrophy observed in both groups during the follow-up period. The study shows that TTLVL is a safe, feasible, and effective minimally invasive surgical alternative to CLVL for the treatment of varicocele. Compared with CLVL, TTLVL may decrease postoperative pain and improve the cosmetic outcomes.

关键词： laparoendoscopic single-site surgery umbilicus varicocelectomy

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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塑性变形演化对螺纹联接松动的影响研究

北京理工大学学报 2015年第9期35卷 924-930页

作者：侯世远廖日东北京理工大学机械与车辆学院北京100081

通过考虑材料的棘轮效应,数值模拟了螺纹联接早期的松动行为,并以此为基础展开了载荷方向、预紧力、侧向载荷幅值、摩擦因数对这一阶段螺纹联接松动的影响规律研究.研究结果显示,首次循环可以使得螺栓张紧力大幅下降;在后续的循环中,螺... 详细信息

通过考虑材料的棘轮效应,数值模拟了螺纹联接早期的松动行为,并以此为基础展开了载荷方向、预紧力、侧向载荷幅值、摩擦因数对这一阶段螺纹联接松动的影响规律研究.研究结果显示,首次循环可以使得螺栓张紧力大幅下降;在后续的循环中,螺纹联接的材料的棘轮效应不可忽视;在所研究的各影响因素中,侧向载荷幅值对本问题的影响最为明显.

关键词：螺纹松动棘轮效应

Crystal Structure of Di[bis(diphenylphosphino)propane]Copper(Ⅰ) Perchlorate Complex

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Chinese Journal of Structural Chemistry 1997年第4期16卷 293-297页

作者： XIE Wen-Gang wang ri-Wei XIONG yuan-Fu(Hunan University of Agriculture, Changsha 410128)YANG Rui-Na wang Dong-Mei JIN Dou-Man(Henan Institute of Chemistry, Zhengzhou 450003)CHEN Liao-Rong LUO Bao-Sheng(Analysis and Testing Centre, Wuhan University, W Hunan University of Agriculture Changsha 410128 China Henan Institute of Chemistry Zhengzhou 450003 China Analysis and Testing Centre Wuhan University Wuhan 430072 China

The complex [Cu (dppp)2] (ClO4) was prepared by the reaction ofcopper (Ⅱ) perchlorate wlth bis(diphenylphosphino) propane (dppp) in methanol, andits crystal structure was determlned by X-ray crystallography. The crystal is monoclin-ic, space group P1, M. = 1019. 90 with cell parameters a = 11. 951 (6), b = 12. 178(4), c=18. 413(5) A, α=70. 52(3), β=83. 56(4), γ=77. 61 (4), V=2465. 2 A3,Z = 2, Dc = 1. 371 g/cm3. The structure was solved by direct methods and refined byblock-diagonal and full-matrix least-squares methods to a final R of 0. 043 for 4085 in-dependent reflections of I>3σ(I). In this complex [Cu (dppp)2] (ClO4), dppp func-tions as a bidentate chelate ligand. The four P atoms from two dppp are coordinated tothe tetrahedral copper (P4).

关键词： copper(Ⅰ) complex crystal structure conductivity