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Current Clinical Research of Acute Kidney Injury in China

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Chinese Medical Journal 2015年第9期128卷 1268-1271页

作者： Bi-Cheng Liu ri-ning tang Zhi-Hong Liu Department of Nephrology Institute of Nephrology Zhongda Hospital Southeast University School of Medicine Nanjing Jiangsu 210009 China Department of Nephrology Institute of Nephrology Jinling Hospital Nanjing University Nanjing Jiangsu 210002 China

INTRODUCTION Acute kidney injury （AKI） is a common clinical syndrome characterized by an abrupt decline of renal function and has been recognized as a major healthcare problem affecting millions of patients *** is strongly associated with increased resource utilization,mortality,and risk for the development of chronic kidney disease （CKD）.[1-3]

关键词： Acute Kidney Injury China Epidemiology

Parathyroid hormone promotes glomerular endothelial-to-mesenchymal transition in experimental secondary hyperparathyroidism

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Parathyroid hormone promotes glomerular endothelial-to-mesen...

中国生理学会肾脏生理专业委员会第二届学术年会

作者：伍敏 ri-ning tang Hong Liu Ming-Ming Pan Min Xu Bi-Cheng Liu Institute of Nephrology Zhongda HospitalSoutheast University

＜正＞Background Secondary hyperparathyroidism（SHPT）is a common complication in patients *** kidney disease,which is considered as a risk factor of progression of ***,the exact mechanism has rarely been *** aim of this study was to investigate the potential role of PTH on endothelial-to-mesenchymal transition（EndMT）in in vivo and in *** Uremia-related SHPT was induced by feeding rats with adenine

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Parathyroid hormone-mediated chondrocyte transition of endothelial cells promotes media calcification in experimental secondary hyperparathyroidism

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Parathyroid hormone-mediated chondrocyte transition of endot...

中国生理学会肾脏生理专业委员会第二届学术年会

作者：伍敏 ri-ning tang Hong Liu Min Gao Ming-Ming Pan Bi-Cheng Liu Institute of Nephrology Zhong Da HospitalSoutheast University Medical School

＜正＞Background Secondary hyperparathyroidism（SHPT）is a common complication of uremia,which is closely associated with development of arterial media calcification（AMC）.Previous studies have shown that heterotopic chondrogenesis contributes to *** this study,we firstly demonstrated that elevation of PTH could induce the transition of endothelial cells

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EVALUATION OF THE ISOLATION AND QUANTIFICATION OF MICRORNA FROM UriNARY EXOSOME FOR BIOMARKER DISCOVERY

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EVALUATION OF THE ISOLATION AND QUANTIFICATION OF MICRORNA F...

中国生理学会肾脏生理专业委员会第二届学术年会

作者：吕林莉 Yuhan Cao Ming Zhen Dan Liu Bi-Cheng Liu Min Xu Hong Liu ri-ning tang Institute of Nephrology Zhong Da HospitalSoutheast University Medical School

＜正＞Objective:Recent studies indicate that microRNA is contained within ***,there are few researches trying to define optimal conditions for urinary exosomal microRNA isolation and detection as a prelude to biomarker discovery *** objective of this study is to validate the methodologies for the isolation and quantification of exosomal microRNA

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Preparation of Modified Composite Nanofiltration Membrane Synergistically Using Carboxylic Multi- walled Carbon Nanotube and β-cyclodextrin

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 232-239页

作者： LIU Peng MAO Junpeng FANG Yanfeng YU Yunwu CHEN Changxiu tang ning WAN Ye GU Yaxin LIU Yunxue WANG Lihua School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China

A new modified blend ultrafiltration(UF)membrane with good hydrophilicity,high porosity and excellent anti-fouling performance was developed by using carboxylic multi-walled carbon nanotube(CMWCNT)as casting solution ***,a composite nanofiltration(NF)membrane with large water flux and good retention rate was fabricated by using the PVDF/CMWCNT blend UF membrane as the substrate,and polyvinyl alcohol(PVA),β-cyclodextrin(β-CD)and polyethylenimine(PEI)as the coating *** results show that with the appropriate addition of CMWCNT in the casting solution,the surface roughness,porosity and recovery rate of the PVDF/CMWCNT blend UF membrane is obviously *** water flux of blend UF membrane is significantly improved when the CMWCNT content increases from 0 wt%to 0.2 wt%.The water flux of blend UF membrane with 0.2 wt%CMWCNT is 162.7 L/(m^(2)·h),which is 44.3%higher than that of the pure PVDF ***β-CD content is 0.8 wt%,the retention rate of Congo red by PVDF/CMWCNT/β-CD composite NF membrane reaches 98.7%,which is 28.3%higher than that of single PVA/PEI modified *** research will provide a new idea and simple method for developing novel high-performance composite NF membranes.

关键词： CMWCNT cyclodextrin nanofiltration membrane

INHIBITION OF MITOCHONDriAL DYSFUNCTION IS THE MECHANISM OF PIRFENIDONE ANTI-TUBULOINTESTITIAL FIBROSIS-AN IN VIVO AND IN VITRO STUDY

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INHIBITION OF MITOCHONDRIAL DYSFUNCTION IS THE MECHANISM OF ...

中国生理学会肾脏生理专业委员会第二届学术年会

作者：陈峻峰 Hong Liu Hai-Feng Ni Lin-Li Lv Ming-Hui Zhang ri-ning tang Jian-Dong Zhang Kun-Ling Ma Ping-Sheng Chen Bi-Cheng Liua Institute of Nephrology Zhong Da HospitalSoutheast University School of Medicine

＜正＞Baekgroud:Dysfunctional mitochondria participate in the progression of chronic kidney disease（CKD）.Pirfenidone is a newly identified anti-fibrotic drug,but its mechanism remains *** dysfunction is an early event that occurs prior to the onset of renal *** this study,we investigated the protective effect of pirfenidone on mitochondria and

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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li Xu Huiming Xu Changyong tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

Industrial Control Anomaly Detection Based on Distributed Linear Deep Learning

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Computers, Materials & Continua 2025年第1期82卷 1129-1150页

作者： Shijie tang Yong Ding Huiyong Wang School of Computer Science and Information Security Guilin University of Electronic TechnologyGuilin541004China School of Electronic Engineering and Automation Guilin University of Electronic TechnologyGuilin541004China Guangxi Engineering Research Center of Industrial Internet Security and Blockchain Guilin University of Electronic TechnologyGuilin541004China Institute of Cyberspace Technology HKCT Institute for Higher EducationHong Kong999077China School of Mathematics&Computing Science Guilin University of Electronic TechnologyGuilin541004China

As more and more devices in Cyber-Physical Systems(CPS)are connected to the Internet,physical components such as programmable logic controller(PLC),sensors,and actuators are facing greater risks of network attacks,and fast and accurate attack detection techniques are *** key problem in distinguishing between normal and abnormal sequences is to model sequential changes in a large and diverse field of time *** address this issue,we propose an anomaly detection method based on distributed deep *** method uses a bilateral filtering algorithm for sequential sequences to remove noise in the time series,which can maintain the edge of discrete *** use a distributed linear deep learning model to establish a sequential prediction model and adjust the threshold for anomaly detection based on the prediction error of the validation *** method can not only detect abnormal attacks but also locate the sensors that cause *** conducted experiments on the Secure Water Treatment(SWAT)and Water Distribution(WADI)public *** experimental results show that our method is superior to the baseline method in identifying the types of attacks and detecting efficiency.

关键词： Anomaly detection CPS deep learning MLP(multi-layer perceptron)

Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug