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Neurological adaptations to hypoxia in Tibetan antelope (Pantholops hodgsonii) with a view of molecular biology of respiratory globin-neuroglobin

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中国应用生理学杂志 2012年第6期28卷 555-560页

作者： Zhen-zhong BAI Ying-zhong YANG Guo-en JIN Lan MA ri-li ge The Research Center for High Altitude Medicine Medical SchoolQinghai University

Neuroglobin(Ngb) is a respiratory protein that is preferentially expressed in brain of mouse and *** this article,Tibetan antelope,living at altitude of 3 000～5 000 m for millions of years,was selected as the model of hypoxia-tolerant adaptation *** reverse transcription polymerase chain reaction(RT-PCR) and Western blot techniques,expression of Ngb gene was amplified and analyzed in antelope brain *** results showed that Ngb homology protein in Tibetan antelope was identified with more sequence similarity with cattle(96%),sheep(95%),and human(95%).We detected that there were some mutations occurred in the Open Reading Frame of Ngb in Tibetan antelope compared with *** analysis of Ngb chain showed that it was closer to cattle than the *** study suggests possible roles of central nervous system enriched Ngb in adaptation of Tibetan antelope to extremely high altitude.

关键词：中枢神经系统藏羚羊脑红蛋白呼吸系统球蛋白分子生物学逆转录聚合酶链反应缺氧

Laparoscopic-assisted vs open transhiatal gastrectomy for Siewert type Ⅱ adenocarcinoma of the esophagogastric junction: A retrospective cohort study

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World Journal of Gastrointestinal Surgery 2022年第4期14卷 304-314页

作者： Qi-Ying Song Xiong-Guang li li-Yu Zhang Di Wu Shuo li Ben-Long Zhang Zi-Yao Xu ri-li-ge Wu Xin Guo Xin-Xin Wang Medical School of Chinese People’s liberation Army Chinese People’s Liberation Army General HospitalBeijing 100853China School of Medicine Nankai UniversityTianjin 300071China Medical Big Data Research Center Chinese PLA General HospitalBeijing 100853China Air Force Medical University Xijing Hospital Xi’an 710000Shaanxi ProvinceChina Department of general Surgery Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND The studies of laparoscopic-assisted transhiatal gastrectomy(LTG) in patients with Siewert type Ⅱ adenocarcinoma of the esophagogastric junction(AEG) are *** To compare the surgical efficiency of LTG with the open transhiatal gastrectomy(OTG) for patients with Siewert type Ⅱ *** We retrospectively evaluated a total of 578 patients with Siewert type Ⅱ AEG who have undergone LTG or OTG at the First Medical Center of the Chinese People’s liberation Army general Hospital from January 2014 to December 2019. The short-term and long-term outcomes were compared between the LTG(n = 382) and OTG(n = 196) *** Compared with the OTG group, the LTG group had a longer operative time but less blood loss, shorter length of abdominal incision and an increased number of harvested lymph nodes(P liquid food, ambulate, expel flatus and discharge sooner than the OTG group(P lications and R0 resection. The 3-year overall survival and disease-free survival performed better in the LTG group compared with that in the OTG group(88.2% vs 79.2%, P = 0.011;79.7% vs 73.0%, P = 0.002, respectively). In the stratified analysis, both overall survival and disease-free survival were better in the LTG group than those in the OTG group for stage Ⅱ/Ⅲ patients(P ge I *** For patients with Siewert type Ⅱ AEG, LTG is associated with better short-term outcomes and similar oncology safety. In addition, patients with advanced stage AEG may benefit more from LTG in the long-term outcomes.

关键词： Adenocarcinoma of the esophagogastric junction Siewert type II Laparoscopic-assisted transhiatal gastrectomy Open transhiatal gastrectomy

MULTIRATE TIME ITERATIVE SCHEME WITH MULTIPHYSICS FINITE ELEMENT METHOD FOR A NONliNEAR POROELASTICITY

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Journal of Computational Mathematics 2024年第2期42卷 597-616页

作者： Zhihao ge Hairun li Tingting li School of Mathematics and Statistics Henan UniversityKaifengHenan 475004China

In this paper,a multirate time iterative scheme with multiphysics finite element method is proposed and analyzed for the nonlinear poroelasticity *** original problem is reformulated into a generalized nonlinear Stokes problem coupled with a diffusion problem of a pseudo pressure field by a new multiphysics approach.A multiphysics finite element method is adopted for the spatial discretization,and the generalized nonlinear Stokes problem is solved in a coarse time step and the diffusion problem is solved in a finer time *** proposed algorithm is a decoupled algorithm,which is easily implemented in computation and reduces greatly computation *** stability analysis and the convergence analysis for the multirate iterative scheme with multiphysics finite element method are *** numerical tests are shown to demonstrate and validate the analysis results.

关键词： Nonlinear poroelasticity model Multiphysics finite element method Multirate iterative scheme

Flocking Effects of the Stochastic Cucker-Smale System with Noise

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Journal of Systems Science & Complexity 2024年第5期37卷 1978-1994页

作者： HAN Ning ge Bin li lin School of Mathematical Sciences Harbin Engineering University

In this paper, the flocking behavior of a Cucker-Smale model with a leader and noise is studied in a finite time. The authors present a Cucker-Smale system with two nonlinear controls for a complex network with stochastic synchronization in probability. Based on the finite-time stability theory of stochastic differential equations, the sufficient conditions for the flocking of stochastic systems in a finite time are obtained by using the Lyapunov function method. Finally, the numerical simulation of the particle system is carried out for the leader and noise, and the correctness of the results is verified.

关键词： Cucker-Smale model flocking behavior leader noise

STABLE RECOVERY OF SPARSELY CORRUPTED SIGNALS THROUGH JUSTICE PURSUIT DE-NOISING

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Journal of Computational Mathematics 2024年第1期42卷 271-288页

作者： Ningning li Wengu Chen Huanmin ge Institute of Applied Physics and Computational Mathematics Beijing 100088China Beijing Sport University Beijing 100084China

This paper considers a corrupted compressed sensing problem and is devoted to recover signals that are approximately sparse in some general dictionary but corrupted by a combination of interference having a sparse representation in a second general dictionary and measurement *** provide new restricted isometry property(riP)analysis to achieve stable recovery of sparsely corrupted signals through Justice Pursuit De-Noising(JPDN)with an additional *** main tool is to adapt a crucial sparse decomposition technique to the analysis of the Justice Pursuit *** proposed riP condition improves the existing representative *** simulations are provided to verify the reliability of the JPDN model.

关键词： Justice Pursuit De-Noising Restricted isometry property Corrupted compressed sensing Signal recovery

A Mitochondrial genome Sequence of the Tibetan Antelope(Pantholops hodgsonii)

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genomics, Proteomics & Bioinformatics 2005年第1期3卷 5-17页

作者： Shu-Qing Xu Ying-Zhong Yang Jun Zhou Guo-En Jing Yun-Tian Chen Jun Wang Huan-Ming Yang Jian Wang Jun Wu Xiao-Guang Zheng and ri-li ge Beijing genomics Institute Chinese Academy of Sciences Beijing 101300 China Research Center forHigh Altitude Medicine Qinghai University Xining 810016 China Kunming Institute of Zoology ChineseAcademy of Sciences Kunming 650223 China Graduate School Chinese Academy of Sciences Beijing100049 China.

To investigate genetic mechanisms of high altitude adaptations of native mammals on the Tibetan Plateau, we compared mitochondrial sequences of the endangered Pantholops hodgsonii with its lowland distant relatives Ovis ames and Capra hircus, as well as other mammals. The complete mitochondrial genome of P. hodgsonii （16,498 bp） revealed a similar gene order as of other mammals. Because of tandem duplications, the control region of P. hodgsonii mitochondrial genome is shorter than those of O. ames and C. hircus, but longer than those of Bos species. Phylogenetic analysis based on alignments of the entire cytochrome b genes suggested that P. hodgsonii is more closely related to O. ames and C. hircus, rather than to species of the Antilopinae subfamily. The estimated divergence time between P. hodgsonii and O. ames is about 2.25 million years ago. Eutther analysis on natural selection indicated that the COXI （cytochrome c oxidase subunit I） gene was under positive selection in P. hodgsonii and Bos grunniens. Considering the same climates and environments shared by these two mammalian species, we proposed that the mitochondrial COXI gene is probably relevant for these native mammals to adapt the high altitude environment unique to the Tibetan Plateau.

关键词： tibetan antelope mitochondrial genome adaptation COXI

Flow Field Simulation and Parameter Analysis of Hydraulic Unbalanced Bionic Self-recovery Actuator for Rotary Equipment

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Journal of Bionic Engineering 2024年第1期21卷 325-343页

作者： Wei li Xin Pan Dehong ge Jinji Gao Key Laboratory of Engine Health Monitoring-Control and Networking of Ministry of Education Beijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of High-End Mechanical Equipment Health Monitoring and Self-Recovery Beijing University of Chemical TechnologyBeijing 100029China

The rotor is the most important component of rotating machinery,and the vibration produced by its mass unbalance has a serious influence on the secure and steady operation of the machine,so an effective online suppression technology is urgently needed.A new hydraulic unbalanced bionic self-recovery system is introduced,imitating the way of manually repairing faulty *** accomplish the effect of actuator mass redistribution,the technology employs pressurized air to drive the quantitative transfer of liquid in the reservoir cavity at opposite *** can complete the online adjustment of the equipment's balancing state and suppress the unbalanced vibration of equipment in real time,which gives the equipment the ability to maintain an autonomous health state and improve equipment *** composition and working principle of the system are introduced in detail,and the key performance parameters,such as the minimum running speed and the balancing liquid transfer speed,are analyzed *** fluid-solid coupling model of the actuator was established,and the two-phase flow from inside the hydraulic unbalanced bionic self-recovery actuator was simulated under multiple working conditions and the performance parameters were quantitatively analyzed.A balancing simulation test bed was built,and its effectiveness was verified by performance parameter tests and unbalanced bionic self-recovery *** experimental results show that the mass distribution adjustment of the balancing disk can be achieved using different viscosity balancing liquid,and the response of liquid viscosity 10 cSt is faster than that of liquid viscosity 100 cSt in the process of balancing liquid transfer,and the time is reduced by more than 75%;the system can reduce the simulated rotor amplitude from 18.3μm to 10.6μm online in real time,which provides technical support for the subsequent development of a new generation of bionic intelligent equipment.

关键词： Engineering self-recovery-Bionics Simulation analysis Self-recovery regulation

Molecular packing tuning via chlorinated end group enables efficient binary organic solar cells over 18.5%

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Carbon Energy 2024年第3期6卷 196-203页

作者： Yafeng li Zhenyu Chen Xingzheng Yan Ziyi ge Zhejiang Business Technology Institute NingboZhejiangChina Zhejiang Engineering Research Center for Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboZhejiangChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina

Designing novel nonfullerene acceptors(NFAs)is of vital importance for the development of organic solar cells(OSC).Modification on the side chain and end group are two powerful tools to construct efficient ***,based on the high-performance L8BO,we selected 3-ethylheptyl to substitute the inner chain of 2-ethylhexyl,obtaining the backbone of *** we introduced different halogen atoms of fluorine and chlorine on 2-(3-oxo-2,3-dihydro-1Hinden-1-ylidene)malononitrile end group(EG)to construct efficient NFAs named BON3-F and BON3-Cl,*** donor D18 was chosen to combine with two novel NFAs to construct OSC ***,D18:BON3-Cl-based device shows a remarkable power conversion efficiency(PCE)of 18.57%,with a high open-circuit voltage(V_(OC))of 0.907 V and an excellent fill factor(FF)of 80.44%,which is one of the highest binary PCE of devices based on D18 as the ***,BON3-F-based device shows a relatively lower PCE of 17.79%with a decreased FF of 79.05%.The better photovoltaic performance is mainly attributed to the red-shifted absorption,higher electron and hole mobilities,reduced charge recombination,and enhanced molecular packing in the D18:BON3-Cl ***,we performed stability tests on two binary systems;the D18:BON3-Cl and D18:BON3-F devices maintain 88.1%and 85.5%of their initial efficiencies after 169 h of storage at 85°C in an N2-filled glove box,*** work demonstrates the importance of selecting halogen atoms on EG and provides an efficient binary system of D18:BON3-Cl for further improvement of PCE.

关键词： binary organic solar cell chlorinated end group molecular packing

Modulated noble metal/2D MOF heterostructures for improved hydrogen storage of MgH_(2)

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Rare Metals 2024年第4期43卷 1672-1685页

作者： Zeng-Yi li li-Xian Sun Fen Xu Yu-Mei Luo Yong-Peng Xia Sheng Wei Chen-Chen Zhang ri-Guang Cheng Chao-Feng Ye Meng-Yuan liu Ju-Lan Zeng Zhong Cao Hong-ge Pan School of Material Science and Engineering Guilin University of Electronic TechnologyGuilin541004China School of Chemistry and Chemical Engineering Changsha University of Science and TechnologyChangsha410114China Institute of Science and Technology for New Energy Xi’an Technological UniversityXi’an710021China

The conjugation of external species with twodimensional(2D)materials has broad application *** this study,we have explored the potential of noble metal/2D MOF heterostructures in hydrogen ***,the MgH_(2)-Ni-MOF@Pd system has shown remarkable hydrogen desorption/sorption performances,starting to liberate hydrogen at 1810C,which is 2300C lower than that of pristine *** the catalytic effect of Ni-MOF@Pd,the dehydrogenation apparent activation energy of MgH2 is noticeably decreased from(133.5±17.5)to(34.58±1.87)kJ·moL^(-1),and the hydrogenation apparent activation energy is reduced from(70.41±7.43)to(25.78±4.64)kJ·moL^(-1),which is lowered by 63.4%.The fully-dehydrogenated MgH2-NiMOF@Pd composite rapidly uptakes hydrogen,with 2.62wt%at 100℃and 6.06 wt%at 150℃within 300 s,*** mechanism analysis of MgH2 catalyzed by Ni-MOF@Pd has revealed that the transformation of Mg_2Ni and Mg_2NiH_4 could act as a"hydrogen pump",providing numerous channels for fast diffusion and transport of hydrogen ***,in the dehydrogenation process,the element Pd reacts with MgH_(2)to form the MgPd alloy phase,which makes MgH_(2)take precedence to decompose through the Mg-Pd alloy rather than self-decomposition,further reducing thermal stability and improving de/hydrogenation *** synergistic effect of Mg-Pd,Mg_2Ni,and the special ultra-thin 2D sheet structure of the additive is the main reason for the good hydrogen storage property of MgH_(2)-Ni-MOF@*** findings provide inspiration for designing efficient multifunctional additives with unique morphologies to optimize the hydrogen desorption/sorption behaviors of hydrogen storage materials.

关键词： Hydrogen storage Magnesium hydride 2D metal-organic framework nanosheets Ni/Pd Synergistic catalysis