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Liver Stiffness Measurement can Predict Liver Inflammation in Chronic Hepatitis B Patients with Normal Alanine Transaminase

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Journal of Clinical and Translational Hepatology 2023年第4期11卷 817-826页

作者： Ling-Ling Huang Xue-Ping Yu Qing-Fa Ruan Yan-Xue Lin Huan Li Wen Jin Rui-Feng Liu Yan-Lan Liang Yu-Rui Liu Yue-Yong Zhu Jia-Ji Jiang ri-cheng mao Da-Wu Zeng Department of Hepatology Hepatology Research InstituteThe First Affiliated hospitalFujian Medical UniversityFuzhouFujianChina Department of Infectious Diseases The First Hospital of Quanzhou Affiliated to Fujian Medical UniversityQuanzhouFujianChina Hepatology Center Xiamen Hospital of Traditional Chinese MedicineXiamenFujianChina Department of Infectious Diseases Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency ResponseNational Medical Center for Infectious DiseasesHuashan HospitalFudan UniversityShanghaiChina Hepatology Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouFujianChina Hepatology Fujian Medical University Xiamen Humanity HospitalXiamenFujianChina

Background and Aims:To determine whether liver stiffness measurement(LSM)indicates liver inflammation in chronic hepatitis B(CHB)with different upper limits of normal(ULNs)for alanine aminotransferase(ALT).Methods:We grouped 439 CHB patients using different ULNs for ALT:cohort I,≤40 U/L(439 subjects);cohort II,≤35/25 U/L(males/females;330 subjects);and cohort III,≤30/19 U/L(males/females;231 subjects).Furthermore,84 and 96 CHB patients with normal ALT(≤40 U/L)formed the external and prospective validation groups,respectively We evaluated the correlation between LSM and biopsy-confirmed liver inflammation,and determined diagnostic accuracy using area under the curve(AUC).A noninvasive LSM-based model was developed using multivariate logistic ***:Fibrosis-adjusted LSM values significantly increased with increasing *** AUCs of LSM in cohorts I,II,and III were 0.799,0.796,and 0.814,respectively,for significant inflammation(A≥2)and 0.779,0.767,and 0.770,respectively,for severe inflammation(A=3).Cutoff LSM values in all cohorts for A≥2and A=3 were 6.3 and 7.5 kPa,***,external,and prospective validations showed high diagnostic accuracy of LSM for A≥2 and A=3,and no significant differences in AUCs among the four *** and globulin independently predicted A≥*** AUC of an LSM-globulin model for A≥2 exceeded those of globulin,ALT,and AST,but was similar to that of ***:LSM predicted liver inflammation and guided the indication of antiviral therapy for CHB in patients with normal ALT.

关键词： Hepatitis B virus Liver inflammation Fibrosis Liver stiffness measurement Alanine aminotransferase

Advantages of a Novel Model for Predicting Hepatic Fibrosis in Chronic Hepatitis B Virus Carriers Compared with APri and FIB-4 Scores

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Journal of Clinical and Translational Hepatology 2022年第3期10卷 412-419页

作者： Na-Ling Kang Qing-Fa Ruan De-Sheng Zhang Xue-Ping Yu Zhen-Ting Hu Zhi-Min Lin Lu-Ying Wu Meng-Xin Lin Zu-Xiong Huang Jia-Ji Jiang Yu-Rui Liu ri-cheng mao Da-Wu Zeng Department of Hepatology Hepatology Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Hepatology Center Xiamen Hospital of Traditional Chinese MedicineXiamenFujianChina Department of Pharmacy the First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Department of Infectious Diseases Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency ResponseNational Medical Center for Infectious DiseasesHuashan HospitalFudan UniversityShanghaiChina Department of Infectious Diseases The First Hospital of Quanzhou Affiliated to Fujian Medical UniversityQuanzhouFujianChina Department of Infectious Disease The Affiliated Hospital of Putian CollegePutianFujianChina Department of Gastroenterology The Second Affiliated Hospital of Xiamen Medical CollegeXiamenFujianChina Hepatology Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhouFujianChina

Background and Aims:Aspartate aminotransferase-toplatelet ratio index(APri)and fibrosis-4 index(FIB-4)are widely used to assess liver fibrosis in chronic hepatitis B virus(HBV)***,the definition of normal alanine aminotransferase(ALT)is *** aimed to examine the diagnostic value of APri and FIB-4 in chronic HBV carriers with different upper limits of normal(ULNs)for ***:581 chronic HBV carriers were divided into the following four groups based on different ULNs for ALT:chronic HBV carriers I,II,III,and ***,106 chronic HBV carriers formed an external validation *** values of APri and FIB-4 were elucidated using the area under the curve(AUC).A liver fibrosis-predictive model-GPSA(named for its measure of gamma glutamyl transpeptidase,platelet count,HBsAg and albumin)was developed using multivariate logistic regression ***:In chronic HBV carriers I,the AUCs of APri and FIB-4 were 0.680 and 0.609 for significant fibrosis and 0.678 and 0.661 for cirrhosis,*** AUCs of GPSA for significant fibrosis in the training group,internal group,and external validation group were 0.877,0.837,and 0.871,*** diagnostic value of GPSA differed among chronic HBV carriers I,II,III,and IV,with AUCs for significant fibrosis being 0.857,0.853,0.868,and 0.905 and AUCs for cirrhosis being 0.901,0.905,0.886,and 0.913,*** showed a higher diagnostic value than APri and FIB-4 for predicting significant fibrosis in the four ***:The GPSA model allows for accurate diagnosis of liver fibrosis in chronic HBV carriers with different ULN for ALT.

关键词： APri FIB-4 Liver fibrosis Chronic HBV carriers HBV

Design strategy and relevant flow mechanisms of highly loaded 3D compressor tandem cascades

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Chinese Journal of Aeronautics 2024年第7期37卷 220-235页

作者： Xiaochen mao Yunyu WANG Zhihua DING Hao cheng Bo LIU School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China The National Key Laboratory of Science and Technology on Aerodynamic Design and Research Xi’an 710129China Xi’an Thermal Power Research Institute Co.Ltd Xi’an 710072China

To investigate the design strategy of highly loaded tandem cascades at both the midspan and endwall,the overall performance and flow mechanisms of four typical tandem cascades based on the optimization were analyzed from multiple perspectives *** results show that the interference effects on the Front Blade(FB)and Rear Blade(RB)should not be overlooked during the design phase,and the design strategies at the midspan and endwall are completely *** the midspan,the optimization aims to increase the interference effects and the strength of the gap jet while maintaining the same load on the FB and ***,the endwall optimal airfoil exhibits weakening interference effects,advancement of the gap jet location,and load transfer from the FB to *** further analysis of flow characteristics,the midspan optimal airfoil is beneficial for inhibiting the low-energy fluid from interacting with the suction surface of RB under the design condition,but results in earlier occurrence of corner *** endwall optimal airfoil helps suppress the development of the secondary flow and delay the onset of corner ***,by combining the benefits of these two design approaches,additional forward sweep effects are achieved,further enhancing the performance of the tandem cascade.

关键词： Tandem cascade Interference effect Vortex structure Load split Compressor

Shape optimisation of basin insulator for DC gas insulated switchgear/gas insulated transmission lines based on artificial bee colony algorithm

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High Voltage 2024年第2期9卷 275-286页

作者： Yi Luo Shiyi mao Ju Tang Zijun Pan cheng Pan State Key Laboratory of Power Grid Environmental Protection School of Electrical Engineering and AutomationWuhan UniversityWuhanChina

The surface charge accumulation on the basin insulator is a particular problem in high-voltage direct current(HVDC)gas insulated switchgears(GIS)and gas insulated trans-mission lines(GIL),which restricts the development and application of extra/ultra high-voltage(EHV/UHV)*** surface charge distribution and anti-flashover performance are closely related to the insulator *** obtain the optimal basin insulator,a shape optimisation model based on artificial bee colony algorithm was established,and the minimisation objective functions based on capacitive(initial)electric field distribution and resistive(steady-state)electric field distribution were respectively *** optimisation results of the two objective functions were calculated,and the electric field and charge distribution on the surface of the insulator before and after optimisation were evaluated and compared using the simulation *** results indicated that the optimisation based on the capacitive electric field can significantly inhibit the surface charge accumulation,and the optimised insulator can significantly reduce the surface normal electric field and make the distribution of the tangential electric field more uniform,and the maximum tangential electric field can be reduced by 10%;the optimisation based on resistive electric field can achieve similar results,but requires more computational *** on the results,the‘anti-charge’basin insulator structure suitable for the DC field was given.

关键词： insulator artificial charge

One-year observation of the mixing states of oxygenated organics-containing single particles in Guangzhou,China

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 155-169页

作者： Liyuan mao Suxia Yang Xiaoya cheng Sulin Liu Duanying Chen Zhen Zhou Mei Li chenglei Pei Chunlei cheng Institute of Mass Spectrometry and Atmospheric Environment Guangdong Provincial Engineering Research Center for the On-line Source Apportionment System of Air PollutionJinan UniversityGuangzhou510632China Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality Guangzhou510632China Guangzhou Research Institute of Environment Protection Co. Ltd.Guangzhou510620China Guangzhou Ecological and Environmental Monitoring Center of Guangdong Province Guangzhou510030China State Key Laboratory of Marine Resource Utilization in South China Sea Hainan UniversityHaikou570228China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy SciencesXi’an710061China

Oxygenated organic molecules(OOMs)play an important role in the formation of secondary organic aerosols(SOAs),but the mixing states of OOMs are still *** study investigates the mixing states of OOM-containing single particles from the measurements taken using a single particle aerosol mass spectrometer in Guangzhou,China in ***,the particle counts of OOM particles and the mass concentration of secondary organic carbon(SOC)exhibited similar temporal trends throughout the entire *** OOM particles were consistently enriched in secondary ions,including ^(16)O^(−),^(26)CN^(−),^(46)NO_(2)^(−),^(62)NO_(3)^(−),and ^(97)HSO_(4)^(−).In contrast,the number fractions and diurnal patterns of OOM particles among the total detected particles showed similar distributions in August and October;however,the SOC ratios in fine particulate matter were quite different,suggesting that there were different mixing states of single-particle oxygenated *** addition,further classification results indicated that the OOM particles were more aged in October than August,even though the SOC ratios were higher in ***,the distribution of hydrocarbon fragments exhibited a notable decrease from January to October,emphasizing the more aged state of the organics in *** addition,the sharp increase in elemental carbon(EC)-OOM particles in the afternoon in October suggests the potential role of EC in the aging process of ***,in contrast to the bulk analysis of SOC mass concentration,the mixing states of the OOM particles provide insights into the formation process of SOAs in field studies.

关键词： Oxygenated organics Single particles Mixing state Secondary formation Photochemistry

Graphene as adsorbent for highly efficient extraction of modified nucleosides in urine prior to liquid chromatography-tandem mass spectrometry analysis

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Chinese Chemical Letters 2024年第4期35卷 490-495页

作者： cheng Guo Xiaoxiao Zhang Xiujuan Hong Yiqiu Hu Lingna mao Kezhi Jiang Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310058China Key Laboratory of Organosilicon Chemistry and Material Technology College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China Department of General Practice The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

RNA modifications have been involved in numerous biological processes, and aberrations of these modifications are tightly associated with various diseases including cancer. Herein, we developed graphenebased solid-phase extraction and robust ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) combined with stable isotope-dilution for simultaneous enrichment and accurate determination of 17 modified nucleosides in human urine. We found graphene could effectively adsorb various modified nucleosides in human urine samples. With this method, we identified and quantified these modified nucleosides in urine samples collected from lung cancer patients and healthy *** revealed that the levels of 12 modified nucleosides were all diminished in urine from lung cancer patients, compared with healthy controls. It is worth noting that we demonstrated, for the first time, the presence of 5,2-O-dimethyluridine(m~5U_m) in human urine. Together, we established a robust analytical method for simultaneous determinations of 17 modified nucleosides in human urine, and our results revealed a close correlation between the concentrations of urinary modified nucleosides and the occurrence of lung cancer, implying the potential applications of these modified nucleosides as noninvasive biomarkers for the early detection of lung cancer. Moreover, this study will stimulate future investigations on the regulatory roles of RNA modifications in the initiation and progression of lung cancer.

关键词： Mass spectrometry RNA modification Modified nucleosides Graphene Biomarker Urine

Enhancing safety and efficiency in automated container terminals: Route planning for hazardous material AGV using LSTM neural network and Deep Q-Network

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Journal of Intelligent and Connected Vehicles

Journal of Intelligent and Connected Vehicles 2024年第1期7卷 64-77页

作者： Fei Li Junchi cheng Zhiqi mao Yuhao Wang Pingfa Feng Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Information Science and Technology College Dalian Maritime UniversityDalian 116000China School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China

As the proliferation and development of automated container terminal continue,the issues of efficiency and safety become increasingly *** container yard is one of the most crucial cargo distribution centers in a *** Guided Vehicles(AGVs)that carry materials of varying hazard levels through these yards without compromising on the safe transportation of hazardous materials,while also maximizing efficiency,is a complex *** research introduces an algorithm that integrates Long Short-Term Memory(LSTM)neural network with reinforcement learning techniques,specifically Deep Q-Network(DQN),for routing an AGV carrying hazardous materials within a container *** objective is to ensure that the AGV carrying hazardous materials efficiently reaches its destination while effectively avoiding AGVs carrying non-hazardous *** real data from the Meishan Port in Ningbo,Zhejiang,China,the actual yard is first abstracted into an undirected *** LSTM neural network can efficiently conveys and represents information in long time sequences and do not causes useful information before long time to be ignored,a two-layer LSTM neural network with 64 neurons per layer was constructed for predicting the motion trajectory of AGVs carrying non-hazardous materials,which are incorporated into the map as background ***,DQN is employed to plan the route for an AGV transporting hazardous materials,aiming to reach its destination swiftly while avoiding encounters with other *** tests have shown that the route planning algorithm proposed in this study improves the level of avoidance of hazardous material AGV in relation to non-hazardous material *** to the method where hazardous material AGV follow the shortest path to their destination,the avoidance efficiency was enhanced by 3.11%.This improvement demonstrates potential strategies for balancing efficiency and safety in automated ***,

关键词： container yard route planning hazardous material Automated Guided Vehicle(AGV) Long Short-Term

Influences of shale microstructure on mechanical properties and bedding fractures distribution

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Petroleum Science 2024年第3期21卷 1944-1954页

作者： Ming-Zhe Gu mao Sheng Shi-Zhong cheng Fan-Hao Gong Gen-Sheng Li State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum-BeijingBeijing2249China College of Petroleum Engineering China University of Petroleum-BeijingBeijing102249China Shenyang Center of China Geological Survey ShenyangLiaoning110034China

The difference in microstructure leads to the diversity of shale mechanical properties and bedding fractures distribution *** this paper,the microstructure and mechanical properties of Longmaxi marine shale and Qingshankou continental shale were studied by X-ray diffractometer(XRD),field emission scanning electron microscope(FE-SEM)with mineral analysis system,and ***,the typical bedding layers area was properly stratified using Focused Ion Beam(FIB),and the effects of microstructure and mechanical properties on the distribution patterns of bedding fractures were *** results show that the Longmaxi marine shale sample contains more clay mineral grains,while the Qingshankou continental shale sample contains more hard brittle mineral grains such as *** Longmaxi marine shale sample,hard brittle minerals with grain sizes larger than 20μm is18.24%and those with grain sizes smaller than 20μm is 16.22%.For Qingshankou continental shale sample,hard brittle minerals with grain sizes larger than 20μm is 40.7%and those with grain sizes smaller than 20μm is 11.82%.In comparison to the Qingshankou continental shale sample,the Longmaxi marine shale sample has a lower modulus,hardness,and *** shales are formed by alternating coarse-grained and fine-grained layers during *** average single-layer thickness of Longmaxi marine shale sample is greater than Qingshankou continental shale *** two types of shale have similar bedding fractures distribution patterns and fractures tend to occur in the transition zone from coarse-grained to fine-grained *** orientation of the fracture is usually parallel to the bedding plane and detour occurs in the presence of hard brittle *** fracture distribution density of the Longmaxi marine shale sample is lower than that of the Qingshankou continental shale sample due to the strong heterogeneity of the Qingshankou continental *** current resea

关键词： Shale Nanoindentation Microstructure Mechanical property Fracture

Exonuclease Ⅰ and Ⅲ improve the detection efficacy of hepatitis B virus covalently closed circular DNA

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Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 458-463页

作者： Pei-Xue Jiang ri-cheng mao Min-Hui Dong Xue-Ping Yu Qi Xun Jin-Yu Wang Li Jing Deng Qiang Ji-Ming Zhang Department of Infectious Diseases Huashan HospitalFudan UniversityShanghaiChina Department of Pathobiology and Key Laboratory of Medical Molecular Virology School of Basic Medical SciencesFudan UniversityShanghaiChina

Background: Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is an important biomarker of hepatitis B virus infection. However, the current methods are not specific and sensitive. The present study aimed to develop a specific and sensitive assay method for the quantification of HBV cccDNA. Methods: Exonuclease Ⅰ(Exo Ⅰ)& Exonuclease Ⅲ(Exo Ⅲ) and specific primer probes are used in real-time PCR. The virus particles isolated from peripheral blood mononuclear cells were used as negative control and HBV1.3 recombinant plasmid 3.2 kb circular DNA fragment was used as positive control. The methods of cccDNA detection were evaluated in cell lines, plasmid, animal model, patient serum and liver biopsies. Results: A linear range of 10 1 –10 7 copies/assay using specific primers for HBV cccDNA was established. HBV cccDNA were only detected in cell lines, animal model and liver tissue. It cannot be detected in serum samples. Intrahepatic HBV cccDNA level had good correlation with intrahepatic total HBV DNA level ( r = 0.765, P < 0.001). Conclusions: The real-time quantitative PCR is an effective and feasible method for sensitive and specific detection of low copy number of cccDNA. The novel detection method is fast, provides high sensitivity and specificity and can be used in clinical practice.

关键词： Hepatitis B virus cccDNA Selective Sensitive