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Chinese Guidelines for the Diagnosis and Management of Atrial Fibrillation

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Journal of Geriatric Cardiology 2024年第3期21卷 251-314页

作者： Chang-Sheng MA Shu-Lin WU Shao-Wen LIU Ya-Ling HAN Chinese Society of Cardiology Chinese Medical Association Heart rhythm Committee of Chinese Society of Biomedical Engineering Beijing Anzhen Hospital Capital Medical University Guandong Provincial People’s Hospital Shanghai First People’s Hospital General Hospital of Northern Theater Command 不详

Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,significantly impacting patients’quality of life and increasing the risk of death,stroke,heart failure,and *** the past two decades,there have been significant breakthroughs in AF risk prediction and screening,stroke prevention,rhythm control,catheter ablation,and integrated *** this period,the scale,quality,and experience of AF management in China have greatly improved,providing a solid foundation for the development of guidelines for the diagnosis and management of *** further promote standardized AF management,and apply new technologies and concepts to clinical practice in a timely and comprehensive manner,the Chinese Society of Cardiology of the Chinese Medical Association and the Heart rhythm Committee of the Chinese Society of Biomedical Engineering have jointly developed the Chinese Guidelines for the Diagnosis and Management of Atrial *** guidelines have comprehensively elaborated on various aspects of AF management and proposed the CHA2DS2-VASc-60 stroke risk score based on the characteristics of AF in the Asian *** guidelines have also reevaluated the clinical application of AF screening,emphasized the significance of early rhythm control,and highlighted the central role of catheter ablation in rhythm control.

关键词： prevention sustained diagnosis

Chinese Guidelines for the Diagnosis and Management of Atrial Fibrillation

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Cardiology Discovery 2024年第2期4卷 89-133页

作者：无 Changsheng Ma Shulin Wu Shaowen Liu Yaling Han Chinese Society of Cardiology Chinese Medical Association Heart rhythm Committee of Chinese Society of Biomedical Engineering 不详

Atrial fibrillation(AF)is the most common sustained cardiac arrhythmia,significantly impacting patients'quality of life and increasing the risk of death,stroke,heart failure,and *** the past 2 decades,there have been significant breakthroughs in AF risk prediction and screening,stroke prevention,rhythm control,catheter ablation,and integrated *** this period,the scale,quality,and experience of AF management in China have greatly improved,providing a solid foundation for the development of guidelines for the diagnosis and management of *** further promote standardized AF management,and apply new technologies and concepts to clinical practice in a timely and comprehensive manner,the Chinese Society of Cardiology of the Chinese Medical Association and the Heart rhythm Committee of the Chinese Society of Biomedical Engineering have jointly developed the Chinese Guidelines for the Diagnosis and Management of Atrial *** guidelines have comprehensively elaborated on various aspects of AF management and proposed the CHA,DS,-VASc-60 stroke risk score based on the characteristics of AF in the Asian *** guidelines have also reevaluated the clinical application of AF screening,emphasized the significance of early rhythm control,and highlighted the central role of catheter ablation in rhythm control.

关键词： Atrial fibrillation Anticoagulation rhythm control Catheter ablation Integrated management Guideline

Molecules against COVID-19:An in Silico Approach for Drug Development

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Journal of Electronic Science and Technology 2021年第1期19卷 14-24页

作者： rhythm Bharti Sandeep Kumar Shukla the Sri Venkateswara College University of DelhiNew Delhi 110021. The Institute of Nuclear Medicine and Allied Sciences Defence Research and Development OrganizationDelhi 110054

A large number of deaths have been caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)worldwide,turning it into a serious and momentous threat to public *** study tends to contribute to the development of effective treatment strategies through a computational approach,investigating the mechanisms in relation to the binding and subsequent inhibition of SARS-CoV-2 ribonucleic acid(RNA)-dependent RNA polymerase(RdRp).Molecular docking was performed to screen six naturally occurring molecules with antineoplastic properties(Ellipticine,Ecteinascidin,Homoharringtonine,Dolastatin 10,Halichondrin,and Plicamycin).Absorption,distribution,metabolism,and excretion(ADME)investigation was also conducted to analyze the druglike properties of these *** docked results have clearly shown binding of ligands to the SARS-CoV-2 RdRp ***,all ligands were found to obey Lipinski’s rule of *** results provide a basis for repurposing and using molecules,derived from plants and animals,as a potential treatment for the coronavirus disease 2019(COVID-19)infection as they could be effective therapeutics for the same.

关键词： Coronavirus disease 2019(COVID-19) drug repurposing,molecular docking natural therapeutics RNA-dependent RNA polymerase(RdRp) severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).

Essential oils and its antibacterial,antifungal and anti-oxidant activity applications:A review

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Food Bioscience 2022年第3期47卷 145-160页

作者： Tianyu Hou Siva Sankar Sana Huizhen Li Yun Xing Anima Nanda vasudeva Reddy Netala Zhijun Zhang School of Chemical Engineering and Technology North University of ChinaTaiyuan030051China Jinzhong Institute of Industrial Technology and Innovation North University of ChinaJinzhong030600China Graduate School of Humanities Nagoya UniversityNagoya464-8601Japan Department of Biomedical Engineering Sathyabama Institute of Science and TechnologyChennaiTamilnaduIndia

Essential oils (EOs) seem to be more versatile and consist of a variety of volatile and organic biological active substances that are also employed as the better substitutes in the bacteria,fungal and various food *** researchers have done detailed research about the antibacterial property of essential oils and their respective *** several pioneering works in the past have explained the mode of action of some compounds,an extensive understanding of most of the substances and their molecular mechanisms is still *** particular,the bioactivity characteristics of EOs were evaluated by the main components found in *** components were commonly utilized in the applications of bactericidal,fungicidal,medicinal and antioxidant *** oils bioactivity can be contrasted with the behavior of pharmaceutical formulations which are produced ***,essential oils are showing promise organic extracts that require further analysis in the nutrition or pharmaceutical companies for potential applications as supplements,additives or *** of their diverse activities like antifungal and antibacterial characteristics,essential oils may be utilized as alternate additives to improve the grain and seed shelf *** review aims to provide a summary of existing information on the antibacterial and antifungal properties of EOs,their mechanism,and ingredients in identifying the areas of study that can promote the implementation in various bacterial and fungal properties.

关键词： Essential oils Terepnoids Antibacterial activity Antifungal activity Antioxidant activity

India and China to Lead Global Economic Recovery

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中印对话（英文版） 2023年第1期 36-37页

作者： PK vasudeva Panjab University in Chandigarh India

The global economy is poised to slow in 2023 before rebounding next *** will remain weak by historical standards as the fight against inflation as well as the Ukraine crisis weighs on economic *** these headwinds,the outlook appears less gloomy,and a turning point could be on the horizon,with growth bottoming out and inflation *** is in the interests of both India and China to increase their trade to become global ***'s GDP reached US$17.9 trillion in 2022,and the fast-growing Indian economy became the world's fth largest.

关键词： turning spite India

FINITE DIFFERENCE METHODS FOR THE HEAT EQUATION WITH A NONLOCAL BOUNDARY CONDITION

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Journal of Computational Mathematics 2015年第1期33卷 17-32页

作者： V. Thomee A.S. vasudeva Murthy Mathematical Sciences Chalmers University of Technology and University of Gothenburg SE-412 96 GSteborg Sweden TIFR Centre for Appl. Math Yelahanka New Town Bangalore India

We consider the numerical solution by finite difference methods of the heat equation in one space dimension, with a nonlocal integral boundary condition, resulting from the truncation to a finite interval of the problem on a semi-infinite interval. We first analyze the forward Euler method, and then the 0-method for 0 〈 θ ≤ 1, in both cases in maximum-norm, showing O（h2 ＋ k） error bounds, where h is the mesh-width and k the time step. We then give an alternative analysis for the case θ= 1/2, the Crank-Nicolson method, using energy arguments, yielding a O（h2 ＋ k3/2） error bound. Special attention is given the approximation of the boundary integral operator. Our results are illustrated by numerical examples.

关键词： Heat equation Artificial boundary conditions unbounded domains productquadrature.

Synthesis and antiepileptic studies of new imidazo[1,2-a]pyridine derivatives

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Chinese Chemical Letters 2013年第9期24卷 853-856页

作者： Shrikanth Ulloora Airody vasudeva Adhikari Ramakrishna Shabaraya Department of Chemistry National Institute of Technology Karnataka Srinivas College of Pharmacy

In this manuscript, we report the synthesis of newly designed imidazo[1,2-a]pyridines carrying active pharmacophores as potential anticonvulsant agents. Newly synthesized target compounds were characterized by FTIR, 1H NMR, 13C NMR, and mass spectroscopy followed by elemental analysis studies. Preliminary anticonvulsant screening study of target compounds was carried out following MES and scPTZ methods. Compounds 6e and 6f, possessing electron rich aryl substituent at position-2 and tolyl substituted oxazolone moiety at the position-3 of imidazoll,2-a]pyridine ring, exhibited activity comparable to standard drug diazepam and emerged as lead compounds. New compounds displayed enhanced activity in scPTZ method, indicating their ability to raise the seizure threshold. Their neurotoxicity study by Rotarod test showed that they are nontoxic at all tested doses.

关键词： Anticonvulsant tudylmidazol 1 2-alpyridineIn vivo studyNeurotoxicity

Natural Products:A safest Approach for Obesity

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Chinese Journal of Integrative Medicine 2012年第6期18卷 473-480页

作者： Neeru vasudeva Neerja Yadav Surendra Kumar Sharma Department of Pharmaceutical Sciences Guru JambheshwarUniversity of Science and Technology

Obesity is recognized as a social problem, associated with serious health risks and increased mortality. Numerous trials have been conducted to find and devetop new anti-obesity drugs through herbal sources to minimize adverse reactions associated with the present anti-obesity drugs. The use of natural products as medicine has been documented for hundreds of years in various traditional systems of medicines throughout the world. This review focuses on the medicinal plants such as Achyranthus aspera, Camellia sinensis, Emblica officinalis, Garcinia cambogia, Terminalia arjuna, etc., being used traditionally in Ayurvedic, Unani, Siddha and Chinese, etc., systems of medicine. The review also highlights recent reported phytechemicals such as escins, perennisosides, dioscin, gracillin, etc., and the various extracts of the plants like Nelumbo nucifera, Panax japonicas, Cichorium intybus, Cyperus rotunclus, Paeonia suffruticosa, etc., which have been successfully identified for the treatment of obesity.

关键词： Ayurveda Chinese medicine obesity Siddha Unani medicine

New carbazole based dyes as effective co-sensitizers for DSSCs sensitized with ruthenium(Ⅱ) complex(NCSU-10)

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Journal of Energy Chemistry 2018年第2期27卷 351-360页

作者： Praveen Naik Rui Su Mohamed R.Elmorsy Ahmed El-Shafei Airody vasudeva Adhikari Organic Materials Laboratory Department of ChemistryNational Institute of Technology Karnataka Polymer and Color Chemistry Program North Carolina State University

Herein, we report the design and synthesis of three new D-A type metal-free carbazole based dyes（S1-3）as effective co-sensitizers for dye-sensitized solar cell（DSSC） sensitized with Ru（Ⅱ） complex（NCSU-10）.In this new design, the electron rich carbazole unit was attached to three different electron withdrawing/anchoring species, viz. 4-amino benzoic acid, sulfanilic acid and barbituric acid. The dyes were characterized by spectral, photophysical and electrochemical analysis. Their optical and electrochemical parameters along with molecular geometries, optimized from DFT have been employed to apprehend the effect of the structures of these co-sensitizers on the photovoltaic performances. Further, S1-3 dyes were co-sensitized along with a well-known NCSU-10 dye in order to broaden the spectral response of the co-sensitized devices and hence improve the efficiency. The photovoltaic performance studies indicated that, the device fabricated using S1 dye as co-sensitizer with 0.2 mM of NCSU-10 exhibited improved PCE of 9.55% with JSC of 22.85 mA cm-2, VOC of 0.672 V and FF of 62.2%, whereas the DSSC fabricated with dye NCSU-10（0.2 mM） alone displayed PCE of 8.25% with JSC of 20.41 mA cm-2, VOC of 0.667 V and FF of 60.6%. Furthermore, electronic excitations simulated using time-dependent DFT, were in good agreement with the experimentally obtained results of the co-sensitizers, indicating that the exchange-correlation function and basis set utilized for predicting the spectra of the co-sensitizers are quite appropriate for the calculations. In conclusion, the results showed the potential of simple organic co-sensitizers in the development of efficient DSSCs.

关键词： Carbazole dyes DSSC DFF NCSU-10 Co-sensitization and photovoltaic performance